CN115038722A - 针对klk5的抗体 - Google Patents

针对klk5的抗体 Download PDF

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Publication number
CN115038722A
CN115038722A CN202180012224.2A CN202180012224A CN115038722A CN 115038722 A CN115038722 A CN 115038722A CN 202180012224 A CN202180012224 A CN 202180012224A CN 115038722 A CN115038722 A CN 115038722A
Authority
CN
China
Prior art keywords
seq
antibody
klk5
cdr
light chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180012224.2A
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English (en)
Chinese (zh)
Inventor
N·德第
P·C·艾略特
S·F·R·雷森
S·马森
D·J·麦克米伦
G·C·奈斯
N·派恩格
M·A·莱德海德
A·图尔奈
K·L·泰森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Biopharma SRL
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CN115038722A publication Critical patent/CN115038722A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN202180012224.2A 2020-02-03 2021-02-01 针对klk5的抗体 Pending CN115038722A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2001447.8 2020-02-03
GBGB2001447.8A GB202001447D0 (en) 2020-02-03 2020-02-03 Antibodies
PCT/EP2021/052245 WO2021156170A1 (en) 2020-02-03 2021-02-01 Antibodies against klk5

Publications (1)

Publication Number Publication Date
CN115038722A true CN115038722A (zh) 2022-09-09

Family

ID=69800047

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202180012224.2A Pending CN115038722A (zh) 2020-02-03 2021-02-01 针对klk5的抗体
CN202180012280.6A Pending CN115052900A (zh) 2020-02-03 2021-02-01 抗klk5抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202180012280.6A Pending CN115052900A (zh) 2020-02-03 2021-02-01 抗klk5抗体

Country Status (20)

Country Link
US (2) US20230070261A1 (https=)
EP (2) EP4100442A1 (https=)
JP (2) JP7837274B2 (https=)
KR (2) KR20220137669A (https=)
CN (2) CN115038722A (https=)
AR (2) AR121255A1 (https=)
AU (2) AU2021217523A1 (https=)
BR (2) BR112022015281A2 (https=)
CA (2) CA3169838A1 (https=)
CL (2) CL2022002079A1 (https=)
CO (2) CO2022012062A2 (https=)
EC (2) ECSP22060844A (https=)
GB (2) GB202001447D0 (https=)
IL (2) IL295247A (https=)
MX (2) MX2022009474A (https=)
PE (2) PE20221921A1 (https=)
PH (2) PH12022551962A1 (https=)
TW (2) TWI861354B (https=)
WO (2) WO2021156171A1 (https=)
ZA (2) ZA202208589B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022192647A1 (en) * 2021-03-12 2022-09-15 Genentech, Inc. Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use

Citations (4)

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US20070071675A1 (en) * 2005-08-19 2007-03-29 Chengbin Wu Dual variable domain immunoglobulin and uses thereof
US20160311903A1 (en) * 2015-03-13 2016-10-27 Cytomx Therapeutics, Inc. Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
US20190078160A1 (en) * 2017-04-21 2019-03-14 Genentech, Inc. Use of klk5 antagonists for treatment of a disease
WO2019178316A1 (en) * 2018-03-14 2019-09-19 Genentech, Inc. Anti-klk5 antibodies and methods of use

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US20160311903A1 (en) * 2015-03-13 2016-10-27 Cytomx Therapeutics, Inc. Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
US20190078160A1 (en) * 2017-04-21 2019-03-14 Genentech, Inc. Use of klk5 antagonists for treatment of a disease
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Publication number Publication date
PH12022551963A1 (en) 2023-10-09
EP4100442A1 (en) 2022-12-14
CO2022012062A2 (es) 2022-08-30
BR112022015281A2 (pt) 2022-09-20
IL295248A (en) 2022-10-01
CA3169838A1 (en) 2021-08-12
PE20221921A1 (es) 2022-12-29
US20230075753A1 (en) 2023-03-09
CN115052900A (zh) 2022-09-13
ZA202208589B (en) 2023-12-20
JP2023512304A (ja) 2023-03-24
US20230070261A1 (en) 2023-03-09
WO2021156170A1 (en) 2021-08-12
KR20220137669A (ko) 2022-10-12
AR121254A1 (es) 2022-05-04
ECSP22060844A (es) 2022-12-30
CA3169842A1 (en) 2021-08-12
TWI861354B (zh) 2024-11-11
CL2022002079A1 (es) 2023-01-06
PE20221922A1 (es) 2022-12-29
MX2022009474A (es) 2022-08-22
CO2022012061A2 (es) 2022-08-30
BR112022015279A2 (pt) 2022-09-20
IL295247A (en) 2022-10-01
WO2021156171A1 (en) 2021-08-12
ZA202208588B (en) 2023-12-20
AU2021217523A1 (en) 2022-09-01
TW202134276A (zh) 2021-09-16
MX2022009475A (es) 2022-08-22
ECSP22060834A (es) 2022-09-30
KR20220137668A (ko) 2022-10-12
JP7837274B2 (ja) 2026-03-30
CL2022002078A1 (es) 2023-01-06
GB202008022D0 (en) 2020-07-15
GB202001447D0 (en) 2020-03-18
JP7839093B2 (ja) 2026-04-01
EP4100441A1 (en) 2022-12-14
JP2023512320A (ja) 2023-03-24
TW202140569A (zh) 2021-11-01
PH12022551962A1 (en) 2023-10-09
AR121255A1 (es) 2022-05-04
AU2021216646A1 (en) 2022-09-01

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