CN114867488A - 一种治疗神经损伤及其相关病症的方法 - Google Patents
一种治疗神经损伤及其相关病症的方法 Download PDFInfo
- Publication number
- CN114867488A CN114867488A CN202180007425.3A CN202180007425A CN114867488A CN 114867488 A CN114867488 A CN 114867488A CN 202180007425 A CN202180007425 A CN 202180007425A CN 114867488 A CN114867488 A CN 114867488A
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- Prior art keywords
- plasminogen
- mice
- plasmin
- group
- spinal cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1722—Plasma globulins, lactoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
一种治疗神经损伤及其相关病症的方法，包括给药受试者治疗有效量的纤维蛋白溶酶原激活途径组分。还提供了用于治疗上述病症的包含纤维蛋白溶酶原激活途径组分的药物、药物组合物、制品、试剂盒。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020072747 | 2020-01-17 | ||
| CNPCT/CN2020/072747 | 2020-01-17 | ||
| PCT/CN2021/072505 WO2021143906A1 (zh) | 2020-01-17 | 2021-01-18 | 一种治疗神经损伤及其相关病症的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114867488A true CN114867488A (zh) | 2022-08-05 |
Family
ID=76863652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180007425.3A Pending CN114867488A (zh) | 2020-01-17 | 2021-01-18 | 一种治疗神经损伤及其相关病症的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230066726A1 (zh) |
| EP (1) | EP4091621A4 (zh) |
| JP (1) | JP2023515916A (zh) |
| KR (1) | KR20220127880A (zh) |
| CN (1) | CN114867488A (zh) |
| CA (1) | CA3165026A1 (zh) |
| WO (1) | WO2021143906A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024094217A1 (zh) * | 2022-11-04 | 2024-05-10 | 泰伦基国际有限公司 | 一种促进病理性tdp-43蛋白降解的方法和药物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| JPH11510170A (ja) | 1995-07-27 | 1999-09-07 | ジェネンテック インコーポレーテッド | タンパク質の処方 |
| AU771635B2 (en) * | 1999-01-05 | 2004-04-01 | American National Red Cross, The | Methods for treating conditions associated with the accumulation of excess extracellular matrix |
| US20030219431A1 (en) * | 2002-05-24 | 2003-11-27 | Empire Pharmaceuticals, Inc. | Treatment of neuronal and neurological damage associated with spinal cord injury |
| CN101886066A (zh) * | 2009-05-13 | 2010-11-17 | 南京大学 | 组织型纤溶酶原激活物环饼结构-2对脑卒中的治疗作用及制备方法 |
| CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
| CN106890325A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性神经损伤及其相关病症的方法 |
| TWI653981B (zh) * | 2015-12-18 | 2019-03-21 | 深圳瑞健生命科學硏究院有限公司 | Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury |
| CN109125715A (zh) * | 2017-06-19 | 2019-01-04 | 深圳瑞健生命科学研究院有限公司 | 一种调控glp-1/glp-1r的方法和药物 |
-
2021
- 2021-01-18 KR KR1020227027834A patent/KR20220127880A/ko unknown
- 2021-01-18 JP JP2022542323A patent/JP2023515916A/ja active Pending
- 2021-01-18 EP EP21741423.4A patent/EP4091621A4/en active Pending
- 2021-01-18 CA CA3165026A patent/CA3165026A1/en active Pending
- 2021-01-18 US US17/793,371 patent/US20230066726A1/en active Pending
- 2021-01-18 CN CN202180007425.3A patent/CN114867488A/zh active Pending
- 2021-01-18 WO PCT/CN2021/072505 patent/WO2021143906A1/zh unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024094217A1 (zh) * | 2022-11-04 | 2024-05-10 | 泰伦基国际有限公司 | 一种促进病理性tdp-43蛋白降解的方法和药物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4091621A4 (en) | 2023-08-02 |
| EP4091621A1 (en) | 2022-11-23 |
| JP2023515916A (ja) | 2023-04-17 |
| KR20220127880A (ko) | 2022-09-20 |
| CA3165026A1 (en) | 2021-07-22 |
| WO2021143906A1 (zh) | 2021-07-22 |
| US20230066726A1 (en) | 2023-03-02 |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination |