CN114981251A - 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途 - Google Patents

一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途 Download PDF

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CN114981251A
CN114981251A CN202180009972.5A CN202180009972A CN114981251A CN 114981251 A CN114981251 A CN 114981251A CN 202180009972 A CN202180009972 A CN 202180009972A CN 114981251 A CN114981251 A CN 114981251A
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mmol
added
furan
reaction
dibenzo
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CN114981251B (zh
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吴俊军
周世强
肖瑛
黄艺
段振芳
黄奕强
陆银锁
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Shenzhen Salubris Pharmaceuticals Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91Dibenzofurans; Hydrogenated dibenzofurans

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

提供了一系列的组织蛋白酶K的抑制剂,尤其提供了一种二苯并呋喃衍生物组织蛋白酶K的抑制剂,属于化学药物技术领域。还涉及包含这些化合物的药物组合物以及使用该化合物治疗骨关节炎等疾病的药物中的用途。

Description

PCT国内申请,说明书已公开。

Claims (15)

  1. PCT国内申请,权利要求书已公开。
CN202180009972.5A 2020-01-21 2021-01-20 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途 Active CN114981251B (zh)

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CN202010069378 2020-01-21
CN2020100693782 2020-01-21
PCT/CN2021/072803 WO2021147882A1 (zh) 2020-01-21 2021-01-20 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途

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CN114981251B CN114981251B (zh) 2023-11-21

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WO (1) WO2021147882A1 (zh)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008802A1 (en) * 1996-08-28 1998-03-05 Smithkline Beecham Corporation Inhibitors of cysteine protease
WO1998009934A1 (en) * 1996-09-04 1998-03-12 Warner-Lambert Company Matrix metalloproteinase inhibitors and their therapeutic uses
CN1310716A (zh) * 1998-07-30 2001-08-29 沃尼尔·朗伯公司 作为基质金属蛋白酶抑制剂的三环磺胺化合物及其衍生物
US6294674B1 (en) * 1996-09-04 2001-09-25 Warner-Lambert Company Dibenzofuran sulfonamide matrix metalloproteinase inhibitors
US20030229226A1 (en) * 2000-04-06 2003-12-11 Osamu Okamoto Cathepsin cysteine protease inhibitors
US20070015797A1 (en) * 1999-09-22 2007-01-18 Cheng Peter T Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
CN102417480A (zh) * 2006-06-01 2012-04-18 塞诺菲-安万特股份有限公司 作为蛋白酶抑制剂的螺环腈类
CN105884752A (zh) * 2015-02-13 2016-08-24 山东轩竹医药科技有限公司 并环类回旋酶和拓扑异构酶iv抑制剂
CN106866502A (zh) * 2015-12-10 2017-06-20 广东东阳光药业有限公司 组织蛋白酶k抑制剂及其用途
US20180230138A1 (en) * 2015-08-29 2018-08-16 Sunshine Lake Pharma Co., Ltd. Cathepsin k inhibitors and application thereof
WO2019218956A1 (zh) * 2018-05-16 2019-11-21 深圳信立泰药业股份有限公司 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008802A1 (en) * 1996-08-28 1998-03-05 Smithkline Beecham Corporation Inhibitors of cysteine protease
WO1998009934A1 (en) * 1996-09-04 1998-03-12 Warner-Lambert Company Matrix metalloproteinase inhibitors and their therapeutic uses
US6294674B1 (en) * 1996-09-04 2001-09-25 Warner-Lambert Company Dibenzofuran sulfonamide matrix metalloproteinase inhibitors
CN1310716A (zh) * 1998-07-30 2001-08-29 沃尼尔·朗伯公司 作为基质金属蛋白酶抑制剂的三环磺胺化合物及其衍生物
US20070015797A1 (en) * 1999-09-22 2007-01-18 Cheng Peter T Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US20030229226A1 (en) * 2000-04-06 2003-12-11 Osamu Okamoto Cathepsin cysteine protease inhibitors
CN102417480A (zh) * 2006-06-01 2012-04-18 塞诺菲-安万特股份有限公司 作为蛋白酶抑制剂的螺环腈类
CN105884752A (zh) * 2015-02-13 2016-08-24 山东轩竹医药科技有限公司 并环类回旋酶和拓扑异构酶iv抑制剂
US20180230138A1 (en) * 2015-08-29 2018-08-16 Sunshine Lake Pharma Co., Ltd. Cathepsin k inhibitors and application thereof
CN106866502A (zh) * 2015-12-10 2017-06-20 广东东阳光药业有限公司 组织蛋白酶k抑制剂及其用途
WO2019218956A1 (zh) * 2018-05-16 2019-11-21 深圳信立泰药业股份有限公司 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
任玉杰,等: "2-咪唑烷酮衍生物的合成研究进展", 上海应用技术学院学报(自然科学版), vol. 12, no. 06, pages 112 - 119 *
朱康乐,等: "蛋白质精氨酸甲基转移酶5抑制剂的设计、合成及活性评价", 药学学报, vol. 11, no. 08, pages 112 - 118 *
赵成英,等: "2010~2013之海洋微生物新天然产物", 有机化学, vol. 25, no. 06, pages 15 - 18 *
马晓东,等: "新型咪唑酮并吡啶类化合物的合成和体外抗肿瘤活性", 中国新药杂志, vol. 01, no. 20, pages 566 - 572 *

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CN114981251B (zh) 2023-11-21

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