CN114949107A - Composition for eliminating gingival swelling and preparation method and application thereof - Google Patents
Composition for eliminating gingival swelling and preparation method and application thereof Download PDFInfo
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- CN114949107A CN114949107A CN202210747706.9A CN202210747706A CN114949107A CN 114949107 A CN114949107 A CN 114949107A CN 202210747706 A CN202210747706 A CN 202210747706A CN 114949107 A CN114949107 A CN 114949107A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a composition for eliminating gingival swelling and redness and a preparation method and application thereof. The composition for eliminating gingival swelling comprises garlic extract and cranberry extract; wherein the weight ratio of the garlic extract to the cranberry extract is 1-5: 1-5; the garlic extract is prepared by the following method: heating and refluxing garlic with a solvent, and concentrating and drying an extracting solution after extraction is finished to obtain the garlic extract. The cranberry extract is prepared by the following method: heating and refluxing cranberries with a solvent, and concentrating and drying an extracting solution after extraction is finished to obtain the cranberry extract. The research shows that the composition has the function of eliminating the redness and swelling of the gum; therefore, the composition has important application prospect when being used as an effective component to prepare medicines, toothpaste or mouthwash with the effect of eliminating the redness and swelling of the gum.
Description
Technical Field
The invention relates to the technical field of natural products, in particular to a composition for eliminating gingival swelling and a preparation method and application thereof.
Background
Redness and swelling of gum refers to redness, swelling and swelling of gum soft tissue around teeth; it is often found in the gingival tissue infectious diseases caused by dental plaque biofilm, and also in local foreign body irritation. However, at present, a special medicine for treating gingival inflammation and daily chemical products such as toothpaste with a remarkable effect of treating gingival inflammation are lacked.
Garlic, name of traditional Chinese medicine. Is bulb of Allium sativum L. of Allium of Liliaceae; has effects in removing toxic materials, relieving swelling, killing parasite, and relieving dysentery; it is commonly used for abscess, sores and ulcers, scabies, tinea, pulmonary tuberculosis, cough, diarrhea and dysentery.
Cranberries, also known as cranberries, grow mainly in the cool, acidic peat soil in the northern hemisphere, and are commonly called the traditional three big fruits in north america with koxter grapes and blueberries; the vegetable fiber is favored by people due to the characteristics of high moisture, low calorie, high fiber and multiple minerals; in addition, it also has effects of caring skin, resisting oxidation, promoting diuresis, removing toxic substances, and protecting cardiovascular system. At present, no research report of garlic and cranberry for eliminating gingival swelling in the prior art exists.
Disclosure of Invention
In order to overcome at least one of the technical problems of the prior art, the present invention provides a composition for eliminating gingival swelling.
The technical problem to be solved by the invention is realized by the following technical scheme:
a composition for eliminating gingival swelling comprises garlic extract and cranberry extract.
The inventor finds that the combination of the garlic extract and the cranberry extract has the effect of eliminating the swelling of the gum.
Preferably, the weight ratio of the garlic extract to the cranberry extract is 1-5: 1-5.
Further preferably, the weight ratio of the garlic extract to the cranberry extract is 1-3: 1-3.
Most preferably, the weight ratio of garlic extract to cranberry extract is 2: 1.
Preferably, the garlic extract is prepared by the following method:
heating and refluxing garlic with a solvent, and concentrating and drying an extracting solution after extraction is finished to obtain the garlic extract.
Preferably, the extraction time is 1-2 h.
Preferably, the weight of the solvent is 5 to 10 times of the weight of the garlic.
Most preferably, the solvent is used in an amount of 8 times the weight of the garlic.
Further preferably, the solvent is water or ethanol water solution.
Preferably, the solvent is a mixed organic solvent consisting of methanol and chloroform.
Preferably, the volume ratio of the methanol to the chloroform is 8-10: 1-2;
most preferably, the volume ratio of methanol to chloroform is 9: 1.
Preferably, the cranberry extract is prepared by the following method:
heating and refluxing cranberries with a solvent, and concentrating and drying an extracting solution after extraction is finished to obtain the cranberry extract.
Preferably, the extraction time is 1-3 h.
Preferably, the weight of the solvent is 10-15 times of the weight of the cranberry.
Most preferably, the amount of solvent used is 12 times the weight of cranberry.
Preferably, the solvent is water or ethanol water solution or ethyl acetate.
The inventor surprisingly discovers in research that the composition obtained by combining the garlic extract obtained by extracting the garlic extract by using the mixed organic solvent consisting of methanol and chloroform and the cranberry extract obtained by extracting the cranberry extract by using ethyl acetate has very excellent effect of eliminating the redness of gum; the effect of eliminating gingival swelling is far higher than that of the composition obtained by combining the garlic extract and the cranberry extract which are extracted by adopting conventional water or ethanol or other organic solvents.
The invention also provides application of the composition for eliminating the gingival swelling in preparation of products with the effect of eliminating the gingival swelling.
Preferably, the product is a medicament, toothpaste or mouthwash.
Has the beneficial effects that: the invention provides a brand new composition containing garlic extract and cranberry extract; the research shows that the composition has the function of eliminating the red swelling of the gum. Particularly, the composition obtained by combining the garlic extract obtained by extracting the garlic extract with the mixed organic solvent consisting of methanol and chloroform and the cranberry extract obtained by extracting the cranberry extract with ethyl acetate has very excellent effect of eliminating swelling of gum. Therefore, the composition provided by the invention has an important application prospect when being used as an effective component to prepare medicines, toothpaste or mouthwash with the function of eliminating redness and swelling of the gum.
Detailed Description
The present invention is further explained below with reference to specific examples, which are not intended to limit the present invention in any way.
Example 1 composition for eliminating redness and swelling of gum
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 8 times of water for 1.5 hr, concentrating the extractive solution, and drying to obtain Bulbus Allii extract.
The cranberry extract is prepared by the following method: heating and refluxing cranberries with water 8 times the weight of the cranberries for 1.5h, and concentrating and drying the extracting solution after extraction to obtain the cranberry extract.
Example 2 composition for eliminating redness and swelling of gum
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 95% ethanol 8 times the weight of Bulbus Allii for 1.5 hr, concentrating the extractive solution, and drying to obtain the Bulbus Allii extract.
The cranberry extract is prepared by the following method: taking cranberries, heating and refluxing the cranberries for 1.5h by using ethanol which is 8 times of the weight of the cranberries and has the volume fraction of 95%, and concentrating and drying an extracting solution after the extraction is finished to obtain the cranberry extract.
Example 3 composition for eliminating redness and swelling of gums
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 8 times of mixed organic solvent composed of methanol and chloroform at volume ratio of 9:1 of Bulbus Allii for 1.5 hr, concentrating the extractive solution, and drying to obtain the Bulbus Allii extract.
The cranberry extract is prepared by the following method: heating and refluxing cranberries with ethyl acetate 8 times the weight of the cranberries for 1.5h, and concentrating and drying the extracting solution after extraction to obtain the cranberry extract.
Example 4 composition for eliminating redness and swelling of gum
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 8 times of mixed organic solvent composed of methanol and chloroform at volume ratio of 9:1 of Bulbus Allii for 1.5 hr, concentrating the extractive solution, and drying to obtain the Bulbus Allii extract.
The cranberry extract is prepared by the following method: heating and refluxing cranberries with water 8 times the weight of the cranberries for 1.5h, and concentrating and drying the extracting solution after extraction to obtain the cranberry extract.
Example 5 composition for eliminating redness and swelling of gum
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 8 times of mixed organic solvent composed of methanol and chloroform at volume ratio of 9:1 of Bulbus Allii for 1.5 hr, concentrating the extractive solution, and drying to obtain the Bulbus Allii extract.
The cranberry extract is prepared by the following method: taking cranberries, heating and refluxing the cranberries for 1.5h by using ethanol which is 8 times of the weight of the cranberries and has the volume fraction of 95%, and concentrating and drying an extracting solution after the extraction is finished to obtain the cranberry extract.
Example 6 composition for eliminating redness and swelling of gingiva
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 8 times of water for 1.5 hr, concentrating the extractive solution, and drying to obtain Bulbus Allii extract.
The cranberry extract is prepared by the following method: heating and refluxing cranberries with ethyl acetate 8 times the weight of the cranberries for 1.5h, and concentrating and drying the extracting solution after extraction to obtain the cranberry extract.
Example 7 composition for eliminating redness and swelling of gingiva
The composition for eliminating gingival swelling is prepared by mixing a garlic extract and a cranberry extract in a weight ratio of 2: 1;
the garlic extract is prepared by the following method: heating and refluxing Bulbus Allii with 95% ethanol 8 times the weight of Bulbus Allii for 1.5 hr, concentrating the extractive solution, and drying to obtain the Bulbus Allii extract.
The cranberry extract is prepared by the following method: heating and refluxing cranberries with ethyl acetate 8 times the weight of the cranberries for 1.5h, and concentrating and drying the extracting solution after extraction to obtain the cranberry extract.
Examples of the experiments
The composition for eliminating redness and swelling of the gum prepared in the embodiments 1 to 7 is added to vaseline by the amount of 3% by weight to prepare a drug to be tested.
The construction method of the guinea pig gingival swelling model comprises the following steps: selecting 300g +/-30 g of guinea pigs, and stabbing the gum between two lower incisors of the guinea pigs with a needle; three days later, guinea pigs with hypertrophied and reddened gums were selected as subjects.
Selecting 48 guinea pigs with red and swollen gums constructed by the method, and dividing the guinea pigs into 8 groups, wherein each group comprises 6 guinea pigs; wherein 7 groups are experimental groups, and 1 group is a control group; in experimental groups 1 to 7, vaseline containing the composition for eliminating redness and swelling of gum in examples 1 to 7 was applied to the redness and swelling of gum of guinea pig 3 times per day; the control group was applied with vaseline without drug; after 7 days of application, the redness and swelling of the gums of each group of guinea pigs was recorded. The test results are shown in table 1.
No improvement was noted for gingival hypertrophy and unchanged or even acute redness; a reduction in gingival hypertrophy or redness reduction is indicated as an improvement; disappearance of the hypertrophic redness of the gums was recorded as return to normal.
Table 1.
As can be seen from the test data in Table 1, the compositions of examples 1-7, which are composed of garlic extract and cranberry extract, have a significant effect of eliminating the redness and swelling of the gums.
As can be seen from the test data in Table 1, the composition described in example 3 is much more effective in eliminating the redness of the gums than the compositions described in examples 1 and 2; this indicates that: the composition obtained by combining the garlic extract extracted by the mixed organic solvent consisting of methanol and chloroform and the cranberry extract extracted by ethyl acetate has the function of eliminating the redness and swelling of the gum, is greatly improved, and has very excellent function of eliminating the redness and swelling of the gum.
As can be seen from the test data in Table 1, the compositions of examples 4-7 have the same effect of eliminating redness of gum as examples 1 and 2, and are also much smaller than example 3; this indicates that: in the preparation process of the garlic extract and the cranberry extract, the selection of an extraction organic solvent is very critical; only the composition obtained by combining the garlic extract extracted by the mixed organic solvent consisting of methanol and chloroform with the cranberry extract extracted by ethyl acetate can greatly improve the gingival swelling eliminating effect, and has very excellent gingival swelling eliminating effect; the combination of the garlic extract and the cranberry extract obtained by adopting other organic solvents or the combination of organic solvents cannot greatly improve the effect of eliminating the redness and swelling of the gum of the composition.
Claims (10)
1. A composition for eliminating gingival redness and swelling, comprising garlic extract and tendrilled vine
Yuanmei extract.
2. The composition for eliminating gingival swelling according to claim 1, wherein the weight ratio of the garlic extract to the cranberry extract is 1-5: 1-5;
further preferably, the weight ratio of the garlic extract to the cranberry extract is 1-3: 1-3;
most preferably, the weight ratio of garlic extract to cranberry extract is 2: 1.
