CN101511461A - Machine for the preparation of pharmaceutical products - Google Patents

Abstract

A machine for the preparation of pharmaceutical products is provided with a gripping and carrier device (14) to transfer at least one container (12) between a magazine (11) and a dosage station (13) for the preparation of a pharmaceutical product, and a box-type holding frame (2) defining a chamber (9) for the housing of magazine (11), gripping and carrier device (14), and dosage station (13); the chamber (9) displaying an access aperture (71) to magazine (11) and being crossed by a sterile air flow adapted to avoid the entry of air from the external environment through aperture (71) itself.

Description

Be used to prepare the machine of medicine

Technical field

The present invention relates to a kind of machine that is used to prepare medicine.

Particularly, the present invention relates to a kind ofly be used to prepare drug toxicity, under the situation that does not break away from general characteristic, now it is clearly illustrated as being used for the machine of chemotherapeutic cytostatic (cytostatic drugs).

Background technology

In the field of preparation cytostatic, known machine comprises: the storage device (magazine) that is used for a plurality of containers; Be used to prepare the dispensing terminal (dosage station) of medicine, wherein, mix with at least a dilution and obtain described medicine by being included at least a cell inhibitory effect compound in the corresponding container; And clamping and conveying device, it transmits container between storage device and dispensing terminal.

This equipment generally includes the boxlike retainer that limits first chamber and second chamber, ccontaining storage device in this first chamber wherein, and be provided with and allow operating personnel to load and/or the hole of unloading storage device; Ccontaining dispensing terminal and clamping and conveying device in this second chamber, and remain on aseptic substantially state, and be connected with first chamber, so that clamping and conveying device can transmit container between storage device and dispensing terminal.

The known machine of the above-mentioned type has some defectives mainly due to following situation, that is: open so that can load and/or during unloading operation when first chamber storage device, first chamber is connected with external environment, and make operating personnel be exposed to fully in the risk relevant, and destroy the aseptic of drug prepared with the existence of used cytostatic in this type of machine.

Summary of the invention

The object of the present invention is to provide a kind of machine that is used to prepare medicine, its can exempt above-mentioned defective and can be simply, implement cost-effectively.

According to the present invention, provide a kind of according to the described machine that is used to prepare medicine of appended claims.

Description of drawings

Accompanying drawing with reference to the example that non-limiting example of the present invention is shown illustrates the present invention, wherein:

Fig. 1 is the front schematic view of a preferred embodiment of machine of the present invention, has wherein for clarity sake removed part-structure;

Fig. 2 is the schematic side elevation of machine among Fig. 1, has wherein for clarity sake removed part-structure;

Fig. 3 is the schematic plan of machine among Fig. 1 and Fig. 2, has wherein for clarity sake removed part-structure;

Fig. 4 is the stereogram of the first thin portion of machine among Fig. 1, Fig. 2 and Fig. 3;

Fig. 5 is the stereogram of the second thin portion of machine among Fig. 1, Fig. 2 and Fig. 3;

Fig. 6 is the front view of the 3rd thin portion of machine among Fig. 1, Fig. 2 and Fig. 3;

Fig. 7 is the sectional view along Fig. 6 center line VII-VII;

Fig. 8 is the stereogram of the 4th thin portion of machine among Fig. 1, Fig. 2 and Fig. 3; And

Fig. 9 is the stereogram of the 5th thin portion of machine among Fig. 1, Fig. 2 and Fig. 3.

The specific embodiment

With reference to figure 1 and Fig. 3, Reference numeral 1 represents to be used to prepare the machine of medicine generally, and in the case, drug toxicity is for example for being used for chemotherapeutic cytostatic.

Machine 1 comprises boxlike retainer 2, this boxlike retainer 2 is essentially parallelepiped-shaped, and by basic horizontal and the lower wall 3 that is parallel to each other and upper wall 4, vertically basic and the antetheca 5 and the rear wall 6 that are parallel to each other and be parallel to each other substantially and define with two sidewalls 7 of wall 3,4,5,6 quadratures.

The inside of frame 2 is divided into upper chamber 9 and lower chambers 10 by the midfeather 8 that is basically parallel to wall 3,4.

Be equipped with in the upper chamber 9: the storage device 11 (will be further elucidated hereinbelow) that is used for a plurality of containers 12; Be used to prepare the dispensing terminal 13 of medicine; And clamping and conveying device 14, be used for making container 12 in chamber 9 displacements.

Storage device 11 comprises axle 15 (Fig. 3), and this axle 15 is rotatably mounted to frame 2, so that be parallel to the longitudinal axis 16 of vertical substantially direction 17 and with respect to optionally intermittently rotation of frame 2 around it under the driving of known motor (not shown); This 15 be contained in the coaxial maintenance tube 18 of axis 16 in and transport dish 19, this coils 19 splined engagement installs orthogonally in the last free end of axle 15 and with axis 16, and supports around axis 16 equally distributed a plurality of unit 20 (be 9 in the case and pinch unit 20) that pinch.

With reference to figure 4, respectively pinch unit 20 and include the hook plate (hooking p1ate) 21 that is fixed on the dish 19, and be provided with that slave plate 21 is upwardly extending lays piece (resting block) 22, and be provided with 3 seats 23 that are used for known type vial (hereinafter representing) separately in the case with 12a.

Plate 21 also is provided with (display) three elongate rod 24; These elongate rod 24 slave plates 21 pass dish 19 and extend downwards, are arranged essentially parallel to direction 17, and are provided with and are used for various various seats 25 with known syringe (hereinafter representing with 12b) of different-diameter and length; Each seat 25 includes and keeps tube 26, and an end of this maintenances tube 26 is by pin 27 sealings that are provided with protective cap 28, and the piston 29 that keeps tube 26 and be provided with head 30 is sliding engaged to, this head 30 be basically flat and with piston 29 quadratures.

Each seat 25 includes two clamping elements 31; Two clamping elements 31 are forked basically, axially separate along corresponding bar 24, and cooperate mutually to hold and to keep corresponding syringe 12b; Syringe 12b is inserted in the element 26 along the direction perpendicular to axis 16, with hour hands 27 up.

At least one bar 24 also is provided with the support component 32 with aperture 33; This aperture 33 is parallel to direction 17 to be passed support component 32 and forms, and is suitable for the pin (not shown) of ccontaining known type therein, hereinafter will the use in aperture 33 be further specified.

Plate 21 also is provided with the carriage (not shown); This carriage slave plate 21 passes dish 19 and extends downwards, and is arranged essentially parallel to direction 17, and free end supports recessed (pocket) 34 under it; This recessed 34 is radially opened wide outwardly, so that be sliding engaged to adaptation element (adapter member) 35; Adaptation element 35 is installed on the plastic material bag (hereinafter representing with 12c) of known type, and is provided with two necks 36 that are used for carrying to and fro from bag 12c fluid.

According to Fig. 5, adaptation element 35 comprises that two are the anchor clamps of flat profile (jaw) 37,38 substantially; The thickness of anchor clamps 37,38 is basically less than the length of neck 36, and hinged each other so that relatively rotate with respect to each other around the axis 39 that is substantially perpendicular to anchor clamps 37,38 between the clip position (not shown) of two necks 36 and off-position (Fig. 5).

Anchor clamps 37,38 are locked in clip position by locking device 40; Locking device 40 comprises crank 41 and pin 43, and crank 41 is hinged to anchor clamps 37 so that rotate with respect to anchor clamps 37 around 39 the axis 42 of paralleling to the axis; Pin 43 parallel to the axis 39 and axis 42 pass crank 41 and install and between off-position (Fig. 5) and latched position (not shown), be shifted by crank 41; Wherein, crank 41 is shifted by the otch 44 that passes anchor clamps 38 and form, thereby pin 43 is bonded on be formed in the seat 45 on the anchor clamps 38.

With reference to figure 1, Fig. 3, Fig. 6, dispensing terminal 13 comprises the basic flat turntable 46 that is; This turntable 46 is attached to frame 2 rotationally, so that rotate with respect to frame 2 around the pivot center 47 that is parallel to direction 48 under the driving of known motor (not shown); This direction 48 is a horizontal direction and perpendicular to direction 17; This turntable 46 supports clamping devices 49, and this clamping device 49 is suitable for the syringe 12b that holds and keep three to have different-diameter and length.

According to Fig. 6, Fig. 7, clamping device 49 comprises slide block 50; This slide block 50 is along extending with the horizontal direction 51 of direction 17,48 quadratures, and be attached to turntable 46 with known manner, so that direction 17 is carried out line shifting with respect to turntable 46 in the driving lower edge of known motor (not shown), and in the case, this clamping device 49 is provided with three clamping elements 52 that distribute along slide block 50 on direction 51.

Each clamping element 52 all 50 stretches out along direction 48 from slide block, and cooperates with two clamping elements 53; Described clamping element 53 46 stretches out along direction 48 from turntable, aligns with clamping element 52 along direction 17, and is essentially the forked of the tube 26 that is suitable for holding and keep corresponding syringe 12b.Clamping element 52 comprises two flat and anchor clamps 54,55 direction 17 quadratures; Wherein anchor clamps 54 are arranged between anchor clamps 55 and the clamping element 53, and are essentially the forked of the piston 29 that is suitable for holding and keep corresponding syringe 12b.

In use, syringe 12b is installed on the turntable 46, with hour hands 27 down; Therefore, be inserted in the process of clamping device 49 at syringe 12b, turntable 46 is provided with the clamping element 53 (Fig. 6, Fig. 7) that is positioned at clamping element 52 belows.

Guarantee that by checkout gear 56 piston 29 correctly is inserted in the anchor clamps 54; This checkout gear 56 comprises the boots portion 57 that is essentially flat; This boots portion 57 is installed between the anchor clamps 54,55 and is attached to anchor clamps 55 slidably, so that carry out line shifting along direction 17 with respect to anchor clamps 55 by the mode that will be further elucidated hereinbelow.

Be inserted into along direction 48 in the process of anchor clamps 54 at piston 29, the head 30 of piston 29 engages with spherical 58, and this spherical 58 is stretched out from boots portion 57 along direction 17, so that promote boots portions 57 along direction 17.When piston 29 and head 30 correctly be inserted in the anchor clamps 54, boots portion 57 was because the gravity effect drops to its original position once more; Otherwise when piston 29 and head 30 correctly were not inserted in the anchor clamps 54, boots portion 57 kept being raised under the thrust of head 30.

Detect the position of boots portion 57 on direction 17 by photoelectric tube 59; This photoelectric tube 59 is installed on the turntable 46, aligns with syringe 12b along direction 17, and is suitable in use detecting the position of piston 29 on direction 17.

According to a kind of unshowned modification, anchor clamps 54,55 are omitted and are replaced by two anchor clamps that are attached to slide block 50 slidably, thereby described anchor clamps can be shifted along direction 17 between the off-position of the head 30 of syringe 12b and clip position toward each other.

With reference to figure 1 and Fig. 3, clamping and conveying device 14 is limited by the robot of known type, and this robot comprises a plurality of joint arms that are hinged and a gripper clamp (gripping clamp); This gripper clamp is installed in the free end of described joint arm, and is configured in order to grasp the adaptation element 35 of bottle 12a, syringe 12b and bag 12c.

Be equipped with in the lower chambers 10 and be used to operate machines 1 electronic control unit 60 and the gathering-device 61 that is used for the refuse of handling machine 1.Gathering-device 61 is arranged on dispensing terminal 13 places, and by hole 62 be connected with upper chamber 9 (Fig. 3); This hole 62 is parallel to direction 17 to be passed midfeather 8 and forms, and is provided with the level retaining door (not shown) that can move (mobile) between the open position in hole 62 and closed position.

According to shown in Figure 8, gathering-device 61 comprises upright slide block 63; This slide block 63 is attached to frame 2 in known manner, so that carry out line shifting in the driving lower edge of known type motor direction 17 with respect to frame 2, and slide block 63 is limited by two side plates 64 that limit the seat that is used for vessel 65 on direction 51.Vessel 65 are arranged between the plate 64 and are positioned at the below in hole 62, simultaneously the concave surface of vessel 65 up, vessel 65 are locked on the slide block 63 along direction 48 by means of a plurality of stop elements 66; This stop element 66 is hinged to slide block 63, so that rotate with respect to slide block 63 around an axis 67 that is parallel to direction 51 separately.

Gathering-device 61 also comprises cross sliding clock 68; This slide block 68 is attached to frame 2 in known manner, so that carry out line shifting in the driving lower edge of known type motor direction 48 with respect to frame 2; This slide block 68 also is provided with a pair of balanced device (equalizer) 69, and described balanced device 69 is hinged to slide block 68, and can move around from the hook position of the closing cap 70 of vessel 65.

Lid 70 stretches out downwards from slide block 68, has the neighboring 70a that is provided with adhesive (adhesive compound); And cover 70 and be arranged on usually near the vessel 65, so that vessel 65 can be arranged in the operating position (not shown) of rising.

Gathering-device 61 also comprises known sensor (not shown), with the packed height of control vessel 65.

In use, in case vessel 65 have been filled and have descended, lid 70 just is shifted above vessel 65 along direction 48, and vessel 65 raise once more so that edge 70a can engage the corresponding neighboring 65a of vessel 65, and feasible cover 70 can airtight sealing vessel 65.

With reference to figure 1 and Fig. 2, upper chamber 9 is connected with external environment by hole 71; This hole 71 is passed frame 2 and is formed along direction 48, so that operating personnel can enter storage device 11, this hole 71 is associated with a vertical retaining door (not shown), this retaining door can move along direction 51 between the open position in hole 71 and closed position, and hole 71 below by estrade 72 restriction, this estrade 72 is for being loaded on the storage device 11 or laying pedestal (resting base) from what bottle 12a, syringe 12b, bag 12c and the pin (not shown) of storage device 11 unloadings limited basic horizontal.

Upper chamber 9 remains on aseptic substantially state by pneumatic means 73, this pneumatic means 73 is configured to pass in order to supply the germ-free air flow of upper chamber 9, to prevent that air from entering into upper chamber 9 from external environment by hole 71, and prevent that germ-free air flow from passing through hole 71 and flowing out from upper chamber 9, and this pneumatic means 73 comprises pneumatic circuit 74 and fan wheel (fan wheel) 75, and this fan wheel 75 is contained in the lower chambers 10 to guarantee that air is along pneumatic circuit 74 circulations.

