CN114984162A - Spleen-strengthening and stomach-harmonizing granules and preparation method thereof - Google Patents

Spleen-strengthening and stomach-harmonizing granules and preparation method thereof Download PDF

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CN114984162A
CN114984162A CN202210816476.7A CN202210816476A CN114984162A CN 114984162 A CN114984162 A CN 114984162A CN 202210816476 A CN202210816476 A CN 202210816476A CN 114984162 A CN114984162 A CN 114984162A
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parts
spleen
stomach
strengthening
harmonizing
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朱冉飞
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Anhui Integrated Traditional Chinese And Western Medicine Hospital Third Affiliated Hospital Of Anhui University Of Traditional Chinese Medicine
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Anhui Integrated Traditional Chinese And Western Medicine Hospital Third Affiliated Hospital Of Anhui University Of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9064Amomum, e.g. round cardamom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention belongs to the technical field of medicaments for treating stomach diseases, and particularly relates to spleen-strengthening and stomach-harmonizing granules and a preparation method thereof. The spleen-strengthening and stomach-harmonizing granule is composed of, by weight, 30-40 parts of codonopsis pilosula, 40-50 parts of bran-fried bighead atractylodes rhizome, 25-30 parts of elecampane, 30-40 parts of fructus amomi, 30-40 parts of mangnolia officinalis, 40-50 parts of calcined concha arcae, 25-30 parts of pericarpium citri reticulatae, 40-45 parts of cuttlebone, 30-40 parts of rhizoma corydalis, 20-30 parts of dextrin and 15-20 parts of lactose. The invention has the advantages of quick curative effect, short administration period and no recurrence.

Description

Spleen-strengthening and stomach-harmonizing granules and preparation method thereof
Technical Field
The invention belongs to the technical field of medicaments for treating stomach diseases, and particularly relates to spleen-strengthening and stomach-harmonizing granules and a preparation method thereof.
Background
The gastric fullness disease is usually caused by spleen deficiency and qi stagnation, is gradually formed, cannot be attributed to a certain pathogenic factor, is usually a combination of multiple factors, but is mainly caused by dysfunction of the three viscera of the stomach, the liver and the spleen, and is closely related to the liver and the spleen. The "Nei Jing" includes the descriptions of stuffiness, fullness, stuffiness and stuffiness. The "Shang Han Lun" is very good at the theory of the principle and the prescription of this disease, for example, "but full without pain, this is called" stuffiness ", which proposes the basic concept of stuffiness and indicates that the pathogenesis is healthy qi deficiency with invasion of pathogen and disorder of ascending and descending. Zhang Xibin (Jingyue quan Shu & Pi Man) is quite detailed in differentiation of the disease: for abdominal mass, the term "stuffiness and stuffiness" means that the patient is not easy to open; when it is full, it is not sufficient to be full. Fullness will cause a nearly distending sensation, while stuffiness will not cause a distending sensation. Therefore, the syndrome of fullness and distension is in the deficiency and excess, and all the cases with pathogenic factors and stagnation and fullness are also with excess and distension; no material, no stagnation and stuffiness, and deficient stuffiness. Those with distending, pain and fullness are also full; there is no distention and pain, and it is full of deficiency and fullness. For fullness and distention, the powder can be eliminated; for fullness and distention due to deficiency, it is not suitable for warming and tonifying. The compendium is provided for the syndrome differentiation of fullness and distension. Spleen deficiency impairs the transportation and transformation of the spleen and stomach, liver depression can lead to qi stagnation which will obstruct the stomach, and epigastric fullness and distending pain are caused by qi obstruction, which leads to smooth liver and harmonized stomach. The commonly used medicine for treating the stomach stuffiness disease can relapse after being taken, and has slow curative effect and long medicine taking period, so the prior art needs further improvement.
Disclosure of Invention
The invention aims to provide spleen-strengthening and stomach-harmonizing granules which have the advantages of quick curative effect, short administration period and no relapse.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
codonopsis pilosula: it enters spleen and lung meridians. Sweet and mild in nature and flavor. Has the effects of invigorating spleen and replenishing qi, and invigorating spleen and lung. It can be used for treating spleen and lung deficiency, short breath, palpitation, anorexia, loose stool, asthma, cough, internal heat, and diabetes. Stir-frying white atractylodes rhizome with bran: it enters spleen and stomach meridians. Bitter and sweet in property and warm in nature. Has the effects of strengthening spleen, tonifying qi, eliminating dampness, inducing diuresis, suppressing sweating and preventing miscarriage. It can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.
Costustoot: it enters spleen, stomach, large intestine, triple energizer and gallbladder meridians. Pungent, bitter and warm in nature. Has the effects of promoting qi circulation, relieving pain, invigorating spleen and promoting digestion. It is mainly used for treating chest and gastric cavity distending pain, dysentery, tenesmus, indigestion, anorexia. Roasted Aucklandia lappa Decne, radix aucklandiae and Cornus Sessima to relieve diarrhea.
Amomum fruit: it enters spleen, stomach and kidney meridians. Pungent and warm in nature and flavor. Has the effects of eliminating dampness, stimulating appetite, warming spleen, relieving diarrhea, regulating qi, and preventing miscarriage. Can be used for treating damp turbidity obstruction in middle energizer, abdominal distention, inappetence, deficiency-cold of spleen and stomach, emesis, diarrhea, vomiting, threatened abortion, and threatened abortion.
Magnolia officinalis: it enters spleen, stomach, lung and large intestine meridians. Bitter and pungent in flavor and warm in nature. It has the actions of drying dampness and resolving phlegm, and descending qi and relieving fullness. It can be used for treating damp stagnation, abdominal distention, emesis, diarrhea, food stagnation, abdominal distention, constipation, phlegm retention, asthma, and cough.
Calcining concha arcae: it enters lung, stomach and liver meridians. Salty and salty in property and mild in taste. Has effects of eliminating phlegm, removing blood stasis, softening and resolving hard mass, relieving hyperacidity and relieving pain. It is used for treating intractable phlegm accumulation, sticky and difficult to be flung, goiter, scrofula, abdominal mass, stomach pain and pantothenic acid.
Dried orange peel: the properties and tastes of the herbs are meridian tropism, bitter, pungent and warm. It enters lung and spleen meridians. Has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm. It is mainly used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Cuttlebone: it enters spleen and kidney meridians. Salty, astringent and warm in nature. Has the effects of astringing to stop bleeding, astringing essence to stop leucorrhea, relieving hyperacidity and healing wound. Can be used for treating gastralgia, acid regurgitation, hematemesis, epistaxis, metrorrhagia, hematochezia, spermatorrhea, and leucorrhea with red and white discharge; and (3) ulcer disease. It is indicated for traumatic hemorrhage with pus and sore.
Corydalis tuber: the flavor is meridian tropism, pungent, bitter and warm. It enters liver and spleen meridians. Has the functions of promoting blood circulation, promoting qi circulation and relieving pain. Can be used for treating chest and hypochondrium, abdominal pain, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, puerperal blood stasis, and traumatic injury with swelling and pain.
The prepared stomach harmonizing granules can strengthen spleen and replenish qi, eliminate dampness and regulate the middle warmer, and relieve hyperacidity and pain, and are used for treating chronic superficial gastritis, chronic atrophic gastritis, functional dyspepsia, peptic ulcer and the like caused by spleen deficiency and qi stagnation, wherein codonopsis pilosula and white atractylodes rhizome stir-fried with bran are used as monarch drugs for strengthening spleen and tonifying qi and harmonizing stomach; sha ren and Hou Po can descend qi and widen middle energizer, remove food retention and remove food stagnation, disperse fullness and relieve distension; wood has fragrant smell, can ventilate, is the essential herb for regulating various qi, and has the effects of pungent flavor, bitter taste, purging, warming and dredging, so as to treat fullness, stuffiness, eructation and regulating stagnation and dissipating qi; the three medicines are monarch medicines and have the effects of removing food retention and relieving fullness; the old cortex is mild, mild and mild, and good at regulating qi-flowing for strengthening spleen, promoting qi-flowing for removing distention. Concha arcae and Os Sepiae are used for relieving hyperacidity and pain, and rhizoma corydalis is used for promoting blood circulation, activating qi-flowing and relieving pain, and has certain effects of relieving pain, tranquilizing mind and hypnotizing. The prescription has the functions of strengthening the spleen and replenishing qi, eliminating dampness and regulating the middle warmer, and relieving hyperacidity and pain, and can obviously improve the symptoms of distention and fullness, acid regurgitation, eructation, hypodynamia and the like for chronic gastroenteropathy accompanied with mild depression and anxiety state and the like. The invention has the advantages of quick curative effect, no relapse and short treatment period.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1:
a spleen-invigorating and stomach-harmonizing granule comprises, by weight, 30 parts of radix Codonopsis, 40 parts of bran-fried rhizoma Atractylodis Macrocephalae, 25 parts of radix aucklandiae, 30 parts of fructus Amomi, 30 parts of cortex Magnoliae officinalis, 40 parts of calcined Concha arcae, 25 parts of pericarpium Citri Reticulatae, 40 parts of Os Sepiae, 30 parts of rhizoma corydalis, 20 parts of dextrin, and 15 parts of lactose.
A method for preparing the spleen and stomach strengthening granules comprises the following steps of (1) grinding radix codonopsitis, bran-fried bighead atractylodes rhizome, costustoot, fructus amomi, mangnolia officinalis, calcined concha arcae, dried tangerine peel, cuttlebone and rhizoma corydalis into powder, then adding water, heating for 10min at 90 ℃, cooling to 40 ℃, adding cellulase and glucosidase, performing enzymolysis for 2h, and heating for 2min at 100 ℃ to obtain mixed liquid after enzymolysis; (2) adding saccharomycetes and bifidobacteria into the mixed solution subjected to enzymolysis in the step (1), and fermenting at 35 ℃ for 2 hours to obtain fermentation liquor; (3) and (3) carrying out rotary evaporation and concentration on the fermentation liquor obtained in the step (2) at 60 ℃ to obtain extract, adding dextrin and lactose, granulating in a granulator, and drying at 40 ℃ to obtain a finished product.
The medicine is taken three times a day with boiled water, and 3 days is a treatment course.
Example 2:
a spleen-invigorating and stomach-harmonizing granule comprises, by weight, 35 parts of radix Codonopsis, 45 parts of bran-fried rhizoma Atractylodis Macrocephalae, 28 parts of radix aucklandiae, 35 parts of fructus Amomi, 35 parts of cortex Magnoliae officinalis, 45 parts of calcined Concha arcae, 28 parts of pericarpium Citri Reticulatae, 42 parts of Os Sepiae, 35 parts of rhizoma corydalis, 25 parts of dextrin, and 18 parts of lactose.
A method for preparing the spleen and stomach strengthening granule comprises the following steps of (1) grinding radix codonopsitis, bran-fried bighead atractylodes rhizome, costustoot, fructus amomi, mangnolia officinalis, calcined concha arcae, dried tangerine peel, cuttlebone and rhizoma corydalis into powder, then adding water, heating at 95 ℃ for 12min, cooling to 45 ℃, adding cellulase and glucosidase, performing enzymolysis for 2.5h, and heating at 150 ℃ for 2.5min to obtain mixed liquid after enzymolysis; (2) adding saccharomycetes and bifidobacteria into the mixed solution subjected to enzymolysis in the step (1), and fermenting at 38 ℃ for 2.8 hours to obtain fermentation liquor; (3) and (3) carrying out rotary evaporation and concentration on the fermentation liquor obtained in the step (2) at 65 ℃ to obtain extract, adding dextrin and lactose, granulating in a granulator, and drying at 42 ℃ to obtain a finished product.
The medicine is taken three times a day with boiled water, and 3 days is a treatment course.
Example 3:
a spleen-invigorating and stomach-harmonizing granule comprises, by weight, 40 parts of radix Codonopsis, 50 parts of bran-fried rhizoma Atractylodis Macrocephalae, 30 parts of radix aucklandiae, 40 parts of fructus Amomi, 40 parts of cortex Magnoliae officinalis, 50 parts of calcined Concha arcae, 30 parts of pericarpium Citri Reticulatae, 45 parts of Os Sepiae, 40 parts of rhizoma corydalis, 30 parts of dextrin, and 20 parts of lactose.
A method for preparing the spleen and stomach strengthening granule comprises the following steps of (1) grinding radix codonopsitis, bran-fried bighead atractylodes rhizome, costustoot, fructus amomi, mangnolia officinalis, calcined concha arcae, dried tangerine peel, cuttlebone and rhizoma corydalis into powder, then adding water, heating for 10-15min at 100 ℃, cooling to 50 ℃, adding cellulase and glucosidase, carrying out enzymolysis for 3h, and heating for 3min at 200 ℃ to obtain mixed liquid after enzymolysis; (2) adding saccharomycetes and bifidobacteria into the mixed solution subjected to enzymolysis in the step (1), and fermenting for 3 hours at 40 ℃ to obtain fermentation liquor; (3) and (3) carrying out rotary evaporation and concentration on the fermentation liquor obtained in the step (2) at 70 ℃ to obtain extract, adding dextrin and lactose, granulating in a granulator, and drying at 45 ℃ to obtain a finished product.
The medicine is taken three times a day with boiled water, and 3 days is a treatment course.
1, medical record:
zhao Zhi, 35 years old, female.
Symptoms are: the granules prepared in the embodiment 1 are taken for 1 treatment course, symptoms such as stomachache, acid regurgitation and the like do not appear any more, and the granules are taken for one treatment course without recurrence phenomenon.
Wherein, during the period of taking the medicine, people need to eat less food and more meals, and the mood is pleasant.
And (3) medical record 2:
yuan Zhi, 42 years old and female.
Symptoms are: stomach distending pain, stomach cold, mental fatigue, lassitude, greasy and yellow tongue coating and symptoms of damp-heat in spleen and stomach, which last about 1 year, and after 1 course of taking the granules prepared in the embodiment 2, the spirit is gradually recovered without stomach pain and recurrence.
3, medical record:
qianzhi, 67 years old, male.
Symptoms are: the stomach is full of gastric cavity, stomach pain caused by catching cold, loose stool, belching, dyspepsia and intense pain caused by pressing the stomach can be caused, the symptoms last for 8-10 years, after 2 courses of taking the granules prepared in the embodiment 3, the stool is normal, the stomach is pressed, no pain exists, the digestive function is gradually recovered, and no recurrence phenomenon exists after 1 course of continuing taking.
And (4) medical record:
yang, 32 years old, male.
Symptoms are: after 7 days, the stomach does not have improvement, and after the granules prepared in the embodiment 2 are taken for one treatment course, symptoms such as stomachache and the like do not exist, and the recurrence phenomenon does not exist. According to the invention, the prepared granules have good treatment effect, quick curative effect and no relapse.