3. The composition for relieving gingival swelling and redness according to claim 1, wherein the garlic extract is prepared by the following method:
heating and refluxing garlic with a solvent, and concentrating and drying an extracting solution after extraction is finished to obtain the garlic extract.
4. The composition for eliminating gingival swelling according to claim 3, wherein the solvent is water or an aqueous ethanol solution.
5. The composition for eliminating gingival swelling according to claim 3, wherein the solvent is a mixed organic solvent consisting of methanol and chloroform.
6. The composition for eliminating gingival swelling according to claim 5, wherein the volume ratio of methanol to chloroform is 8-10: 1-2;
most preferably, the volume ratio of methanol to chloroform is 9: 1.
7. The composition for eliminating gingival swelling according to claim 1, wherein the cranberry extract is prepared by the following method:
heating and refluxing cranberries with a solvent, and concentrating and drying an extracting solution after extraction is finished to obtain the cranberry extract.
8. The composition for eliminating redness and swelling of gum according to claim 7, wherein said solvent is water or aqueous ethanol or ethyl acetate.
9. Use of the composition for eliminating gingival swelling according to any one of claims 1 to 8 in the preparation of a product with the effect of eliminating gingival swelling.
10. Use according to claim 9, wherein the product is a medicament, toothpaste or mouthwash.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210747706.9A CN114949107A (en) | 2022-06-29 | 2022-06-29 | Composition for eliminating gingival swelling and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210747706.9A CN114949107A (en) | 2022-06-29 | 2022-06-29 | Composition for eliminating gingival swelling and preparation method and application thereof |
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| CN114949107A true CN114949107A (en) | 2022-08-30 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555777A (en) * | 2003-12-30 | 2004-12-22 | 李杏健 | Garlic antitoxic bactericidal tooth paste |
| CN102090998A (en) * | 2009-12-10 | 2011-06-15 | 蒋健 | Tooth whitening powder |
| CN103610659A (en) * | 2013-12-06 | 2014-03-05 | 湖南中南大学湘雅口腔医院 | Allicin medicinal composition and preparation method thereof |
| CN103874424A (en) * | 2011-08-11 | 2014-06-18 | 罗蒂株式会社 | Spice extract-containing composition for oral cavity |
| CN105997780A (en) * | 2016-05-20 | 2016-10-12 | 秦瑜 | Cosmetic for reducing fine wrinkles and tightening face |
| CN110366415A (en) * | 2017-10-15 | 2019-10-22 | 消化系统疾病中心 | For treating, mitigating and preventing the composition and method of helicobacter pylori infections |
| CN111838496A (en) * | 2020-08-05 | 2020-10-30 | 江苏薇芝泽海洋生物科技有限公司 | Probiotic solid beverage beneficial to oral health and preparation method thereof |
-
2022
- 2022-06-29 CN CN202210747706.9A patent/CN114949107A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555777A (en) * | 2003-12-30 | 2004-12-22 | 李杏健 | Garlic antitoxic bactericidal tooth paste |
| CN102090998A (en) * | 2009-12-10 | 2011-06-15 | 蒋健 | Tooth whitening powder |
| CN103874424A (en) * | 2011-08-11 | 2014-06-18 | 罗蒂株式会社 | Spice extract-containing composition for oral cavity |
| CN103610659A (en) * | 2013-12-06 | 2014-03-05 | 湖南中南大学湘雅口腔医院 | Allicin medicinal composition and preparation method thereof |
| CN105997780A (en) * | 2016-05-20 | 2016-10-12 | 秦瑜 | Cosmetic for reducing fine wrinkles and tightening face |
| CN110366415A (en) * | 2017-10-15 | 2019-10-22 | 消化系统疾病中心 | For treating, mitigating and preventing the composition and method of helicobacter pylori infections |
| CN111838496A (en) * | 2020-08-05 | 2020-10-30 | 江苏薇芝泽海洋生物科技有限公司 | Probiotic solid beverage beneficial to oral health and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| MADEMOISELLE B: "爱牙营养攻略" * |
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