Loop 74 comprises: chamber 76, this chamber 76 is installed on the upper wall 4 of frame 2, be connected to fan wheel 75 by pipeline 77, and be connected with upper chamber 9 by the sterilizing filter 78 (only showing a pair of among Fig. 2) that plugs two pairs of known types, described two pairs of sterilizing filters 78 respectively at storage device 11 places and dispensing terminal 13 places be mounted to chamber 76; Outlet 79, this outlet 79 is connected with external environment, and also is connected to chamber 76 by the sterilizing filter 80 that plugs known type; And the valve 81 of known type, it optionally controls the air velocity that is fed to outlet 79.

The germ-free air flow that is fed in the upper chamber 9 71 partly turns to towards the hole by first steering component 82, the profile of this first steering component 82 is configured in order to 71 places form the filtrated air barrier in the hole, and this first steering component 82 descends from the top towards estrade 72, enters into upper chamber 9 to prevent air from external environment.

Loop 74 also comprises second steering component 83 that is essentially column; This second steering component 83 is mounted to estrade 72 and is connected to estrade 72, and the germ-free air flow that is suitable for descending turns to towards upper chamber 9, so that estrade 72 is cleaned and prevent that air from flowing out from chamber 9.

Loop 74 also is provided with the 3rd steering component 84 that is essentially column; The below that the 3rd steering component 84 is mounted to estrade 72 is along direction 48 zone (band) relative with second steering component 83, and the 3rd steering component 84 is connected to estrade 72; In the case, the 3rd steering component 84 has the radius of curvature littler than the radius of curvature of element 83, is suitable for germ-free air flow is redirect in the pipeline 85 of inclination; This pipeline 85 extends below estrade 72, be connected with fan wheel 75 by plugging sterilizing filter 86 and offer inlet 87, this inlet 87 is connected with external environment so that be substantially equal to via exporting 79 air velocities that are drained into the external environment from the air velocity of external environment suction.

With reference to first kind of operator scheme of description of drawings, suppose to make single medicine, and from the following time:

A plurality of seats 23 partly are mounted with the bottle 12a that fills dilution (for example physiological solution or glucose solution (glucosated solution)), partly be mounted with and fill the bottle 12a that liquid cellular propagation suppresses compound, and partly be mounted with the bottle 12a that fills pulverous cell inhibitory effect compound;

A plurality of seat 25 empty syringe 12b that are mounted with separately;

A plurality of recessed 34 bag 12c that are mounted with separately, bag 12c is provided with corresponding adaptation element 35 and fills dilution, as physiological solution or glucose solution;

A plurality of support components 32 are mounted with various pin (not shown); And

The vessel 65 of gathering-device 61 are increased near hole 62.

Lay respectively among corresponding seat 25 and corresponding recessed 34 by means of corresponding known photoelectric tube (not shown) control syringe 12b and a bag 12c, described photoelectric tube is installed on the axle 15 and towards radially passing the respective slide (not shown) that keeps tube 18 and form; Control a bottle 12a and be arranged in corresponding seat 23 by means of being installed in the corresponding photoelectric tube of dish on 19.

By before being fixed in the bar code reader (not shown) of frame 2, making the storage device displacement, discern syringe 12b and the bag 12c that is loaded in respectively in corresponding 25 and corresponding recessed 34 around axis 16.

Clamping and conveying device 14 takes out syringe 12b earlier from corresponding seat 25; Then syringe 12b is inserted in the clamping device 49, makes pin 27 (Fig. 1, Fig. 6, Fig. 7) down simultaneously; At last, clamping and conveying device 14 removes protective cap 28 from pin 27; Turntable 46 rotates 180 °, with locating injection device 12b, makes pin 27 simultaneously up.

Therefore, clamping and conveying device 14 will fill bottle 12a taking-up from corresponding seat 23 that liquid cellular propagation suppresses compound, and it is placed into (Fig. 3) on the turntable 88; This turntable 88 is installed in rotation on the frame 2, so that under the driving of known motor (not shown), rotate with respect to frame 2 around the pivot center 89 that is parallel to direction 17, and turntable 88 forms the part of the recognition device 90 of known type, the camera (not shown) that this recognition device 90 also comprises the light source (not shown) and is suitable for the label that is located on bottle 12a is scanned.

Obviously, can discern bottle 12a, syringe 12b and bag 12c by means of the bar code, label, RFID label or other identification parts that are located on the container 12.

When discerning by recognition device 90, the bottle 12a that at first weighing is considered on measurer (scale) 91 of known type; Then, bottle 12a is sent to the seal removing (seal-remover device) 92 (Fig. 1 and Fig. 3) of known type, and sealing part provision for disengagement 92 is suitable for removing the metal seal (not shown) on the elastic membrane (not shown) that is located at bottle 12a usually and is suitable for this metal seal (not shown) is discharged in the vessel 65 via hole 62; At last, bottle 12a is put upside down place on the syringe 12b that engages with pin 27.

At this moment, slide block 50 descends along direction 17, so that anchor clamps 54 can keep tube 26 to make piston 29 reductions in the control lower edge of corresponding photoelectric tube 59, and makes syringe 12b can extract the liquid cellular propagation inhibition compound of the amount of determining from bottle 12a; Bottle 12a and pin 27 break away from, and are discharged in the vessel 65, perhaps are sent on dispenser (resting shelf) (not shown), perhaps are sent to storage device 11 once more; Turntable 46 rotates 180 °, with locating injection device 12b, with hour hands 27 once more down.

After this, clamping and conveying device 14 takes out a new bottle 12a who fills dilution from storage device 11; By recognition device 90 identification bottle 12a; Measuring cup 12a on measurer 91; Bottle 12a is sent to seal removing 92 to remove corresponding metal or plastic seal; At last, bottle 12a is moved to the below of the syringe 12b that engages with pin 27.

At last, slide block 50 descends along direction 17, so that anchor clamps 55 are engaged with head 30, thereby under the control of corresponding photoelectric tube 59, make piston 29 along keeping tube 26 to descend, and will be contained in liquid cellular propagation among the syringe 12b and suppress compound and be injected among the new bottle 12a; Bottle 12a and pin 27 with medicine of newly preparing break away from, and measuring cup 12a on measurer 91 is sent to storage device 11 with bottle 12a, take out thereby bottle 12a can be operated personnel; And syringe 12b is discharged in the vessel 65.

The difference of the pattern of second kind of operator scheme and above-mentioned explanation only is that liquid cellular propagation suppresses compound and dilution is all extracted by syringe 12b, and the syringe 12b that will fill the medicine of newly preparing is sent to storage device 11, takes out thereby syringe 12b can be operated personnel.Obviously, dilution both can extract from bottle 12a, also can extract from bag 12c.

The difference of the pattern of the third operator scheme and above-mentioned explanation only is that medicine prepares in bag 12c.

In the case, at first from storage device 11, take out the bag 12c that is considered by means of clamping and conveying device 14; Then, weighing bag 12c on measurer 91; At last, bag 12c is sent to aspirator 93 (pumping device) (Fig. 3), wherein aspirator 93 has been equipped with one of them pin (not shown) of a plurality of support component 32, so that extract the dilution of the amount that is substantially equal to be expelled to the cell inhibitory effect compound bag 12c from bag 12c.

In order to make aspirator 93 correctly extract dilution, bag 12c is placed in a pair of from frame 2 along direction on the 51 pin (not shown) that stretch out with downward-sloping pose, the anchor clamps 37,38 of adaptation element 35 are with a pair of the 48 pin (not shown) that stretch out engage from aspirator 93 along direction, and the pin (not shown) of aspirator 93 is engaged in the neck 36 of bag 12c in one of them.

When finishing the extraction of dilution, bag 12c is sent to dispensing terminal 13 from clamping and conveying device 14 earlier, so that ccontaining cell inhibitory effect compound from syringe 12b; Then, bag 12c is transferred into storage device 11, takes out thereby bag 12c can be operated personnel.

The difference of the 4th kind of operator scheme and previously described pattern only is that medicine is to use the cell inhibitory effect compound of powder or freeze-drying to make.

In the case, syringe 12b extracts the dilution of the amount of determining earlier from corresponding bottle 12a or corresponding bag 12c; Then, dilution is injected among the bottle 12a of the cell inhibitory effect compound that fills powder or freeze-drying.

At this moment, the bottle 12a that fills the cell inhibitory effect compound of dilution and powder or freeze-drying is sent to mixing arrangement 94 from clamping and conveying device 14, so that dilution and cell inhibitory effect compound are together.

With reference to figure 9, mixing arrangement 94 comprises gripper shoe 95; This gripper shoe 95 is fixed in the midfeather 8 of frame 2, is limited by the surface 96 that tilts with respect to direction 17 up, and supports rotor plate 97; This rotor plate 97 is attached to gripper shoe 95 in known manner, so as under the driving of known motor (not shown) around axis 98 clockwise and/or rotate counterclockwise with respect to gripper shoe 95, this axis 98 is non-90 ° angle setting with respect to wall 8.

Plate 97 comprises a plurality of seat 99 (being four seats 99 in the case), is suitable for ccontaining corresponding bottle 12a (a bottle 12a also can have the size that differs from one another) in the described seat 99, and described seat 99 evenly distributes and extends perpendicular to axis 98 around axis 98.

Each 99 by two be parallel to each other basically and perpendicular to the sidewall 100 of axis 98 along circumferentially restriction, also radially limit by outer end stop element 101 and inner stop element 102, wherein this outer end stop element 101 parallels to the axis and 98 is installed on the periphery of rotor plate 97, and this inner stop element 102 is 99 shared and be installed on the central authorities of plate 97 coaxially with axis 98 for all.

A plurality of ring-shaped rubber elements 103 (being four ring-shaped rubber elements 103 in the case) are installed on the upper surface 96 of gripper shoe 95; Described ring-shaped rubber element 103 is all coaxial with axis 98, and to extend to limit the free section on surface 96 around axis 98 less than 360 ° angle, and described ring-shaped rubber element 103 engages corresponding otch (slit) 104, and described otch 104 98 ground that parallel to the axis pass each diapire of 99 105 and form.

During use, in axis 98 rotating process, the rotation of each bottle 12a around its longitudinal axis A determined in the friction that produces between the bottle 12a in the ring-shaped rubber element 103 and ccontaining present 99 at plate 97.Plate 97 combines around the rotation of corresponding axis A with each bottle 12a around the rotation of axis 98, has improved the efficient of mixing arrangement 94.

Plate 97 is controlled as when plate 97 is stopped around the rotation of axis 98, and the seat 99 of bottle 12a to be removed is provided with and is positioned at the free section on surface 96 (that is: the part that does not have ring-shaped rubber element 103 on surface 96) all the time downwards.In this manner, bottle 12a to be removed is arranged on the identical position central authorities of corresponding seat 99 (that is: be positioned at) all the time and contacts with corresponding outer end stop element 101, so that clamping and conveying device 14 can correctly take out a bottle 12a.

Therefore, can under any one pattern in aforementioned three kinds of operator schemes, use new composite bottle 12a.

At last, should be noted that when finishing the attended operation of machine 1, be fixed in ultraviolet lamp (not shown) frame 2, known upper chamber 9 is carried out disinfection by means of a plurality of.

According to a kind of unshowned modification, in machine 1, also can use to be provided with single neck that is similar to neck 36 in fact and the plastic material bottles that is similar to the adaptation element of element 35 in fact.

In the case, clamping and conveying device 14 takes out bag 12c from storage device 11, and bag 12c is sent to dispensing terminal 13, and syringe 12b extracts the dilution of the amount of determining from bag 12c at dispensing terminal 13 places.

Therefore, clamping and conveying device 14 takes out above-mentioned bottle, and bottle is sent to dispensing terminal 13, and syringe 12b injects at dispensing terminal 13 places from the new dilution that extracts of bag 12c, and device 14 places bottle on the dispenser.

Thereafter, clamping and conveying device 14 is discharged into syringe 12b in the vessel 65, and new syringe 12b is sent to dispensing terminal 13 from storage device 11, and syringe 12b extracts the liquid cellular propagation inhibition compound of the amount of determining from bottle 12a at dispensing terminal 13 places.

At last, the cell inhibitory effect compound that newly extracts is injected into the bottle that places in advance on the dispenser, and once more bottle is sent to storage device 11, take out thereby bottle can be operated personnel.

Claims (43)

1. machine that is used to prepare medicine comprises: be used for the storage device (11) of a plurality of containers (12), all fill medicine compounds and/or dilution to small part container (12) in the described container (12); Dispensing terminal (13) is used to prepare the medicine that comprises at least a described medicine compounds and at least a described dilution; Clamping and conveying device (14) is used for transmitting described container (12) between described storage device (11) and described dispensing terminal (13); Boxlike retainer (2) limits the chamber (9) that is used for ccontaining described storage device (11), described dispensing terminal (13) and described clamping and conveying device (14); And pneumatic means (73), be used to provide the germ-free air flow that passes whole described chamber (9); It is characterized in that, described chamber (9) have lead to described storage device (11) enter hole (71); Described pneumatic means (73) comprises pneumatic circuit (74), and described pneumatic circuit (74) is configured to locate to form in described hole (71) be suitable for preventing that air from entering into the filtrated air barrier of described chamber (9) from external environment.

2. machine according to claim 1, wherein, described pneumatic circuit (74) extends along circular path; Described pneumatic means (73) also comprises feedway (75), to push air along described pneumatic circuit (74).

3. machine according to claim 1 and 2, wherein, described pneumatic means (73) also comprises first transfer (82), is used to make the described germ-free air flow to small part to turn to towards described hole (71), so that form described filtrated air barrier.

4. according to the described machine of aforementioned each claim, wherein, described pneumatic means (73) also comprises second transfer (83), flows out to external environment to prevent germ-free air flow by described hole (71).

5. according to the described machine of aforementioned each claim, wherein, described pneumatic means (73) also comprises first transfer (82) and second transfer (83,84), described first transfer (82) makes to the described germ-free air flow of small part and turns to towards described hole (71), so that form described filtrated air barrier, described second transfer (83,84) prevents that germ-free air flow from flowing out to external environment by described hole (71); Described first transfer (82) and described second transfer (83,84) are arranged on the opposed area of described hole (71) on the direction that air moves forward along described pneumatic circuit (74).

6. according to claim 4 or 5 described machines, wherein, described pneumatic circuit (74) comprises and is connected with external environment and is arranged at the inlet of locating in described hole (71) (87).

7. machine according to claim 6, wherein, described second transfer (83,84) comprises first steering surface (83), is used to prevent that germ-free air flow from flowing out to external environment by described hole (71).

8. machine according to claim 7, wherein, described second transfer (83,84) also comprises second steering surface (84), is used to make air to turn to towards described inlet (87) from described first steering surface (83).

9. machine according to claim 8, wherein, described first steering surface (83) and described second steering surface (84) are column basically.

10. machine according to claim 9, wherein, the radius of curvature of described first steering surface (83) is greater than the radius of curvature of described second steering surface (84).

11. each described machine in 10 according to Claim 8, wherein, described hole (71) are provided with bracing or strutting arrangement (72), and described bracing or strutting arrangement (72) limits the pedestal of laying that is used for the container (12) that will transmit back and forth from described storage device (11); The described pedestal of laying is connected to described first steering surface (83) and described second steering surface (83,84).

12. machine according to claim 11, wherein, described inlet (87) is arranged on described below of laying pedestal.

13. according to each described machine in the claim 6 to 12, wherein, described pneumatic circuit (74) also comprises and being used for air from the outlet (79) of described pneumatic circuit (74) row to external environment.

14. machine according to claim 13, wherein, described inlet (87) and described outlet (79) are constructed so that being fed to air velocity in the described pneumatic circuit (74) by described inlet (87) is substantially equal to be discharged into air velocity in the external environment by described outlet (79).

15. according to each described machine in the claim 6 to 14, wherein, described pneumatic means (73) also comprises first filter (86), is used for the air that is fed to described pneumatic circuit (74) by described inlet (87) is filtered.

16. according to each described machine in the claim 2 to 15, wherein, described pneumatic means (73) also comprises second filter (78), described second filter (78) is arranged between described feedway (75) and the described chamber (9), so that the air that is fed to described chamber (9) is filtered.

17. according to each described machine in the claim 13 to 16, wherein, described pneumatic means (73) also comprises the 3rd filter (80), described the 3rd filter (80) is arranged between described feedway (75) and the described outlet (79), so that the air that is fed to described outlet (79) is filtered.

18. according to each described machine in the claim 13 to 17, wherein, described pneumatic means (73) also comprises valve gear (81), and described valve gear (81) is provided with along described pneumatic circuit (74), optionally to control the supply of air to described outlet (79) and described chamber (9).

19. a machine that is used to prepare medicine comprises: be used for the storage device (11) of a plurality of containers (12), all fill medicine compounds and/or dilution to small part container (12) in the described container (12); Dispensing terminal (13) is used to prepare the medicine that comprises at least a described medicine compounds and at least a described dilution; Clamping and conveying device (14) is used for transmitting described container (12) between described storage device (11) and described dispensing terminal (13); And gathering-device (61), being used to handle the refuse of described machine, described gathering-device (61) comprises vessel (65) and is used for the closing cap (70) of described vessel (65); It is characterized in that described gathering-device (61) also comprises actuating device (63,68), so that described vessel (65) and described lid (70) are shifted toward each other along two orthogonal basically directions (17,48).

20. machine according to claim 19, wherein, a direction in the described direction is first direction (17), and described first direction (17) is vertical basically.

21. according to claim 19 or 20 described machines, wherein, a direction in the described direction is second direction (48), described second direction (48) is level basically.

22. according to each described machine in the claim 19 to 21, wherein, described vessel (65) and described lid (70) have corresponding neighboring (65a, 70a), and described neighboring (65a, 70a) is suitable for after the displacement of described vessel (65) and described lid (70) forming each other in the closed position of described vessel (65) and contacts; At least one neighboring (70a) in the described neighboring has fluid sealant.

23. according to each described machine in the claim 19 to 22, wherein, described gathering-device (61) also comprises first bracing or strutting arrangement (63) that is used for described vessel (65) and second bracing or strutting arrangement (68) that is used for described lid (70).

24. according to each described machine in the claim 19 to 23, wherein, described gathering-device (61) also comprises the checkout gear of the packed height that is used to detect described vessel (65).

25. according to each described machine in the claim 19 to 24, also comprise: chamber (9) is used for ccontaining described storage device (11), described dispensing terminal (13) and described clamping and conveying device (14); Partition wall (8) is used to make described chamber (9) and described gathering-device (61) separated from one another; And hole (62), described hole (62) form and pass described partition wall (8), so that described chamber (9) interconnects with described gathering-device (61).