Claims (3)

1. The spleen-strengthening and stomach-harmonizing granule is characterized by comprising, by weight, 30-40 parts of codonopsis pilosula, 40-50 parts of bran-fried bighead atractylodes rhizome, 25-30 parts of elecampane, 30-40 parts of fructus amomi, 30-40 parts of mangnolia officinalis, 40-50 parts of calcined concha arcae, 25-30 parts of pericarpium citri reticulatae, 40-45 parts of cuttlebone, 30-40 parts of rhizoma corydalis, 20-30 parts of dextrin and 15-20 parts of lactose.
2. The spleen-strengthening and stomach-harmonizing granule as claimed in claim 1, is composed of (by weight parts) radix Codonopsis 34, bran-fried Atractylodis rhizoma 42, radix aucklandiae 28, fructus Amomi 34, cortex Magnolia officinalis 34, Concha arcae 42, pericarpium Citri Tangerinae 28, Os Sepiae 42, rhizoma corydalis 34, dextrin 25, and lactose 18.
3. A method for preparing the spleen and stomach strengthening granule as claimed in claim 1, which is characterized by comprising the following steps of (1) grinding radix codonopsitis, bran-fried rhizoma atractylodis macrocephalae, radix aucklandiae, fructus amomi, mangnolia officinalis, calcined concha arcae, dried orange peel, cuttlebone and rhizoma corydalis into powder, then adding water, heating at 90-100 ℃ for 10-15min, cooling to 40-50 ℃, adding cellulase and glucosidase, carrying out enzymolysis for 2-3h, and then heating at 100-200 ℃ for 2-3min to obtain a mixed solution after enzymolysis; (2) adding saccharomycetes and bifidobacteria into the mixed liquid obtained after enzymolysis in the step (1), and fermenting for 2-3h at 35-40 ℃ to obtain fermentation liquid; (3) and (3) carrying out rotary evaporation and concentration on the fermentation liquor obtained in the step (2) at the temperature of 60-70 ℃ to obtain extract, adding dextrin and lactose, granulating in a granulator, and drying at the temperature of 40-45 ℃ to obtain a finished product.
CN202210816476.7A 2022-07-12 2022-07-12 Spleen-strengthening and stomach-harmonizing granules and preparation method thereof Pending CN114984162A (en)

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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN102988870A (en) * 2012-11-30 2013-03-27 北京中融阳光投资管理有限公司 Oral liquid for treating diseases of liver, gall, stomach and intestinal canal

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