CN114935662A

CN114935662A - Integrated biological sample processing system

Info

Publication number: CN114935662A
Application number: CN202210856142.2A
Authority: CN
Inventors: 冀闪; 易木林
Original assignee: Hunan Huize Bio Pharmaceutical Co ltd
Current assignee: Hunan Huize Bio Pharmaceutical Co ltd
Priority date: 2022-07-21
Filing date: 2022-07-21
Publication date: 2022-08-23
Also published as: CN219266313U

Abstract

The invention discloses an integrated biological sample processing system which comprises an original sample tube storage mechanism, an original sample tube taking and placing mechanism, an original sample tube rotary processing unit, a rotary sampling unit, a new sample tube rotary processing unit, a new sample tube taking and placing mechanism and a new sample tube storage mechanism which are sequentially connected in series. The device can be suitable for processing tubular sample tubes of various specifications, can realize continuous sampling detection operation under the synergistic action of the rotary original sample tube rotary processing unit, the rotary new sample tube rotary processing unit, the rotary sample tube cap opening and closing mechanism and the like, and is improved from the original one-by-one reciprocating detection process to batch rotary flow operation, so that the detection efficiency is greatly improved, and compared with the prior art, the overall processing efficiency is improved by at least 80%.

Description

Integrated biological sample processing system

Technical Field

The invention relates to biological sample detection equipment, in particular to an integrated biological sample processing system, and belongs to the technical field of in-vitro medical detection.

Background

As the demand for medical diagnostics increases, the volume and number of clinical samples to be processed is gradually increasing. The processing of clinical samples and specimens may involve transferring the original sample or specimen to a new reservoir or container suitable for performing diagnostic tests. The processing of biological samples and specimens may include the steps of: for example by removing the lid of the initial reservoir or container and into the contents of the initial reservoir or container, then removing a portion of the contents, and transferring the portion of the contents to the intended reservoir or container. In some cases, the processing may further include: repositioning the lid of the initial reservoir or container or otherwise closing the initial reservoir or container to preserve the remaining contents for further testing or archiving.

The processing of large numbers of samples and specimens increases the time to provide a diagnostic result, increases the likelihood of worker exposure to repetitive motion disorder and potentially biohazardous materials, decreases the consistency of sample or specimen preparation, and increases the cost of the diagnostic procedure. As the volume of medical diagnostic tests increases, the number of samples and specimens required to be processed increases. Automated systems for sample preparation processing for medical diagnostic testing address the above-mentioned problems by reducing the time required to process specimens, reducing the likelihood of worker exposure to repetitive motion and biohazardous materials, ensuring consistency in sample processing, and helping to limit the cost of processing samples.

In-vitro diagnostic equipment such as a chemiluminescence immunoassay analyzer adopts a direct chemiluminescence method based on acridinium ester, is used together with a matched detection reagent, and is clinically used for qualitatively or quantitatively detecting analytes in body fluid of a human body, wherein the analytes comprise autoimmune items, infectious disease items, hormone items and tumor-related items. The sample devices such as serum, plasma, urine, cerebrospinal fluid and the like are arranged in sample tubes, and different types of sample tubes are arranged in different hospitals. In the prior art, on one hand, a single chemiluminescence immunoassay analyzer can only identify one type of sample tube. Sample tube types of different hospitals are inconsistent and difficult to adapt, and the sample tubes which are adapted by manual sorting are generally placed into corresponding in-vitro diagnostic equipment such as a chemiluminescence immunoassay analyzer for testing, so that the operation method is easy to make mistakes and the detection and analysis cost is high; on the other hand, in the process of sampling and detecting a certain sample, the existing automatic processing equipment generally takes the sample out of the sample set, then removes the cover, samples, covers the cover again, and finally puts the sample set back to the next sample in the sample set; while efficiency is greatly improved over manual processing, better and faster processing of large numbers of samples has become a new challenge for increasing numbers of samples. Even if the processing time of a single sample is shortened by a dozen seconds or even a few seconds, the total processing time is greatly shortened for thousands of sample sets, so that the detection result can be better and faster obtained, and the method can well play a positive role in timely treatment of the state of an illness or timely coping treatment of emergencies, and even play a decisive role.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides an integrated biological sample processing system which can be suitable for processing tubular sample tubes with various specifications, can realize continuous and uninterrupted sampling detection function through the synergistic effect of a rotary original sample tube rotary processing unit, a rotary new sample tube rotary processing unit, a rotary sample tube cap disengaging and engaging mechanism and the like, and improves the original one-by-one reciprocating detection process into batch rotary flow operation, thereby greatly improving the detection efficiency, and compared with the prior art, the overall processing efficiency is improved by at least 80%.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

an integrated biological sample processing system comprises an original sample tube storing mechanism, an original sample tube taking and placing mechanism, an original sample tube rotary processing unit, a rotary sampling unit, a new sample tube rotary processing unit, a new sample tube taking and placing mechanism and a new sample tube storing mechanism. The original sample tube storage mechanism, the original sample tube rotary processing unit, the new sample tube rotary processing unit and the new sample tube storage mechanism are sequentially connected in series. The original sample tube taking and placing mechanism is arranged between the original sample tube storing mechanism and the original sample tube rotary processing unit and is positioned above the original sample tube storing mechanism and the original sample tube rotary processing unit. The rotary sampling unit is arranged between the original sample tube rotary processing unit and the new sample tube rotary processing unit and is positioned above the original sample tube rotary processing unit and the new sample tube rotary processing unit. The new sample tube taking and placing mechanism is arranged between the new sample tube rotary processing unit and the new sample tube storage mechanism and is positioned above the new sample tube rotary processing unit and the new sample tube storage mechanism. And an original sample tube cap disengaging and engaging mechanism is further arranged above the original sample tube rotary processing unit. And a new sample tube cap opening and closing mechanism is also arranged above the new sample tube rotary processing unit.

Preferably, the original sample tube picking and placing mechanism comprises a front end moving support, a front end mechanical arm and a front end clamp. The front end moving support comprises a front cross beam and a front longitudinal beam which are arranged above the original sample tube storage mechanism and the front section of the original sample tube rotary processing unit. The top end of the front end mechanical arm is movably connected with the front end moving support, namely the top end of the front end mechanical arm freely moves between a front cross beam and a front longitudinal beam of the front end moving support. The front end clamp is arranged at the bottom end of the front end mechanical arm. The front end mechanical arm is of a telescopic structure.

Preferably, the new sample tube picking and placing mechanism comprises a rear end moving support, a rear end mechanical arm and a rear end gripper. The rear end moving support comprises a rear cross beam and a rear longitudinal beam which are arranged above the rear section of the new sample tube rotary processing unit and the new sample tube storage mechanism. The top end of the rear mechanical arm is movably connected with the rear movable support, namely the top end of the rear mechanical arm freely moves between the rear cross beam and the rear longitudinal beam of the rear movable support. The rear end gripper is arranged at the bottom end of the rear end mechanical arm. The rear end mechanical arm is of a telescopic structure.

Preferably, the original sample tube rotary processing unit comprises a front-end sample feeding platform, a front-end cap removing platform, a front-end sampling platform, a front-end cap closing platform and a front-end sample returning platform. The front end sample feeding platform, the front end cap removing platform, the front end sampling platform, the front end cap closing platform and the front end sample returning platform are sequentially arranged in series in the horizontal plane in a clockwise direction or an anticlockwise direction through the rotary mechanism, and the front end sample feeding platform and the front end sample returning platform are arranged on one side close to the original sample tube storage mechanism in parallel.

Preferably, the original sample tube cap disengaging mechanism is arranged above the front end disengaging platform, the front end sampling platform and the front end closing platform and comprises a front end rotating disk and a front end tube cap disengaging clamp. The front end tube cover disengaging clamp is connected with the front end rotating disk through a front end telescopic rotating shaft. The front end pipe cover disengaging and engaging clamp can rotate along with the rotation of the front end rotating disc, and can lift and rotate automatically under the action of the front end telescopic rotating shaft. The lower surface of the front-end rotating disk is at least provided with three front-end tube cap disengaging clamps, and the rotation of the front-end rotating disk drives the three front-end tube cap disengaging clamps to perform rotary movement between the front-end cap disengaging platform and the front-end cap closing platform. The upper surface of the front-end rotating disc is also provided with a front-end rotating disc rotating shaft.

Preferably, the new sample tube rotary processing unit comprises a rear-end sample feeding platform, a rear-end cap removing platform, a rear-end sampling platform, a rear-end cap closing platform and a rear-end sample returning platform. The rear-end sample feeding platform, the rear-end cap removing platform, the rear-end sampling platform, the rear-end cap closing platform and the rear-end sample returning platform are sequentially arranged in series in the horizontal plane in a clockwise direction or an anticlockwise direction through the rotary mechanism, and the rear-end sample feeding platform and the rear-end sample returning platform are arranged on one side close to the new sample tube storage mechanism in parallel.

Preferably, the new sample tube cap opening and closing mechanism is arranged above the rear end opening and closing platform, the rear end sampling platform and the rear end closing and closing platform and comprises a rear end rotating disk and a rear end tube cap opening and closing clamp. The rear end pipe cover disengaging clamp is connected with the rear end rotating disk through a rear end telescopic rotating shaft. The rear end tube cap disengaging and engaging clamp can rotate along with the rotation of the rear end rotating disk, and can lift and rotate automatically under the action of the rear end telescopic rotating shaft. The lower surface of the rear-end rotating disk is at least provided with three rear-end tube cap disengaging clamps, and the rotation of the rear-end rotating disk drives the three rear-end tube cap disengaging clamps to perform rotary movement between the rear-end disengaging platform and the rear-end closing platform. The upper surface of the rear-end rotating disk is also provided with a rear-end rotating disk rotating shaft.

Preferably, the rotating mechanism is a closed guide rail structure and comprises a rotating track and a sample tube connecting groove. The rotary tracks are arranged between the platforms of the original sample tube rotary processing unit and between the platforms of the new sample tube rotary processing unit in a closed manner. At least five sample tube connecting grooves are formed in the rotary rail. Any sample tube connecting groove can perform rotary movement between the platforms of the original sample tube rotary processing unit and between the platforms of the new sample tube rotary processing unit through the rotary track.

Or, rotation mechanism is discoid structure, including rotating electrical machines, disk body and appearance pipe connecting groove. The tray body is movably arranged on each platform of the original sample tube rotary processing unit and each platform of the new sample tube rotary processing unit. The top end of the rotating shaft of the rotating motor is connected with the center of the bottom of the disc body. At least five sample tube connecting grooves are arranged on the upper surface of the tray body. The rotating motor drives the disc body to rotate, and then drives the sample tube connecting grooves to rotate between the platforms of the original sample tube rotation processing unit and between the platforms of the new sample tube rotation processing unit.

Or, rotation mechanism is rib structure, including rotating electrical machines, connecting rod and appearance pipe connecting groove. The top end of the rotating shaft of the rotating motor is connected with the inner ends of at least five connecting rods through a rotating ring. The outer end part of any connecting rod is provided with the sample tube connecting groove. The rotating motor drives the connecting rod to rotate through the rotating ring, and then drives the sample tube connecting groove to rotate between each platform of the original sample tube rotation processing unit and between each platform of the new sample tube rotation processing unit.

Preferably, the system further comprises an atmosphere protection mechanism. The atmosphere protection mechanism comprises a front end dust cover, a rear end dust cover and a sterile gas injection pipe.

Preferably, the front end dust cover is an inverted U-shaped structure which is continuously covered on the front end uncovering platform, the front end sampling platform and the front end covering platform, and through holes are formed in the positions, corresponding to the positions of the front end uncovering platform, the front end sampling platform and the front end covering platform, of the cover top. The rear end dust cover is continuously covered and arranged at the inverted U-shaped structure on the rear end cap removing platform, the rear end sampling platform and the rear end cap closing platform, and through holes are formed in the positions, corresponding to the cap tops, of the rear end cap removing platform, the rear end sampling platform and the rear end cap closing platform. The sterile gas spraying pipe is arranged inside the front end dust cover and the rear end dust cover, and the height of the sterile gas spraying pipe is not higher than the height of a pipe opening of the sample pipe when the sample pipe passes through the front end dust cover and the rear end dust cover. The air outlet of the aseptic air injection pipe faces downwards, and the air inlet end of the aseptic air injection pipe is communicated with an air source. The lower ends of the front end dust cover and the rear end dust cover are both in a reducing opening type design.

Preferably, the system further comprises an identification unit comprising an original sample tube label scanning mechanism and a new sample tube label scanning mechanism. The original sample tube label scanning mechanism is arranged on one side of the front end sample feeding platform and the outer side of the front end cover removing platform. The new sample tube label scanning mechanism is arranged on one side of the outer portions of the rear end uncapping platform and the rear end sampling platform. The original sample tube label scanning mechanism and the new sample tube label scanning mechanism are in radio signal connection, so that the original sample tube label scanning mechanism can synchronize the sample information scanned in the label of the original sample tube to the label of the new sample tube through the new sample tube label scanning mechanism.

Preferably, the rotary sampling unit comprises a middle section moving support, a middle section suspension arm and a sampling gun. The middle section moving support comprises a middle section cross beam and a middle section longitudinal beam which are arranged above the rear section of the original sample tube rotary processing unit and the front section of the new sample tube rotary processing unit. The top end of the middle section suspension arm is movably connected with the middle section moving support, namely the top end of the middle section suspension arm freely moves between the middle section cross beam and the middle section longitudinal beam of the middle section moving support. The bottom of middle section davit is connected with the flexible arm in at least three middle section through rotatory ball valve to the bottom of the flexible arm in middle section is all installed the rifle of taking a sample.

Preferably, the rotary sampling unit further comprises a gun head automatic replacing mechanism, and the gun head automatic replacing mechanism is arranged on one side below the middle section suspension arm.

Preferably, the system further comprises a control unit, wherein the control unit comprises a control system, a display screen and a control panel. The control system is in wired or wireless electric signal connection with the original sample tube taking and placing mechanism, the original sample tube rotary processing unit, the rotary sampling unit, the new sample tube rotary processing unit, the new sample tube taking and placing mechanism, the original sample tube cap disengaging and engaging mechanism, the new sample tube cap disengaging and engaging mechanism, the rotary mechanism, the atmosphere protection mechanism and the identification unit, and controls the original sample tube taking and engaging mechanism, the original sample tube cap disengaging and engaging mechanism, the rotary mechanism, the atmosphere protection mechanism and the identification unit to start and stop.

In the prior art, in the sample processing instrument in the prior art, in order to avoid cross contamination caused by mistaken capping of the tube cap, a one-by-one reciprocating processing flow is generally adopted: the method comprises the steps of taking a target sample out of a sample set, sequentially removing a cover, sampling, returning to the cover removing position, covering the cover, and finally returning to the sample set, wherein the next target sample in the sample set can be processed only after a row of operations. That is, after the target sample is taken out from the sample set by the sampler, the target sample needs to be put back into the sample set after the processes of cover-removing processing, sampling processing, cover-closing processing and the like of the target sample are sequentially waited, and at this time, the processing process of one sample can be finished. Therefore, the processing time period of the target sample is the sum of the time periods taken for the respective processes. Tests show that in general, the time spent on processing a sample is 30-60 s; the time taken to process 10000 samples is at least 83.3 hours, and one device takes about 10 days to complete the processing of 10000 samples in 8 hours of working hours per day.

In the invention, the original sample tube rotary processing unit, the new sample tube rotary processing unit, and the rotary original sample tube cap disengaging mechanism and the rotary new sample tube cap disengaging mechanism which are matched with the original sample tube rotary processing unit and the new sample tube rotary processing unit respectively are adopted, and synchronous rotary flow line operation of the target sample tube and the new sample tube can be realized under the linkage of the rotary sampling unit, namely, the processes of taking and placing the target sample tube and the new sample tube, disengaging, sampling (injecting sample), closing and the like are sequentially and synchronously carried out, namely, the sample tube taking and placing process can continuously take and place the next target sample tube, and the second sample is not required to be taken and placed after the processing of other processes is finished (other processes are also the same and are not limited by other processes). Each procedure of the invention is independently and continuously operated without the limitation of other procedures, the processing efficiency is greatly improved, and the total processing time of a single sample is the time of the single procedure which consumes the longest time.

In the invention, an original sample tube rotary processing unit and a new sample tube rotary processing unit (hereinafter collectively referred to as rotary processing units) respectively comprise a front (rear) end sample conveying platform (hereinafter collectively referred to as sample conveying platforms), a front (rear) end cap removing platform (hereinafter collectively referred to as cap removing platforms), a front (rear) end sampling platform (hereinafter collectively referred to as sampling platforms), a front (rear) end cap closing platform (hereinafter collectively referred to as cap closing platforms) and a front (rear) end sample returning platform (hereinafter collectively referred to as sample returning platforms); the sample feeding platform, the cover removing platform, the sampling platform, the cover closing platform and the sample returning platform are sequentially arranged in series end to end clockwise or anticlockwise; wherein, the sample sending platform and the sample returning platform are arranged in parallel at one side close to the original sample tube storage mechanism and/or the new sample tube storage mechanism. That is, in the present invention, when the first target sample is taken out from the sample tube storage mechanism by the sample tube picking and placing mechanism and placed on the sample feeding platform, then under the rotation action of the rotation mechanism, the first target sample is sequentially fed to the cap removing platform for cap removing, the sampling platform for sampling, the cap closing platform for cap closing, and finally returned to the sample returning platform and placed back to the sample tube storage mechanism by the sample tube picking and placing mechanism. In the process, when the first target sample tube is positioned on the sample returning platform, the second target sample is positioned on the cover closing platform for cover closing treatment, the third target sample is positioned on the sampling platform for sampling treatment, the fourth target sample is positioned on the cover removing platform for cover removing treatment, and the fifth target sample is just placed on the sample sending platform by the sample tube taking and placing mechanism; and when the sample tube taking and placing mechanism completely places the fifth target sample on the lofting platform, the sample tube taking and placing mechanism can move to the sample returning platform to clamp and place the processed first target sample back into the sample tube storage mechanism, and continuously carry out taking and placing operation on the sixth target sample. The rotary processing unit can realize the continuous flow operation of a plurality of sample tubes, and greatly improves the processing efficiency of the sample tubes. Similarly, in terms of the total amount of 10000 samples, the longest time of a sample processing single procedure is counted by 6s, except that the total processing time of the first sample is 30s, the average time of each subsequent sample is 6s, so that the total time of processing 10000 samples is about 16.6h, and the overall efficiency is improved by about 80% for 83.3h in the prior art.

In the invention, a tube cap disengaging mechanism (comprising an original sample tube cap disengaging mechanism and a new sample tube cap disengaging mechanism) is arranged on the rotary processing unit in a matching way; the tube cover disengaging mechanism is also designed in a rotary mode and comprises a rotary disk (comprising a front-end rotary disk and a rear-end rotary disk) and a tube cover disengaging clamp (comprising a front-end tube cover disengaging clamp and a rear-end tube cover disengaging clamp); the number of the pipe cover disengaging and closing clamps is three, the pipe cover disengaging and closing clamps are respectively and correspondingly arranged above the disengaging and closing platform, and the pipe cover disengaging and closing clamps synchronously rotate along with the directions of the disengaging and closing platform, the sampling platform and the closing platform. Namely, a first tube cap disengaging clamp is arranged on a cap disengaging platform to perform cap disengaging treatment on a first sample tube, the sample tube after cap disengaging is rotated to a sampling platform, and meanwhile, a tube cap is synchronously rotated on the first tube cap disengaging clamp to be away from the upper part of the cap disengaging platform and face the sampling platform (it needs to be explained that the first tube cap disengaging clamp with the tube cap faces the sampling platform but is not positioned right above the sampling platform in order not to influence the sampling operation on the sampling platform at the moment); the sample tube after sampling is transferred to a cover closing platform, the first tube cover opening and closing clamp which clamps the tube cover is synchronously transferred to the position right above the cover closing platform, the first sample tube after sampling is subjected to cover closing operation, and so on, the second tube cover opening and closing clamp performs the same cover opening and closing treatment on the second sample tube, and the third tube cover opening and closing clamp performs the same cover opening and closing treatment on the third sample tube; when the third tube cover disengaging clamp closes the third sample tube, the first tube cover disengaging clamp returns to the disengaging platform to disengage the cover of the fourth sample tube, and so on. The rotary pipe cover disengaging and engaging mechanism designed by the invention is matched with the rotary processing unit, on one hand, the smooth running water type processing operation of the rotary processing unit can be effectively ensured, on the other hand, the phenomena of cover error and cover leakage of the pipe cover can be avoided in the synchronous rotation process, the cross contamination of samples is avoided, and the guarantee is provided for the secondary sampling detection of the samples.

In the invention, the rotary sampling unit is structurally designed with at least three sampling guns, and the three sampling guns perform rotary motion among the front-end sampling platform, the rear-end sampling platform and the automatic gun head replacing mechanism, so that continuous operations of sampling, sample injection and gun head replacement are realized, and the flow type processing operation of the rotary processing unit is further promoted and ensured.

In the invention, an atmosphere protection mechanism with an inverted-U-shaped structure is also arranged on the cover removing platform, the sampling platform and the cover closing platform of the rotary processing unit, the atmosphere protection mechanism comprises a dust cover which is continuous from the cover removing platform to the cover closing platform and is similar to a tunnel structure through the sampling platform and a sterile gas spraying pipe arranged in the cover, and only through holes are arranged at the top of the cover above the corresponding cover removing platform, the sampling platform and the cover closing platform; the sterile gas jet delivery pipe is arranged on the inner wall of the dust cover, the height of the sterile gas jet delivery pipe is higher than the height of a pipe orifice of the sample pipe when the sample pipe passes through the dust cover, the gas jet opening of the sterile gas jet delivery pipe faces downwards, and the gas inlet end of the sterile gas jet delivery pipe is communicated with a gas source. The lower end of the dust cover is of a tapered mouth design. That is to say, when the uncapped sample tube passes through the tunnel-type dust cover, the sterile gas is continuously injected through the sterile gas injection tube, so that the whole dust cover is always protected by sterile atmosphere, thereby not only effectively avoiding the external air from the inlet, the outlet and the bottom of the dust cover from entering, but also isolating the cross-propagation infection which may exist among the uncapped sample tubes which are positioned in the dust cover at the same time (the whole detection equipment in the prior art is designed to be sterile environment, not only is set to be higher, but also cannot effectively prevent the cross-contamination which may exist among the various sample tubes inside, and the reason why the next sample processing can be carried out after a certain sample is completely processed in the prior art is also one of the reasons why the next sample processing can be carried out after the sample is completely processed in the prior art). Generally, an air suction device (such as an air suction device) can be arranged at the tapered opening at the bottom end of the dust cover, so as to further ensure the negative pressure in the dust cover and timely output the blown sterile gas from the sterile gas injection pipe to the outside of the system for treatment. The atmosphere protection mechanism is arranged in a matched manner aiming at the specially designed rotary processing unit, and has the advantages of simple structure and good protection effect.

In the present invention, the system further comprises an identification unit comprising an original sample tube label scanning mechanism and a new sample tube label scanning mechanism. The original sample tube label scanning mechanism is arranged on one side of the outer portions of the front end sample conveying platform and the front end cover removing platform. The new sample tube label scanning mechanism is arranged on one side of the outer portions of the rear end uncapping platform and the rear end sampling platform. The original sample tube label scanning mechanism and the new sample tube label scanning mechanism are in radio signal connection, so that the original sample tube label scanning mechanism can synchronize the sample information scanned in the label of the original sample tube to the label of the new sample tube through the new sample tube label scanning mechanism. The initial label content of the new sample tube is blank, and the new sample tube is synchronously read and recorded in the sampling process, so that the label content of the new sample tube after sample injection is consistent with the original sample information, sampling errors are avoided, meanwhile, the new sample tube with the blank label does not need to be recorded with information in advance and is placed in correspondence with the original sample tube, and the sample processing flow and time are greatly saved.

Compared with the prior art, the invention has the following beneficial technical effects:

1: the invention can realize the synchronous rotation operation of the target sample tube and the new sample tube by adopting the linkage of the rotary processing unit, the rotary tube cap disengaging mechanism and the rotary sampling unit, can realize the continuous flow operation of a plurality of sample tubes, and greatly improves the processing efficiency of the sample tubes. The overall efficiency is improved by about 80% compared to the prior art.

2: the invention adopts the specially designed atmosphere protection mechanism, which can effectively avoid the pollution of the outside air to the sample, and can isolate the cross propagation infection possibly existing among the uncapped sample tubes positioned in the dust cover at the same time, thereby further ensuring the flowing-type efficient operation of the rotary processing unit.

3: the biological sample processing system also has the characteristics of simple equipment structure, low design and manufacturing cost, high stability, easy operation, high detection efficiency and easy large-scale popularization and application.

Drawings

FIG. 1 is a schematic diagram of a biological sample processing system according to the present invention.

Fig. 2 is a schematic structural diagram of the track-type slewing mechanism of the present invention.

Fig. 3 is a schematic structural diagram of the disc type rotating mechanism of the present invention.

Fig. 4 is a schematic structural view of the umbrella rib type rotating mechanism of the present invention.

FIG. 5 is a schematic structural view of a front-end recognition unit and an atmosphere protection mechanism according to the present invention.

Fig. 6 is a schematic structural diagram of the back-end identification unit and the atmosphere protection mechanism of the present invention.

FIG. 7 is a schematic cross-sectional view of the atmosphere protecting mechanism of the present invention.

FIG. 8 is a simplified diagram of a control mechanism according to the present invention.

Reference numerals: 1: a raw sample tube storage mechanism; 2: a raw sample tube taking and placing mechanism; 201: a front end moving bracket; 202: a front end mechanical arm; 203: a front end gripper; 3: a rotary processing unit of the original sample tube; 301: a front-end sample sending platform; 302: a front end uncapping platform; 303: a front end sampling platform; 304: the front end covers the platform; 305: a front end sample return platform; 4: a rotary sampling unit; 401: a middle section moving bracket; 402: a middle section suspension arm; 403: a sampling gun; 404: rotating the ball valve; 405: a middle section telescopic arm; 406: a gun head automatic replacing mechanism; 5: a new sample tube rotation processing unit; 501: a rear-end sample presentation platform; 502: a rear end uncapping platform; 503: a rear sampling platform; 504: the rear end is covered with the platform; 505: a rear-end sample returning platform; 6: a new sample tube pick-and-place mechanism; 601: a rear end moving support; 602: a rear end mechanical arm; 603: a rear end gripper; 7: a new sample tube storage mechanism; 8: the original sample tube cap disengaging mechanism; 801: a front end rotating disc; 802: the front end pipe cover is disengaged from and clamped with the clamp; 803: a front end telescopic rotating shaft; 804: a front end turntable rotating shaft; 9: a new sample tube cap disengaging mechanism; 901: a rear end rotating disc; 902: the rear end pipe cover is disengaged and clamped; 903: a rear end telescopic rotating shaft; 904: a rear end turntable rotating shaft; 10: a swing mechanism; 1001: a revolving track; 1002: connecting grooves of the sample tubes; 1003: a rotating electric machine; 1004: a tray body; 1005: a connecting rod; 1006: a rotating ring; 11: an atmosphere protection mechanism; 1101: a front end dust cover; 1102: a rear end dust cover; 1103: a sterile gas injection pipe; 12: an identification unit; 1201: an original sample tube label scanning mechanism; 1202: a new sample tube label scanning mechanism; 13: a control unit.

Detailed Description

The technical solution of the present invention is illustrated below, and the claimed scope of the present invention includes, but is not limited to, the following examples.

An integrated biological sample processing system comprises an original sample tube storing and placing mechanism 1, an original sample tube taking and placing mechanism 2, an original sample tube rotary processing unit 3, a rotary sampling unit 4, a new sample tube rotary processing unit 5, a new sample tube taking and placing mechanism 6 and a new sample tube storing mechanism 7. The original sample tube storage mechanism 1, the original sample tube rotary processing unit 3, the new sample tube rotary processing unit 5 and the new sample tube storage mechanism 7 are sequentially connected in series. The original sample tube picking and placing mechanism 2 is disposed between and above the original sample tube storing mechanism 1 and the original sample tube rotary processing unit 3. The rotary sampling unit 4 is disposed between and above the original sample tube rotary processing unit 3 and the new sample tube rotary processing unit 5. A new sample tube pick and place mechanism 6 is arranged between and above the new sample tube rotary processing unit 5 and the new sample tube storage mechanism 7. And an original sample tube cap disengaging and closing mechanism 8 is also arranged above the original sample tube rotary processing unit 3. A new sample tube cap disengaging mechanism 9 is also arranged above the new sample tube rotary processing unit 5.

Preferably, the sample tube picking and placing mechanism 2 includes a front end moving frame 201, a front end robot 202, and a front end gripper 203. The front end moving support 201 includes a front cross member and a front side member which are disposed above the front sections of the raw sample tube storage mechanism 1 and the raw sample tube rotary processing unit 3. The top end of the front end mechanical arm 202 is movably connected with the front end moving support 201, that is, the top end of the front end mechanical arm 202 freely moves between the front cross beam and the front longitudinal beam of the front end moving support 201. The front end gripper 203 is provided at the bottom end of the front end robot 202. The front end robot 202 has a telescopic structure.

Preferably, the new sample tube picking and placing mechanism 6 comprises a rear moving rack 601, a rear robot 602 and a rear gripper 603. The rear end moving support 601 comprises a rear cross beam and a rear longitudinal beam which are arranged above the rear section of the new sample tube rotary processing unit 5 and the new sample tube storage mechanism 7. The top end of the rear end mechanical arm 602 is movably connected with the rear end moving support 601, that is, the top end of the rear end mechanical arm 602 freely moves between the rear cross beam and the rear longitudinal beam of the rear end moving support 601. The rear gripper 603 is arranged at the bottom end of the rear robot 602. The rear end robot 602 is a telescopic structure.

Preferably, the original sample tube rotary processing unit 3 includes a front end sample feeding platform 301, a front end cap removing platform 302, a front end sampling platform 303, a front end cap closing platform 304, and a front end sample returning platform 305. The front end sample feeding platform 301, the front end cap removing platform 302, the front end sampling platform 303, the front end cap closing platform 304 and the front end sample returning platform 305 are sequentially arranged in series in the horizontal plane in a clockwise direction or an anticlockwise direction through the rotary mechanism 10, wherein the front end sample feeding platform 301 and the front end sample returning platform 305 are arranged in parallel on one side close to the original sample tube storage mechanism 1.

Preferably, the raw sample tube cap removing mechanism 8 is disposed above the front end cap removing platform 302, the front end sampling platform 303, and the front end cap closing platform 304, and includes a front end rotating disk 801 and a front end tube cap removing clamp 802. The front end cap engaging and disengaging clamp 802 is connected to the front end rotating disk 801 via a front end telescopic rotating shaft 803. That is, the front end cap engaging and disengaging clamp 802 can rotate with the rotation of the front end rotating disk 801, and can lift and rotate automatically under the action of the front end telescopic rotating shaft 803. The lower surface of the front end rotating disc 801 is at least provided with three front end tube cap disengaging clamps 802, and the rotation of the front end rotating disc 801 drives the three front end tube cap disengaging clamps 802 to perform rotary movement between the front end cap disengaging platform 302 and the front end cap closing platform 304. The upper surface of the front end rotating disc 801 is also provided with a front end rotating disc rotating shaft 804.

Preferably, the new sample tube rotation processing unit 5 includes a rear end sample feeding platform 501, a rear end cap removing platform 502, a rear end sampling platform 503, a rear end cap closing platform 504 and a rear end sample returning platform 505. The rear-end sample feeding platform 501, the rear-end cap removing platform 502, the rear-end sampling platform 503, the rear-end cap closing platform 504 and the rear-end sample returning platform 505 are sequentially arranged in series in a clockwise direction or a counterclockwise direction in a horizontal plane through the rotating mechanism 10, wherein the rear-end sample feeding platform 501 and the rear-end sample returning platform 505 are arranged in parallel on one side close to the new sample tube storage mechanism 7.

Preferably, the new tube cap disengaging mechanism 9 is disposed above the rear-end disengaging platform 502, the rear-end sampling platform 503 and the rear-end engaging platform 504, and comprises a rear-end rotating disc 901 and a rear-end tube cap disengaging clamp 902. The rear end cap engaging and disengaging clamp 902 is connected to the rear end rotating disk 901 via a rear end telescopic rotating shaft 903. That is, the rear-end cap engaging and disengaging clamp 902 can rotate along with the rotation of the rear-end rotating disk 901, and can lift and rotate automatically under the action of the rear-end telescopic rotating shaft 903. At least three rear end tube cap disengaging clamps 902 are arranged on the lower surface of the rear end rotating disc 901, and the rotation of the rear end rotating disc 901 drives the three rear end tube cap disengaging clamps 902 to perform rotary movement between the rear end disengaging platform 502 and the rear end closing platform 504. A rear end turntable rotating shaft 904 is also provided on the upper surface of the rear end rotating disk 901.

Preferably, the rotating mechanism 10 is a closed guide structure, and includes a rotating track 1001 and a sample tube connecting groove 1002. The rotary rails 1001 are provided between the stages of the original sample tube rotary processing unit 3 and between the stages of the new sample tube rotary processing unit 5 in a closed manner. At least five sample tube connecting grooves 1002 are arranged on the rotary track 1001. Any sample tube connecting groove 1002 can perform rotary movement between the respective stages of the original sample tube rotary processing unit 3 and between the respective stages of the new sample tube rotary processing unit 5 via the rotary rail 1001.

Alternatively, the rotation mechanism 10 has a disc-shaped structure and includes a rotation motor 1003, a tray 1004, and a sample tube connecting slot 1002. The tray 1004 is movably disposed on each stage of the original sample tube rotary processing unit 3 and each stage of the new sample tube rotary processing unit 5. The top end of the rotating shaft of the rotating motor 1003 is connected to the bottom center of the tray body 1004. At least five cuvette connection slots 1002 are provided in the upper surface of the tray 1004. The rotary motor 1003 drives the disc body 1004 to rotate, and further drives the sample tube connecting groove 1002 to rotate between each platform of the original sample tube rotation processing unit 3 and each platform of the new sample tube rotation processing unit 5.

Alternatively, the rotation mechanism 10 has an umbrella-shaped structure, and includes a rotation motor 1003, a link 1005, and a sample tube connection groove 1002. The top end of the rotating shaft of the rotating motor 1003 is connected to the inner ends of at least five links 1005 via a rotating ring 1006. The sample tube connecting groove 1002 is provided at the outer end of any one of the connecting rods 1005. The rotating motor 1003 drives the connecting rod 1005 to rotate through the rotating ring 1006, and further drives the sample tube connecting groove 1002 to rotate between each platform of the original sample tube rotation processing unit 3 and each platform of the new sample tube rotation processing unit 5.

Preferably, the system further comprises an atmosphere protection mechanism 11. The atmosphere protection mechanism 11 includes a front end dust cover 1101, a rear end dust cover 1102, and a sterile gas injection pipe 1103.

Preferably, the front dust covers 1101 are n-shaped structures continuously covering the front uncapping platform 302, the front sampling platform 303, and the front capping platform 304, and through holes are formed at the tops of the covers corresponding to the positions of the front uncapping platform 302, the front sampling platform 303, and the front capping platform 304. The rear end dust cover 1102 is of an inverted U-shaped structure which is continuously covered on the rear end uncovering platform 502, the rear end sampling platform 503 and the rear end covering platform 504, and through holes are formed in the positions, corresponding to the positions of the rear end uncovering platform 502, the rear end sampling platform 503 and the rear end covering platform 504, of the cover tops. Sterile gas ejection tube 1103 is disposed inside front end dust cover 1101 and rear end dust cover 1102, and is disposed at a height not higher than the tube opening height when a sample tube passes through front end dust cover 1101 and rear end dust cover 1102. The air outlet of the aseptic air injection pipe 1103 faces downward, and the air inlet end thereof is communicated with an air source. The lower ends of the front and rear dust caps 1101, 1102 are of a tapered mouth design.

Preferably, the system further comprises an identification unit 12 comprising an original sample tube label scanning mechanism 1201 and a new sample tube label scanning mechanism 1202. The original sample tube label scanning mechanism 1201 is disposed on the outer side of the front end sample feeding stage 301 and the front end cap removing stage 302. A new sample tube label scanning mechanism 1202 is disposed on an exterior side of the rear end decapping platform 502 and the rear end sampling platform 503. The original sample tube label scanning mechanism 1201 is in radio signal connection with the new sample tube label scanning mechanism 1202, so that the original sample tube label scanning mechanism 1201 synchronizes the sample information scanned in the label of the original sample tube to the label of the new sample tube through the new sample tube label scanning mechanism 1202.

Preferably, the rotary sampling unit 4 comprises a middle moving frame 401, a middle boom 402 and a sampling gun 403. The middle section moving support 401 includes a middle section beam and a middle section longitudinal beam which are arranged above the rear section of the original sample tube rotary processing unit 3 and the front section of the new sample tube rotary processing unit 5. The top end of the middle section suspension arm 402 is movably connected with the middle section moving support 401, that is, the top end of the middle section suspension arm 402 freely moves between the middle section beam and the middle section longitudinal beam of the middle section moving support 401. The bottom end of the middle section suspension arm 402 is connected with at least three middle section telescopic arms 405 through a rotary ball valve 404, and the sampling gun 403 is installed at the bottom end of each middle section telescopic arm 405.

Preferably, the rotary sampling unit 4 further includes an automatic lance head replacement mechanism 406, and the automatic lance head replacement mechanism 406 is disposed below the middle suspension arm 402.

Preferably, the system further comprises a control unit 13, and the control unit 13 comprises a control system, a display screen and a control panel. The control system is in wired or wireless electric signal connection with the original sample tube taking and placing mechanism 2, the original sample tube rotary processing unit 3, the rotary sampling unit 4, the new sample tube rotary processing unit 5, the new sample tube taking and placing mechanism 6, the original sample tube cap disengaging and engaging mechanism 8, the new sample tube cap disengaging and engaging mechanism 9, the rotary mechanism 10, the atmosphere protection mechanism 11 and the identification unit 12, and controls the original sample tube taking and placing mechanism, the original sample tube rotary processing unit 3, the rotary sampling unit 4, the new sample tube rotary processing unit 5, the new sample tube cap disengaging and engaging mechanism 11 and the identification unit 12 to start and stop the original sample tube taking and placing mechanism and the original sample tube rotary processing unit 3, the rotary sampling unit 4, the new sample tube rotary processing unit 5, the new sample tube cap disengaging and engaging mechanism 8, the new sample tube cap disengaging and engaging mechanism 9, the rotary mechanism 10, the atmosphere protection mechanism 11 and the identification unit 12.

Example 1

As shown in fig. 1-8, a biological sample processing system comprises an original sample tube storage mechanism 1, an original sample tube picking and placing mechanism 2, an original sample tube rotary processing unit 3, a rotary sampling unit 4, a new sample tube rotary processing unit 5, a new sample tube picking and placing mechanism 6, and a new sample tube storage mechanism 7. The original sample tube storage mechanism 1, the original sample tube rotary processing unit 3, the new sample tube rotary processing unit 5 and the new sample tube storage mechanism 7 are sequentially connected in series. The original sample tube picking and placing mechanism 2 is disposed between and above the original sample tube storing mechanism 1 and the original sample tube rotary processing unit 3. The rotary sampling unit 4 is disposed between and above the original sample tube rotary processing unit 3 and the new sample tube rotary processing unit 5. A new sample tube pick and place mechanism 6 is arranged between and above the new sample tube rotary processing unit 5 and the new sample tube storage mechanism 7. And an original sample tube cap disengaging and closing mechanism 8 is also arranged above the original sample tube rotary processing unit 3. A new sample tube cap disengaging and closing mechanism 9 is also arranged above the new sample tube rotary processing unit 5.

Example 2

Example 1 was repeated except that the sample tube taking and placing mechanism 2 included a front end moving frame 201, a front end robot 202, and a front end gripper 203. The front end moving support 201 includes a front cross member and a front side member which are disposed above the front sections of the raw sample tube storage mechanism 1 and the raw sample tube rotary processing unit 3. The top end of the front end mechanical arm 202 is movably connected with the front end moving bracket 201, that is, the top end of the front end mechanical arm 202 freely moves between the front cross beam and the front longitudinal beam of the front end moving bracket 201. The front gripper 203 is disposed at the bottom end of the front robot arm 202. The front end robot 202 has a telescopic structure.

Example 3

Example 2 is repeated except that the new sample tube pick and place mechanism 6 comprises a rear moving rack 601, a rear robot 602 and a rear gripper 603. The rear end moving support 601 comprises a rear cross beam and a rear longitudinal beam which are arranged above the rear section of the new sample tube rotary processing unit 5 and the new sample tube storage mechanism 7. The top end of the rear end mechanical arm 602 is movably connected with the rear end moving support 601, that is, the top end of the rear end mechanical arm 602 freely moves between the rear cross beam and the rear longitudinal beam of the rear end moving support 601. The rear gripper 603 is arranged at the bottom end of the rear robot 602. The rear end robot 602 is a telescopic structure.

Example 4

Embodiment 3 is repeated except that the raw sample tube rotary processing unit 3 includes a front end sample feeding platform 301, a front end cap removing platform 302, a front end sampling platform 303, a front end cap closing platform 304, and a front end sample returning platform 305. The front end sample feeding platform 301, the front end cap removing platform 302, the front end sampling platform 303, the front end cap closing platform 304 and the front end sample returning platform 305 are sequentially and serially arranged in a horizontal plane in a clockwise direction through the rotating mechanism 10, wherein the front end sample feeding platform 301 and the front end sample returning platform 305 are arranged on one side close to the original sample tube storage mechanism 1 in parallel.

Example 5

Embodiment 4 is repeated, except that the original sample tube cap opening and closing mechanism 8 is arranged above the front end opening and closing platform 302, the front end sampling platform 303 and the front end closing and closing platform 304, and comprises a front end rotating disc 801 and a front end tube cap opening and closing clamp 802. The front end cap engaging and disengaging clamp 802 is connected to the front end rotating disk 801 via a front end retractable rotating shaft 803. That is, the front-end tube cover engaging and disengaging clamp 802 can rotate with the rotation of the front-end rotating disk 801, and can lift and rotate automatically by the action of the front-end telescopic rotating shaft 803. The lower surface of the front end rotating disc 801 is at least provided with three front end tube cap disengaging clamps 802, and the rotation of the front end rotating disc 801 drives the three front end tube cap disengaging clamps 802 to perform rotary movement between the front end disengaging platform 302 and the front end closing platform 304. The upper surface of the front end rotating disc 801 is also provided with a front end rotating disc rotating shaft 804.

Example 6

Example 5 is repeated except that the new sample tube rotary processing unit 5 includes a rear end sample feeding platform 501, a rear end cap removing platform 502, a rear end sampling platform 503, a rear end cap closing platform 504 and a rear end sample returning platform 505. The rear-end sample sending platform 501, the rear-end cap removing platform 502, the rear-end sampling platform 503, the rear-end cap closing platform 504 and the rear-end sample returning platform 505 are sequentially connected in series in the horizontal plane in the clockwise direction through the rotating mechanism 10, wherein the rear-end sample sending platform 501 and the rear-end sample returning platform 505 are arranged in parallel at one side close to the new sample tube storage mechanism 7.

Example 7

Example 6 is repeated except that the new sample tube cap engaging and disengaging mechanism 9 is disposed above the rear end engaging and disengaging platform 502, the rear end sampling platform 503 and the rear end engaging and disengaging platform 504, and comprises a rear end rotating disk 901 and a rear end tube cap engaging and disengaging clamp 902. The rear end cap engaging and disengaging clamp 902 is connected to the rear end rotating disk 901 via a rear end telescopic rotating shaft 903. That is, the rear-end cap engaging and disengaging clamp 902 can rotate along with the rotation of the rear-end rotating disk 901, and can lift and rotate automatically under the action of the rear-end telescopic rotating shaft 903. The lower surface of the rear end rotating disk 901 is provided with at least three rear end tube cap disengaging clamps 902, and the rotation of the rear end rotating disk 901 drives the three rear end tube cap disengaging clamps 902 to perform rotary movement between the rear end disengaging platform 502 and the rear end closing platform 504. A rear end turntable rotating shaft 904 is also provided on the upper surface of the rear end rotating disk 901.

Example 8

Example 7 is repeated except that the turntable 10 is a closed track structure comprising a turntable 1001 and a coupon connection slot 1002. The rotary rails 1001 are provided between the stages of the original sample tube rotary processing unit 3 and between the stages of the new sample tube rotary processing unit 5 in a closed manner. At least five sample tube connecting grooves 1002 are arranged on the rotary rail 1001. Any sample tube connecting groove 1002 can perform rotary movement between the stages of the original sample tube rotary processing unit 3 and between the stages of the new sample tube rotary processing unit 5 through the rotary rail 1001.

Example 9

Embodiment 7 is repeated except that the turntable 10 has a disc-shaped structure and includes a rotary motor 1003, a disc 1004 and a sample tube connecting slot 1002. The tray 1004 is movably disposed on each stage of the original sample tube rotary processing unit 3 and each stage of the new sample tube rotary processing unit 5. The top end of the rotating shaft of the rotating motor 1003 is connected to the bottom center of the tray body 1004. At least five cuvette connection slots 1002 are provided in the upper surface of the tray 1004. The rotary motor 1003 drives the disc body 1004 to rotate, and further drives the sample tube connecting groove 1002 to rotate between each platform of the original sample tube rotation processing unit 3 and each platform of the new sample tube rotation processing unit 5.

Example 10

Embodiment 7 is repeated except that the turning mechanism 10 has an umbrella rib structure, and includes a rotating electric machine 1003, a link 1005, and a sample tube connecting groove 1002. The top end of the rotating shaft of the rotating motor 1003 is connected to the inner ends of at least five links 1005 via a rotating ring 1006. The sample tube connecting groove 1002 is arranged at the end part of the outer end of any connecting rod 1005. The rotating motor 1003 drives the connecting rod 1005 to rotate through the rotating ring 1006, and further drives the sample tube connecting groove 1002 to rotate between each platform of the original sample tube rotation processing unit 3 and each platform of the new sample tube rotation processing unit 5.

Example 11

Example 10 was repeated except that the system further included an atmosphere protection mechanism 11. The atmosphere protection mechanism 11 includes a front end dust cover 1101, a rear end dust cover 1102, and a sterile gas injection pipe 1103.

Example 12

The embodiment 11 is repeated except that the front dust covers 1101 are n-shaped structures continuously covering the front uncapping platform 302, the front sampling platform 303 and the front cover closing platform 304, and through holes are formed at the tops of the covers corresponding to the positions of the front uncapping platform 302, the front sampling platform 303 and the front cover closing platform 304. The rear-end dust covers 1102 are n-shaped structures continuously covering the rear-end cap removing platform 502, the rear-end sampling platform 503 and the rear-end cap closing platform 504, and through holes are formed in the tops of the covers corresponding to the positions of the rear-end cap removing platform 502, the rear-end sampling platform 503 and the rear-end cap closing platform 504. Sterile gas injection tube 1103 is disposed inside front end dust cover 1101 and rear end dust cover 1102, and its set height is not higher than the nozzle height when a sample tube passes through front end dust cover 1101 and rear end dust cover 1102. The air outlet of the aseptic air injection pipe 1103 faces downward, and the air inlet end thereof is communicated with an air source. The lower ends of the front and rear dust caps 1101, 1102 are of a tapered mouth design.

Example 13

Example 12 is repeated except that the system further comprises an identification unit 12 comprising an original sample tube label scanning mechanism 1201 and a new sample tube label scanning mechanism 1202. The original sample tube label scanning mechanism 1201 is disposed on the outer side of the front end sample feeding stage 301 and the front end cap removing stage 302. A new sample tube label scanning mechanism 1202 is disposed on the exterior side of back-end decapping platform 502 and back-end sampling platform 503. The original sample tube label scanning mechanism 1201 is in radio signal connection with the new sample tube label scanning mechanism 1202, so that the original sample tube label scanning mechanism 1201 synchronizes the sample information scanned in the label of the original sample tube to the label of the new sample tube through the new sample tube label scanning mechanism 1202.

Example 14

Example 13 is repeated except that the rotary sampling unit 4 comprises a mid-travel carriage 401, a mid-boom 402 and a sampling gun 403. The middle section moving support 401 includes a middle section beam and a middle section longitudinal beam which are arranged above the rear section of the original sample tube rotary processing unit 3 and the front section of the new sample tube rotary processing unit 5. The top end of the middle section suspension arm 402 is movably connected with the middle section moving support 401, that is, the top end of the middle section suspension arm 402 freely moves between the middle section beam and the middle section longitudinal beam of the middle section moving support 401. The bottom end of the middle section suspension arm 402 is connected with at least three middle section telescopic arms 405 through a rotary ball valve 404, and the sampling gun 403 is installed at the bottom end of each middle section telescopic arm 405.

Example 15

Example 14 was repeated except that the rotary sampling unit 4 further included an automatic lance head changing mechanism 406, and the automatic lance head changing mechanism 406 was disposed on the lower side of the mid-section boom 402.

Example 16

Embodiment 15 is repeated except that the system further comprises a control unit 13, the control unit 13 comprising a control system, a display screen and a control panel. The control system is in wireless electric signal connection with the original sample tube taking and placing mechanism 2, the original sample tube rotary processing unit 3, the rotary sampling unit 4, the new sample tube rotary processing unit 5, the new sample tube taking and placing mechanism 6, the original sample tube cap disengaging and engaging mechanism 8, the new sample tube cap disengaging and engaging mechanism 9, the rotary mechanism 10, the atmosphere protection mechanism 11 and the identification unit 12, and controls the original sample tube taking and placing mechanism, the original sample tube rotary processing unit 3, the rotary sampling unit 4, the new sample tube rotary processing unit 5, the new sample tube cap disengaging and engaging mechanism 11 and the identification unit 12 to start and stop the original sample tube taking and placing mechanism and the original sample tube rotary processing unit 3, the rotary sampling unit 4, the new sample tube rotary processing unit 5, the new sample tube cap disengaging and engaging mechanism 9, the rotary mechanism 10, the atmosphere protection mechanism 11 and the identification unit 12.

Claims

1. Integrated biological sample processing system, its characterized in that: the system comprises an original sample tube storage mechanism (1), an original sample tube taking and placing mechanism (2), an original sample tube rotary processing unit (3), a rotary sampling unit (4), a new sample tube rotary processing unit (5), a new sample tube taking and placing mechanism (6) and a new sample tube storage mechanism (7); the original sample tube storage mechanism (1), the original sample tube rotary processing unit (3), the new sample tube rotary processing unit (5) and the new sample tube storage mechanism (7) are sequentially connected in series; the original sample tube taking and placing mechanism (2) is arranged between the original sample tube storing mechanism (1) and the original sample tube rotary processing unit (3) and is positioned above the original sample tube storing mechanism and the original sample tube rotary processing unit; the rotary sampling unit (4) is arranged between the original sample tube rotary processing unit (3) and the new sample tube rotary processing unit (5) and is positioned above the original sample tube rotary processing unit and the new sample tube rotary processing unit; the new sample tube taking and placing mechanism (6) is arranged between the new sample tube rotary processing unit (5) and the new sample tube storage mechanism (7) and is positioned above the new sample tube rotary processing unit and the new sample tube storage mechanism; an original sample tube cap opening and closing mechanism (8) is further arranged above the original sample tube rotary processing unit (3); and a new sample tube cap opening and closing mechanism (9) is also arranged above the new sample tube rotary processing unit (5).

2. The processing system of claim 1, wherein: the original sample tube taking and placing mechanism (2) comprises a front end moving support (201), a front end mechanical arm (202) and a front end clamp holder (203); the front end moving support (201) comprises a front cross beam and a front longitudinal beam which are arranged above the front sections of the original sample tube storage mechanism (1) and the original sample tube rotary processing unit (3); the top end of the front end mechanical arm (202) is movably connected with the front end movable support (201), namely the top end of the front end mechanical arm (202) freely moves between a front cross beam and a front longitudinal beam of the front end movable support (201); the front end gripper (203) is arranged at the bottom end of the front end mechanical arm (202); the front end mechanical arm (202) is of a telescopic structure.

3. The processing system according to claim 1 or 2, characterized in that: the new sample tube taking and placing mechanism (6) comprises a rear end moving support (601), a rear end mechanical arm (602) and a rear end gripper (603); the rear end moving support (601) comprises a rear cross beam and a rear longitudinal beam which are arranged at the rear section of the new sample tube rotary processing unit (5) and above the new sample tube storage mechanism (7); the top end of the rear-end mechanical arm (602) is movably connected with the rear-end movable support (601), namely the top end of the rear-end mechanical arm (602) freely moves between a rear cross beam and a rear longitudinal beam of the rear-end movable support (601); the rear-end clamp holder (603) is arranged at the bottom end of the rear-end mechanical arm (602); the rear end mechanical arm (602) is of a telescopic structure.

4. The processing system of claim 3, wherein: the original sample tube rotary processing unit (3) comprises a front-end sample feeding platform (301), a front-end cap removing platform (302), a front-end sampling platform (303), a front-end cap closing platform (304) and a front-end sample returning platform (305); the front-end sample feeding platform (301), the front-end cap removing platform (302), the front-end sampling platform (303), the front-end cap closing platform (304) and the front-end sample returning platform (305) are sequentially arranged in series in a horizontal plane in a clockwise direction or an anticlockwise direction through a rotating mechanism (10), wherein the front-end sample feeding platform (301) and the front-end sample returning platform (305) are arranged on one side close to the original sample tube storage mechanism (1) in parallel;

the original sample tube cap disengaging mechanism (8) is arranged above the front end cap disengaging platform (302), the front end sampling platform (303) and the front end cap closing platform (304), and comprises a front end rotating disc (801) and a front end tube cap disengaging clamp (802); the front end tube cover disengaging clamp (802) is connected with the front end rotating disc (801) through a front end telescopic rotating shaft (803); namely, the front end pipe cover disengaging clamp (802) can rotate along with the rotation of the front end rotating disc (801), and can lift and rotate automatically under the action of the front end telescopic rotating shaft (803); the lower surface of the front end rotating disc (801) is at least provided with three front end tube cover disengaging clamps (802), and the rotation of the front end rotating disc (801) drives the three front end tube cover disengaging clamps (802) to perform rotary movement between the front end disengaging platform (302) and the front end closing platform (304); the upper surface of the front end rotating disc (801) is also provided with a front end rotating disc rotating shaft (804).

5. The processing system of claim 4, wherein: the new sample tube rotary processing unit (5) comprises a rear-end sample feeding platform (501), a rear-end cap removing platform (502), a rear-end sampling platform (503), a rear-end cap closing platform (504) and a rear-end sample returning platform (505); the rear-end sample feeding platform (501), the rear-end cap removing platform (502), the rear-end sampling platform (503), the rear-end cap closing platform (504) and the rear-end sample returning platform (505) are sequentially arranged in series in the horizontal plane through the rotating mechanism (10) in the clockwise direction or the anticlockwise direction, wherein the rear-end sample feeding platform (501) and the rear-end sample returning platform (505) are arranged on one side close to the new sample tube storage mechanism (7) in parallel;

the new sample tube cap disengaging mechanism (9) is arranged above the rear end cap disengaging platform (502), the rear end sampling platform (503) and the rear end cap closing platform (504), and comprises a rear end rotating disc (901) and a rear end tube cap disengaging clamp (902); the rear end pipe cover disengaging clamp (902) is connected with the rear end rotating disc (901) through a rear end telescopic rotating shaft (903); namely, the rear end pipe cover disengaging clamp (902) can rotate along with the rotation of the rear end rotating disc (901), and can lift and rotate automatically under the action of the rear end telescopic rotating shaft (903); the lower surface of the rear end rotating disc (901) is at least provided with three rear end pipe cover disengaging clamps (902), and the rotation of the rear end rotating disc (901) drives the three rear end pipe cover disengaging clamps (902) to perform rotary movement between the rear end disengaging platform (502) and the rear end closing platform (504); the upper surface of the rear-end rotating disk (901) is also provided with a rear-end rotating disk rotating shaft (904).

6. The processing system according to claim 4 or 5, wherein: the swing mechanism (10) is of a closed guide rail structure and comprises a swing track (1001) and a sample tube connecting groove (1002); the rotary track (1001) is arranged between each platform of the original sample tube rotary processing unit (3) and each platform of the new sample tube rotary processing unit (5) in a closed manner; at least five sample tube connecting grooves (1002) are formed in the rotary track (1001); any sample tube connecting groove (1002) can perform rotary movement between each platform of the original sample tube rotary processing unit (3) and each platform of the new sample tube rotary processing unit (5) through a rotary track (1001);

or the rotary mechanism (10) is of a disc-shaped structure and comprises a rotary motor (1003), a disc body (1004) and a sample tube connecting groove (1002); the tray body (1004) is movably arranged on each platform of the original sample tube rotary processing unit (3) and each platform of the new sample tube rotary processing unit (5); the top end of a rotating shaft of the rotating motor (1003) is connected with the center of the bottom of the disc body (1004); at least five sample tube connecting grooves (1002) are arranged on the upper surface of the tray body (1004); the rotating motor (1003) drives the disc body (1004) to rotate, and further drives the sample tube connecting groove (1002) to rotate between each platform of the original sample tube rotary processing unit (3) and each platform of the new sample tube rotary processing unit (5);

or the rotating mechanism (10) is of an umbrella-shaped structure and comprises a rotating motor (1003), a connecting rod (1005) and a sample tube connecting groove (1002); the top end of the rotating shaft of the rotating motor (1003) is connected with the inner ends of at least five connecting rods (1005) through a rotating ring (1006); the sample tube connecting groove (1002) is formed in the end part of the outer end of any connecting rod (1005); the rotating motor (1003) drives the connecting rod (1005) to rotate through the rotating ring (1006), and then drives the sample tube connecting groove (1002) to rotate between each platform of the original sample tube rotation processing unit (3) and each platform of the new sample tube rotation processing unit (5).

7. The processing system of claim 6, wherein: the system also comprises an atmosphere protection mechanism (11); the atmosphere protection mechanism (11) comprises a front end dust cover (1101), a rear end dust cover (1102) and a sterile gas injection pipe (1103);

the front end dust cover (1101) is of an inverted-U-shaped structure which is continuously covered on the front end cover removing platform (302), the front end sampling platform (303) and the front end cover closing platform (304), and through holes are formed in the positions, corresponding to the positions of the front end cover removing platform (302), the front end sampling platform (303) and the front end cover closing platform (304), of the cover tops; the rear end dust covers (1102) are n-shaped structures which are continuously covered on the rear end cover removing platform (502), the rear end sampling platform (503) and the rear end cover closing platform (504), and through holes are formed in the cover tops corresponding to the positions of the rear end cover removing platform (502), the rear end sampling platform (503) and the rear end cover closing platform (504); the sterile gas injection pipe (1103) is arranged inside the front end dust cover (1101) and the rear end dust cover (1102), and the height of the sterile gas injection pipe is not higher than the height of a pipe orifice when a sample pipe passes through the front end dust cover (1101) and the rear end dust cover (1102); the air outlet of the sterile air injection pipe (1103) faces downwards, and the air inlet end of the sterile air injection pipe is communicated with an air source; the lower ends of the front end dust cover (1101) and the rear end dust cover (1102) are both of a tapered mouth type design.

8. The processing system of claim 7, wherein: the system further comprises an identification unit (12) comprising an original sample tube label scanning mechanism (1201) and a new sample tube label scanning mechanism (1202); the original sample tube label scanning mechanism (1201) is arranged at one side of the outer parts of the front end sample feeding platform (301) and the front end cap removing platform (302); the new sample tube label scanning mechanism (1202) is arranged on one side of the outer parts of the rear end uncapping platform (502) and the rear end sampling platform (503); the original sample tube label scanning mechanism (1201) is in radio signal connection with the new sample tube label scanning mechanism (1202), so that the original sample tube label scanning mechanism (1201) synchronizes the sample information scanned in the label of the original sample tube to the label of the new sample tube through the new sample tube label scanning mechanism (1202).

9. The processing system of claim 8, wherein: the rotary sampling unit (4) comprises a middle section moving support (401), a middle section suspension arm (402) and a sampling gun (403); the middle section moving support (401) comprises a middle section beam and a middle section longitudinal beam which are arranged above the rear section of the original sample tube rotary processing unit (3) and the front section of the new sample tube rotary processing unit (5); the top end of the middle section suspension arm (402) is movably connected with the middle section moving support (401), namely the top end of the middle section suspension arm (402) freely moves between a middle section beam and a middle section longitudinal beam of the middle section moving support (401); the bottom end of the middle section suspension arm (402) is connected with at least three middle section telescopic arms (405) through rotary ball valves (404), and the bottom ends of the middle section telescopic arms (405) are provided with the sampling guns (403);

the rotary sampling unit (4) further comprises an automatic gun head replacing mechanism (406), and the automatic gun head replacing mechanism (406) is arranged on one side below the middle section suspension arm (402).

10. The processing system of claim 9, wherein: the system also comprises a control unit (13), wherein the control unit (13) comprises a control system, a display screen and an operation panel; the control system is in wired or wireless electric signal connection with the original sample tube taking and placing mechanism (2), the original sample tube rotary processing unit (3), the rotary sampling unit (4), the new sample tube rotary processing unit (5), the new sample tube taking and placing mechanism (6), the original sample tube cap disengaging mechanism (8), the new sample tube cap disengaging mechanism (9), the rotary mechanism (10), the atmosphere protection mechanism (11) and the identification unit (12), and controls the original sample tube taking and placing mechanism, the original sample tube rotary processing unit, the new sample tube cap disengaging mechanism and the identification unit to control the original sample tube taking and placing mechanism and the original sample tube cap disengaging mechanism and the identification unit to start and stop.