CN114958602B - Cell therapy culture bag with filtering function - Google Patents
Cell therapy culture bag with filtering function Download PDFInfo
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- CN114958602B CN114958602B CN202210438786.XA CN202210438786A CN114958602B CN 114958602 B CN114958602 B CN 114958602B CN 202210438786 A CN202210438786 A CN 202210438786A CN 114958602 B CN114958602 B CN 114958602B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/46—Means for fastening
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
Abstract
The utility model provides a cell therapy is with cultivateing bag with filtering capability, includes the bottom plate, bottom plate one side up end is connected with the support column, and this support column up end is connected with the support cover body, and this support cover body one side is connected with the backup pad, and support cover body inside is provided with guiding mechanism, and this guiding mechanism one end is connected with vibrations mechanism, backup pad internally mounted has slide mechanism, and this slide mechanism lower extreme is connected with slewing mechanism, and this slewing mechanism internally connected has conveying mechanism, at first utilizes the bottom plate to let the support column and the support cover body fixed with the backup pad, installs the injection tube on conveying mechanism in one side of adjusting plate, after the installation, lets the stand pipe perpendicularly downwards and pass first running roller and second running roller between the department, places the cultivation bag in the holding tank again to in the connection of stand pipe lower extreme, after the connection, usable personnel exert force for the handle on the guiding mechanism, let the handle rotate and drive first running shaft and rotate.
Description
Technical Field
The invention relates to the technical field of biological cell culture, in particular to a culture bag with a filtering function for cell therapy.
Background
In the fields of immune cell therapy of tumors and scientific researches of biology, immunity, medicine and the like, a cell culture technology is often used and is also the basis of almost all cell biology experiments. During the cell culture period, the cells can be continuously grown and reach a certain number by passage and fluid replacement. To achieve higher numbers of cells, larger cell culture bags are often used. When a cell culture bag is used for culturing cells for passage or fluid infusion, a syringe of a 50ml syringe is generally used as a funnel to be connected with the cell culture bag, and then culture fluid is poured into the syringe and flows into the cell culture bag through the syringe to complete the passage or fluid infusion process.
Because among the prior art, the model of culture bag has big or small, after the pipeline of culture bag switch-on culture solution, can appear crooked sometimes or pipeline length not enough problem, general syringe is fixed, can't adjust the position, and culture bag also places a position and can't move, if remove can appear culture solution in pipeline velocity of flow slow sometimes or blocking phenomenon, reduce work efficiency, culture bag can appear the cell coagulation in long-time stay, can not let the culture solution carry out the fluid infusion, cell coagulation's speed is not according to when different temperatures also can, can cause the waste of culture solution and culture bag.
In order to solve the above problems, the present invention proposes a culture bag for cell therapy having a filtration function.
Disclosure of Invention
(1) Technical problem to be solved
The present invention is directed to overcoming the problems of the prior art and meeting the practical needs, and provides a culture bag for cell therapy having a filtering function to solve the above-mentioned problems.
(2) Technical scheme
In order to realize the purpose of the invention, the technical scheme adopted by the invention is as follows: the utility model provides a cell therapy is with cultivateing bag with filtering capability, includes the bottom plate, bottom plate one side up end is connected with the support column, and this support column up end is connected with the supporting cover body, and this supporting cover body one side is connected with the backup pad, and supports the internal portion of cover and be provided with guiding mechanism, and this guiding mechanism one end is connected with vibrations mechanism, backup pad internally mounted has slide mechanism, and this slide mechanism lower extreme is connected with slewing mechanism, and this slewing mechanism internally connected has conveying mechanism.
Preferentially, the adjusting mechanism comprises a handle, a first rotating shaft is connected to the middle of the outer surface of the handle, a first rotating groove is connected to one end of the first rotating shaft in a sliding mode, the first rotating groove is formed in one side wall inside the supporting cover body, a worm is connected to the middle of the rotating shaft, a worm wheel is meshed with the outer contour of the worm wheel, a second rotating shaft is sleeved inside the worm wheel, a second rotating groove is connected to one end of the second rotating shaft in a sliding mode, the second rotating groove is formed in one side wall of the supporting cover body, the inner portion of the worm wheel is sleeved on the outer surface of one end of the second rotating shaft, the outer contour of the worm wheel is sleeved on the outer surface of one end of the second rotating shaft, a rack is meshed with the outer contour of the gear, the upper end face of the rack penetrates through the upper end of the supporting cover body, a first buckle plate is connected to one side of the upper end face of the rack, a moving plate is connected to the lower end face of the rack, a limiting block is connected to one side of the upper end face of the first spring body, and the lower end face of the moving plate is connected to the limiting block.
Preferentially, the vibration mechanism comprises a cam disc, the outer surface of the cam disc is connected to one end of a second rotating shaft, two sides of the outer contour of the cam disc are connected with a convex block, the outer contour of the cam disc is connected with a third rotating groove in a rotating mode, the outer surface of the convex block is abutted to a transmission plate, the outer surface of the transmission plate is connected with a first slide channel in a sliding mode, the first slide channel and the third rotating groove are jointly formed in one side wall of the supporting cover body, the first slide channel penetrates through the third rotating groove, one side of the lower end of the transmission plate is connected with a push plate, the bottom of the transmission plate is connected with a second spring body, one end of the second spring body is connected to the bottom of the first slide channel, the second slide channel is formed in one side of the upper end of the push plate and is connected with a press plate in a sliding mode, a tightening rod penetrates through one side of the push plate, the lower end face of the press plate faces the press plate, and the lower end face of the press plate is connected to one side of the upper end face of the moving plate.
Preferably, the sliding mechanism comprises a transfer rod, the transfer rod penetrates through the inside of the support plate, the lower end face of the transfer rod is connected with a first sliding portion, the outer surface of the first sliding portion is connected with a third sliding channel in a sliding mode, the third sliding channel is arranged on one side of the support plate, and one side of the first sliding portion is connected with the adjusting plate.
Preferentially, slewing mechanism includes the connecting plate, and this connecting plate upper end is connected at the inside upper wall of the support cover body, and the connecting plate lower extreme is connected with the rotation frame, should rotate the inside one side of frame and be connected with the third axis of rotation, and this third axis of rotation surface cover is equipped with first running roller, and this first running roller surface is just to having the second running roller, and the inside cover of this second running roller is equipped with the fourth axis of rotation, and this fourth axis of rotation both ends are connected in the one side of rotating the frame, should rotate the frame up end and just to having the through-hole, and this through-hole is seted up in the upper end wall one side of the support cover body.
Preferentially, conveying mechanism includes the culture solution bottle, and the syringe is installed to this culture solution bottle lower terminal surface, and this syringe is installed in one side of adjusting plate, and syringe internal connection has the filter screen, and the terminal surface is connected with the stand pipe under the syringe, and this stand pipe lower extreme runs through between first running roller and second running roller, and the stand pipe lower terminal surface is connected with cultivates the bag, and the holding tank has been placed to this cultivation bag surface, and this holding tank is seted up in one side of removing the dish.
Preferentially, one side of the upper end face of the supporting cover body is connected with a fixing plate, the upper end of the fixing plate is connected with a second buckling plate, and the outer surface of the second buckling plate abuts against the outer surface of the first buckling plate.
Preferably, the lower end of the rack is connected with a second sliding part, the outer surface of the second sliding part is connected with a fourth sliding channel in a sliding manner, and the fourth sliding channel is arranged on one side of the inner part of the movable plate.
(3) Has the advantages that:
A. firstly, fixing a support column and a support cover body with a support plate by using a bottom plate, installing an injection tube on a conveying mechanism at one side of an adjusting plate, after installation, enabling a guide tube to vertically downwards penetrate through a position between a first roller and a second roller, then placing a culture bag in a containing tank, connecting the lower end of the guide tube, after connection, applying force to a handle on the adjusting mechanism by using personnel, enabling the handle to rotate and drive a first rotating shaft to rotate, enabling the first rotating shaft to rotate in a first rotating groove, simultaneously driving a worm to rotate, enabling the worm to be meshed with the worm wheel, driving a second rotating shaft while the worm wheel rotates, enabling one end of the second rotating shaft to rotate in a second rotating groove, enabling a second rotating shaft to drive the gear and be meshed with a rack, enabling the rack to vertically move upwards, simultaneously driving a moving plate and a limiting block to vertically upwards, simultaneously driving the culture bag on the containing tank to upwards move, and enabling a first buckle plate on the rack to buckle a second buckle plate to buckle plate after the rack drives a certain length, so that the position of the culture bag is fixed;
B. meanwhile, the second rotating shaft can drive a cam disc and a convex block on the vibrating mechanism at one end, the cam disc and the convex block rotate in a third rotating groove under the driving of the second rotating shaft, the convex block is abutted against one end of the transmission plate in a rotating mode, the transmission plate slides in the first sliding channel and is extruded downwards in the second spring body, meanwhile, the pushing plate is driven to move downwards together, the pressing plate is abutted against the upper end of the pressing rod downwards, the moving disc slides vertically downwards on the outer surface of the second sliding part through the fourth sliding channel and is extruded downwards in the first spring body to stretch, after the convex block is abutted, the transmission plate is reset through the second spring body, the moving disc is reset through the first spring body and is sequentially circulated, the moving disc is vibrated, the culture bag on the accommodating groove is prevented from being solidified, the phenomenon that the cells are solidified when the culture bag stays for a long time is favorably prevented, and the culture bag is prevented from being solidified through vibration;
C. after the vibration is finished, a rack buckled on a second buckle plate is taken down, a gear is meshed with the outer surface of the rack, the gear is meshed with the rack to adjust a moving plate by utilizing the rotation of a handle, the moving plate drives a culture bag on a holding tank to adjust the position, the position is adjusted to be that the lower end surface of a guide pipe is vertically connected with the culture bag to form a straight line, in the adjusting process, the outer surface of the guide pipe can rotate through the outer surfaces of a first roller and a second roller on a rotating mechanism, the first roller and the second roller can rotate on the outer surfaces of a third rotating shaft and a fourth rotating shaft, the guide pipe can slide rapidly to prevent the guide pipe from bending, after the adjustment is finished, the guide pipe can be loosened through a tightening rod, the pressing plate can slide vertically upwards in a second slide groove to avoid the pressing plate at the upper end of the pressing rod, the pressing plate can be prevented from abutting against the pressing rod, when the liquid is supplemented, the pressing rod is prevented from generating vibration, the phenomenon that the connecting part of the culture bag and the guide pipe can be leaked can be prevented from generating the liquid leakage phenomenon at the adjustable position through the sliding mechanism, after the adjustment is finished, the adjustment, the adjustable working efficiency can be improved through the adjustable mechanism, and the adjustable working mechanism;
D. in the process of rack meshing adjustment, the device can also be matched with a sliding mechanism for adjustment, if the length of the guide pipe is too long, the device still has a bending phenomenon after the rack meshing adjustment, the adjusting rod on the sliding mechanism can be used, the first sliding part can slide in the third slide channel and move upwards, and meanwhile, the adjusting plate can be driven to move upwards, in the moving process, the position of the injection pipe can be adjusted, the guide pipe can be vertically in a straight line, if the length of the guide pipe is too short, otherwise, after all work adjustment, a culture solution bottle is installed on the upper end face of the injection pipe, and liquid supplementing work is started.
Drawings
FIG. 1 is a schematic perspective view of a culture bag for cell therapy having a filtration function according to the present invention;
FIG. 2 is a schematic full sectional view of an adjusting mechanism and a sliding mechanism of a cell culture bag for cell therapy having a filter function according to the present invention;
FIG. 3 is a partially enlarged view of a first fastening plate and a second fastening plate of the culture bag for cell therapy having a filtering function according to the present invention;
FIG. 4 is a schematic configuration diagram of a second sliding part and a fourth chute of the culture bag for cell therapy having a filtration function according to the present invention;
FIG. 5 is a partially enlarged view of a vibration mechanism of a culture bag for cell therapy having a filtering function according to the present invention;
FIG. 6 is a partially enlarged view of a pressing plate and a pressing rod of a culture bag for cell therapy having a filtering function according to the present invention;
FIG. 7 is a schematic view of a whole section of a rotating mechanism of a culture bag for cell therapy having a filtering function according to the present invention;
FIG. 8 is a schematic full-sectional view of a transfer mechanism of a culture bag for cell therapy having a filter function according to the present invention.
The reference numbers are as follows:
1-bottom plate, 11-support column, 12-support cover, 121-first rotation groove, 122-second rotation groove, 123-third rotation groove, 124-first runner groove, 125-through hole, 126-fixing plate, 127-second buckle plate, 13-support plate, 131-third runner groove, 2-adjustment mechanism, 21-handle, 22-first rotation shaft, 23-worm, 24-worm wheel, 25-second rotation shaft, 26-gear, 27-rack, 271-first buckle plate, 272-second sliding part, 28-moving disk, 281-fourth runner groove, 29-limiting block, 291-first spring body, 3-vibration mechanism, 31-cam plate, 32-lug, 33-transmission plate, 34-pushing plate, 35-second spring body, 36-second runner groove, 37-pressing plate, 38-loosening rod, 39-pressing rod, 4-sliding mechanism, 41-rotating rod, 42-first sliding part, 43-adjustment plate, 5-rotation frame, 56-fourth runner groove, 37-pressing plate, 38-loosening rod, 39-pressing rod, 4-sliding mechanism, 41-rotating shaft, 42-first sliding part, 43-first sliding adjustment plate, 5-rotating frame, 56-fourth runner groove, 55-fourth runner groove, 61-guide tube, 61-fourth runner groove, 24-third rotation mechanism, and fourth runner guide tube.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
The invention will be further illustrated with reference to the following figures 1 to 8 and examples:
in this embodiment, as shown in fig. 1 to 8, a culture bag for cell therapy with a filtering function includes a bottom plate 1, a support column 11 is connected to an upper end surface of one side of the bottom plate 1, a support cover 12 is connected to an upper end surface of the support column 11, a support plate 13 is connected to one side of the support cover 12, an adjusting mechanism 2 is arranged inside the support cover 12, one end of the adjusting mechanism 2 is connected to a vibrating mechanism 3, a sliding mechanism 4 is installed inside the support plate 13, a rotating mechanism 5 is connected to a lower end of the sliding mechanism 4, and a conveying mechanism 6 is connected inside the rotating mechanism 5. Firstly, the support column 11 and the support cover body 12 are fixed with the support plate 13 by using the bottom plate 1, then the injection tube 62 on the conveying mechanism 6 is arranged at one side of the adjusting plate 43, after the injection tube is arranged, the guide tube 64 vertically downwards passes through the position between the first roller 54 and the second roller 55, and then the culture bag 65 is placed in the accommodating groove 66 and is connected with the lower end of the guide tube 64, thereby being beneficial to stable fixation.
In this embodiment, the adjusting mechanism 2 includes a handle 21, a first rotating shaft 22 is connected to an outer surface of the handle 21, a first rotating groove 121 is connected to one end of the first rotating shaft 22 in a sliding manner, the first rotating groove 121 is formed in one side wall of the supporting cover 12, a worm 23 is connected to an intermediate portion of the rotating shaft 22, a worm wheel 24 is engaged with an outer contour of the worm 23, a second rotating shaft 25 is sleeved on the worm wheel 24, a second rotating groove 122 is connected to one end of the second rotating shaft 25 in a sliding manner, the second rotating groove 122 is formed in one side wall of the supporting cover 12, the worm wheel 24 is sleeved on an outer surface of one end of the second rotating shaft 25, an outer surface of the worm wheel 24 is sleeved on an outer surface of one end of the second rotating shaft 25, a rack 27 is engaged with a gear 26, an upper end surface of the rack 27 penetrates through an upper end of the supporting cover 12, a first buckle 271 is connected to one side of an upper end surface of the rack 27, a lower end surface of the rack 27 is connected to a moving plate 28, a lower end surface of the rack 27 is connected to a stopper 29, an upper end surface of the stopper 29 is connected to a first spring 291, and an outer contour of the first spring is connected to a lower end surface of the moving plate 28. An available person applies force to the handle 21 on the adjusting mechanism 2, so that the handle 21 rotates and drives the first rotating shaft 22 to rotate, the first rotating shaft 22 rotates in the first rotating groove 121, simultaneously drives the worm 23 to rotate, the worm 23 is meshed with the worm wheel 24, the worm wheel 24 rotates and simultaneously drives the second rotating shaft 25, one end of the second rotating shaft 25 rotates in the second rotating groove 122, the second rotating shaft 25 drives the gear 26 to be meshed with the rack 27, the rack 27 moves vertically upwards, simultaneously drives the moving plate 28 and the limiting block 29 to move vertically upwards, and simultaneously drives the culture bag 65 on the accommodating groove 66 to move upwards, after the rack 27 rises for a certain length, the first clamping plate 271 on the rack 27 is clamped on the second clamping plate 127, and at the moment, the lower part of the rack 27 is not meshed with the gear 26, namely, the gear 26 rotates and cannot further drive the rack 27 to rise, and further limits the moving plate 28 to a fixed position, thereby ensuring that the position of the culture bag 65 is unchanged.
In this embodiment, the vibration mechanism 3 includes a cam plate 31, an outer surface of the cam plate 31 is connected to one end of the second rotating shaft 25, two sides of an outer contour of the cam plate 31 are connected to a protrusion 32, an outer contour of the cam plate 31 is connected to a third rotating groove 123 in a rotating manner, an outer surface of the protrusion 32 is abutted to a transmission plate 33, an outer surface of the transmission plate 33 is connected to a first sliding groove 124 in a sliding manner, the first sliding groove 124 and the third rotating groove 123 are opened on one side wall of the inside of the supporting housing 12 together, the first sliding groove 124 and the third rotating groove 123 penetrate through, a lower end side of the transmission plate 33 is connected to a pushing plate 34, a bottom of the transmission plate 33 is connected to a second spring body 35, one end of the second spring body 35 is connected to a bottom of the first sliding groove 124, a second sliding groove 36 is opened on an upper end side of the pushing plate 34, the second sliding groove 36 is connected to a pressing plate 37 in a sliding manner, a tightening rod 38 penetrates through one side of the pushing plate 34, a lower end surface of the pressing plate 37 is opposite to a pressing rod 39, and a lower end surface of the pressing rod is connected to one side of an upper end surface of the moving plate 28. The second rotating shaft 25 drives the cam plate 31 and the protrusion 32 on the vibrating mechanism 3 at one end, the cam plate 31 and the protrusion 32 rotate in the third rotating groove 123 by the driving of the second rotating shaft 25, the protrusion 32 rotates to abut against one end of the driving plate 33, the driving plate 33 slides in the first sliding groove 124 and is pressed downward against the second spring body 35, and at the same time, the driving plate 34 is driven downward, the pressing plate 37 is pressed downward against the upper end of the pressing rod 39, the moving plate 28 slides vertically downward on the outer surface of the second sliding portion 272 through the fourth sliding groove 281, and is pressed downward and stretches under the first spring body 291, after the abutment of the protrusion 32, the driving plate 33 is reset through the second spring body 35, the moving plate 28 is reset next to the first spring body 291, the moving plate 28 is sequentially circulated, the moving plate 28 vibrates, the culture bag 65 on the accommodating groove 66 is prevented from solidifying, which is beneficial to prevent the culture bag from being solidified for a long time, the solidification of the culture bag 65 is prevented by the vibration, when the culture bag 65 is adjusted, the pressing rod 38 is loosened, the pressing rod 38 is pressed into the sliding groove 37, the pressing rod 39 is connected to the pressing rod 39, and the pressing rod 39 is prevented from being connected to the vertical leakage of the pressing rod 39.
In this embodiment, the sliding mechanism 4 includes an actuating rod 41, the actuating rod 41 penetrates the supporting plate 13, a first sliding portion 42 is connected to a lower end surface of the actuating rod 41, a third sliding groove 131 is slidably connected to an outer surface of the first sliding portion 42, the third sliding groove 131 is opened on one side of the supporting plate 13, and an adjusting plate 43 is connected to one side of the first sliding portion 42. In the process of the meshing adjustment of the rack 27, the rack can be matched with the sliding mechanism 4 for adjustment, if the length of the guide pipe 64 is too long, and the rack 27 is still bent after the meshing adjustment, the adjusting rod 41 on the sliding mechanism 4 can be used to make the first sliding part slide in the third sliding channel 131 and move upwards, and meanwhile, the adjusting plate 43 is driven to move upwards, in the moving process, the position of the injection pipe 62 can be adjusted, the guide pipe 64 is vertically straight, if the length of the guide pipe 64 is too short, otherwise, the guide pipe 64 can be prevented from being bent, and the flow rate can be accelerated.
In this embodiment, the rotating mechanism 5 includes a connecting plate 51, the upper end of the connecting plate 51 is connected to the inner upper wall of the supporting cover 12, the lower end of the connecting plate 51 is connected to a rotating frame 52, one side of the inner portion of the rotating frame 52 is connected to a third rotating shaft 53, the outer surface of the third rotating shaft 53 is sleeved with a first roller 54, the outer surface of the first roller 54 is over against to a second roller 55, the inner portion of the second roller 55 is sleeved with a fourth rotating shaft 56, two ends of the fourth rotating shaft 56 are connected to one side of the rotating frame 52, the upper end surface of the rotating frame 52 is over against to a through hole 125, and the through hole 125 is opened on one side of the upper end wall of the supporting cover 12. In the adjusting process, the outer surface of the guide tube 64 can rotate through the outer surfaces of the first roller 54 and the second roller 55 on the rotating mechanism 5, and the first roller 54 and the second roller 55 can rotate on the outer surfaces of the third rotating shaft 53 and the fourth rotating shaft 56, so that the guide tube 64 can slide rapidly, and the guide tube 64 is prevented from being bent.
In this embodiment, the conveying mechanism 6 includes a culture solution bottle 61, an injection tube 62 is installed on the lower end face of the culture solution bottle 61, the injection tube 62 is installed on one side of the adjusting plate 43, a filter screen 63 is connected to the inside of the injection tube 62, a guide tube 64 is connected to the lower end face of the injection tube 62, the lower end face of the guide tube 64 penetrates between the first roller 54 and the second roller 55, a culture bag 65 is connected to the lower end face of the guide tube 64, an accommodating groove 66 is placed on the outer surface of the culture bag 65, a heating sheet is connected to the inside of the accommodating groove 66, the type of the heating sheet is a PTC heating sheet, in the solution supplementing process, the heating sheet inside the accommodating groove 66 is utilized, cells in the culture bag 65 are heated at constant temperature, cell coagulation is prevented, the culture solution can be supplemented at constant temperature, the cell supplementing process is facilitated, the cell supplementing solution is better, waste of the culture solution and the culture bag is prevented, and the accommodating groove 66 is arranged on one side of the moving plate 28. The culture solution bottle 61 is attached to the upper end surface of the injection tube 62, the culture solution in the culture solution bottle 61 flows into the injection tube 62, impurities are filtered by the filter screen 63 in the injection tube 62, after the filtration, the culture solution is guided to the guide tube 64 by one end of the injection tube 62, and the cells in the culture bag 65 are replenished by the guide tube 64.
In this embodiment, a fixing plate 126 is connected to one side of the upper end surface of the supporting cover 12, a second buckle plate 127 is connected to the upper end of the fixing plate 126, and the outer surface of the second buckle plate 127 abuts against the outer surface of the first buckle plate 271. After the rack 27 rises for a certain length, the first buckle plate 271 on the rack 27 is buckled with the second buckle plate 127, and at this time, the lower part of the rack 27 is not meshed with the gear 26, that is, the gear 26 rotates and cannot further drive the rack 27 to rise.
In this embodiment, a second sliding portion 272 is connected to a lower end of the rack 27, a fourth sliding groove 281 is slidably connected to an outer surface of the second sliding portion 272, and the fourth sliding groove 281 is opened in an inner side of the movable tray 28. The pressing plate 37 abuts against the upper end of the pressing rod 39 downward, so that the moving plate 28 slides on the outer surface of the second sliding portion 272 through the fourth sliding groove 281 and vertically downward, and is pressed against the first spring body 291 to stretch downward, which is beneficial to generating vibration of the moving plate 28.
The invention has the beneficial effects that:
firstly, the support column 11 and the support cover 12 are fixed with the support plate 13 by the bottom plate 1, the injection tube 62 on the conveying mechanism 6 is installed on one side of the adjusting plate 43, after the installation, the guide tube 64 vertically passes downwards and through the position between the first roller 54 and the second roller 55, then the culture bag 65 is placed in the accommodating groove 66 and is connected with the lower end of the guide tube 64, after the connection, the user can apply force to the handle 21 on the adjusting mechanism 2 to rotate the handle 21 and drive the first rotating shaft 22 to rotate, the first rotating shaft 22 rotates in the first rotating groove 121 and simultaneously drives the worm 23 to rotate, the worm 23 is meshed with the worm wheel 24, the worm wheel 24 also drives the second rotating shaft 25 when rotating, one end of the second rotating shaft 25 rotates in the second rotating groove 122, the second rotating shaft 25 drives the gear buckle plate 26 to be meshed with the rack 27, the rack 27 vertically moves upwards, simultaneously drives the rack moving plate 28 and the limiting block 29 vertically upwards, and simultaneously drives the culture bag 65 on the accommodating groove 66 to move upwards, and after the rack 27 ascends for a certain length, the first buckle 271 on the rack 27 drives the second rack 27 to be meshed with the gear 127, and the rack 26 without further rotating, and the rack 26 further rotating.
