CN114931513A - 包含凝胶的清洁组合物 - Google Patents
包含凝胶的清洁组合物 Download PDFInfo
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- CN114931513A CN114931513A CN202210579369.7A CN202210579369A CN114931513A CN 114931513 A CN114931513 A CN 114931513A CN 202210579369 A CN202210579369 A CN 202210579369A CN 114931513 A CN114931513 A CN 114931513A
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- gel
- cleaning solution
- cleaning
- composition
- cleansing composition
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Abstract
本发明属于洗化日用品领域，具体涉及一种包含凝胶的清洁组合物，所述清洁液包括表面活性剂、保湿剂、植物提取物、抑菌剂、辅料；所述凝胶为交联水凝胶，25℃水中最大溶胀率≤500％，最大溶胀24h内凝胶干重损失≤5％(质量)；所述凝胶占包含凝胶的清洁组合物总质量的50％～90％；所述凝胶与清洁液分别制备，凝胶于清洁液溶胀，使用时凝胶接触皮肤，更加温和，此外凝胶增强了清洁液在皮肤表面的滞留时间，两者协同作用实现了温和，生物降解性好，广谱抗菌性、良好生物相容性的优势，适用于皮肤敏感者。
Description
技术领域
本发明属于洗化日用品领域，具体涉及一种包含凝胶的清洁组合物。
背景技术
随着年龄的增加，人的皮脂腺功能逐渐减退，出现皮肤问题几率越来越大，像是湿疹、银屑病、皮炎、皮肤干燥症等多种皮肤疾病使得皮肤敏感性大大增加。
目前，常用皮肤外用物包括洗手液、香皂、保湿剂、护肤水等，这些皮肤外用物的功能多种多样，通过改善各种组分，具有抑菌，清洁，缓解皮肤过敏等等的功能。
然而，现有的皮肤外用清洁物对因皮肤疾病、过敏或其他原因导致的皮肤过度敏感人群不友好，例如洗手液使用后需要双手涂抹，易使皮肤二次受伤，香皂等固态清洁物则需要揉搓泡沫来使用，其刺激性较前者更大，此外目前各类抑菌洗手液或香皂的成分刺激性较大，不适合皮肤敏感者。
因此，寻求一种温和，高效抑菌，使用方便的清洁组合物是亟待解决的问题。
发明内容
为了解决上述技术问题，本发明提供一种温和、高效抑菌的包含凝胶的清洁组合物，采用表面活性剂增加清洁能力，并且通过添加抑菌剂可以有效抑制常见细菌，关键的本发明包含凝胶的清洁组合物分为凝胶和清洁液，使用时凝胶接触皮肤，更加温和，此外凝胶增强了清洁液在皮肤表面的滞留时间。
具体的，本发明的技术方案如下：
包含凝胶的清洁组合物，包括凝胶和清洁液；
所述清洁液包括表面活性剂、保湿剂、植物提取物、抑菌剂、辅料；
所述凝胶为交联水凝胶，25℃水中最大溶胀率≤500％，最大溶胀24h内凝胶干重损失≤5％(质量)；
所述凝胶占包含凝胶的清洁组合物总质量的50％～90％；
所述凝胶与清洁液分别制备，凝胶于清洁液溶胀。
优选的，表面活性剂为常用于洗化用品或药物的任何类型的表面活性剂，其用于降低界面的表面张力，达到清洁、乳化、稳定体系之目的，所述表面活性剂的实例包括但不限于脂肪酸皂(例如月桂酸钠、棕榈酸钠等)、高级烷基硫酸盐(例如月桂基硫酸钠等)、N-酰基肌氨酸(例如月桂酰基肌氨酸钠等)、高级脂肪酸酰胺磺酸盐(例如月桂基甲基牛磺酸钠等)、烷基苯磺酸盐、高级脂肪酸酯硫酸盐(例如硬化椰子油脂肪酸甘油硫酸钠等)、N-酰基谷氨酸盐、氨基葡萄糖月桂酰胺、月桂基二甲氨基乙酸甜菜碱、烷基甜菜碱、酰氨基甜菜碱、脱水山梨糖醇脂肪酸酯类(例如，脱水山梨糖醇单油酸酯、脱水山梨糖醇单异硬脂酸酯、脱水山梨糖醇单月桂酸酯、脱水山梨糖醇单棕榈酸酯、脱水山梨糖醇单硬脂酸酯、脱水山梨糖醇倍半油酸酯)、甘油聚甘油脂肪酸酯类(例如，单芥酸甘油酯、倍半油酸甘油酯、单硬脂酸甘油酯、单硬脂酸甘油苹果酸酯等)、PEG-脂肪酸酯类(例如，PEG-二硬脂酸酯、二硬脂酸乙二醇酯等)、PEG-烷基醚类、蔗糖脂肪酸酯、聚季铵盐-7、聚乙烯醇等中的一种或多种。本领域技术人员可以根据所需选择其类型及用量。
更优选的，本发明表面活性剂包括氨基葡萄糖月桂酰胺、磺基咪唑啉甜菜碱、N-月桂酰基肌氨酸钠、聚季铵盐-7中的至少一种。
通常，在本发明的包含凝胶的清洁组合物中，所述表面活性剂占清洁液总重量的0.01-50％。
所述保湿剂的实例包括但不限于甘油、海藻糖、蔗糖、泛醇、丙二醇、1,2-戊二醇、甘露醇、甘油聚醚-26、鼠李糖、棉子糖、赤藓醇、聚乙二醇-8、聚乙二醇-32、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、PEG/PPG-17/6共聚物、聚谷氨酸钠、木糖醇、尿素、水解小核菌胶、聚谷氨酸钠、甘油葡糖苷、PPG-10甲基葡糖醚、出芽短梗酶多糖、银耳多糖、PPG-20甲基葡糖醚等中的一种或多种。
通常，在本发明包含凝胶的清洁组合物中，所述保湿剂占清洁液的1％～20％(重量)。
所述植物提取物的成分是本领域己知的用于滋养皮肤的成分，包括但不限于苦参提取物、丹皮酚、芳樟醇、桉油素、冰片、硫磺、蝉蜕、蛇床子提取物、地肤子提取物、拳参提取物、紫苏提取物、炉甘石、无患子皂苷、马齿苋提取物、甘草酸铵、松油烯-4-醇、芦荟大黄素等。
通常，在本发明的包含凝胶的清洁组合物中，所述植物提取物占清洁液的0.01-10％(重量)。
所述辅料包括但不限于乳化剂、增稠剂、防腐剂、香料、pH调节剂。
所述乳化剂包括但不限于山梨坦橄榄油酸酯、硬脂醇聚瞇-21、PEG-60氢化蓖麻油、甘油硬脂酸酯/PEG-100硬脂酸酯、PPG-13-癸基十四醇聚醚-24、鲸蜡硬脂基葡糖苷、聚甘油-10肉豆蔻酸酯、鲸蜡硬脂基葡糖苷、聚甘油-10硬脂酸酯、聚甘油-10二油酸酯等中的一种或多种。通常，在本发明的皮肤外用组合物中，所述乳化剂占所述清洁液的0.01-5％(重量)。
所述增稠剂的实例包括但不限于羟乙基纤维素、羟丙基纤维素、卡波姆、黄原胶、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物中的一种或多种，本领域技术人员可根据需要具体选择其类型和用量。
所述防腐剂的实例包括但不限于羟苯甲酯、羟苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、山梨酸钾、苯甲酸钠、氯苯甘瞇等中的一种或多种及其它防腐增效剂，如戊二醇、己二醇、辛甘醇、对羟基苯乙酮等。
通常，在本发明的皮肤外用组合物中，所述防腐剂占所述清洁液的0.01-5％(重量)。
所述pH调节剂的实例包括但不限于柠檬酸、柠檬酸钠、精氨酸、三乙醇胺中的一种或多种，本领域技术人员可根据具体需要选择其类型和用量。
优选的，所述凝胶的组分为任选的可交联的具有良好生物相容性的天然多糖，可用于制备无毒聚合水凝胶的单体(化学交联由聚合物链之间的共价键组成)，包括但不限于海藻酸钠、瓜尔胶、黄原胶，各类葡聚糖、果胶、透明质酸。所述凝胶包括聚丙烯酰胺、聚乙烯醇、聚丙烯酸及其衍生物(包括聚丙烯酸盐等)、聚乙烯吡咯烷酮、聚磷腈、聚氧化乙烯及其衍生物。
更优选的，本发明清洁液包括如下含量的组分：
优选的，所述凝胶的组分包括聚丙烯酸。
优选的，抑菌剂包括松油烯-4-醇、芦荟大黄素和苯并异噻唑啉酮中的至少一种。
本发明中松油烯-4-醇、芦荟大黄素即是植物提取物也有抑菌效果，因此在作为植物提取物添加时，本领域技术人员可选择性的再添加或不添加抑菌剂。
优选的，所述凝胶的含水量为50％～90％(质量)；
优选的，所述凝胶的含水量为50％～70％(质量)；
优选的，所述凝胶的含水量为51％～69％(质量)；
优选的，所述凝胶的含水量为52％～68％(质量)；
优选的，所述凝胶的含水量为53％～67％(质量)；
优选的，所述凝胶的含水量为54％～66％(质量)；
优选的，所述凝胶的含水量为55％～65％(质量)；
进一步的，本发明还提供包含凝胶的清洁组合物的制备步骤，如下：
S1混匀器中将去离子水加热至65～75℃，连续均匀加入聚乙烯醇，搅拌至完全溶解；
S2加入氨基葡萄糖月桂酰胺、磺基咪唑啉甜菜碱和N-月桂酰基肌氨酸钠中的至少一种，保温搅拌至体系均匀；
S3加入聚季铵盐-7和甘油，继续搅拌至均匀；
S4体系均匀后，将温度降至35～40℃，加入植物提取物，抑菌剂，搅拌均匀，得到清洁液。
S5水中交联凝胶基质或聚合单体，调整凝胶交联剂或控制聚合分子量，使水凝胶最大溶胀≤500％，得到交联水凝胶；
S6将交联水凝胶烘干至含水量≤30％；
S7烘干后的交联水凝胶于清洁液中浸泡，至溶胀率为110％～200％，得到包含凝胶的清洁组合物。
此外可以添加交联剂来控制溶胀率，任选的生物相容性好的化学交联剂，也在包括在本发明包含凝胶的清洁组合物的组分之内。
进一步的，本发明实现了包含凝胶的清洁组合物在皮肤外用组合物中的应用。
本发明的有益效果在于：
1.通过优化各组分含量，科学配比，制备了体系稳定温和有效的清洁液，并将清洁液同水凝胶结合，使用时凝胶与皮肤表面摩擦起泡，增强了清洁液在皮肤表面的滞留时间，让适用群体更易接受，更适用于皮肤敏感者；
2.本发明的通过调整水凝胶交联或聚合时的分子量，实现了对水凝胶分子量范围的控制，从而使得水凝胶在水中的最大溶胀≤500％，防止水凝胶过渡溶胀导致向溶胶转变从而无法使用的情况，此外，保证水凝胶的良好交联使凝胶在清洗液浸泡时凝胶本体重量损失≤5％(24h内)，而在日常使用时，可根据使用频次，调整浸泡时间，或配合能定量补充清洁液的肥皂盒循环使用；
3.本发明采用多种表面活性剂协同凝胶多孔结构，起泡快速丰富，性质温和，生物降解性好，毒性低；广谱抗菌性、生物相容性和良好的螯合能力等优点，添加植物提取物和抑菌剂，对大肠杆菌、金黄色葡萄球菌、黑霉菌等均有良好的抑制作用。
具体实施方式
下面通过具体的实施方案叙述本发明。除非特别说明，本发明中所用的技术手段均为本领域技术人员所公知的方法。另外，实施方案应理解为说明性的，而非限制本发明的范围，本发明的实质和范围仅由权利要求书所限定。对于本领域技术人员而言，在不背离本发明实质和范围的前提下，对这些实施方案中的物料成分和用量进行的各种改变或改动也属于本发明的保护范围。
实施例1
包含凝胶的清洁组合物的清洁液组分如下：
此外，还具有0.1％(重量)精氨酸、0.1％(重量)羟苯甲酯，柠檬酸。
包含凝胶的清洁组合物制备方法如下：
S1混匀器磁力搅拌，按上述浓度比例，将750ml去离子水加热至70℃，连续均匀加入聚乙烯醇5g，搅拌至完全溶解；
S2按比例依次加入氨基葡萄糖月桂酰胺20g、磺基咪唑啉甜菜碱15g和N-月桂酰基肌氨酸钠5g、二乙醇胺2g、精氨酸1g、羟苯甲酯1g、，保温搅拌至体系均匀；
S3加入保湿剂甘油5g(3.9mL)，抑菌剂苯并异噻唑啉酮0.1g，继续搅拌至均匀；
S4体系均匀后，将温度降至40℃，加入植物提取物松油烯-4-醇6g、芦荟大黄素0.5g，加入柠檬酸调节pH为6.5，搅拌60min至均匀，呈现浅黄色透明微粘状液体，味清香，制得清洁液。
S5取10g海藻酸钠磁力搅拌溶解于50mL水中，滴加4wt％的Ca2+溶液至交联，加入羧甲基纤维素钠0.1g增强交联，使水凝胶最大溶胀率为328％(25℃水中)，得到交联水凝胶；
S6将交联水凝胶烘干至含水量55％(称重法)；
S7取烘干后的交联水凝胶20g于清洁液中浸泡2h，至溶胀率为200％，取出溶胀后的凝胶，得到包含凝胶的清洁组合物40.8g。
溶胀率的计算公式为：
SR＝[(Wt-Ws)/Ws]×100％
式中：Wt表示t时刻凝胶的总质量；Ws表示干凝胶的质量。
实施例2
包含凝胶的清洁组合物的清洁液组分如下：
此外，还具有0.1％(重量)精氨酸、0.1％(重量)羟苯甲酯，柠檬酸。
包含凝胶的清洁组合物制备方法如下：
S1混匀器磁力搅拌，按上述浓度比例，将800ml去离子水加热至65℃，连续均匀加入聚乙烯醇10g，搅拌至完全溶解；
S2按比例依次加入氨基葡萄糖月桂酰胺40g、磺基咪唑啉甜菜碱32g和N-月桂酰基肌氨酸钠7.5g、二乙醇胺6g、精氨酸1g、羟苯甲酯1g、，保温搅拌至体系均匀；
S3加入保湿剂甘油15g(3.9mL)，抑菌剂苯并异噻唑啉酮0.3g，继续搅拌至均匀；
S4体系均匀后，将温度降至35℃，加入植物提取物松油烯-4-醇8g、芦荟大黄素1g，加入柠檬酸调节pH为6.5，搅拌60min至均匀，呈现白色透明微粘状液体，味清香，制得清洁液。
S5取5ml丙烯酸磁力搅拌溶解于30ml水中，加入0.02gKPS引发剂(单体质量的0.4％)，60℃磁力搅拌引发聚合(32min聚合完成)，聚丙烯酸水凝胶最大溶胀率为438％(25℃水中)，得到交联水凝胶；
S6将交联水凝胶烘干至含水量55％(称重法)；
S7取烘干后的交联水凝胶20g于清洁液中浸泡2h，至溶胀率为200％，取出溶胀后的凝胶，得到包含凝胶的清洁组合物40.8g。
本实施例中，通过调配丙烯酸的单体浓度，实现了溶胀率的控制，实验表明，随着单体浓度的增加，溶胀率大体呈现上升趋势，单体浓度100％时，溶胀率最大。这是因为随着聚丙烯酸分子量的逐渐增大，聚丙烯酸的分子链变长，网状结构增加，溶胀率就大。
实施例3
本实施例制备方法及其他部分同实施例1，区别在于清洁液组分，具体如下：
凝胶制备后烘干至含水量60％，与清洁液中溶胀至216％，制得得到包含凝胶的清洁组合物45g。
实施例4
同实施例1，区别在于，清洁液表面活性剂选择5％十二烷基硫酸钠和5％十二烷基硫酸铵。
实施例5
同实施例1，区别在于，清洁液的表面活性剂选择5％脂肪酸聚氧乙烯醚硫酸钠和10％α-烯烃磺酸钠。
对比例1
本对比例采用市场常见的抑菌洗手液，该抑菌洗手液原料组成：双十烷基二甲基乙酸铵，椰油酰胺基丙基甜菜碱，聚葡萄糖苷，大豆油乙氧基化物，丙二醇，羧甲基纤维素钠，柠檬酸，绿茶香精，嫩绿色素，水。
抗菌抑菌效果实验
对实施例1～5和对比例1进行抗菌抑菌效果验证，测试参照QB/T2738-2012《日化产品抗菌抑菌效果的评价方法》(实验条件：作用时间2分钟，作用浓度1：1)。结果如表1所示：
表1抗菌抑菌效果对比
| 抑菌项目 | 实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 对比例1 |
| 大肠杆菌 | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞85.1％ |
| 金黄色葡萄球菌 | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞86.3％ |
| 黑霉菌 | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞99.9％ | ＞83.3％ |
由表1数据可以看出，本发明的包含凝胶的清洁组合物具有良好的抗菌抑菌效果，对大肠杆菌、金黄色葡萄球菌、黑霉菌等均有很好的抑制作用。
综上所述，本发明包含凝胶的清洁组合物采用氨基葡萄糖月桂酰胺、磺基咪唑啉甜菜碱、N-月桂酰基肌氨酸钠等温和、易降解的新型表面活性剂，并且通过添加抑菌剂松油烯-4-醇和芦荟大黄素，科学配比，可以有效抑制常见细菌。具有温和不伤手、抑菌效果好等优点，是一种温和、高效的抑菌清洁组合物。
保水率实验
由于本发明在日常使用中类似肥皂使用，相比单纯的洗手液和肥皂，凝胶更易失水变干，导致使用效果下降，因此本发明测试了各实施例包含凝胶的清洁组合物的保水率。
表2各实施例包含凝胶的清洁组合物保水效果比较(25℃，空气湿度35％)
上述数据表明，本发明具有良好的保水性，在日常使用不会出现清洁液粘度增加，凝胶变干的情况，这主要是本发明保湿剂的添加使得水分散失和补偿平衡。
感官评价
将20名测试人员平均分为4组，按“双盲”试验随机给予测试组样品，要求测试人员按自身日常洗手习惯洗手(即洗手液用量，洗手方式，冲水时间不做限定)，依次评价洗手液洗手时的起泡性、去污能力、刺激性、冲洗难度和洗手清爽感。测试者依据自己的感觉进行评分，评分标准采用5分制，其中起泡性、去污能力、洗后清爽感以1分最差，5分最好计算：刺激性、冲洗难度以1分最好，5分最差计算，最后以平均数值记录各实施例的感官效果评分，见下表3所示。
表3包含凝胶的清洁组合物洗手/清洁效果的感官评价
| 起泡性 | 去污能力 | 刺激性 | 冲洗难度 | 清凉感 | |
| 实施例1 | 4.3 | 4.5 | 1.0 | 1.2 | 4.6 |
| 实施例2 | 4.1 | 4.2 | 1.1 | 1.4 | 4.8 |
| 实施例3 | 4.2 | 4.3 | 1.1 | 1.3 | 4.6 |
| 实施例4 | 4.0 | 4.0 | 1.0 | 1.2 | 4.7 |
| 实施例5 | 4.0 | 4.5 | 1.2 | 1.1 | 4.5 |
由上述表3的内容可知，5个实施例在去污能力评价方面上的得分差别不大。实施例的配方组成除抑菌剂外其他成分对抑菌效果作用不大，实施例1、实施例2和实施例3的起泡能力强于实施例4和实施例5，这主要是本发明优选方案的多种表面活性剂协同凝胶多孔结构导致的。
Claims (10)
1.包含凝胶的清洁组合物，其特征在于，包括凝胶和清洁液；
所述清洁液包括表面活性剂、保湿剂、植物提取物、抑菌剂、辅料；
所述凝胶为交联水凝胶，25℃水中最大溶胀率≤500％，最大溶胀24h内凝胶干重损失≤5％(质量)；
所述凝胶占包含凝胶的清洁组合物总质量的50％～90％；
所述凝胶与清洁液分别制备，凝胶于清洁液溶胀。
2.如权利要求1所述的包含凝胶的清洁组合物，所述表面活性剂为聚乙烯醇、氨基葡萄糖月桂酰胺、磺基咪唑啉甜菜碱、聚季铵盐-7和N-月桂酰基肌氨酸钠中的至少一种。
3.如权利要求1所述的包含凝胶的清洁组合物，其特征在于，所述凝胶的组分包括海藻酸钠、交联剂。
4.如权利要求1所述的包含凝胶的清洁组合物，其特征在于，所述凝胶的组分包括聚丙烯酸。
5.如权利要求1所述的包含凝胶的清洁组合物，其特征在于，所述抑菌剂包括松油烯-4-醇、芦荟大黄素和苯并异噻唑啉酮中的至少一种。
6.如权利要求1所述的包含凝胶的清洁组合物，其特征在于，所述凝胶的含水量为50％～90％(质量)。
7.如权利要求1所述的包含凝胶的清洁组合物，其特征在于，所述凝胶的含水量为50％～70％(质量)。
8.如权利要求2所述的包含凝胶的清洁组合物，其特征在于，制备步骤如下：
(1)制备清洁液；
(2)交联凝胶基质或聚合单体，得到交联水凝胶；
(3)将交联水凝胶烘干至含水量≤30％；
(4)烘干后的交联水凝胶于清洁液中浸泡，至溶胀率为110％～200％，得到包含凝胶的清洁组合物。
9.如权利要求8所述的包含凝胶的清洁组合物，其特征在于，(1)中，清洁液制备步骤如下：
S1混匀器中将去离子水加热至65～75℃，连续均匀加入聚乙烯醇，搅拌至完全溶解；
S2加入氨基葡萄糖月桂酰胺、磺基咪唑啉甜菜碱和N-月桂酰基肌氨酸钠中的至少一种，保温搅拌至体系均匀；
S3加入聚季铵盐-7和保湿剂，继续搅拌至均匀；
S4体系均匀后，将温度降至35～40℃，加入植物提取物，抑菌剂，搅拌均匀，得到清洁液。
10.权利要求1所述的包含凝胶的清洁组合物在皮肤外用组合物中的用途。
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|---|---|---|---|---|
| JP2007254432A (ja) * | 2006-03-25 | 2007-10-04 | Kose Corp | ゲル状洗浄料及びその製造方法 |
| CN104000869A (zh) * | 2014-06-23 | 2014-08-27 | 宁夏都顺生物科技有限公司 | 一种含苦豆草总生物碱的外用凝胶型洗剂的制法和应用 |
| CN114392204A (zh) * | 2021-12-24 | 2022-04-26 | 广州那比昂生物科技有限公司 | 一种皮肤清洁组合物及其制备方法与应用 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007254432A (ja) * | 2006-03-25 | 2007-10-04 | Kose Corp | ゲル状洗浄料及びその製造方法 |
| CN104000869A (zh) * | 2014-06-23 | 2014-08-27 | 宁夏都顺生物科技有限公司 | 一种含苦豆草总生物碱的外用凝胶型洗剂的制法和应用 |
| CN114392204A (zh) * | 2021-12-24 | 2022-04-26 | 广州那比昂生物科技有限公司 | 一种皮肤清洁组合物及其制备方法与应用 |
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