CN114945584A - 重组肽-mhc复合物结合蛋白及其生成和用途 - Google Patents

重组肽-mhc复合物结合蛋白及其生成和用途 Download PDF

Info

Publication number
CN114945584A
CN114945584A CN202080093380.1A CN202080093380A CN114945584A CN 114945584 A CN114945584 A CN 114945584A CN 202080093380 A CN202080093380 A CN 202080093380A CN 114945584 A CN114945584 A CN 114945584A
Authority
CN
China
Prior art keywords
amino acid
seq
binding
repeat domain
target peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080093380.1A
Other languages
English (en)
Chinese (zh)
Inventor
V·勒维斯基
N·维内特兹
M·瓦尔瑟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Partners AG
Original Assignee
Molecular Partners AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Partners AG filed Critical Molecular Partners AG
Publication of CN114945584A publication Critical patent/CN114945584A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN202080093380.1A 2019-12-11 2020-12-11 重组肽-mhc复合物结合蛋白及其生成和用途 Pending CN114945584A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19215436.7 2019-12-11
EP19215436 2019-12-11
PCT/EP2020/085864 WO2021116470A2 (en) 2019-12-11 2020-12-11 Recombinant peptide-mhc complex binding proteins and their generation and use

Publications (1)

Publication Number Publication Date
CN114945584A true CN114945584A (zh) 2022-08-26

Family

ID=68886964

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080093380.1A Pending CN114945584A (zh) 2019-12-11 2020-12-11 重组肽-mhc复合物结合蛋白及其生成和用途

Country Status (7)

Country Link
US (1) US20230041822A1 (https=)
EP (1) EP4073093A2 (https=)
JP (1) JP2023506763A (https=)
CN (1) CN114945584A (https=)
AU (1) AU2020401363A1 (https=)
CA (1) CA3161319A1 (https=)
WO (1) WO2021116470A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL293698A (en) 2019-12-11 2022-08-01 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins, their production and use
JP2023525518A (ja) 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
US20240279290A1 (en) 2020-05-14 2024-08-22 Molecular Partners Ag Multispecific proteins
US11981710B2 (en) 2020-08-18 2024-05-14 Athebio Ag N-terminal capping modules of ankyrin repeat domains
EP3957649A1 (en) 2020-08-18 2022-02-23 Athebio AG Improved n-terminal capping modules of ankyrin repeat domains
BR112023018293A2 (pt) 2021-03-09 2023-10-31 Molecular Partners Ag Acopladores de célula t multiespecíficos à base de darpin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
CN103864893B (zh) * 2007-07-27 2017-01-04 伊玛提克斯生物技术有限公司 免疫疗法的免疫抗原表位
US9365629B2 (en) 2007-09-24 2016-06-14 University Of Zurich Designed armadillo repeat proteins
PL2643349T3 (pl) 2010-11-26 2020-03-31 Molecular Partners Ag Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy
BR112016018100A2 (pt) * 2014-02-07 2018-02-20 Univ Mcmaster acoplador antigênico de células t trifuncional, métodos e usos do mesmo
KR102427117B1 (ko) 2015-04-02 2022-07-29 몰리큘라 파트너스 아게 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인
US12065479B2 (en) * 2017-11-16 2024-08-20 The Regents Of The University Of California Force sensor cleavage domain containing chimeric polypeptides and methods of use thereof
EP3731876A4 (en) * 2017-12-28 2022-04-06 Gritstone bio, Inc. ANTIGEN-BINDING PROTEINS TARGETING SHARED ANTIGENS
CN114270815B (zh) * 2019-06-06 2025-03-18 弗劳恩霍夫应用研究促进协会 多通道成像设备和具有多孔径成像设备的设备

Also Published As

Publication number Publication date
WO2021116470A2 (en) 2021-06-17
EP4073093A2 (en) 2022-10-19
JP2023506763A (ja) 2023-02-20
CA3161319A1 (en) 2021-06-17
AU2020401363A1 (en) 2022-06-16
WO2021116470A3 (en) 2021-10-28
US20230041822A1 (en) 2023-02-09

Similar Documents

Publication Publication Date Title
US20230243070A1 (en) Recombinant peptide-mhc complex binding proteins and their generation and use
CN114945584A (zh) 重组肽-mhc复合物结合蛋白及其生成和用途
JP6041799B2 (ja) Ｔｒａｉｌｒ２特異的多量体足場
JP6783797B2 (ja) 抗がん融合ポリペプチド
JP6410724B2 (ja) 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質
JP2016521688A (ja) 肝細胞増殖因子に結合する設計アンキリン反復タンパク質
CN115916234A (zh) 靶向ras蛋白的分子
CN111378040B (zh) 检测多种恶性肿瘤细胞的抗体及其应用
CN111378039A (zh) 治疗恶性肿瘤的抗体及其应用
KR20220143730A (ko) 단백질을 표적화하는 분자
AU2015263827B2 (en) Bak binding proteins
JP2024529467A (ja) Ｃｔ４５に特異的に結合する抗原結合タンパク質
CN121263440A (zh) 重组cd2结合蛋白及其用途
HK40080054A (en) Molecules targeting proteins
HK40080053A (en) Molecules targeting mutant ras protein
WO2011132940A2 (ko) Rtk에 특이적으로 결합하는 rtk-bpb
BR112015012436B1 (pt) Proteína de ligação recombinante e formulação farmacêutica

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination