CN115070379B - ELISA plate assembling equipment and assembling method thereof - Google Patents
ELISA plate assembling equipment and assembling method thereof Download PDFInfo
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- CN115070379B CN115070379B CN202210796429.0A CN202210796429A CN115070379B CN 115070379 B CN115070379 B CN 115070379B CN 202210796429 A CN202210796429 A CN 202210796429A CN 115070379 B CN115070379 B CN 115070379B
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- elisa plate
- pressing
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- 238000002965 ELISA Methods 0.000 title claims abstract description 140
- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000007246 mechanism Effects 0.000 claims abstract description 103
- 238000003825 pressing Methods 0.000 claims abstract description 80
- 102000004190 Enzymes Human genes 0.000 claims description 31
- 108090000790 Enzymes Proteins 0.000 claims description 31
- 230000007306 turnover Effects 0.000 claims description 13
- 230000000149 penetrating effect Effects 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 3
- 238000013459 approach Methods 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims 2
- 238000007906 compression Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- 238000007599 discharging Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P19/00—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes
- B23P19/02—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes for connecting objects by press fit or for detaching same
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P19/00—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes
- B23P19/001—Article feeders for assembling machines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P19/00—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes
- B23P19/001—Article feeders for assembling machines
- B23P19/007—Picking-up and placing mechanisms
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Labeling Devices (AREA)
- Auxiliary Devices For And Details Of Packaging Control (AREA)
Abstract
The invention provides an ELISA plate assembling device and an assembling method thereof, wherein the assembling device comprises a workbench, and an ELISA plate positioning mechanism, an ELISA plate conveying mechanism, an ELISA plate frame conveying mechanism, a pressing device and a blanking mechanism which are arranged on the workbench.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an assembling device and an assembling method for automatically assembling an ELISA plate by an ELISA strip and an ELISA frame.
Background
The ELISA plate is a detection carrier assembled by an ELISA frame and an ELISA strip, in an ELISA adsorption test, the purity, concentration and proportion of antigens, antibodies, labeled antibodies or antigens participating in immunological reaction, the type of buffer solution, concentration and ionic strength, pH value, reaction temperature, time and other conditions play a key role, in the prior art, the ELISA strip and the ELISA frame are assembled by adopting a manual operation mode or a semi-automatic operation mode, and the assembly mode has low production efficiency and risk of polluting an observation surface to influence the production yield.
Disclosure of Invention
In view of the above, it is necessary to provide an assembling apparatus and an assembling method for automatically assembling an elisa strip and an elisa frame to form an elisa plate.
The invention provides an ELISA plate assembling device, which comprises:
A work table;
The ELISA strip positioning mechanism is arranged on the workbench and comprises a first sliding seat and a positioning device, and the positioning device is slidingly arranged on the first sliding seat and used for positioning a plurality of ELISA strips;
the ELISA strip conveying mechanism is arranged at one side of the ELISA strip positioning mechanism and is used for placing the ELISA strips with the bottoms upwards on the positioning device;
the enzyme label frame conveying mechanism is arranged on the other side of the enzyme label strip positioning mechanism and is used for sleeving the enzyme label strips positioned on the enzyme label strips with the front face of one enzyme label frame downwards;
the compressing device is arranged above the ELISA strip positioning mechanism and is used for compressing the ELISA strips in the ELISA frame to form an ELISA plate;
and the blanking mechanism is arranged at the rear of the pressing device and is used for transferring the ELISA plate to a designated position.
Further, the compressing device includes:
The first pressing mechanism comprises a first mounting seat, a first pressing plate and a first driving device, wherein the first driving device is arranged on the first mounting seat and drives the first pressing plate to move up and down right above the positioning device, a convex part is arranged at the bottom of the enzyme label frame, and the first driving device drives the first pressing plate to move downwards and press down the convex part;
The second pressing mechanism comprises a sliding table, a second mounting seat, a second pressing plate and a second driving device, and the second driving device is arranged on the second mounting seat and drives the second pressing plate to move up and down right above the sliding table;
The turnover device is arranged between the first pressing mechanism and the second pressing mechanism and comprises a supporting seat, a turnover shaft and a first clamping jaw, the turnover shaft is rotationally arranged on the supporting seat, the first clamping jaw is arranged on the turnover shaft and used for clamping the ELISA plate after being pre-pressed by the first pressing mechanism, the bottom of the ELISA plate is upward, the ELISA plate is placed on the sliding table, and the second pressing mechanism is used for pressing the ELISA plate on the sliding table again.
Further, the device also comprises a camera, wherein the camera is arranged at the rear of the pressing device and is used for detecting the ELISA plate.
Further, the unloading mechanism includes first conveyer belt, ELISA plate transfer manipulator and pin, first conveyer belt is used for right the ELISA plate is carried, pin liftable locate first conveyer belt top is used for right on the first conveyer belt the ELISA plate is blockked so that the camera detects, the ELISA plate transfer manipulator is used for with the yields that the camera detected shifts to appointed position.
Further, the blanking mechanism further comprises an ELISA plate stacking device and a second conveying belt, the ELISA plate stacking device vertically penetrates through the workbench, the second conveying belt is connected to one side of the ELISA plate stacking device and located below the workbench, the ELISA plate stacking device comprises a first supporting plate, a pushing plate and a third mounting seat, the first supporting plate is arranged on the third mounting seat in a lifting mode, the pushing plate is arranged on the first supporting plate and located on one side far away from the second conveying belt, after a certain number of ELISA plates are stacked on the first supporting plate, the first supporting plate moves downwards and is located on the same horizontal plane with the second conveying belt, and the pushing plate moves towards the direction of the second conveying belt to push the stacked ELISA plates onto the second conveying belt.
Further, the elisa strip conveying mechanism includes:
the distance changing device comprises a sliding rail, a plurality of jigs and a fourth driving device, wherein the jigs are slidably arranged on the sliding rail and used for placing the ELISA strips with the bottoms upwards and sliding on the sliding rail under the driving of the fourth driving device, a pull rod is connected between two adjacent jigs, and at least one jig can move relative to the pull rod;
And the ELISA strip transferring manipulator is arranged between the distance changing device and the positioning device and is used for transferring the plurality of ELISA strips which are arranged side by side after the distance changing device changes the distance to the positioning device, wherein the bottoms of the ELISA strips are upwards.
Further, the positioning device comprises a bottom plate, a second clamping jaw and a second supporting plate, wherein the second supporting plate is arranged on the bottom plate, the second clamping jaw comprises a fifth driving device and two clamping arms, the two clamping arms are respectively arranged on opposite sides of the second supporting plate and are centered to approach or separate away from each other through the fifth driving device, a plurality of concave surfaces are respectively arranged on clamping surfaces of the two clamping arms, one concave surface corresponds to one end part of the ELISA strip, and one concave surface opposite to the two clamping arms is used for centering the ELISA strip.
The invention also provides an ELISA plate assembling method, which is applied to the ELISA plate assembling device in any scheme, and is used for assembling a plurality of ELISA strips into an ELISA frame to form an ELISA plate, and the assembling method comprises the following steps:
Placing the plurality of ELISA strips with the bottoms upwards on a positioning device through an ELISA strip conveying mechanism;
Positioning the plurality of ELISA strips by the positioning device;
sleeving the positioned plurality of ELISA strips with the front face of an ELISA frame downwards through an ELISA frame conveying mechanism;
The plurality of ELISA strips are pressed in the ELISA frame by a pressing device to form the ELISA plate;
and transferring the ELISA plate to a designated position through a blanking mechanism.
Further, the step of pressing the plurality of elisa strips in the elisa frame by a pressing device to form the elisa plate includes:
Prepressing the enzyme label frame with the upward bottom and the plurality of enzyme label strips with the upward bottom on the positioning device through a first pressing mechanism;
the bottom of the pre-pressed ELISA plate is placed on a sliding table downwards through a turnover device;
And compacting the ELISA plate on the sliding table again through a second compacting mechanism.
Further, after the plurality of elisa strips are compressed in the elisa frame by the compressing device to form the elisa plate, the assembling method further includes:
and detecting the ELISA plate by a camera.
Compared with the prior art, the invention has the beneficial effects that: according to the invention, the bottom parts of the ELISA strips are upwards placed on the positioning device through the ELISA strip conveying mechanism, so that the bottom parts of the ELISA strips serving as the observation surface are prevented from being polluted, the ELISA strips are positioned through the positioning device, so that the ELISA frame conveying mechanism is used for sleeving the ELISA frames on the positioned ELISA strips with the front faces downwards, the ELISA strips are tightly pressed in the ELISA frames through the pressing device to form the ELISA plates, and the ELISA plates are transferred to the designated positions through the blanking mechanism, thereby completing the automatic assembly of the ELISA plates, not only improving the production efficiency, but also improving the production yield.
Drawings
FIG. 1 is a schematic diagram of an ELISA strip, an ELISA frame and an ELISA plate.
Fig. 2 is an overall schematic of an embodiment of the present invention.
FIG. 3 is a schematic diagram of an embodiment of the ELISA strip positioning mechanism of the invention.
Fig. 4 is a schematic view of an embodiment of the pressing device of the present invention.
Fig. 5 is a schematic view of a first embodiment of the pressing mechanism of the present invention.
Fig. 6 is a schematic view of a second embodiment of the pressing mechanism of the present invention.
Fig. 7 is a schematic view of an embodiment of the turning device of the present invention.
Fig. 8 is a schematic view of an embodiment of the positioning device of the present invention.
FIG. 9 is a schematic diagram of an embodiment of the ELISA strip-feeding mechanism of the invention.
FIG. 10 is a schematic view of an embodiment of the pitch device of the present invention.
FIG. 11 is a schematic diagram of an embodiment of a microplate reader delivery mechanism of the present invention.
Fig. 12 is a schematic view of an embodiment of the blanking mechanism of the present invention.
FIG. 13 is a schematic view showing an embodiment of the ELISA plate stacking apparatus of the invention.
FIG. 14 is a first flow chart of the assembly method of the present invention.
Fig. 15 is a second flow chart of the assembly method of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention. It is to be understood that the drawings are designed solely for the purposes of illustration and not as a definition of the limits of the invention. The connection relationships shown in the drawings are for convenience of clarity of description only and are not limiting on the manner of connection.
It is noted that when one component is considered to be "connected" to another component, it may be directly connected to the other component, or intervening components may also be present. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It should also be noted that the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected, unless otherwise specifically defined and limited; either mechanically or electrically, or by communication between two components. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
It should be further noted that, in the description of the present invention, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are based on directions or positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific direction, be configured and operated in the specific direction, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Referring to fig. 1-3, the present invention provides an elisa plate assembling apparatus for assembling a plurality of elisa strips 1 with an elisa frame 2 to form an elisa plate 3, where the assembling apparatus includes a workbench 100, and an elisa strip positioning mechanism 10, an elisa strip conveying mechanism 20, an elisa frame conveying mechanism 30, a pressing device 40, a camera 50 and a blanking mechanism 60 disposed on the workbench 100.
The ELISA strip positioning mechanism 10 comprises a first slide 11 and a positioning device 12, wherein the positioning device 12 is slidably arranged on the first slide 11 and the position of the positioning device on the first slide 11 is changed by a sixth driving device 13, so that the positioning device 12 can move among the ELISA strip conveying mechanism 20, the ELISA frame conveying mechanism 30 and the compacting device 40.
Wherein, the positioning device 12 is used for positioning the plurality of ELISA strips 1.
The elisa strip conveying mechanism 20 is disposed at one side of the elisa strip positioning mechanism 10, and is configured to place the plurality of elisa strips 1 with bottoms facing upwards on the positioning device 12.
The enzyme label frame conveying mechanism 30 is arranged at the other side of the enzyme label strip positioning mechanism 10, and is used for sleeving the enzyme label strips 1 positioned with the enzyme label frame 2 with the front face facing downwards.
The pressing device 40 is arranged above the elisa strip positioning mechanism 10, and is used for pressing the plurality of elisa strips 1 into the elisa frame 2 to form the elisa plate 3.
The camera 50 is disposed at the rear of the pressing device 40, and is configured to detect the elisa plate 3 pressed by the pressing device 40, so as to avoid the defect of the elisa strip 1 or the defect of the broken elisa strip 1, such as the fact that the elisa plate 3 flows into a good product.
The blanking mechanism 60 is disposed at the rear of the pressing device 40, and is used for transferring the elisa plate 3 to a designated position.
Referring to fig. 4, the pressing device 40 includes a first pressing mechanism 41, a second pressing mechanism 42, and a turning device 43.
Referring to fig. 5, the first pressing mechanism 41 is configured to pre-press the plurality of elisa strips 1 and the elisa frame 2 located on the positioning device 12 to form the pre-pressed elisa plate 3.
The first pressing mechanism 41 includes a first mounting seat 411, a first pressing plate 412, and a first driving device 413.
The first driving device 413 is disposed on the first mounting seat 411, and drives the first pressing plate 412 to move up and down directly above the positioning device 12.
In one embodiment, the output end of the first driving device 413 is further connected with at least one first guide plate 414, a first guide sleeve 415 is penetrated on the first guide plate 414, a first guide rod 416 vertically arranged is penetrated on the first guide sleeve 415, one end of the first guide rod 416 is connected with the upper surface of the first pressing plate 412, and the other end of the first guide rod 416 is movably penetrated on the first mounting seat 411 and always keeps at least partially extending out of the first mounting seat 411.
In another embodiment, the first guide plate 414 is provided with a plurality of first guide sleeves 415 in a penetrating manner, and one first guide rod 416 is provided on one first guide sleeve 415 in a penetrating manner.
In other embodiments, the output end of the first driving device 413 is further connected to a first fixing plate 417, the first fixing plate 417 is located between the first guide plate 414 and the first pressing plate 412, and one end of the first guide rod 416 away from the first mounting seat 411 is connected to the first fixing plate 417.
The bottom of the ELISA plate 2 is provided with a convex part 4, the first driving device 413 drives the first pressing plate 412 to move downwards and press the convex part 4 downwards, so that the first pressing plate 412 can not contact with the observation surfaces 5 of the ELISA strips 1 when pressing the ELISA plate 2 downwards, the observation surfaces 5 are prevented from being polluted, and the production yield of the ELISA plate 3 is effectively improved. The observation surface 5 is the bottom surface of the ELISA strip 1.
Referring to fig. 6, the second pressing mechanism 42 is disposed behind the first pressing mechanism 41, and is configured to press the elisa plate 3 pre-pressed by the first pressing mechanism 41 again to obtain the assembled elisa plate 3.
The second pressing mechanism 42 includes a sliding table 421, a second sliding seat 422, a second mounting seat 423, a second pressing plate 424, and a second driving device 425.
The sliding table 421 is slidably disposed on the second sliding base 422, and is driven by a seventh driving device 426 to change the position of the sliding table 421 on the second sliding base 422.
The sliding table 421 has a feeding position, a press-fitting position, and a discharging position on the second sliding seat 422.
The loading position corresponds to the turning device 43, and is configured to receive the elisa plate 3 turned by the turning device 43, with the front side facing upwards and after being pre-pressed.
The press-fitting position is located right below the second pressing plate 424, and is used for cooperating with the second pressing plate 424 to compress the pre-pressed and right-side-up elisa plate 3 again.
The height of the elisa strip 1 is smaller than that of the elisa frame 2, so that when the second pressing plate 424 presses the opening surface of the elisa strip 1 and the front surface of the elisa frame 2 to the same plane, the viewing surface 5 of the elisa strip 1 does not protrude out of the protrusion 4 of the elisa frame 2.
The discharging position corresponds to the discharging mechanism 60, and is used for transferring the enzyme-labeled plate 3 which is finally pressed to the discharging mechanism 60.
The second driving device 425 is disposed on the second mounting seat 423, and drives the second pressing plate 424 to move up and down directly above the sliding table 421.
In one embodiment, the output end of the second driving device 425 is further connected with at least one second guide plate 427, a second guide sleeve 4271 is disposed on the second guide plate 427 in a penetrating manner, a second guide rod 4272 disposed vertically is disposed on the second guide sleeve 4271 in a penetrating manner, one end of the second guide rod 4272 is connected with the upper surface of the second pressing plate 424, and the other end of the second guide rod 4272 is movably disposed on the second mounting seat 423 in a penetrating manner and always keeps at least partially extending out of the second mounting seat 423.
In another embodiment, the second guide plate 427 is perforated with a plurality of second guide sleeves 4271, and one second guide rod 4272 is perforated on one second guide sleeve 4271.
In other embodiments, the output end of the second driving device 425 is further connected to a second fixing plate 428, the second fixing plate 428 is located between the second guiding plate 427 and the second pressing plate 424, and one end of the second guide rod 4272 away from the second mounting seat 423 is connected to the second fixing plate 428.
Referring to fig. 7, the turning device 43 is disposed between the first pressing mechanism 41 and the second pressing mechanism 42, and is configured to turn the pre-pressed and bottom-up elisa plate 3 to a bottom-down position and place the same on the second pressing mechanism 42.
The tilting device 43 comprises a support 431, a tilting shaft 432, an eighth driving device 433 and a first clamping jaw 434.
The turnover shaft 432 is rotatably provided on the support 431 and is rotated by the eighth driving device 433.
The first clamping jaw 434 is disposed on the turnover shaft 432, and is used for clamping the elisa plate 3 after the first pressing mechanism 41 is pre-pressed and with the bottom facing upwards, and placing the elisa plate 3 on the sliding table 421 with the bottom facing downwards, so that the second pressing plate 424 is convenient for pressing the elisa plate 3 on the sliding table 421 again.
Specifically, the first jaw 434 has a gripping position and a release position. The gripping position and the releasing position are switched by driving the turning shaft 432 to rotate by the eighth driving device 433.
Preferably, the first jaw 434 is flipped 180 degrees from the gripping position to the release position.
When the first clamping jaw 434 is located at the clamping position, the first clamping jaw 434 clamps the pre-pressed enzyme-labeled frame 3 with the bottom up on the positioning device 12.
When the first clamping jaw 434 is located at the release position, the first clamping jaw 434 turns the pre-pressed elisa plate 3 to be placed on the sliding table 421 located at the feeding position with the bottom facing downwards.
Preferably, a third fixing plate 435 is further disposed below the support seat 431, a plurality of third guide sleeves 436 are disposed on the third fixing plate 435, a third guide rod 437 is vertically disposed on the third guide sleeve 436 in a penetrating manner, a top end of the third guide rod 437 is connected with the support seat 431, and a first lifting driving device 438 for driving the support seat 431 to move in a vertical direction is further disposed on the third fixing plate 435, so that lifting adjustment of the first clamping jaw 434 can be further achieved.
Referring to fig. 8 in combination with fig. 3, the positioning device 12 includes a bottom plate 121, a second clamping jaw 122, and a second supporting plate 123, where the second supporting plate 123 is disposed on the bottom plate 121.
The second clamping jaw 122 includes a fifth driving device 1221 and two clamping arms 1222, and the two clamping arms 1222 are respectively disposed on opposite sides of the second supporting plate 123 and are centered close to or far away from each other by the fifth driving device 1221.
In one embodiment, two clamping arms 1222 are slidably disposed on the bottom plate 121, and the two clamping arms 1222 are respectively spaced from the side surface of the corresponding second support plate 123 by the same distance.
The bottom plate 121 is provided with a rotation shaft 124, the rotation shaft 124 is located under the center line of the second support plate 123, and a first rotation arm 125 is hinged to the rotation shaft 124, where the distance between two ends of the first rotation arm 125 and the rotation shaft 124 is equal.
The two ends of the first rotating arm 125 are respectively hinged to one clamping arm 1222 through a second rotating arm 126, and the fifth driving device 1221 drives one clamping arm 1222 to move, so that the other clamping arm 1222 moves synchronously in a direction approaching or separating the two clamping arms 1222 relative to the second supporting plate 123 under the combined action of the rotating shaft 124, the first rotating arm 125 and the second rotating arm 126.
Further, the clamping surfaces of the two clamping arms 1222 are respectively provided with a plurality of concave surfaces 1223, one concave surface 1223 corresponds to an end of one elisa strip 1, and one concave surface 1223 opposite to the two clamping arms 1222 is used for centering one elisa strip 1, so as to avoid that the two elisa strips 1 deviate between the two clamping arms 1222 when the two clamping arms 1222 center the plurality of elisa strips 1, which results in the misalignment.
Referring to fig. 9-10, the elisa strip conveying mechanism 20 includes a distance-changing device 21 and an elisa strip transferring manipulator 22, wherein the elisa strip transferring manipulator 22 is disposed between the distance-changing device 21 and the positioning device 12, and is configured to transfer the plurality of elisa strips 1, which are arranged side by side and separated by the distance-changing device 21, from the bottom upwards to the positioning device 12.
Specifically, the distance-changing device 21 is slidably disposed on the third slide seat 23, and is configured to cooperate with the elisa strip transferring manipulator 22 to transfer the plurality of elisa strips 1 after distance change.
In one embodiment, the distance-varying device 21 may be used to connect with an elisa strip forming apparatus (not shown), and is configured to vary distances between the plurality of elisa strips 1 produced by the elisa strip forming apparatus at different distances, so that the sides of the plurality of elisa strips 1 abut against each other, so that the plurality of elisa strips 1 are placed on the positioning device 12 to perform alignment, thereby realizing the production of the elisa strip forming apparatus and the elisa plate assembling apparatus by connecting wires.
The distance-changing device 21 comprises a sliding rail 211, a plurality of jigs 212 and a fourth driving device 213, wherein the jigs 212 are slidably arranged on the sliding rail 211 and used for placing the elisa strips 1 with the bottoms upwards, and slide on the sliding rail 211 under the driving of the fourth driving device 213, wherein a pull rod 214 is connected between two adjacent jigs 212, and at least one jig 212 can move relative to the pull rod 214.
Specifically, at least two positioning nozzles 215 are disposed on one of the jigs 212, and when the inverted buckle of one of the elisa strips 1 is disposed on the jig 212, at least two elisa holes 6 of the elisa strip 1 are respectively covered on one of the positioning nozzles 215.
Referring to fig. 11, the microplate frame transferring mechanism 30 includes a conveyor assembly 31, a lifting device 32 and a microplate frame transferring robot 33.
The conveyor belt assembly 31 is used for conveying the enzyme label frames 2 one by one, and the jacking device 32 is used for jacking up the enzyme label frames 2 on the conveyor belt assembly 31, so that the enzyme label frame transferring manipulator 33 grabs and sleeves the enzyme label frames 2 on the aligned enzyme label strips 1 on the positioning device 12.
The conveyor belt assembly 31 comprises a conveyor bracket 311 and a conveyor belt 312, the conveyor belt 312 is arranged on the conveyor bracket 311, and gaps are reserved between two sides of the conveyor belt 312 and the conveyor bracket 311, so that the jacking device 32 can conveniently jack the microplate reader frame 2 through the gaps.
In one embodiment, the microplate frames 2 may be manually placed one by one on the conveyor 312 and transported back through the conveyor 312.
In another embodiment, the feeding end of the conveyor belt 312 may be connected to a microplate-reader forming device (not shown), so that the microplate-reader 2 produced by the microplate-reader forming device is directly conveyed onto the conveyor belt 312, and the in-line production of the microplate-reader forming device and the microplate assembly device is achieved.
The jacking device 32 comprises a second lifting driving device 321 and a plurality of jacking rods 322, wherein the jacking rods 322 are vertically arranged on the second lifting driving device 321, and the second lifting driving device 321 drives the enzyme label frame 2 to move upwards and penetrate through the gaps to jack the enzyme label frame upwards.
Preferably, a guiding inclined plane is disposed at an end of the ejector rod 322 away from the second lifting driving device 321.
Referring to fig. 12-13, the blanking mechanism 60 includes a first conveyor belt 61, an elisa plate transferring manipulator 62 and a stop lever 63, wherein the first conveyor belt 61 is used for conveying the elisa plate 3, the stop lever 63 is liftable disposed above the first conveyor belt 61 and is used for blocking the elisa plate 3 on the first conveyor belt 61 so as to facilitate the detection of the camera 50, and the elisa plate transferring manipulator 62 is used for transferring good products detected by the camera 50 to the designated positions.
Specifically, the second sliding seat 422 is provided with a notch 4221 corresponding to the discharging position of the sliding table 421, and the feeding end of the first conveying belt 61 is disposed at the notch 4221. The second mounting seat 423 is provided with a push rod 4231 opposite to the notch 4221, and when the elisa plate 3 moves to the notch 4221 via the sliding table 421, the push rod 4231 moves towards the first conveyor belt 61 and pushes the elisa plate 3 onto the first conveyor belt 61.
Further, the end of the first conveyor 61 is further provided with a waste box 70, and the elisa plate 3 identified by the camera 50 as a defective product will not be transferred to the designated position by the elisa plate transfer robot 62, but will be continuously and backwardly conveyed by the first conveyor 61 to the end of the first conveyor 61 and directly fall into the waste box 70.
Further, the blanking mechanism 60 further includes an elisa plate stacking device 64 and a second conveyor belt 65. The elisa plate stacking device 64 is vertically penetrating through the workbench 100, and is used for stacking the good products identified by the camera 50. The second conveyor belt 65 is connected to one side of the microplate reader 64 and located below the table 100 for conveying the plurality of stacked microplate readers 64 back to the designated position.
The second conveyor belt 65 is arranged below the workbench 100, and the transfer efficiency of the ELISA plate 3 is higher through the ELISA plate transfer manipulator 62 and the ELISA plate stacking device 64, and the space below the workbench is fully utilized.
The elisa plate stacking device 64 comprises a first support plate 641, a push plate 642 and a third mounting seat 643, wherein the first support plate 641 is arranged on the third mounting seat 643 in a lifting manner, and the stacked elisa plates 3 are limited through the third mounting seat 643.
Specifically, the third mounting seat 643 is provided with a third lifting driving device 644, and the first support plate 641 is lifted by the third lifting driving device 644.
Preferably, the first support plate 641 is further provided with a plurality of limit bars 645, and the plurality of limit bars 645 are limited to the peripheral side of the elisa plate 3 when the elisa plate 3 is transferred onto the elisa plate stacking device 64 by the elisa plate transfer robot 62.
In one embodiment, the push plate 642 is disposed on the first support plate 641 and located at a side away from the second conveyor belt 65, and when a certain number of the elisa plates 3 are stacked on the first support plate 641, the first support plate 641 moves downward and is in the same horizontal plane as the second conveyor belt 65, and the push plate 642 moves in the direction of the second conveyor belt 65 to push the stacked elisa plates 3 onto the second conveyor belt 65.
In another embodiment, the push plate 642 is disposed at the bottom of the third mount 643 and is away from the side of the second conveyor belt 65.
Referring to fig. 2 again, in one embodiment, the elisa positioning mechanism 10, the elisa conveying mechanism 20, the elisa frame conveying mechanism 30, the compacting device 40, the camera 50 and the blanking mechanism 60 are each provided with one group.
In another embodiment, the elisa strip positioning mechanism 10, the elisa strip conveying mechanism 20, the elisa frame conveying mechanism 30, the pressing device 40, the camera 50 and the blanking mechanism 60 are respectively provided with two groups, so that the assembly equipment is in a double-station production mode.
In other embodiments, one of the elisa strip conveying mechanisms 20 corresponds to one of the elisa frame conveying mechanisms 30, two of the elisa strip positioning mechanisms 10, two of the pressing devices 40, two of the cameras 50 and one of the blanking mechanisms 60.
Referring to fig. 14, the present invention further provides an assembly method of an elisa plate, which is applied to the above-mentioned assembly device of an elisa plate, and the assembly method includes the following steps:
Placing the plurality of ELISA strips 1 with the bottoms upwards on the positioning device 12 through the ELISA strip conveying mechanism 20 (S10);
Positioning the plurality of enzyme-linked immunosorbent assay strips 1 by the positioning device 12 (S20);
Sleeving the positioned plurality of ELISA strips 1 with the front face of an ELISA frame 2 downwards through an ELISA frame conveying mechanism 30 (S30);
the plurality of ELISA strips 1 are pressed into the ELISA plate 2 by a pressing device 40 to form the ELISA plate 3 (S40);
The ELISA plate 3 is transferred to a designated position by a discharging mechanism 60 (S50).
Referring to fig. 15, further, the step of pressing the plurality of elisa strips 1 in the elisa frame 2 by the pressing device 40 to form the elisa plate 3 (S40) includes:
prepressing the enzyme label frame 2 with the bottom upwards and the enzyme label strips 1 with the bottom upwards, which are positioned on the positioning device 12, through a first pressing mechanism 41 (S41);
placing the pre-pressed ELISA plate 3 on a sliding table 421 with the bottom downward through a turnover device 43 (S42);
the ELISA plate 3 placed on the slide 421 is again pressed by the second pressing mechanism 42 (S43).
Further, after the plurality of elisa strips 1 are compressed in the elisa frame 2 by the compressing device 40 to form the elisa plate 3 (S40), the assembling method further includes:
the ELISA plate 3 is detected by the camera 50 (S60).
In the description and claims of the present application, the words "comprise/comprising" and the words "have/include" and variations thereof are used to specify the presence of stated features, values, steps, or components, but do not preclude the presence or addition of one or more other features, values, steps, components, or groups thereof.
Some features of the invention, which are, for clarity of illustration, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, some features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable combination in different embodiments.
The foregoing description of the preferred embodiment of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (9)
1. ELISA plate equipment, its characterized in that includes:
A work table;
The ELISA strip positioning mechanism is arranged on the workbench and comprises a first sliding seat and a positioning device, and the positioning device is slidingly arranged on the first sliding seat and used for positioning a plurality of ELISA strips;
the ELISA strip conveying mechanism is arranged at one side of the ELISA strip positioning mechanism and is used for placing the ELISA strips with the bottoms upwards on the positioning device;
the enzyme label frame conveying mechanism is arranged on the other side of the enzyme label strip positioning mechanism and is used for sleeving the enzyme label strips positioned on the enzyme label strips with the front face of one enzyme label frame downwards;
the compressing device is arranged above the ELISA strip positioning mechanism and is used for compressing the ELISA strips in the ELISA frame to form an ELISA plate;
the blanking mechanism is arranged behind the pressing device and used for transferring the ELISA plate to a designated position;
The compressing apparatus includes:
The first pressing mechanism comprises a first mounting seat, a first pressing plate and a first driving device, wherein the first driving device is arranged on the first mounting seat and drives the first pressing plate to move up and down right above the positioning device, a convex part is arranged at the bottom of the enzyme label frame, and the first driving device drives the first pressing plate to move downwards and press down the convex part;
The second pressing mechanism comprises a sliding table, a second mounting seat, a second pressing plate and a second driving device, and the second driving device is arranged on the second mounting seat and drives the second pressing plate to move up and down right above the sliding table;
The turnover device is arranged between the first pressing mechanism and the second pressing mechanism and comprises a supporting seat, a turnover shaft and a first clamping jaw, the turnover shaft is rotationally arranged on the supporting seat, the first clamping jaw is arranged on the turnover shaft and used for clamping the ELISA plate after being pre-pressed by the first pressing mechanism, the bottom of the ELISA plate is upward, the ELISA plate is placed on the sliding table, and the second pressing mechanism is used for pressing the ELISA plate on the sliding table again.
2. The microplate assembly apparatus of claim 1, further comprising a camera disposed behind the hold down device for detecting the microplate.
3. The elisa plate assembling device according to claim 2, wherein the blanking mechanism comprises a first conveyor belt, an elisa plate transferring manipulator and a stop lever, the first conveyor belt is used for conveying the elisa plate, the stop lever is arranged above the first conveyor belt in a lifting manner and is used for blocking the elisa plate on the first conveyor belt so as to facilitate the detection of the camera, and the elisa plate transferring manipulator is used for transferring good products detected by the camera to the designated position.
4. The elisa plate assembling apparatus according to claim 3, wherein the blanking mechanism further comprises an elisa plate stacking device and a second conveyor belt, the elisa plate stacking device is vertically arranged on the workbench in a penetrating manner, the second conveyor belt is connected to one side of the elisa plate stacking device and is positioned below the workbench, the elisa plate stacking device comprises a first support plate, a push plate and a third mounting seat, the first support plate is arranged on the third mounting seat in a lifting manner, the push plate is arranged on the first support plate and is positioned on one side far away from the second conveyor belt, and when a certain number of elisa plates are stacked on the first support plate, the first support plate moves downwards and is positioned on the same horizontal plane as the second conveyor belt, and the push plate moves towards the direction of the second conveyor belt to push the stacked elisa plates onto the second conveyor belt.