26. machine according to claim 25 also comprises: locking device, described locking device can move between the open position (71) of described hole (62) and closed position.

27. a machine that is used to prepare medicine comprises: be used for the storage device (11) of a plurality of containers (12), all fill medicine compounds and/or dilution to small part container (12) in the described container (12); Dispensing terminal (13) is used for preparing the medicine that comprises at least a described medicine compounds and at least a described dilution in first container (12) of described container; Clamping and conveying device (14) is used for transmitting described container (12) between described storage device (11) and described dispensing terminal (13); And mixing arrangement (94), be used to mix described first container (12), to mix described medicine compounds and described dilution, described mixing arrangement (94) comprises rotor plate (97), described rotor plate (97) has definite first longitudinal axis (98) and is provided with the seat (99) that at least one is used for described first container (12), and described mixing arrangement (94) also comprises first actuating device, so that described rotor plate (97) rotates around described first longitudinal axis (98); It is characterized in that, described mixing arrangement (94) also comprises second actuating device (103), be used for described rotor plate (97) around described first longitudinal axis (98) to the small part rotation process, described first container (12) is rotated around second longitudinal axis of determining (A).

28. machine according to claim 27, wherein, described first longitudinal axis (98) with respect to the datum level (8) of basic horizontal with non-90 ° angle setting.

29. according to claim 27 or 28 described machines, wherein, described second actuating device (103) comprises the actuation element (103) that at least one is fixing, and described actuation element (103) is set to contact so that described first container (12) is rotated around described second longitudinal axis (A) with described first container (12).

30. machine according to claim 29, wherein, described actuation element (103) comprises the ring-type element (103) that extends around described first longitudinal axis (98).

31. machine according to claim 30, wherein, described ring-type element (103) extends around described first longitudinal axis (98) with the angle less than 360 °.

32. according to claim 30 or 31 described machines, wherein, described mixing arrangement (94) also comprises gripper shoe (95), described gripper shoe (95) engages rotationally with described rotor plate (97), and supports described ring-type element (103); Described seat (99) has at least one otch (104), and described otch (104) forms and passes described rotor plate (97), and engages with described ring-type element (103).

33. according to each described machine in the claim 30 to 32, wherein, described second actuating device (103) comprises a plurality of described ring-type element of installing concentrically with respect to one another (103); Described seat (99) has the respective cut (104) that is used for each ring-type element (103), and described otch (104) forms and passes described rotor plate (97), and engages with described ring-type element (103).

34. according to each described machine in the claim 27 to 33, wherein, described rotor plate (97) is provided with a plurality of described seat (99) that distributes around described first longitudinal axis (98).

35. according to each described machine in the claim 27 to 34, wherein, the medicine compounds that described medicine compounds is powder or freeze-drying.

36. machine that is used to prepare medicine, comprise: the storage device (11) that is used at least one container (12), described storage device (11) has at least one neck (36) that is used for carrying to and fro from described container (12) fluid, and described storage device (11) is provided with the adaptation element (35) that is installed on the described neck (36); Dispensing terminal (13) is used to prepare the medicine that comprises at least a described medicine compounds and at least a described dilution; And clamping and conveying device (14), it is suitable for grasping described adaptation element (35) so that transmit described container (12) between described storage device (11) and described dispensing terminal (13); It is characterized in that described adaptation element (35) comprising: two anchor clamps (37,38), described anchor clamps (37,38) can move between the clip position of described neck (36) and off-position; And locking device (40), be used for described anchor clamps (37,38) are locked in described clip position.

37. machine according to claim 36, wherein, the thickness of described anchor clamps (37,38) is less than the length of described neck (36).

38. according to claim 36 or 37 described machines, wherein, described locking device (40) comprising: seat (45) is formed in first anchor clamps (38) in described two anchor clamps; And locking member (43), transport by second anchor clamps (37) in described two anchor clamps, and can move to and fro from the joint operating position of described seat (45).

39. according to each described machine in the claim 36 to 38, wherein, described anchor clamps (37,38) are hinged to relatively rotate with respect to each other around an axis (39) of determining.

40. according to the described machine of claim 39, wherein, described locking device (40) comprising: seat (45) is formed in first anchor clamps (38) in described two anchor clamps; Pin (43) is basically parallel to described axis (39); And being used for the support crank (41) of described pin (43), described support crank (41) is hinged to second anchor clamps (37) in described two anchor clamps, so that described pin (43) is shifted to and fro from the joint operating position of described seat (45).

41. according to each described machine in the claim 36 to 40, wherein, at least one in the described anchor clamps (37,38) is configured to connect with at least one bracing or strutting arrangement (34).

42. according to each described machine in the claim 36 to 41, wherein, described container (12) is the plastic material bag.

43. according to each described machine in the claim 36 to 41, wherein, described container (12) is a plastic material bottles.

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