CN115066253A - Il2突变蛋白 - Google Patents

Il2突变蛋白 Download PDF

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Publication number
CN115066253A
CN115066253A CN202180009469.XA CN202180009469A CN115066253A CN 115066253 A CN115066253 A CN 115066253A CN 202180009469 A CN202180009469 A CN 202180009469A CN 115066253 A CN115066253 A CN 115066253A
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China
Prior art keywords
wild type
polypeptide
mutein
cells
wild
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Pending
Application number
CN202180009469.XA
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English (en)
Chinese (zh)
Inventor
J·埃默里希
S·考德
S·A·麦克考雷
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Sindkain Co ltd
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Sindkain Co ltd
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Priority to CN202511566818.4A priority Critical patent/CN121319219A/zh
Priority to CN202511566821.6A priority patent/CN121554597A/zh
Publication of CN115066253A publication Critical patent/CN115066253A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
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  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
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  • Virology (AREA)
  • Pulmonology (AREA)
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  • Rheumatology (AREA)
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CN202180009469.XA 2020-01-14 2021-01-14 Il2突变蛋白 Pending CN115066253A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202511566818.4A CN121319219A (zh) 2020-01-14 2021-01-14 Il2突变蛋白
CN202511566821.6A CN121554597A (zh) 2020-01-14 2021-01-14 Il2突变蛋白

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062960847P 2020-01-14 2020-01-14
US62/960,847 2020-01-14
PCT/US2021/013514 WO2021146481A1 (en) 2020-01-14 2021-01-14 Il2 muteins

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202511566821.6A Division CN121554597A (zh) 2020-01-14 2021-01-14 Il2突变蛋白
CN202511566818.4A Division CN121319219A (zh) 2020-01-14 2021-01-14 Il2突变蛋白

Publications (1)

Publication Number Publication Date
CN115066253A true CN115066253A (zh) 2022-09-16

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Application Number Title Priority Date Filing Date
CN202180009469.XA Pending CN115066253A (zh) 2020-01-14 2021-01-14 Il2突变蛋白
CN202511566821.6A Pending CN121554597A (zh) 2020-01-14 2021-01-14 Il2突变蛋白
CN202511566818.4A Pending CN121319219A (zh) 2020-01-14 2021-01-14 Il2突变蛋白

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CN202511566821.6A Pending CN121554597A (zh) 2020-01-14 2021-01-14 Il2突变蛋白
CN202511566818.4A Pending CN121319219A (zh) 2020-01-14 2021-01-14 Il2突变蛋白

Country Status (10)

Country Link
US (1) US20230210951A1 (https=)
EP (1) EP4090354A4 (https=)
JP (1) JP2023510871A (https=)
KR (1) KR20220127866A (https=)
CN (3) CN115066253A (https=)
AU (1) AU2021207661A1 (https=)
CA (1) CA3166009A1 (https=)
IL (1) IL294070A (https=)
MX (1) MX2022008770A (https=)
WO (1) WO2021146481A1 (https=)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
KR102777151B1 (ko) 2017-11-21 2025-03-05 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인터루킨-2의 부분 효능제
WO2021146436A2 (en) 2020-01-14 2021-07-22 Synthekine, Inc. Biased il2 muteins methods and compositions
EP4357357A4 (en) * 2021-07-30 2025-01-08 Dracoterpin Biomedicine LLC HUMAN INTERLEUKIN-2 VARIANT AND ITS USE
CA3234552A1 (en) 2021-10-20 2023-04-27 Synthekine, Inc. Heterodimeric fc cytokines and uses thereof
WO2024086739A1 (en) 2022-10-20 2024-04-25 Synthekine, Inc. Methods and compositions of il12 muteins and il2 muteins

Citations (3)

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US9567399B1 (en) * 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
WO2019092181A1 (en) * 2017-11-10 2019-05-16 Agency For Science, Technology And Research Il2rbeta/common gamma chain antibodies
WO2019104092A1 (en) * 2017-11-21 2019-05-31 The Board Of Trustees Of The Leland Stanford Junior University Partial agonists of interleukin-2

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DZ2788A1 (fr) * 1998-05-15 2003-12-01 Bayer Ag Agonistes et antagonistes selectifs à IL-2.
CA2644513A1 (en) * 2006-03-03 2007-09-07 London Health Sciences Centre Research Inc. Preventing il-2 mediated inflammation in epithelial cells
AU2010206840B2 (en) * 2009-01-21 2015-02-05 Amgen Inc. Compositions and methods of treating inflammatory and autoimmune diseases
CA2860170C (en) * 2010-12-22 2022-06-14 The Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
WO2015164815A1 (en) * 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
EP3538548A4 (en) * 2016-11-08 2020-08-19 Delinia, Inc. IL-2 VARIANTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
KR20250156190A (ko) * 2018-06-22 2025-10-31 큐진 인크. 인터루킨-2 변이체 및 이의 사용 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9567399B1 (en) * 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
WO2019092181A1 (en) * 2017-11-10 2019-05-16 Agency For Science, Technology And Research Il2rbeta/common gamma chain antibodies
WO2019104092A1 (en) * 2017-11-21 2019-05-31 The Board Of Trustees Of The Leland Stanford Junior University Partial agonists of interleukin-2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUMAN MITRA: "Interleukin-2 Activity can be Fine-Tuned with Engineered Receptor Signaling Clamps", 《IMMUNITY》, vol. 42, no. 5, 1 May 2015 (2015-05-01), pages 1, XP055539278, DOI: 10.1016/j.immuni.2015.04.018 *

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KR20220127866A (ko) 2022-09-20
EP4090354A4 (en) 2024-05-22
CA3166009A1 (en) 2021-07-22
AU2021207661A1 (en) 2022-07-21
CN121554597A (zh) 2026-02-24
JP2023510871A (ja) 2023-03-15
EP4090354A1 (en) 2022-11-23
WO2021146481A1 (en) 2021-07-22
IL294070A (en) 2022-08-01
MX2022008770A (es) 2022-10-07
CN121319219A (zh) 2026-01-13
US20230210951A1 (en) 2023-07-06

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Application publication date: 20220916