5. The microplate assembly apparatus of claim 1, wherein the microplate strip conveying mechanism comprises:
the distance changing device comprises a sliding rail, a plurality of jigs and a fourth driving device, wherein the jigs are slidably arranged on the sliding rail and used for placing the ELISA strips with the bottoms upwards and sliding on the sliding rail under the driving of the fourth driving device, a pull rod is connected between two adjacent jigs, and at least one jig can move relative to the pull rod;
And the ELISA strip transferring manipulator is arranged between the distance changing device and the positioning device and is used for transferring the plurality of ELISA strips which are arranged side by side after the distance changing device changes the distance to the positioning device, wherein the bottoms of the ELISA strips are upwards.
6. The elisa plate assembling device according to claim 1, wherein the positioning device comprises a bottom plate, a second clamping jaw and a second supporting plate, the second supporting plate is arranged on the bottom plate, the second clamping jaw comprises a fifth driving device and two clamping arms, the two clamping arms are respectively arranged on opposite sides of the second supporting plate and are centered to approach or separate from each other through the fifth driving device, a plurality of concave surfaces are respectively arranged on clamping surfaces of the two clamping arms, one concave surface corresponds to one end part of the elisa strip, and one concave surface opposite to the two clamping arms is used for centering one elisa strip.
7. An elisa plate assembling method applied to the elisa plate assembling apparatus of any one of claims 1 to 6 for assembling a plurality of elisa strips into an elisa frame to form an elisa plate, comprising the steps of:
Placing the plurality of ELISA strips with the bottoms upwards on a positioning device through an ELISA strip conveying mechanism;
Positioning the plurality of ELISA strips by the positioning device;
sleeving the positioned plurality of ELISA strips with the front face of an ELISA frame downwards through an ELISA frame conveying mechanism;
The plurality of ELISA strips are pressed in the ELISA frame by a pressing device to form the ELISA plate;
and transferring the ELISA plate to a designated position through a blanking mechanism.
8. The method of assembling an elisa plate of claim 7 wherein the step of compressing the plurality of elisa strips within the elisa frame by a compression device comprises:
Prepressing the enzyme label frame with the upward bottom and the plurality of enzyme label strips with the upward bottom on the positioning device through a first pressing mechanism;
the bottom of the pre-pressed ELISA plate is placed on a sliding table downwards through a turnover device;
And compacting the ELISA plate on the sliding table again through a second compacting mechanism.
9. The method of assembling an elisa plate of claim 7 wherein after the plurality of elisa strips are compressed within the elisa frame by a compression device to form the elisa plate, the method further comprises:
and detecting the ELISA plate by a camera.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210796429.0A CN115070379B (en) | 2022-07-06 | 2022-07-06 | ELISA plate assembling equipment and assembling method thereof |
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| CN202210796429.0A CN115070379B (en) | 2022-07-06 | 2022-07-06 | ELISA plate assembling equipment and assembling method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207081740U (en) * | 2017-06-30 | 2018-03-09 | 武汉道培胎盘干细胞生物技术有限公司 | A kind of multichannel ELIASA |
| CN108190507A (en) * | 2018-02-08 | 2018-06-22 | 东莞凯钛塑胶制品有限公司 | The automatic assembly line of cosmetic container |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101839909A (en) * | 2010-05-07 | 2010-09-22 | 杭州南开日新生物技术有限公司 | Method for preparing chloramphenicol detecting reagent plate |
| CN208758926U (en) * | 2018-07-13 | 2019-04-19 | 东莞市伟力合机器人有限公司 | A kind of charging tray assembling device with turn over function |
| CN209736971U (en) * | 2019-03-11 | 2019-12-06 | 杭州百殷生物科技有限公司 | Elisa plate dismounting device |
| KR20210036579A (en) * | 2019-09-26 | 2021-04-05 | 현대자동차주식회사 | Parts assembling system and method |
| CN114901423B (en) * | 2020-03-31 | 2024-01-16 | 广东利元亨智能装备股份有限公司 | Assembly line of phase actuator |
| CN212705374U (en) * | 2020-04-23 | 2021-03-16 | 南京埃肯度智能科技有限公司 | Medical kit assembling machine |
| CN212145232U (en) * | 2020-05-06 | 2020-12-15 | 开平赛道龙头配件有限公司 | Automatic valve element assembly line |
| CN212173775U (en) * | 2020-11-20 | 2020-12-18 | 山东畜牧兽医职业学院 | ELIASA plate conveyor for ELIASA |
| CN216807250U (en) * | 2022-03-12 | 2022-06-24 | 赛诺医疗智能科技(深圳)有限公司 | Enzyme label clamping mechanism |
-
2022
- 2022-07-06 CN CN202210796429.0A patent/CN115070379B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207081740U (en) * | 2017-06-30 | 2018-03-09 | 武汉道培胎盘干细胞生物技术有限公司 | A kind of multichannel ELIASA |
| CN108190507A (en) * | 2018-02-08 | 2018-06-22 | 东莞凯钛塑胶制品有限公司 | The automatic assembly line of cosmetic container |
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