CN114949117A - 治疗紫癜的药物组合物 - Google Patents
治疗紫癜的药物组合物 Download PDFInfo
- Publication number
- CN114949117A CN114949117A CN202210806074.9A CN202210806074A CN114949117A CN 114949117 A CN114949117 A CN 114949117A CN 202210806074 A CN202210806074 A CN 202210806074A CN 114949117 A CN114949117 A CN 114949117A
- Authority
- CN
- China
- Prior art keywords
- mixing
- rhizoma
- radix
- concentrating
- supernatant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗紫癜的药物组合物,其由下述重量份的原料制成:黄芪20~30g,白术10~20g,山药15~25g,神曲15~25g,黄连5~15g,栀子10~14g,双花10~20g,连翘10~20g,黄柏5~15g,白及5~15g,赤芍10~20g,茜草10~20g,侧柏叶10~20g,三七1~3g,仙鹤草15~25g,地榆炭10~20g,儿茶5~15g,川芎5~15g,鸡内金10~20g,元胡10~20g,虫草0.4~0.6g,紫草20~30克,黄芩10~14克作原料药制成。本发明药物原料都是采用中药,方便制备和携带,没有西药的副作用,且提高疗效。
Description
技术领域
本发明涉及中药领域,特别是涉及一种治疗紫癜的药物组合物。
背景技术
紫癜性肾炎是过敏性紫癜的常见类型,目前西医暂无统一治疗方案,虽然应用左西替利嗪胶囊、糖皮质激素和免疫抑制剂后部分病例可获得疗效,但效果小,且副作用明显。因此,积极寻求中医治疗该病的有效方药。中医学将紫癜性肾炎归属“紫癜”、 “血尿”、“水肿”等范畴 ,热蓄下焦和灼伤阴络为其主要病机。到目前为止,西医也尚缺乏对其进行特异性治疗的有效药物。
发明内容
针对上述情况,为了克服现有技术的缺陷,本发明提供一种治疗紫癜的药物组合物。
本发明是通过下述技术方案来解决上述技术问题的:一种治疗紫癜的药物组合物,其特征在于,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪20~30g,白术10~20g,山药15~25g,神曲15~25g,黄连5~15g,栀子10~14g,双花10~20g,连翘10~20g,黄柏5~15g,白及5~15g,赤芍10~20g,茜草10~20g,侧柏叶10~20g,三七1~3g,仙鹤草15~25g,地榆炭10~20g,儿茶5~15g,川芎5~15g,鸡内金10~20g,元胡10~20g,虫草0.4~0.6g,紫草20~30克,黄芩10~14克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将上述清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 12g~14g / 包。
优选地,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪25g,白术15g,山药20g,神曲20g,黄连10g,栀子12g,双花15g,连翘15g,黄柏10g,白及10g,赤芍15g,茜草15g,侧柏叶15g,三七2g,仙鹤草20g,地榆炭15g,儿茶10g,川芎10g,鸡内金15g,元胡15g,虫草0.5g,紫草25克,黄芩12克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将上述清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 12g/包。
优选地,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪20g,白术20g,山药15g,神曲25g,黄连5g,栀子14g,双花10g,连翘20g,黄柏5g,白及15g,赤芍10g,茜草20g,侧柏叶10g,三七3g,仙鹤草15g,地榆炭20g,儿茶5g,川芎15g,鸡内金10g,元胡20g,虫草0.4g,紫草30克,黄芩10克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数(比如3~5克)的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将的清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 10g/ 包。
优选地,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪30g,白术10g,山药25g,神曲15g,黄连15g,栀子10g,双花20g,连翘10g,黄柏15g,白及5g,赤芍20g,茜草10g,侧柏叶20g,三七1g,仙鹤草25g,地榆炭10g,儿茶15g,川芎5g,鸡内金20g,元胡10g,虫草0.6g,紫草20克,黄芩14克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将上述清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 14g/包。
优选地,所述粉碎是采用粉碎机或破壁机进行粉碎的。
本发明的积极进步效果在于:本发明药物原料都是采用中药,方便制备和携带,没有西药的副作用,且提高疗效。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将对本发明实施例中的技术方案进行清楚、完整地描述。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市售购买获得的常规产品。
实施例1
本发明治疗紫癜的药物组合物由下述重量份的原料制成:黄芪25g,白术15g,山药20g,神曲20g,黄连10g,栀子12g,双花15g,连翘15g,黄柏10g,白及10g,赤芍15g,茜草15g,侧柏叶15g,三七2g,仙鹤草20g,地榆炭15g,儿茶10g,川芎10g,鸡内金15g,元胡15g,虫草0.5g,紫草25克,黄芩12克作原料药制成,采用以下步骤进行制备:
步骤一,将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数(比如3~5克)的阿胶细粉,浓缩至清膏;
步骤二,将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
步骤三,将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
步骤四,将步骤一的清膏、步骤二的稠膏、步骤三的醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 12g/ 包。
实施例2
黄芪20g,白术20g,山药15g,神曲25g,黄连5g,栀子14g,双花10g,连翘20g,黄柏5g,白及15g,赤芍10g,茜草20g,侧柏叶10g,三七3g,仙鹤草15g,地榆炭20g,儿茶5g,川芎15g,鸡内金10g,元胡20g,虫草0.4g,紫草30克,黄芩10克作原料药制成,采用以下步骤进行制备:
步骤十一,将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数(比如3~5克)的阿胶细粉,浓缩至清膏;
步骤十二,将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
步骤十三,将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
步骤十四,将步骤十一的清膏、步骤十二的稠膏、步骤十三的醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 10g/ 包。
实施例3
黄芪30g,白术10g,山药25g,神曲15g,黄连15g,栀子10g,双花20g,连翘10g,黄柏15g,白及5g,赤芍20g,茜草10g,侧柏叶20g,三七1g,仙鹤草25g,地榆炭10g,儿茶15g,川芎5g,鸡内金20g,元胡10g,虫草0.6g,紫草20克,黄芩14克作原料药制成,采用以下步骤进行制备:
步骤二十一,将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数(比如3~5克)的阿胶细粉,浓缩至清膏;
步骤二十二,将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
步骤二十三,将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
步骤二十四,将步骤二十一的清膏、步骤二十二的稠膏、步骤二十三的醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 14g/ 包。
黄芪具有健脾补中,升阳举陷,益卫固表,利尿,托毒生肌的功效,主治脾气虚证,肺气虚证,气虚自汗证,气血亏虚,疮疡难溃难腐,或溃久难敛等。黄芪配白术的效果如下:黄芪长于益气补虚;白术善于健脾益气,两药配伍,可增强补气健脾的作用,适用于气虚脾弱所致倦怠乏力、气短等。
白术是一种常用重要的大宗中药材,具补脾健胃、燥湿利水、止汗安胎等功能。白术根茎含挥发油,油中主要成分为苍术酮、苍术醇、白术内酯等,对治疗肝硬化腹水、原发性肝癌、美尼尔氏综合症、慢性腰痛、急性肠炎及白细胞减少症等有一定疗效。白术用途广泛,除了医疗配方用药外,又是四十多种中成药制剂的重要原料。
山药用于健脾,补肺,固肾,益精。治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数,补脾养胃,生津益肺,补肾涩精,还用于脾虚食少、久泻不止、肺虚喘咳、肾虚遗精、带下、尿频、虚热消渴。
神曲健脾开胃、消食化积,神曲中主要成分为酵母菌,还有淀粉酶、挥发油、脂肪油,还有维生素B等,神曲里的这些酶主要作用是促进消化,因此对于消化不良、食欲不振、腹胀吐泻等症状有一定的治疗作用,还具有下气调中健脾和胃的功效。
黄连用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,心悸不宁,血热吐衄,目赤,牙痛,消渴,痈肿疔疮。
栀子具有护肝、利胆、降压、镇静、止血、消肿等作用,在中医临床常用于治疗黄疸型肝炎、扭挫伤 、高血压、糖尿病、紫癜等。
双花又称金银花,用于清热解毒,治疗温病发热,热毒血痢,痈疡等病症,亦用于风热感冒,支气管炎等病症。
连翘用于清热解毒,散结,消肿,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。
黄柏有清热燥湿,泻火除蒸,解毒疗疮的功效。
白及具有收敛、止血、消肿、生肌等功效,还具有美白、消斑等功效,对于普通女性的色素沉着、色斑、痤疮,以及皮炎痊愈之后,遗留的皮肤色泽暗淡,具有一定美白、消斑的作用。
赤芍用于热入营血,温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,瘾瘕腹痛,跌扑损伤,痈肿疮疡。
茜草具有以下作用,一、止血,止血是中药茜草的重要作用之一,它能促进血液凝固,提高凝血酶的活性,平时人们出现外伤出血时可以把茜草制成炭状以后直接外敷,就能快速止血。二、止咳化痰,平时它煎制以后能稀释人体内的痰液,也能止咳润肺,能让人们咳嗽痰多的症状很快好转。三、抗菌消炎,它的提取物对人体内的金黄色葡萄球菌与肺炎球菌还能流感病菌都有很好的抑制和消除作用,能减少人体内多种炎症的发生,对人类高发的气管炎和肺炎以及咽喉炎都有很好的预防和治疗作用。
侧柏叶用于吐血,衄血,咯血,便血,崩漏下血,肺热咳嗽,血热脱发。
三七有清热解毒、止血、破血散瘀、消炎定痛和滋补的功效,为治疗跌打损伤的主要药物。
仙鹤草有收敛止血、消炎、止痢、解毒、杀虫、益气强心的功能。
地榆炭用于便血,痔血,血痢,崩漏,水火烫伤,痈肿疮毒。
儿茶用于跌扑伤痛,外伤出血,吐血衄血,疮疡不敛,湿疹、湿疮,肺热咳嗽。
川芎可以活血祛瘀,适宜瘀血阻滞各种病症;可治头风头痛、风湿痹痛等症。
鸡内金用于健胃消食,涩精止遗,通淋化石。
元胡有活血散瘀,理气止痛的作用,主治胃痛、痛经、跌打损伤等。
虫草具有补肾益肺,止血化痰功效,主治腰膝酸痛、久咳虚喘、劳嗽痰血等。
紫草具有凉血活血清热解毒透疹的功效,治疗温热斑疹、湿热黄胆、吐血、蛆血、尿血、淋浊、血痢、热结便秘、烧伤、湿疹、丹毒等病。
黄芩有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等病症。
上述步骤中的所有煎煮所花时间为二至四小时,优选为三小时,使反应充分且有效成分尽量提取出来。
其中,粉碎是可以采用粉碎机或破壁机进行粉碎的,使人体轻易地消化和吸收,提高使用效果。优选采用破壁机,粉碎效果更好。
其中,混合可以采用搅拌机进行搅拌混合,提高混合效率和效果。
上述药物原料都是采用中药,方便制备和携带,没有西药的副作用,且提高疗效。
疗效评定方式、结果等如下:治疗组口服本发明制备的治疗紫癜的药物组合物,每次12g,每日2次,如果症状得到很好控制则保持用量,如果症状得不到控制则每次增加1g,直到症状得到控制,治疗周期6周。对照组单独服用左西替利嗪胶囊。疗效如表1所示。
表1
组别 | 人数 | 临床治愈 | 显效 | 有效 | 无效 | 有效率 | 副作用 |
治疗组 | 70 | 50 | 12 | 5 | 3 | 95.71% | 无 |
对照组 | 60 | 26 | 10 | 7 | 17 | 71.67% | 有 |
从表1可以看出,采用本发明的治疗紫癜疾病的药物组合物能控制和改善患者紫癜发病的频率,且无副作用。
以上所描述的实施例是本发明一部分实施例,而不是全部的实施例。本发明的实施例的详细描述并非旨在限制要求保护的本发明的范围,而是仅仅表示本发明的选定实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
Claims (5)
1.一种治疗紫癜的药物组合物,其特征在于,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪20~30g,白术10~20g,山药15~25g,神曲15~25g,黄连5~15g,栀子10~14g,双花10~20g,连翘10~20g,黄柏5~15g,白及5~15g,赤芍10~20g,茜草10~20g,侧柏叶10~20g,三七1~3g,仙鹤草15~25g,地榆炭10~20g,儿茶5~15g,川芎5~15g,鸡内金10~20g,元胡10~20g,虫草0.4~0.6g,紫草20~30克,黄芩10~14克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将上述清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 12g~14 g /包。
2.如权利要求1所述的治疗紫癜的药物组合物,其特征在于,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪25g,白术15g,山药20g,神曲20g,黄连10g,栀子12g,双花15g,连翘15g,黄柏10g,白及10g,赤芍15g,茜草15g,侧柏叶15g,三七2g,仙鹤草20g,地榆炭15g,儿茶10g,川芎10g,鸡内金15g,元胡15g,虫草0.5g,紫草25克,黄芩12克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将上述清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 12g/ 包。
3.如权利要求1所述的治疗紫癜的药物组合物,其特征在于,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪20g,白术20g,山药15g,神曲25g,黄连5g,栀子14g,双花10g,连翘20g,黄柏5g,白及15g,赤芍10g,茜草20g,侧柏叶10g,三七3g,仙鹤草15g,地榆炭20g,儿茶5g,川芎15g,鸡内金10g,元胡20g,虫草0.4g,紫草30克,黄芩10克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数(比如3~5克)的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将的清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 10g/ 包。