Meanwhile, the second rotating shaft 25 drives the cam plate 31 and the projection 32 on the vibrating mechanism 3 at one end, the cam plate 31 and the projection 32 rotate in the third rotating groove 123 under the driving of the second rotating shaft 25, the projection 32 rotates to abut against one end of the driving plate 33, the driving plate 33 slides in the first sliding groove 124 and is pressed downward by the second spring body 35, and simultaneously drives the pushing plate 34 downward, the pressing plate 37 is pressed downward to abut against the upper end of the pressing rod 39, the moving plate 28 slides vertically downward on the outer surface of the second sliding portion 272 through the fourth sliding groove 281, and is pressed downward by the first spring body 291, after the projection 32 abuts against the driving plate 33 is reset by the second spring body 35, the moving plate 28 is reset by the first spring body 291, and the circulation is performed sequentially, and the vibration is generated on the moving plate 28, so that the culture bag 65 on the accommodating groove 66 is prevented from being solidified, which is beneficial for preventing the cells from being solidified due to the culture bag 65 from being stopped for a long time, and preventing the culture bag from being solidified by the vibration.
After the vibration is completed, the rack 27 buckled on the second buckle plate 127 is taken down, the gear 26 is meshed with the outer surface of the rack 27, the gear 26 is meshed with the rack 27 by utilizing the rotation of the handle 21 to adjust the movable disc 28, the movable disc 28 carries the culture bag 65 on the containing groove 66 to adjust the position, the guide pipe 64 is vertically connected with the lower end surface of the culture bag 65 to form a straight line, in the adjusting process, the outer surface of the guide pipe 64 rotates through the outer surfaces of the first roller 54 and the second roller 55 on the rotating mechanism 5, the first roller 54 and the second roller 55 can rotate on the outer surfaces of the third rotating shaft 53 and the fourth rotating shaft 56, the guide pipe 64 can rapidly slide, and the guide pipe 64 is prevented from being bent, after the adjustment, accessible elasticity pole 38 is tight and loose, let clamp plate 37 slide perpendicularly upwards in second slide groove 36, let clamp plate 37 avoid the upper end at depression bar 39, guarantee that clamp plate 37 can not the butt in depression bar 39, prevent when the fluid infusion, produce vibrations because of butt depression bar 39, can let the junction of cultivateing bag 65 and stand pipe 64 weeping phenomenon appear, after the adjustment is accomplished, fasten elasticity pole 38, be favorable to when the model of cultivateing the bag is perhaps big or little, guarantee that the pipeline is a straight line, accessible slide mechanism 4 lets injection tube 62 adjustable position, also let cultivateing bag 65 pass through adjustment mechanism 2 adjustable position, improve the culture solution through the removal and in pipeline velocity of flow nature or prevent to take place blocking phenomenon, improve work efficiency.
In the process of meshing adjustment of the rack 27, the adjustment can be performed in cooperation with the sliding mechanism 4, if the length of the guide tube 64 is too long, and the rack 27 is still bent after meshing adjustment, the adjustment rod 41 on the sliding mechanism 4 can be used to slide the first sliding part in the third slide channel 131 and move upwards, and simultaneously drive the adjustment plate 43 to move upwards, in the moving process, the position of the injection tube 62 can be adjusted, the guide tube 64 is vertically in a straight line, if the length of the guide tube 64 is too short, otherwise, after the work adjustment, the culture solution bottle 61 is installed on the upper end surface of the injection tube 62 to start the solution supplementing work, in the solution supplementing process, the heating sheet inside the accommodating groove 66 is used to heat the cells in the culture bag 65 at constant temperature to prevent the cells from solidifying, which is favorable for maintaining the temperature of the culture solution during the solution supplementing process, and better supplementing the cells can be performed, thereby preventing the waste of the culture solution and the culture bag.
The working principle is as follows:
firstly, the support column 11 and the support cover 12 are fixed with the support plate 13 by the bottom plate 1, the injection tube 62 on the conveying mechanism 6 is installed on one side of the adjusting plate 43, after the installation, the guide tube 64 vertically passes downwards and through the position between the first roller 54 and the second roller 55, then the culture bag 65 is placed in the accommodating groove 66 and is connected with the lower end of the guide tube 64, after the connection, the user can apply force to the handle 21 on the adjusting mechanism 2 to rotate the handle 21 and drive the first rotating shaft 22 to rotate, the first rotating shaft 22 rotates in the first rotating groove 121 and simultaneously drives the worm 23 to rotate, the worm 23 is meshed with the worm wheel 24, the worm wheel 24 also drives the second rotating shaft 25 when rotating, one end of the second rotating shaft 25 rotates in the second rotating groove 122, the second rotating shaft 25 drives the gear buckle plate 26 to be meshed with the rack 27, the rack 27 vertically moves upwards, simultaneously drives the rack moving plate 28 and the limiting block 29 vertically upwards, and simultaneously drives the culture bag 65 on the accommodating groove 66 to move upwards, and after the rack 27 ascends for a certain length, the first buckle 271 on the rack 27 drives the second rack 27 to be meshed with the gear 127, and the rack 26 without further rotating, and the rack 26 further rotating.
Meanwhile, the second rotating shaft 25 drives the cam plate 31 and the projection 32 on the vibrating mechanism 3 at one end, the cam plate 31 and the projection 32 rotate in the third rotating groove 123 under the driving of the second rotating shaft 25, the projection 32 rotates to abut against one end of the driving plate 33, the driving plate 33 slides in the first sliding groove 124 and is pressed downward by the second spring body 35, and simultaneously drives the pushing plate 34 downward, the pressing plate 37 is pressed downward to abut against the upper end of the pressing rod 39, the moving plate 28 slides vertically downward on the outer surface of the second sliding portion 272 through the fourth sliding groove 281, and is pressed downward by the first spring body 291, after the projection 32 abuts against the driving plate 33 is reset by the second spring body 35, the moving plate 28 is reset by the first spring body 291, and the circulation is performed sequentially, and the vibration is generated on the moving plate 28, so that the culture bag 65 on the accommodating groove 66 is prevented from being solidified, which is beneficial for preventing the cells from being solidified due to the culture bag 65 from being stopped for a long time, and preventing the culture bag from being solidified by the vibration.
After the vibration is completed, the rack 27 buckled on the second buckle plate 127 is taken down, the gear 26 is meshed with the outer surface of the rack 27, the gear 26 is meshed with the rack 27 by utilizing the rotation of the handle 21 to adjust the movable disc 28, the movable disc 28 carries the culture bag 65 on the containing groove 66 to adjust the position, the guide pipe 64 is vertically connected with the lower end surface of the culture bag 65 to form a straight line, in the adjusting process, the outer surface of the guide pipe 64 rotates through the outer surfaces of the first roller 54 and the second roller 55 on the rotating mechanism 5, the first roller 54 and the second roller 55 can rotate on the outer surfaces of the third rotating shaft 53 and the fourth rotating shaft 56, the guide pipe 64 can rapidly slide, and the guide pipe 64 is prevented from being bent, after the adjustment, accessible elasticity pole 38 is tight and loose, let clamp plate 37 slide perpendicularly upwards in second slide groove 36, let clamp plate 37 avoid the upper end at depression bar 39, guarantee that clamp plate 37 can not the butt in depression bar 39, prevent when the fluid infusion, produce vibrations because of butt depression bar 39, can let the junction of cultivateing bag 65 and stand pipe 64 weeping phenomenon appear, after the adjustment is accomplished, fasten elasticity pole 38, be favorable to when the model of cultivateing the bag is perhaps big or little, guarantee that the pipeline is a straight line, accessible slide mechanism 4 lets injection tube 62 adjustable position, also let cultivateing bag 65 pass through adjustment mechanism 2 adjustable position, improve the culture solution through the removal and in pipeline velocity of flow nature or prevent to take place blocking phenomenon, improve work efficiency.
In the process of meshing adjustment of the rack 27, the adjustment can be performed in cooperation with the sliding mechanism 4, if the length of the guide tube 64 is too long, and the rack 27 is still bent after meshing adjustment, the adjustment rod 41 on the sliding mechanism 4 can be used to slide the first sliding part in the third slide channel 131 and move upwards, and simultaneously drive the adjustment plate 43 to move upwards, in the moving process, the position of the injection tube 62 can be adjusted, the guide tube 64 is vertically in a straight line, if the length of the guide tube 64 is too short, otherwise, after the work adjustment, the culture solution bottle 61 is installed on the upper end surface of the injection tube 62 to start the solution supplementing work, in the solution supplementing process, the heating sheet inside the accommodating groove 66 is used to heat the cells in the culture bag 65 at constant temperature to prevent the cells from solidifying, which is favorable for maintaining the temperature of the culture solution during the solution supplementing process, and better supplementing the cells can be performed, thereby preventing the waste of the culture solution and the culture bag.
The embodiments of the present invention are disclosed as the preferred embodiments, but not limited thereto, and those skilled in the art can easily understand the spirit of the present invention and make various extensions and changes without departing from the spirit of the present invention.
Claims (3)
1. A culture bag with a filtering function for cell therapy comprises a bottom plate (1) and is characterized in that the upper end face of one side of the bottom plate (1) is connected with a support column (11), the upper end face of the support column (11) is connected with a support cover body (12), one side of the support cover body (12) is connected with a support plate (13), an adjusting mechanism (2) is arranged in the support cover body (12), one end of the adjusting mechanism (2) is connected with a vibrating mechanism (3), a sliding mechanism (4) is arranged in the support plate (13), the lower end of the sliding mechanism (4) is connected with a rotating mechanism (5), and a conveying mechanism (6) is connected in the rotating mechanism (5);
the adjusting mechanism (2) comprises a handle (21), a first rotating shaft (22) is connected to the middle of the outer surface of the handle (21), a first rotating groove (121) is connected to one end of the first rotating shaft (22) in a sliding manner, the first rotating groove (121) is formed in one side wall of the inner portion of the supporting cover body (12), a worm (23) is connected to the middle of the first rotating shaft (22), a worm wheel (24) is meshed with the outer contour of the worm (23), a second rotating shaft (25) is sleeved inside the worm wheel (24), a second rotating groove (122) is connected to one end of the second rotating shaft (25) in a sliding manner, the second rotating groove (122) is formed in one side wall of the supporting cover body (12), the inner portion of the worm wheel (24) is sleeved on the outer surface of one end of the second rotating shaft (25), a gear (26) is rightly arranged on the outer surface of the worm wheel (24), a rack (27) is sleeved inside the outer contour of one end of the second rotating shaft (25), a rack (26) is meshed with the rack (27), the upper end surface of the rack (27) penetrates through the upper end face of the supporting cover body (12), a first moving end face (27) is connected with a limiting block (29), a limiting block (291), a lower end face (29) is connected to a spring disc (27) connected to a limiting block (291), the upper end of the first spring body (291) is connected with the lower end surface of the moving disc (28);
the vibration mechanism (3) comprises a cam disc (31), the outer surface of the cam disc (31) is connected to one end of a second rotating shaft (25), two sides of the outer contour of the cam disc (31) are connected with a convex block (32), the outer contour of the cam disc (31) is connected with a third rotating groove (123) in a rotating mode, the outer surface of the convex block (32) is abutted to a transmission plate (33), the outer surface of the transmission plate (33) is connected with a first sliding channel groove (124) in a sliding mode, the first sliding channel groove (124) and the third rotating groove (123) are jointly arranged on one side wall of the inner portion of the supporting cover body (12), the first sliding channel groove (124) and the third rotating groove (123) penetrate through, one side of the lower end of the transmission plate (33) is connected with a pushing plate (34), the bottom of the transmission plate (33) is connected with a second spring body (35), one end of the second spring body (35) is connected to the bottom of the first sliding channel groove (124), one side of the upper end of the pushing plate (34) is provided with a second sliding channel groove (36), one side of the moving plate (36) is connected with a pressing plate (37), and one side of a pressing rod (39) penetrates through the lower end of the pushing plate (39), and a pressing rod (39) is connected to the lower end of a pressing rod (39);
the sliding mechanism (4) comprises a regulating rod (41), the regulating rod (41) penetrates through the support plate (13), the lower end face of the regulating rod (41) is connected with a first sliding part (42), the outer surface of the first sliding part (42) is connected with a third sliding channel groove (131) in a sliding mode, the third sliding channel groove (131) is formed in one side of the support plate (13), and one side of the first sliding part (42) is connected with an adjusting plate (43);
the rotating mechanism (5) comprises a connecting plate (51), the upper end of the connecting plate (51) is connected to the inner upper wall of the supporting cover body (12), the lower end of the connecting plate (51) is connected with a rotating frame (52), one side of the inner part of the rotating frame (52) is connected with a third rotating shaft (53), a first roller (54) is sleeved on the outer surface of the third rotating shaft (53), a second roller (55) is over against the outer surface of the first roller (54), a fourth rotating shaft (56) is sleeved on the inner part of the second roller (55), two ends of the fourth rotating shaft (56) are connected to one side of the rotating frame (52), a through hole (125) is over against the upper end face of the rotating frame (52), and the through hole (125) is formed in one side of the upper end wall of the supporting cover body (12);
conveying mechanism (6) are including culture solution bottle (61), injection tube (62) are installed to this culture solution bottle (61) lower terminal surface, one side at adjusting plate (43) is installed in this injection tube (62), and injection tube (62) internal connection has filter screen (63), and the terminal surface is connected with stand pipe (64) under injection tube (62), this stand pipe (64) lower extreme runs through between first running roller (54) and second running roller (55), and the terminal surface is connected with cultivation bag (65) under stand pipe (64), holding tank (66) have been placed to this cultivation bag (65) surface, one side at removal dish (28) is seted up in this holding tank (66).
2. The culture bag for cell therapy having a filtration function according to claim 1, wherein: one side of the upper end surface of the supporting cover body (12) is connected with a fixing plate (126), the upper end of the fixing plate (126) is connected with a second buckle plate (127), and the outer surface of the second buckle plate (127) is abutted against the outer surface of the first buckle plate (271).
3. A culture bag for cell therapy having a filtering function according to claim 1, wherein: a second sliding portion (272) is connected to the lower end of the rack (27), a fourth sliding groove (281) is connected to the outer surface of the second sliding portion (272) in a sliding mode, and the fourth sliding groove (281) is formed in one side of the inner portion of the moving disc (28).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210438786.XA CN114958602B (en) | 2022-04-21 | 2022-04-21 | Cell therapy culture bag with filtering function |
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| CN202210438786.XA CN114958602B (en) | 2022-04-21 | 2022-04-21 | Cell therapy culture bag with filtering function |
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| CN114958602B true CN114958602B (en) | 2023-02-28 |
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| CN114958602A (en) | 2022-08-30 |
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