CN114904172A - Portable nerve regulation and control device and regulation and control method based on low-intensity focused ultrasound - Google Patents
Portable nerve regulation and control device and regulation and control method based on low-intensity focused ultrasound Download PDFInfo
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- CN114904172A CN114904172A CN202210456163.5A CN202210456163A CN114904172A CN 114904172 A CN114904172 A CN 114904172A CN 202210456163 A CN202210456163 A CN 202210456163A CN 114904172 A CN114904172 A CN 114904172A
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- A61N7/00—Ultrasound therapy
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Abstract
The invention discloses a portable nerve regulation and control device and a regulation and control method based on low-intensity focused ultrasound.A user operates an add-subtract button to input frequency in a display screen and confirms the frequency through a confirmation button; the main control chip loads frequency control words in a parallel or serial mode, the main control chip controls the signal generator to output an excitation signal, the excitation signal is amplified by the power amplifier to obtain a high-power electric signal, the ultrasonic transducer converts the electric signal into ultrasonic waves, and the ultrasonic waves act on a target human body through the couplant. The invention adopts low-intensity focused ultrasound for interventional therapy, has no wound when in use, does not need to carry out complex operation to go deep into the cerebral cortex, avoids wound infection and immunoreaction, overcomes the defects of high price and complex operation of clinical ultrasonic equipment based on portable design, can be used in various scenes and has no other side effect.
Description
Technical Field
The invention relates to the technical field of ultrasonic medical instruments, in particular to a portable nerve regulation and control device and a regulation and control method based on low-intensity focused ultrasound.
Background
The nerve regulation and control technology is a biomedical engineering technology which utilizes the physical stimulation of electricity, magnetism, light, sound and the like introduced into a nerve circuit or the chemical reaction of medicines to change the functional activity of a nervous system so as to improve the symptoms of neurological diseases and improve the quality of life. The physical factor is used for the activation effect of the neural circuit, and the change of the functional structure of the nervous system can be observed, and the method for intervening and treating related neurological diseases can be researched, so that the neural regulation and control technology is widely applied and rapidly developed in life science research and medical clinical diagnosis and treatment. The currently common physical factor nerve regulation and control means comprise deep brain stimulation, transcranial direct current stimulation, repeated transcranial magnetic stimulation, optogenetics or light-operated gene technology and the like. Deep brain stimulation requires implanting stimulating electrodes into deep brain region with focus by stereotactic technique, and introducing pulsed electric field with appropriate intensity to stimulate nervous tissue of the brain region and stimulate cell electrical activity to realize regulation and control of nervous system physiological function activity. Deep brain stimulation has the advantages of high targeting property, adjustability, good time and spatial resolution and the like, and has great potential advantages in treating diseases such as Parkinson's disease, epilepsy, Alzheimer's disease and the like, so the deep brain stimulation is often clinically adopted in the cranial nerve department. However, the deep brain stimulation of the technology needs to be implanted into deep electrodes of the cerebral cortex by means of a more complicated operation, and the danger of wound infection or immune reaction is difficult to avoid. Transcranial direct current stimulation and repeated transcranial magnetic stimulation are non-invasive intracerebral physical stimulation means, and utilize physical factors of electricity and magnetism to regulate the activity of cerebral cortex neurons, but the focusing range and the penetration depth are relatively limited, and the focusing performance and the stimulation depth of the two stimulation technologies are related to the size of a stimulation coil or an electrode. The larger the coil diameter, the deeper the stimulation depth, and the poorer the focality of the repeated transcranial magnetic stimulation. While the spatial resolution of transcranial direct current stimulation is worse compared to repeated transcranial magnetic stimulation. These limitations have resulted in a significant inhibition of disease efficacy by means of electrical and magnetic stimulation interventions. The light-operated gene technology enables receptor neurons to generate photosensitive protein through a gene engineering method to play a role in treatment, but sensitive light beams can be introduced only by implanting optical fibers in an operation to excite the receptor neurons, so that the clinical application is limited due to the fact that the operation is difficult to infringe.
In view of the disadvantages of the existing neuromodulation technologies and the sensitive safety factors involved in the clinical application short-circuit board, people are prompted to seek to stimulate neuromodulation methods by using new physical factors.
The ultrasonic wave has the advantages of good propagation directivity, strong penetrating power, good focusing effect and the like, the low-intensity ultrasonic wave propagates in a living body without damaging the secondary effect of the tissue, and researches find that the weak biological effect can be induced by irradiating the living body tissue with the low-intensity ultrasonic wave (LIFU). For the central nervous system, low intensity ultrasound was first discovered to have a neuromodulatory effect in the 50's of the 20 th century and did not induce tissue damage. The method meets the requirements of searching other physical stimulation factors for safe neural regulation, can not only be used for inducing biological effect without damage on neural tissues, but also can not produce accidental damage on organisms. On the basis, people research and discover that the low-intensity focused ultrasound not only can perform nerve regulation on cerebral cortex and brain regions, but also can non-invasively stimulate deep brain regions such as hippocampus, thalamus and the like, so as to realize function regulation on deep brain tissues, and has important application value for treating nervous system diseases.
The ultrasonic equipment used clinically at present is expensive, complex in operation, most of which is applied to clinical research and is inconvenient to be applied to clinical treatment in a large area, so that the invention of the ultrasonic focusing device which is portable, simple in operation and generally applicable is beneficial to further development of the technology.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a portable nerve regulation and control device and a regulation and control method based on low-intensity focused ultrasound, which are used for interventional therapy without wound in use and complex operation without deep penetration into the cerebral cortex, so that wound infection and immune reaction are avoided.
In order to solve the technical problems, the invention adopts the technical scheme that:
a portable nerve regulation and control device based on low-intensity focused ultrasound comprises a regulation and control device body, a control panel, a main control chip, a signal generator, a power amplifier and an ultrasonic transducer.
The regulating device body is a shell structure which wraps the main control chip, the signal generator and the power amplifier and forms a closed space; the ultrasonic transducer is arranged outside the regulating device body and is electrically connected with the regulating device body.
The control panel is embedded in the outer surface of the regulating device body and is electrically connected with the main control chip; the control panel is provided with a power switch, a display screen, an add-subtract button and a confirm button.
The main control chip is connected with the input end of the signal generator, and the output end of the signal generator is connected to the ultrasonic transducer through the power amplifier.
A user turns on a power switch, operates the add-subtract button to input frequency in the display screen and confirms the frequency through the confirmation button; the main control chip loads frequency control words in a parallel or serial mode, the main control chip controls the signal generator to output an excitation signal, the excitation signal is amplified by the power amplifier to obtain a high-power electric signal, the ultrasonic transducer converts the electric signal into ultrasonic waves, and the ultrasonic waves act on a target human body through the couplant.
As a further preferred embodiment of the present invention, the signal generator is a DDS signal generator, and is selected from a model of AD9953, AD9951, or AD 9833.
As a further preferred embodiment of the present invention, the power amplifier includes a first-stage same-ratio amplifying circuit, a second-stage amplifying circuit, and a high-frequency filter circuit; the main control chip is connected with the digital potentiometer in the primary same-proportion amplifying circuit, and the output power is controlled by adjusting the output resistance value of the digital potentiometer and controlling the output voltage; the output end of the first-stage same-proportion amplifying circuit is connected with the input end of the second-stage amplifying circuit, and the second-stage amplifying circuit is used for amplifying power with fixed gain; the output end of the secondary amplifying circuit is connected with a high-frequency filter circuit, and the high-frequency filter circuit is used for filtering the influence of high-frequency noise on output signals.
As a further preferable aspect of the present invention, the present invention further includes a frequency switching circuit; the input end of the frequency switching circuit is connected with the main control chip, and the output end of the frequency switching circuit is connected with the ultrasonic transducer; the frequency switching circuit samples voltage and current signals of the ultrasonic transducer, the sampled current and voltage signals are rectified and then pass through the phase demodulation circuit to obtain phase difference signals, and the main control chip controls and adjusts the output frequency of the DDS signal generator according to the phase difference signals until the phase difference becomes zero, so that the ultrasonic transducer accurately works at a resonance point.
As a further preferable aspect of the present invention, the frequency adjustment range of the DDS signal generator is 0.1-20 MHz; the power regulation range of the power amplifier is 1W-5W.
As a further preferred feature of the present invention, the control panel further comprises a front and rear selection button, the front and rear selection button being electrically connected to the main control chip; the front and back selection buttons are used for switching between output frequency setting, output power setting and duty ratio setting, and the confirmation button is used for confirming through adding and subtracting the button to select a numerical value.
As a further preferred feature of the present invention, the control panel further comprises a mode selection button, the mode selection button being electrically connected to the main control chip; three output modes, namely a high-intensity mode, a medium-intensity mode and a low-intensity mode, are preset in the mode selection button;
the parameters of the high intensity mode are 5W of power and 100% of duty ratio; the parameters of the medium intensity mode are power 3W and 80% duty ratio; the parameters of the low intensity mode are power 1W, 50% duty cycle.
As a further preferred embodiment of the present invention, the ultrasonic transducer further comprises a physiological signal acquisition circuit, wherein an input end of the physiological signal acquisition circuit is connected to the human body through an electrode, an output end of the physiological signal acquisition circuit is connected to the main control chip, and the frequency, the power and the duty ratio of the ultrasonic transducer are adjusted through the feedback of the electrocardiosignals of the human body.
A regulation and control method of a portable nerve regulation and control device based on low-intensity focused ultrasound specifically comprises the following steps:
step 1, connecting a nerve regulation and control device, and coating a coupling agent on the surface of an ultrasonic transducer;
step 2, turning on a power switch of the control panel, observing the display screen, switching between output frequency setting, output power setting and duty ratio setting by operating front and rear selection buttons, selecting a numerical value by adding and subtracting the buttons, and confirming the buttons;
step 3, directly selecting a preset high-intensity mode, a preset medium-intensity mode or a preset low-intensity mode through a mode selection button;
step 4, after parameter setting is finished, attaching the ultrasonic transducer to the surface of the target human skin;
step 5, acquiring electrocardiosignals of the patient fed back by the circuit according to the physiological signals, and adjusting parameters on a control panel; if the electrocardiosignal of the patient is detected to be unchanged, increasing the output power until the electrocardiosignal is changed and reaches the preset change amplitude; if the electrocardiosignal of the patient is detected to have a change amplitude exceeding the expected change amplitude after being regulated, the output power is reduced;
and 6, after the work is finished, taking down the ultrasonic transducer and turning off a power switch.
The invention has the following beneficial effects:
1. the nerve regulation and control device provided by the invention adopts low-intensity focused ultrasound for interventional therapy, can improve the nerve function in a non-invasive manner, and effectively makes up the harm of an injury treatment method; the device not only has the function of regulating and controlling the central nervous system, but also has the similar regulating and controlling functions on the peripheral nervous system and the autonomic nervous system, and is beneficial to treating related diseases.
2. The nerve regulation and control device has no wound when in use, does not need to carry out complex operation to deeply penetrate into the cerebral cortex, avoids wound infection and immunoreaction, and is convenient for clinical and household use.
3. The nerve regulation and control device provided by the invention can be used for treating nerve functions by regulating cells through low-power ultrasound, and cannot cause local fever and other side effects.
4. The portable wearable ultrasonic equipment overcomes the defects of high price and complex operation of clinical ultrasonic equipment based on portable wearable design, and can be used in various scenes; and the use parameters are adjustable, and parameter optimization can be carried out according to individual differences of patients.
Drawings
Fig. 1 is a schematic structural diagram of a portable nerve regulation device based on low-intensity focused ultrasound.
Fig. 2 is a control circuit diagram of a portable neuromodulation device based on low-intensity focused ultrasound.
FIG. 3 is a circuit diagram of the frequency adjustment of a portable neuromodulation device based on low-intensity focused ultrasound.
Among them are: 10. a regulating device body; 20. a control panel; 21. a power switch; 22. a display screen; 23. adding and subtracting buttons; 24. a confirmation button; 25. a front and rear selection button; 26. a mode selection button; 30. a main control chip; 40. a signal generator; 50. a power amplifier; 60. an ultrasonic transducer; 70. a frequency switching circuit; 80. a physiological signal acquisition circuit.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific preferred embodiments.
In the description of the present invention, it is to be understood that the terms "left side", "right side", "upper part", "lower part", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and that "first", "second", etc., do not represent an important degree of the component parts, and thus are not to be construed as limiting the present invention. The specific dimensions used in the present example are only for illustrating the technical solution and do not limit the scope of protection of the present invention.
The invention is described in further detail below with reference to the drawings and the detailed description of preferred embodiments.
As shown in fig. 1 and 2, a portable nerve regulation and control device based on low-intensity focused ultrasound comprises a regulation and control device body 10, a control panel 20, a main control chip 30, a signal generator 40, a power amplifier 50, an ultrasonic transducer 60, a frequency switching circuit 70 and a physiological signal acquisition circuit 80.
The regulating device body 10 is a shell structure which wraps the main control chip 30, the signal generator 40 and the power amplifier 50 and forms a closed space; the ultrasonic transducer 60 is disposed outside the control device body 10 and electrically connected to the control device body 10.
An ultrasonic transducer is a piezoelectric ceramic that resonates at an ultrasonic frequency, and converts an electrical signal into mechanical vibration by the piezoelectric effect of a material. The working principle of medical ultrasound transducers (ultrasound probes) is substantially the same, and they usually contain an electrical energy storage element and a mechanical vibration system inside. When the transducer is used as a transmitter, an electric oscillating signal from an excitation power supply will cause a change in the electric or magnetic field in the electrical energy storage element in the transducer, which change will produce an impetus to the mechanical vibration system of the transducer to bring it into a vibrating state, thereby propelling the medium in contact with the mechanical vibration system of the transducer to vibrate and radiate sound waves into the medium. The process of receiving sound waves is opposite to that of receiving sound waves, and external sound waves act on a vibration surface of the transducer, so that a mechanical vibration system of the transducer vibrates, an electric field or a magnetic field in an energy storage element of the transducer is changed correspondingly, and an electric output end of the transducer generates voltage and current corresponding to sound signals. The ultrasonic transducer 60 can also be arranged inside the body casing of the control device, but is connected outside by a power line and a signal line to be used more flexibly and conveniently.
The control panel 20 is embedded in the outer surface of the regulating device body 10, and the control panel 20 is electrically connected with the main control chip 30; the control panel 20 is provided with a power switch 21, a display 22, an add-drop button 23, a confirm button 24, a front-rear selection button 25, and a mode selection button 26.
The power switch is used for controlling the on and off of the regulating device; the display screen displays various parameters required by regulation and control, including output frequency, output power and duty ratio; the addition and subtraction button is used for adjusting the numerical value of each parameter; the front and back selection buttons are used for switching among various numerical values, and the confirmation button is used for confirming the adjusted parameter numerical value; the mode selection button is preset with three output modes, namely a high-intensity mode, a medium-intensity mode and a low-intensity mode, wherein the parameters of the high-intensity mode are 5W of power and 100% of duty ratio; the parameters of the medium intensity mode are power 3W and 80% duty ratio; the parameters for the low intensity mode are power 1W, 50% duty cycle. The duty ratio is the proportion of the power-on time in one pulse cycle, and the adjustable range is 0-100%.
The main control chip 30 is connected to the input terminal of the signal generator 40, and the output terminal of the signal generator 40 is connected to the ultrasonic transducer 60 through the power amplifier 50. The signal generator 40 is a DDS signal generator with a frequency adjustment range of 0.1-20MHz, preferably AD9953 or AD9951 or AD 9833.
The user turns on the power switch 21, operates the add-subtract button 23 to input the frequency in the display screen 22, and confirms through the confirmation button 24; the main control chip 30 loads the frequency control words in a parallel or serial manner, the main control chip 30 controls the signal generator 40 to output an excitation signal, the excitation signal is amplified by the power amplifier 50 to obtain a high-power electrical signal, the ultrasonic transducer 60 converts the electrical signal into ultrasonic waves, and the ultrasonic waves act on a target human body through a coupling agent.
The power amplifier 50 is a general power amplifier device, and is not limited to a model. The power amplifier 50 includes a first-stage same-proportion amplifying circuit, a second-stage amplifying circuit and a high-frequency filter circuit; the main control chip 30 is connected with the digital potentiometer in the first-stage same-proportion amplifying circuit, and controls the output voltage by adjusting the output resistance value of the digital potentiometer, so as to control the output power; the output end of the first-stage same-proportion amplifying circuit is connected with the input end of the second-stage amplifying circuit, and the second-stage amplifying circuit is used for amplifying power with fixed gain; the output end of the secondary amplifying circuit is connected with a high-frequency filter circuit, and the high-frequency filter circuit is used for filtering the influence of high-frequency noise on the output signal.
The power regulation range of the power amplifier of the device is 1W-5W, the nerve function is treated by regulating cells by using low-power ultrasound, and local heat and other side effects cannot be caused.
As shown in fig. 3, the input end of the frequency switching circuit 70 is connected to the main control chip 30, and the output end of the frequency switching circuit 70 is connected to the ultrasonic transducer 60; the frequency switching circuit 70 samples the voltage and current signals of the ultrasonic transducer 60, the sampled current and voltage signals are rectified and then pass through the phase discrimination circuit to obtain a phase difference signal, and the main control chip 30 controls and adjusts the output frequency of the DDS signal generator according to the phase difference signal until the phase difference becomes zero, so that the ultrasonic transducer 60 accurately works at a resonance point.
The input end of the physiological signal acquisition circuit 80 is connected with the target human body through an electrode, the output end is connected with the main control chip 30, and the frequency, the power and the duty ratio of the ultrasonic transducer 60 are adjusted through the feedback of the electrocardiosignals of the human body. The regulating device of the device is small and exquisite in body, and all circuit devices are distributed and fixed in the shell in an integrated mode, so that the device is convenient to carry; by using the portable wearing design, a user can use the portable wearing design with the help of medical care personnel or adjust and control the portable wearing design by the user through the handheld ultrasonic transducer, so that the defects of high price and complex operation of clinical ultrasonic equipment are overcome, and the portable wearing design can be used in various scenes; and the use parameters are adjustable, and parameter optimization can be carried out according to individual differences of patients.
A regulation and control method of a portable nerve regulation and control device based on low-intensity focused ultrasound specifically comprises the following steps:
step 1, connecting a nerve regulation and control device, and smearing a coupling agent on the surface of an ultrasonic transducer 60;
step 2, turning on a power switch 21 of the control panel 20, observing the display screen 22, switching between output frequency setting, output power setting and duty ratio setting by operating a front and back selection button 25, selecting a numerical value by an add-subtract button 23, and confirming by a confirmation button 24;
step 3, directly selecting a preset high-intensity mode, a preset medium-intensity mode or a preset low-intensity mode through a mode selection button 26;
step 4, after parameter setting is finished, the ultrasonic transducer 60 is attached to the surface of the skin of a target human body, and the position of the selected part is usually near the heart and can be adjusted;
step 5, adjusting parameters on the control panel 20 according to the electrocardiosignals of the patient fed back by the physiological signal acquisition circuit 80; if the electrocardiosignal of the patient is detected to be kept unchanged, increasing the output power until the electrocardiosignal changes and reaches a preset change amplitude;
if the electrocardiosignal of the patient is detected to have a change amplitude exceeding the expected change amplitude after being regulated, the output power is reduced;
and 6, after the work is finished, taking down the ultrasonic transducer 60 and turning off a power switch.
The device adopts low-intensity focused ultrasound for interventional therapy, can improve the nerve function in a non-invasive way, and effectively makes up the harm of an injury therapy method; the low-intensity ultrasound has no secondary effect on injurious tissues in vivo, has a nerve regulation effect on the central nervous system and the low-intensity ultrasound, does not induce tissue damage, can non-invasively stimulate deep brain regions such as hippocampus, thalamus and the like, realizes the function regulation on the deep brain tissues, and has important application value for treating nervous system diseases; the use has no wound, does not need to implement complex operation to go deep into the cerebral cortex, avoids wound infection and immunoreaction, and is convenient for clinical and household use.
Although the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the details of the embodiments, and various equivalent modifications can be made within the technical spirit of the present invention, and the scope of the present invention is also within the scope of the present invention.
Claims (9)
1. The utility model provides a portable neural regulation and control device based on low-intensity focused ultrasound which characterized in that: the ultrasonic wave power generation device comprises a regulation and control device body (10), a control panel (20), a main control chip (30), a signal generator (40), a power amplifier (50) and an ultrasonic transducer (60);
the regulating and controlling device body (10) is a shell structure which wraps the main control chip (30), the signal generator (40) and the power amplifier (50) and forms a closed space; the ultrasonic transducer (60) is arranged outside the regulating device body (10) and is electrically connected with the regulating device body (10);
the control panel (20) is embedded in the outer surface of the regulating and controlling device body (10), and the control panel (20) is electrically connected with the main control chip (30); a power switch (21), a display screen (22), an add-subtract button (23) and a confirmation button (24) are arranged on the control panel (20);
the main control chip (30) is connected with the input end of the signal generator (40), and the output end of the signal generator (40) is connected to the ultrasonic transducer (60) through the power amplifier (50);
the user turns on the power switch (21), operates the add-subtract button (23) to input frequency in the display screen (22), and confirms through the confirmation button (24); the main control chip (30) loads the frequency control words in a parallel or serial mode, the main control chip (30) controls the signal generator (40) to output an excitation signal, the excitation signal is amplified by the power amplifier (50) to obtain a high-power electric signal, the ultrasonic transducer (60) converts the electric signal into ultrasonic waves, and the ultrasonic waves act on a target human body through the couplant.
2. The portable neuromodulation device based on low-intensity focused ultrasound as claimed in claim 1, wherein: the signal generator (40) is a DDS signal generator.
3. The portable neuromodulation device based on low-intensity focused ultrasound as claimed in claim 2, wherein: the power amplifier (50) comprises a primary same-proportion amplifying circuit, a secondary amplifying circuit and a high-frequency filter circuit; the main control chip (30) is connected with the digital potentiometer in the primary same-proportion amplifying circuit, and the output power is controlled by adjusting the output resistance value of the digital potentiometer and controlling the output voltage; the output end of the first-stage same-proportion amplifying circuit is connected with the input end of the second-stage amplifying circuit, and the second-stage amplifying circuit is used for amplifying power with fixed gain; the output end of the secondary amplifying circuit is connected with a high-frequency filter circuit, and the high-frequency filter circuit is used for filtering the influence of high-frequency noise on the output signal.
4. The portable neuromodulation device based on low-intensity focused ultrasound as claimed in claim 3, wherein: further comprising a frequency switching circuit (70); the input end of the frequency switching circuit (70) is connected with the main control chip (30), and the output end of the frequency switching circuit (70) is connected with the ultrasonic transducer (60); the frequency switching circuit (70) samples voltage and current signals of the ultrasonic transducer (60), the sampled current and voltage signals are rectified and then pass through the phase discrimination circuit to obtain phase difference signals, and the main control chip (30) controls and adjusts the output frequency of the DDS signal generator according to the phase difference signals until the phase difference becomes zero, so that the ultrasonic transducer (60) accurately works at a resonance point.
5. The portable neuromodulation device as in claim 4, wherein the neuromodulation device comprises: the frequency adjusting range of the DDS signal generator is 0.1-20 MHz; the power regulation range of the power amplifier is 1W-5W.
6. The portable neuromodulation device as in claim 5, wherein the neuromodulation device comprises: the control panel (20) further comprises a front and rear selection button (25), and the front and rear selection button (25) is electrically connected with the main control chip (30); the front and rear selection buttons (25) are used for switching between output frequency setting, output power setting and duty ratio setting, and the numerical value is selected by the addition and subtraction buttons (23), and the confirmation is performed by the confirmation button (24).
7. The portable neuromodulation device as in claim 6, wherein the neuromodulation device comprises: the control panel (20) further comprises a mode selection button (26), and the mode selection button (26) is electrically connected with the main control chip (30); three output modes, namely a high-intensity mode, a medium-intensity mode and a low-intensity mode, are preset in the mode selection button (26);
the parameters of the high intensity mode are 5W of power and 100% of duty ratio; the parameters of the medium intensity mode are power 3W and 80% duty ratio; the parameters for the low intensity mode are power 1W, 50% duty cycle.
8. The portable neuromodulation device as in claim 7, wherein the neuromodulation device comprises: the ultrasonic transducer also comprises a physiological signal acquisition circuit (80), wherein the input end of the physiological signal acquisition circuit (80) is connected with a target human body through an electrode, the output end of the physiological signal acquisition circuit is connected with the main control chip (30), and the frequency, the power and the duty ratio of the ultrasonic transducer (60) are adjusted through the feedback of human body electrocardiosignals.
9. The method for regulating the portable nerve regulation and control device based on the low-intensity focused ultrasound as claimed in claim 8, wherein the method comprises the following steps: the method specifically comprises the following steps:
step 1, connecting a nerve regulation and control device, and coating a coupling agent on the surface of an ultrasonic transducer (60);
step 2, turning on a power switch (21) of a control panel (20), observing a display screen (22), switching between output frequency setting, output power setting and duty ratio setting by operating a front and rear selection button (25), selecting a numerical value by an add-subtract button (23), and confirming by a confirmation button (24);
step 3, directly selecting a preset high-intensity mode, a preset medium-intensity mode or a preset low-intensity mode through a mode selection button (26);
step 4, after parameter setting is finished, attaching the ultrasonic transducer (60) to the surface of the skin of the target human body;
step 5, adjusting parameters on a control panel (20) according to the electrocardiosignals of the patient fed back by the physiological signal acquisition circuit (80); if the electrocardiosignal of the patient is detected to be kept unchanged, increasing the output power until the electrocardiosignal changes and reaches a preset change amplitude;
if the electrocardiosignal of the patient is detected to have a change amplitude exceeding the expected amplitude after the application of regulation and control, the output power is reduced;
and 6, after the work is finished, taking down the ultrasonic transducer (60) and turning off a power switch.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210456163.5A CN114904172A (en) | 2022-04-27 | 2022-04-27 | Portable nerve regulation and control device and regulation and control method based on low-intensity focused ultrasound |
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| CN202210456163.5A CN114904172A (en) | 2022-04-27 | 2022-04-27 | Portable nerve regulation and control device and regulation and control method based on low-intensity focused ultrasound |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024109759A1 (en) * | 2022-11-25 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Variable-frequency ultrasonic regulation apparatus |
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2022
- 2022-04-27 CN CN202210456163.5A patent/CN114904172A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024109759A1 (en) * | 2022-11-25 | 2024-05-30 | 中国科学院深圳先进技术研究院 | Variable-frequency ultrasonic regulation apparatus |
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Application publication date: 20220816 |