CN114929683B - 作为钙激活氯化物通道调节剂的吡啶衍生物 - Google Patents
作为钙激活氯化物通道调节剂的吡啶衍生物 Download PDFInfo
- Publication number
- CN114929683B CN114929683B CN202080053457.2A CN202080053457A CN114929683B CN 114929683 B CN114929683 B CN 114929683B CN 202080053457 A CN202080053457 A CN 202080053457A CN 114929683 B CN114929683 B CN 114929683B
- Authority
- CN
- China
- Prior art keywords
- compound
- amino
- pyridine
- acetyl
- indazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1910608.7 | 2019-07-24 | ||
| GBGB1910608.7A GB201910608D0 (en) | 2019-07-24 | 2019-07-24 | Compounds |
| PCT/GB2020/051785 WO2021014172A1 (en) | 2019-07-24 | 2020-07-24 | Pyridine derivatives as calcium-activated chloride channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114929683A CN114929683A (zh) | 2022-08-19 |
| CN114929683B true CN114929683B (zh) | 2024-09-03 |
Family
ID=67839705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080053457.2A Active CN114929683B (zh) | 2019-07-24 | 2020-07-24 | 作为钙激活氯化物通道调节剂的吡啶衍生物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12545658B2 (https=) |
| EP (1) | EP4003977B1 (https=) |
| JP (1) | JP7682850B2 (https=) |
| CN (1) | CN114929683B (https=) |
| GB (1) | GB201910608D0 (https=) |
| WO (1) | WO2021014172A1 (https=) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019145726A1 (en) * | 2018-01-26 | 2019-08-01 | Enterprise Therapeutics Limited | Compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2291749A1 (fr) * | 1974-11-20 | 1976-06-18 | Delalande Sa | Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique |
| US6262040B1 (en) * | 1996-09-04 | 2001-07-17 | Pfizer Inc | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) |
| CA2419224A1 (en) * | 2000-09-15 | 2002-03-21 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds |
| US7642277B2 (en) * | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| UY32138A (es) * | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| US9550737B2 (en) * | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| US9458124B2 (en) * | 2013-02-06 | 2016-10-04 | Wayne State University | Substituted pyran derivatives |
| AU2016247768B2 (en) * | 2015-04-17 | 2019-03-07 | Corteva Agriscience Llc | Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto |
| HUE064145T2 (hu) * | 2016-04-15 | 2024-03-28 | Epizyme Inc | Amin-szubsztituált aril- vagy heteroaril vegyületek, mint EHMT1 és EHMT2 inhibitorok |
| GB201610854D0 (en) * | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) * | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| AU2018211529A1 (en) * | 2017-01-27 | 2019-08-29 | Genfit | N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating autoimmune diseases |
| US11358947B2 (en) * | 2017-04-17 | 2022-06-14 | The Regents Of The University Of California | Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel TMEM16A |
-
2019
- 2019-07-24 GB GBGB1910608.7A patent/GB201910608D0/en not_active Ceased
-
2020
- 2020-07-24 JP JP2022504580A patent/JP7682850B2/ja active Active
- 2020-07-24 EP EP20751239.3A patent/EP4003977B1/en active Active
- 2020-07-24 CN CN202080053457.2A patent/CN114929683B/zh active Active
- 2020-07-24 WO PCT/GB2020/051785 patent/WO2021014172A1/en not_active Ceased
-
2022
- 2022-01-21 US US17/581,520 patent/US12545658B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019145726A1 (en) * | 2018-01-26 | 2019-08-01 | Enterprise Therapeutics Limited | Compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114929683A (zh) | 2022-08-19 |
| US20220144803A1 (en) | 2022-05-12 |
| EP4003977B1 (en) | 2026-04-15 |
| JP7682850B2 (ja) | 2025-05-26 |
| EP4003977A1 (en) | 2022-06-01 |
| WO2021014172A1 (en) | 2021-01-28 |
| GB201910608D0 (en) | 2019-09-04 |
| US12545658B2 (en) | 2026-02-10 |
| JP2022541638A (ja) | 2022-09-26 |
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| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
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