4.如权利要求1所述的治疗紫癜的药物组合物,其特征在于,所述治疗紫癜的药物组合物由下述重量份的原料制成:黄芪30g,白术10g,山药25g,神曲15g,黄连15g,栀子10g,双花20g,连翘10g,黄柏15g,白及5g,赤芍20g,茜草10g,侧柏叶20g,三七1g,仙鹤草25g,地榆炭10g,儿茶15g,川芎5g,鸡内金20g,元胡10g,虫草0.6g,紫草20克,黄芩14克作原料药制成,采用以下步骤进行制备:
将黄芪、白术、山药、神曲、黄连、栀子、双花、连翘、黄柏、白及、赤芍、茜草、侧柏叶混合并加水煎煮,过滤合并煎煮液并浓缩适量;上述过滤后的药渣中加入乙醇,加热回流提取,合并醇提液并浓缩,煎煮浓缩液及醇提浓缩液合并混匀,并加入选定重量份数的阿胶细粉,浓缩至清膏;
将三七、仙鹤草、地榆炭、儿茶、川芎、鸡内金混合并取饮片用水浸泡,再加水煎煮二次,弃渣过滤合并两次滤液,沉淀,取上清液浓缩成稠膏;
将元胡、虫草、紫草、黄芩混合并加水煎煮,两次煎煮,合并煎液,离心得提取上清液,提取上清液继续浓缩后,醇沉,得醇沉上清液备用;
将上述清膏、稠膏、醇沉上清液混合,干燥,粉碎,制成细颗粒剂后分装成 14g/ 包。
5.如权利要求1所述的治疗紫癜的药物组合物,其特征在于,所述粉碎是采用粉碎机或破壁机进行粉碎的。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210806074.9A CN114949117A (zh) | 2022-07-10 | 2022-07-10 | 治疗紫癜的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210806074.9A CN114949117A (zh) | 2022-07-10 | 2022-07-10 | 治疗紫癜的药物组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114949117A true CN114949117A (zh) | 2022-08-30 |
Family
ID=82967184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210806074.9A Pending CN114949117A (zh) | 2022-07-10 | 2022-07-10 | 治疗紫癜的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114949117A (zh) |
-
2022
- 2022-07-10 CN CN202210806074.9A patent/CN114949117A/zh active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102000175B (zh) | 一种治疗痔疮的中药组合物及其制备方法 | |
CN102657835B (zh) | 治疗高血压或/和类风湿性关节炎的组合物、药酒及其制备方法和应用 | |
CN108030864B (zh) | 一种治疗跌打损伤、烧伤及炎症的壮药药液 | |
CN101502588B (zh) | 一种美容祛痘组合物及其制备方法 | |
CN105497439A (zh) | 一种治疗妇产科术后低热症的药物组合物 | |
CN101361911A (zh) | 一种具有祛皱等功效皮肤外用组合物及其制法 | |
CN104922426A (zh) | 一种治疗妇产科术后低热症的药物组合物 | |
CN115282229B (zh) | 一种治疗气虚血淤型冠心病的中药组合物及其制备方法 | |
CN107296935B (zh) | 一种治疗周围性面瘫的中药组合物及中药制剂 | |
CN104940886A (zh) | 一种治疗脂溢性脱发的外用制剂及制法 | |
CN106039148B (zh) | 一种保肝蒙药 | |
CN103520421A (zh) | 一种治疗狐臭的中药组合物 | |
CN114949117A (zh) | 治疗紫癜的药物组合物 | |
CN113797294A (zh) | 一种治疗萎缩性胃炎的药物组合物及制备方法 | |
CN103463519B (zh) | 治疗瘀阻脉络症型瘰疬病的中药 | |
CN108619471B (zh) | 一种丹黄祛瘀胶囊及其制备工艺 | |
CN112587645A (zh) | 治疗不孕症的中药组合物、中药制剂和中药制品 | |
CN105832972A (zh) | 一种制备治疗痔疮的中药组合物的方法 | |
CN102908532A (zh) | 一种治疗血栓性脉管炎的中药 | |
CN116763883B (zh) | 一种含中药提取物的泡腾片洗剂及其制备方法 | |
CN102631660A (zh) | 一种治疗肠梗阻的中药 | |
CN108567926B (zh) | 一种治疗瘀血阻络型自身免疫性肝炎的中药组合物及其制备方法 | |
CN106110190B (zh) | 一种养血调经的中药组合物及中药制剂 | |
CN105343688A (zh) | 一种治疗心肌梗塞的药物组合物及其应用 | |
CN110898162A (zh) | 治疗紫癜的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication |