CN114929267A - 使用靶向cd70的基因工程化t细胞的肾细胞癌（rcc）疗法 - Google Patents

使用靶向cd70的基因工程化t细胞的肾细胞癌（rcc）疗法 Download PDF

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CN114929267A
CN114929267A CN202080090978.5A CN202080090978A CN114929267A CN 114929267 A CN114929267 A CN 114929267A CN 202080090978 A CN202080090978 A CN 202080090978A CN 114929267 A CN114929267 A CN 114929267A
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cells
car
dose
cell
ctx130
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J.A.特雷特
M-L.德奎安特
M.威尔
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CRISPR Therapeutics AG
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CRISPR Therapeutics AG
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN202080090978.5A 2019-11-13 2020-11-13 使用靶向cd70的基因工程化t细胞的肾细胞癌（rcc）疗法 Pending CN114929267A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962934961P 2019-11-13 2019-11-13
US62/934,961 2019-11-13
US202063034552P 2020-06-04 2020-06-04
US63/034,552 2020-06-04
PCT/IB2020/060719 WO2021095010A1 (en) 2019-11-13 2020-11-13 Renal cell carcinoma (rcc) therapy using genetically engineered t cells targeting cd70

Publications (1)

Publication Number Publication Date
CN114929267A true CN114929267A (zh) 2022-08-19

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CN202080090978.5A Pending CN114929267A (zh) 2019-11-13 2020-11-13 使用靶向cd70的基因工程化t细胞的肾细胞癌（rcc）疗法

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US (1) US20220387572A1 (enExample)
EP (1) EP4058053A1 (enExample)
JP (1) JP2023501602A (enExample)
KR (1) KR20220100913A (enExample)
CN (1) CN114929267A (enExample)
AU (1) AU2020383021A1 (enExample)
BR (1) BR112022009204A2 (enExample)
CA (1) CA3158110A1 (enExample)
IL (1) IL292468A (enExample)
MX (1) MX2022005821A (enExample)
WO (1) WO2021095010A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117844811A (zh) * 2024-03-08 2024-04-09 上海恒润达生生物科技股份有限公司 靶向敲除CD70基因的sgRNA组合物及其应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
KR20220101128A (ko) * 2019-11-13 2022-07-19 크리스퍼 테라퓨틱스 아게 Cd70을 표적화하는 유전자 조작된 t 세포를 사용하는 cd70+ 고형 종양 치료법
MX2022015586A (es) 2020-06-12 2023-03-15 Nkarta Inc Linfocitos citolíticos naturales modificados genéticamente para inmunoterapia de cáncer dirigida a cd70.
EP4305153A1 (en) * 2021-03-09 2024-01-17 CRISPR Therapeutics AG Genetically engineered t cells with ptpn2 knockout have improved functionality and anti-tumor activity
US20220378829A1 (en) * 2021-05-12 2022-12-01 Crispr Therapeutics Ag Genetically engineered immune cells targeting cd70 for use in treating solid tumors
WO2023072307A1 (zh) * 2021-10-25 2023-05-04 重庆精准生物技术有限公司 一种靶向cd70的抗原结合片段、单链抗体和嵌合抗原受体及其应用
EP4482872A4 (en) * 2022-03-07 2026-03-18 Nkarta Inc Multiplex gene-edited cells for CD70-led cancer immunotherapy
KR20250109947A (ko) 2024-01-11 2025-07-18 재단법인 아산사회복지재단 흉선 세포 또는 흉선 상피세포를 유효성분으로 포함하는 암 예방용 약학적 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018007263A1 (en) * 2016-07-06 2018-01-11 Cellectis Sequential gene editing in primary immune cells
WO2019097305A2 (en) * 2017-05-12 2019-05-23 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
WO2019152742A1 (en) * 2018-02-01 2019-08-08 Pfizer Inc. Chimeric antigen receptors targeting cd70

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11352631B2 (en) * 2015-12-18 2022-06-07 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
US20200063100A1 (en) 2018-05-11 2020-02-27 Crispr Therapeutics Ag Methods and compositions for treating cancer
KR20220101128A (ko) * 2019-11-13 2022-07-19 크리스퍼 테라퓨틱스 아게 Cd70을 표적화하는 유전자 조작된 t 세포를 사용하는 cd70+ 고형 종양 치료법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018007263A1 (en) * 2016-07-06 2018-01-11 Cellectis Sequential gene editing in primary immune cells
WO2019097305A2 (en) * 2017-05-12 2019-05-23 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
WO2019152742A1 (en) * 2018-02-01 2019-08-08 Pfizer Inc. Chimeric antigen receptors targeting cd70

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117844811A (zh) * 2024-03-08 2024-04-09 上海恒润达生生物科技股份有限公司 靶向敲除CD70基因的sgRNA组合物及其应用

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CA3158110A1 (en) 2021-05-20
US20220387572A1 (en) 2022-12-08
JP2023501602A (ja) 2023-01-18
IL292468A (en) 2022-06-01
WO2021095010A1 (en) 2021-05-20
MX2022005821A (es) 2022-08-16
EP4058053A1 (en) 2022-09-21
BR112022009204A2 (pt) 2022-07-26
KR20220100913A (ko) 2022-07-18
AU2020383021A1 (en) 2022-05-19

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Application publication date: 20220819