CN114929752A - 嵌合细胞因子受体 - Google Patents

嵌合细胞因子受体 Download PDF

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Publication number
CN114929752A
CN114929752A CN202080084817.5A CN202080084817A CN114929752A CN 114929752 A CN114929752 A CN 114929752A CN 202080084817 A CN202080084817 A CN 202080084817A CN 114929752 A CN114929752 A CN 114929752A
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cells
optionally
icd
csfr
seq
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Chinese (zh)
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B.奈尔森
M.富勒
M.J.布朗格
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Victoria Industrial Co ltd, University of
Provincial Health Services Authority
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Victoria Industrial Co ltd, University of
Provincial Health Services Authority
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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CN202080084817.5A 2019-10-08 2020-10-08 嵌合细胞因子受体 Pending CN114929752A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962912223P 2019-10-08 2019-10-08
US62/912,223 2019-10-08
PCT/CA2020/051346 WO2021068068A1 (en) 2019-10-08 2020-10-08 Chimeric cytokine receptors

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CN114929752A true CN114929752A (zh) 2022-08-19

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CN202080084817.5A Pending CN114929752A (zh) 2019-10-08 2020-10-08 嵌合细胞因子受体

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US (1) US20240122979A1 (https=)
EP (1) EP4041893A4 (https=)
JP (2) JP2022552949A (https=)
KR (1) KR20220108768A (https=)
CN (1) CN114929752A (https=)
AU (1) AU2020362554A1 (https=)
BR (1) BR112022006782A2 (https=)
CA (1) CA3151472A1 (https=)
IL (1) IL291282A (https=)
MX (1) MX2022003885A (https=)
WO (1) WO2021068068A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022254143A1 (en) * 2021-04-07 2023-11-23 Provincial Health Services Authority Modified granulocyte colony-stimulating factor (g-csf) and chimeric cytokine receptors binding same
WO2023192948A1 (en) * 2022-04-01 2023-10-05 Seattle Children's Hospital (dba Seattle Children's Research Institute) Chimeric cytokine receptors
CA3259305A1 (en) * 2022-07-11 2024-01-18 Sonoma Biotherapeutics, Inc. RECOMBINANT CYTOKINE RECEPTORS AND METHODS OF USE
JP2025529913A (ja) * 2022-08-26 2025-09-09 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー キメラサイトカイン受容体及び使用方法
IL322949A (en) 2023-03-03 2025-10-01 Arsenal Biosciences Inc Systems targeting PSMA and CA9
WO2026055342A1 (en) * 2024-09-04 2026-03-12 Arsenal Biosciences, Inc. Synthetic pathway activators
CN119912588B (zh) * 2025-04-01 2025-08-12 浙江大学 嵌合抗原受体、人诱导多能干细胞、髓系前体细胞样巨噬细胞及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022914A1 (en) * 1993-04-06 1994-10-13 Fred Hutchinson Cancer Research Center Chimeric cytokine receptors in lymphocytes
WO2014127261A1 (en) * 2013-02-15 2014-08-21 The Regents Of The University Of California Chimeric antigen receptor and methods of use thereof
WO2015075468A1 (en) * 2013-11-21 2015-05-28 Ucl Business Plc Cell
WO2017180993A1 (en) * 2016-04-14 2017-10-19 Bluebird Bio, Inc. Salvage chimeric antigen receptor systems

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482927B1 (en) * 1995-11-27 2002-11-19 Millennium Pharmaceuticals, Inc. Chimeric proteins comprising the extracellular domain of murine Ob receptor
US20060257381A1 (en) * 2003-06-27 2006-11-16 Keiya Ozawa Method for transplanting lymphohematopoietic cells into mammal
US7939634B2 (en) * 2004-01-27 2011-05-10 Compugen Ltd. Polynucleotides encoding polypeptides and methods using same
EP1878745B1 (en) * 2005-04-22 2011-06-15 Keio University Humanin receptor or humanin-like polypeptide receptor
WO2016075612A1 (en) * 2014-11-12 2016-05-19 Rinat Neuroscience Corp. Inhibitory chimeric antigen receptors
WO2017184901A1 (en) * 2016-04-20 2017-10-26 Fred Hutchinson Cancer Research Center Immunomodulatory il2r fusion proteins and uses thereof
CN111819192A (zh) * 2018-03-02 2020-10-23 艾洛基治疗公司 可诱导的嵌合细胞激素受体
EP4041760A4 (en) * 2019-10-08 2023-10-11 Zymeworks BC Inc. Modified extracellular domain of granulocyte colony-stimulating factor receptor (g-csfr) and cytokines binding same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022914A1 (en) * 1993-04-06 1994-10-13 Fred Hutchinson Cancer Research Center Chimeric cytokine receptors in lymphocytes
WO2014127261A1 (en) * 2013-02-15 2014-08-21 The Regents Of The University Of California Chimeric antigen receptor and methods of use thereof
WO2015075468A1 (en) * 2013-11-21 2015-05-28 Ucl Business Plc Cell
WO2017180993A1 (en) * 2016-04-14 2017-10-19 Bluebird Bio, Inc. Salvage chimeric antigen receptor systems

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KLOSS等: "Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells", NAT BIOTECHNOL, vol. 31, no. 1, 31 January 2013 (2013-01-31), pages 71 - 75, XP055130697, DOI: 10.1038/nbt.2459 *
KOAY DC等: "Distinct region of the granulocyte colony-stimulating factor receptor mediates proliferative signaling through activation ol Janus kinase 2 and p44/42 mitogen-activated protein kinase", CELLULAR SIGNALLING, vol. 14, 31 December 2002 (2002-12-31), pages 239 - 247, XP055817108 *
TRAXLMAYR等: "Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library*", J BIOL CHEM, vol. 291, no. 43, 21 October 2016 (2016-10-21), pages 22496 - 22508, XP055532600, DOI: 10.1074/jbc.M116.741314 *

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WO2021068068A1 (en) 2021-04-15
US20240122979A1 (en) 2024-04-18
IL291282A (en) 2022-05-01
KR20220108768A (ko) 2022-08-03
MX2022003885A (es) 2022-07-13
AU2020362554A1 (en) 2022-05-12
BR112022006782A2 (pt) 2022-09-06
JP2025163198A (ja) 2025-10-28
JP2022552949A (ja) 2022-12-21
CA3151472A1 (en) 2021-04-15
EP4041893A4 (en) 2023-08-30

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