CN114945355B - 具有用于改进胃驻留的长丝的胃驻留系统 - Google Patents

具有用于改进胃驻留的长丝的胃驻留系统

Info

Publication number
CN114945355B
CN114945355B CN202080091456.7A CN202080091456A CN114945355B CN 114945355 B CN114945355 B CN 114945355B CN 202080091456 A CN202080091456 A CN 202080091456A CN 114945355 B CN114945355 B CN 114945355B
Authority
CN
China
Prior art keywords
gastric
arm
arms
polymer
gastric resident
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080091456.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN114945355A (zh
Inventor
R·卡纳斯蒂
T·格兰特
J·H·杨
D·C·杜富尔
E·R·W·赖德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lindera Treatment Co
Original Assignee
Lindera Treatment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lindera Treatment Co filed Critical Lindera Treatment Co
Publication of CN114945355A publication Critical patent/CN114945355A/zh
Application granted granted Critical
Publication of CN114945355B publication Critical patent/CN114945355B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1042—Alimentary tract
    • A61M2210/1053—Stomach

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202080091456.7A 2019-11-08 2020-11-06 具有用于改进胃驻留的长丝的胃驻留系统 Active CN114945355B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962933211P 2019-11-08 2019-11-08
US62/933,211 2019-11-08
US202062992075P 2020-03-19 2020-03-19
US62/992,075 2020-03-19
PCT/US2020/059533 WO2021092483A1 (en) 2019-11-08 2020-11-06 Gastric residence systems having a filament for improved gastric residence

Publications (2)

Publication Number Publication Date
CN114945355A CN114945355A (zh) 2022-08-26
CN114945355B true CN114945355B (zh) 2025-11-21

Family

ID=75849559

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080091456.7A Active CN114945355B (zh) 2019-11-08 2020-11-06 具有用于改进胃驻留的长丝的胃驻留系统

Country Status (7)

Country Link
US (1) US20220409528A1 (https=)
EP (1) EP4054538A4 (https=)
JP (1) JP2022553867A (https=)
CN (1) CN114945355B (https=)
AU (1) AU2020379040A1 (https=)
CA (1) CA3160659A1 (https=)
WO (1) WO2021092483A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020117855A1 (en) 2018-12-03 2020-06-11 Lyndra, Inc. Stomach simulating device
BR112021018496A2 (pt) 2019-03-20 2021-11-30 Lyndra Therapeutics Inc Cápsulas e revestimento de cápsula para formas de dosagem de residência gástrica
AU2020242062B2 (en) 2019-03-20 2025-12-11 Nortiva Bio, Inc. Coatings for gastric residence dosage forms
JP7847119B2 (ja) 2020-07-29 2026-04-16 ザ・セカント・グループ・エルエルシー 架橋ポリ（セバシン酸グリセロール）を含む構造を含む形状誘導型制御放出および保持
US20220142566A1 (en) * 2020-09-09 2022-05-12 Massachusetts Institute Of Technology Closed-loop detection and treatment of radiation and toxic agents
US20240390270A1 (en) * 2021-01-19 2024-11-28 Lyndra Therapeutics, Inc. Gastric residence systems for administration of risperidone
AU2023209872A1 (en) * 2022-01-19 2024-08-01 Nortiva Bio, Inc. Dosage forms for gastric retention
US20250367418A1 (en) * 2022-04-04 2025-12-04 Celero Systems, Inc. Gastric residency system for electronic ingestible devices
JP7832721B2 (ja) * 2022-06-03 2026-03-18 ジュニオン ラブズ ピーティーイー． リミテッド 経口投与用の胃内滞留装置
CN121752250A (zh) * 2023-08-24 2026-03-27 厦门君德医药科技有限公司 一种口服胃滞留物
WO2025148850A1 (zh) * 2024-01-09 2025-07-17 厦门君德医药科技有限公司 一种胃滞留装置
WO2025199123A1 (en) * 2024-03-19 2025-09-25 Lyndra Therapeutics, Inc. Flexible line configurations for gastric residence systems
WO2025195482A1 (zh) * 2024-03-22 2025-09-25 厦门君德医药科技有限公司 一种胃滞留装置
CN120267955B (zh) * 2025-06-06 2025-09-19 浙江大学 一种自发电胃驻留电子胶囊及其应用
CN120507243B (zh) * 2025-07-21 2025-10-24 中国直升机设计研究所 一种直升机复合材料桨毂破损安全试验谱编制方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060458A1 (en) * 2017-09-20 2019-03-28 Lyndra, Inc. ENCAPSULATION OF GASTRIC SYSTEMS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002772A (en) * 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
US7699863B2 (en) * 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US20100286628A1 (en) * 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
NZ727659A (en) * 2014-06-11 2021-12-24 Massachusetts Inst Technology Residence structures and related methods
WO2017100367A1 (en) * 2015-12-08 2017-06-15 Lyndra, Inc. Geometric configurations for gastric residence systems
JP2019532947A (ja) * 2016-09-30 2019-11-14 リンドラ，インコーポレイティド アダマンタン系薬物の持続的送達のための胃内滞留システム

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060458A1 (en) * 2017-09-20 2019-03-28 Lyndra, Inc. ENCAPSULATION OF GASTRIC SYSTEMS

Also Published As

Publication number Publication date
CN114945355A (zh) 2022-08-26
US20220409528A1 (en) 2022-12-29
EP4054538A4 (en) 2024-02-07
CA3160659A1 (en) 2021-05-14
JP2022553867A (ja) 2022-12-26
WO2021092483A1 (en) 2021-05-14
EP4054538A1 (en) 2022-09-14
AU2020379040A8 (en) 2022-06-23
AU2020379040A1 (en) 2022-06-09

Similar Documents

Publication Publication Date Title
CN114945355B (zh) 具有用于改进胃驻留的长丝的胃驻留系统
US20240423909A1 (en) Materials architecture for gastric residence systems
US20240342081A1 (en) Geometric configurations for gastric residence systems
TWI811221B (zh) 具有釋放速率調節膜之胃的滯留系統
JP2022553862A (ja) 活性剤投与用胃内滞留型システム
US20220387312A1 (en) Gastric residence systems having arms with controlled stiffness for improved gastric residence
US20240398701A1 (en) Manufacturing methods for gastric residence systems
TWI837082B (zh) 用於胃滯留系統之材料架構
US20250295901A1 (en) Flexible line configurations for gastric residence systems
HK40106006A (en) Geometric configurations for gastric residence systems
RU2806007C2 (ru) Геометрические компоновки систем длительного нахождения в желудке
TW202500122A (zh) 用於胃滯留系統之材料架構
HK1259225B (en) Geometric configurations for gastric residence systems

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant