CN114917249B - 紫磷在肿瘤治疗、肿瘤抑制剂制备中的应用及肿瘤抑制剂 - Google Patents
紫磷在肿瘤治疗、肿瘤抑制剂制备中的应用及肿瘤抑制剂 Download PDFInfo
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- CN114917249B CN114917249B CN202210717167.4A CN202210717167A CN114917249B CN 114917249 B CN114917249 B CN 114917249B CN 202210717167 A CN202210717167 A CN 202210717167A CN 114917249 B CN114917249 B CN 114917249B
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- purple phosphorus
- tumor
- purple
- cold plasma
- phosphorus
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- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 229910052698 phosphorus Inorganic materials 0.000 title claims abstract description 104
- 239000011574 phosphorus Substances 0.000 title claims abstract description 104
- 238000011282 treatment Methods 0.000 title claims abstract description 29
- 206010028980 Neoplasm Diseases 0.000 title abstract description 48
- 239000002246 antineoplastic agent Substances 0.000 title abstract description 13
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 230000005495 cold plasma Effects 0.000 claims abstract description 79
- 239000002135 nanosheet Substances 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000002064 nanoplatelet Substances 0.000 claims description 59
- 239000000243 solution Substances 0.000 claims description 57
- 210000004881 tumor cell Anatomy 0.000 claims description 20
- 239000007789 gas Substances 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 4
- 239000001307 helium Substances 0.000 claims description 4
- 229910052734 helium Inorganic materials 0.000 claims description 4
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000005229 chemical vapour deposition Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000008346 aqueous phase Substances 0.000 claims 2
- 238000004299 exfoliation Methods 0.000 claims 2
- 238000009832 plasma treatment Methods 0.000 abstract description 20
- 230000002829 reductive effect Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 description 36
- 230000000052 comparative effect Effects 0.000 description 22
- 238000011580 nude mouse model Methods 0.000 description 21
- 241000699660 Mus musculus Species 0.000 description 18
- 230000006907 apoptotic process Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 4
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 230000005284 excitation Effects 0.000 description 3
- 239000010453 quartz Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000011889 copper foil Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 239000002055 nanoplate Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210717167.4A CN114917249B (zh) | 2022-06-23 | 2022-06-23 | 紫磷在肿瘤治疗、肿瘤抑制剂制备中的应用及肿瘤抑制剂 |
Applications Claiming Priority (1)
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CN202210717167.4A CN114917249B (zh) | 2022-06-23 | 2022-06-23 | 紫磷在肿瘤治疗、肿瘤抑制剂制备中的应用及肿瘤抑制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN114917249A CN114917249A (zh) | 2022-08-19 |
CN114917249B true CN114917249B (zh) | 2024-03-08 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202210717167.4A Active CN114917249B (zh) | 2022-06-23 | 2022-06-23 | 紫磷在肿瘤治疗、肿瘤抑制剂制备中的应用及肿瘤抑制剂 |
Country Status (1)
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CN (1) | CN114917249B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107496444A (zh) * | 2017-08-29 | 2017-12-22 | 深圳大学 | 一种硒掺杂黑磷前药及其制备方法 |
CN108514565A (zh) * | 2018-06-13 | 2018-09-11 | 湖北中科墨磷科技有限公司 | 磷基材料在制备治疗肿瘤的药物中的应用 |
WO2021084361A1 (en) * | 2019-10-29 | 2021-05-06 | Materias S.R.L. | Use of exfoliated black phosphorus for the treatment of prostate cancers |
CA3174611A1 (en) * | 2020-04-10 | 2021-10-14 | Jerome Canady Research Institute For Advanced Biological And Technolo... | System and method for treatment of respiratory infections and lung cancer with cold atmospheric plasma |
CN114452300A (zh) * | 2020-11-09 | 2022-05-10 | 深圳先进技术研究院 | 黑磷纳米片在制备抑制肿瘤迁移和侵袭的药物中的用途 |
-
2022
- 2022-06-23 CN CN202210717167.4A patent/CN114917249B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107496444A (zh) * | 2017-08-29 | 2017-12-22 | 深圳大学 | 一种硒掺杂黑磷前药及其制备方法 |
CN108514565A (zh) * | 2018-06-13 | 2018-09-11 | 湖北中科墨磷科技有限公司 | 磷基材料在制备治疗肿瘤的药物中的应用 |
WO2021084361A1 (en) * | 2019-10-29 | 2021-05-06 | Materias S.R.L. | Use of exfoliated black phosphorus for the treatment of prostate cancers |
CA3174611A1 (en) * | 2020-04-10 | 2021-10-14 | Jerome Canady Research Institute For Advanced Biological And Technolo... | System and method for treatment of respiratory infections and lung cancer with cold atmospheric plasma |
CN114452300A (zh) * | 2020-11-09 | 2022-05-10 | 深圳先进技术研究院 | 黑磷纳米片在制备抑制肿瘤迁移和侵袭的药物中的用途 |
Non-Patent Citations (3)
Title |
---|
Pang et al..Investigation of the chemical characteristics and anticancer effect of plasma-activated water: The effect of liquid temperature.《Plasma Process Polym》.2021,第19卷(第1卷),摘要及结论部分. * |
莫健斌.二维磷基纳米材料的合成与生物活性研究.《中国博士学位论文全文数据库 工程科技Ⅰ辑》.2022,(第5期),第15、116页. * |
许德晖 等.等离子体医学及其在肿瘤治疗中的应用.《生物化学与生物物理进展》.2017,第44卷(第44卷),摘要、第281页3.2节. * |
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CN114917249A (zh) | 2022-08-19 |
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CB03 | Change of inventor or designer information |
Inventor after: Xu Dehui Inventor after: Zhao Xinyi Inventor after: Qi Miao Inventor after: Zhang Huaiyan Inventor after: Zhao Xuewen Inventor after: Zhang Jinying Inventor before: Xu Dehui |
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TA01 | Transfer of patent application right |
Effective date of registration: 20240205 Address after: No. 2, No. 32, the Pearl River Road, Yantai Area, China (Shandong) Pilot Free Trade Zone, Yantai City, Shandong Province, 264000 Applicant after: Yantai Mengchong Le Medical Technology Co.,Ltd. Country or region after: China Address before: Room 2801, Block 4, Hailun International Building, East Section of Xiying Road, Yanta District, Xi'an City, Shaanxi Province 710043 Applicant before: Xi'an Chunhui Information Consulting Co.,Ltd. Country or region before: China |
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