CN114847490A

CN114847490A - Tablet for improving sleep quality and preparation method thereof

Info

Publication number: CN114847490A
Application number: CN202210339381.0A
Authority: CN
Inventors: 张志敏
Original assignee: Guangzhou Niubinle Nutrition Technology Co ltd
Current assignee: Guangzhou Niubinle Nutrition Technology Co ltd
Priority date: 2022-04-01
Filing date: 2022-04-01
Publication date: 2022-08-05

Abstract

The application relates to the field of health-care food, in particular to a tablet for improving sleep quality and a preparation method thereof. A tablet for improving sleep quality comprises the following components in percentage by weight: 10-65% of casein hydrolysate peptide, 1-30% of theanine, 1-5% of inulin and 21-82% of auxiliary material. It is effective in improving sleep problems such as insomnia, night wake, and difficulty in falling asleep caused by anxiety and stress, promoting deep sleep, improving sleep quality, relieving nervous excitation, improving anxiety, and promoting mental health. The application also provides a preparation method of the tablet for improving the sleep quality, and the preparation method is simple and is convenient to carry and take.

Description

Tablet for improving sleep quality and preparation method thereof

Technical Field

The application relates to the field of health-care food, in particular to a tablet for improving sleep quality and a preparation method thereof.

Background

The society is rapidly developed at present, the rhythm of life of people is faster and faster, and many people have sleep problems under the influence of anxiety and stress. Data show that 27% of people worldwide have sleep problems, while 57% of the adult population have sleep problems, which seriously affect human health. The sleeping problems mainly include difficulty in falling asleep, easy awakening after falling asleep, insomnia and dreaminess, and the like. On an individual level, if the sleep is poor for a long time, it will lead to poor concentration, hypomnesis, listlessness, resistance deterioration, etc., affecting the mental state of the person, and thus affecting the working state. Inadequate sleep can also lead to the development of chronic metabolic disorders such as obesity, diabetes and hypertension.

At present, melatonin is mainly taken as a food for improving sleep in the market, which can improve sleep quality, but has no treatment effect on insomnia, and has poor effect after long-term administration, and has side effects of dizziness, headache, muscular soreness and the like. There are also fragrance candles and sleep spray products that claim to promote sleep, it is highly unknown that sleep is a state of depression and calmness of the brain and body, and that fragrance, medication, etc. odor stimuli work against it, only to make the brain more exciting.

Barbiturates, benzodiazepines, non-benzodiazepines and the like are generally used for clinically treating sleep disorder, and the medicines have quick response, definite action mechanism and good curative effect, but are easy to generate side effects such as residual effect, amnesic effect, withdrawal effect and the like after long-term administration.

Disclosure of Invention

The purpose of the application is to provide a tablet for improving sleep quality, which is beneficial to improving sleep problems such as insomnia, night awakening, difficulty in falling asleep and the like caused by anxiety and stress, promoting deep sleep, improving sleep quality, relieving nervous excitation, improving anxiety and promoting mental health.

Another object of the present application is to provide a method for preparing a tablet for improving sleep quality, which is simple and convenient to carry and take.

The technical problem to be solved by the application is solved by adopting the following technical scheme.

In one aspect, the present application provides a tablet for improving sleep quality, which includes, by weight: 10-65% of casein hydrolysate peptide, 1-30% of theanine, 1-5% of inulin and 21-82% of auxiliary material.

In another aspect, embodiments of the present application provide a method for preparing a tablet for improving sleep quality, which includes:

s1, extraction of casein hydrolysate peptides: carrying out enzymolysis, enzyme deactivation, separation, concentration, sterilization and spray drying on a milk casein aqueous solution to obtain casein hydrolysate peptide;

s2, extracting theanine: pulverizing folium Camelliae sinensis, extracting with water for several times, mixing filtrates, concentrating, precipitating with 95% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine;

s3, pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide obtained in S1 and theanine obtained in S2, granulating, drying, mixing, and tabletting.

Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:

the application provides a tablet for improving sleep quality, which comprises the following components in percentage by weight: 10-65% of casein hydrolysate peptide, 1-30% of theanine, 1-5% of inulin and 21-82% of auxiliary material. The casein hydrolysis peptide can effectively relieve symptoms such as insomnia, dreaminess and the like caused by stress, has the functions of relaxing people, soothing nerves and helping sleep, and the theanine has the effects of reducing blood pressure, soothing nerves, improving sleep, promoting brain functions and the like, activates inhibitory nerves of brain, calms excitatory nerves, thereby improving sleep condition and prompting people to sleep soundly. The casein hydrolysate peptide is matched with theanine, so that the sleep quality problems of insomnia, night awakening, difficulty in falling asleep and the like caused by stress, anxiety and the like can be effectively improved, and no side effect is caused.

The embodiment of the application provides a preparation method of a tablet for improving sleep quality, which comprises the following steps: extraction of casein hydrolysate peptides: mixing and hydrolyzing milk casein water solution and compound hydrolase, ultrafiltering and drying to obtain casein hydrolysate peptide; extracting theanine: pulverizing folium Camelliae sinensis, extracting with water for several times, mixing filtrates, concentrating, precipitating with 95% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine; pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide and theanine, granulating, drying, mixing, and tabletting to obtain tablet. The method has high extraction efficiency, and the obtained tablet is convenient for carrying and administration.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.

In one aspect, the present application provides a tablet for improving sleep quality, comprising, in weight percent: 10-65% of casein hydrolysate peptide, 1-30% of theanine, 1-5% of inulin and 21-82% of auxiliary material.

Casein hydrolysate peptide is milk protein hydrolysate, contains bioactive decapeptide, can relieve stress symptoms, and has relaxing effect and no side effect. Decapeptides are functional small molecule peptides that resist gastrointestinal digestion, retain biological activity, and pass through small intestinal epithelial cells to a site of action. The mechanism solves the problem that the absorption of sleep-aiding components in the milk by a human body is limited, and also solves the trouble that the human body cannot drink the milk due to physical reasons such as intestines and stomach. Correctly and scientifically supplement casein hydrolysate peptide before sleep, can promote sleep and improve human health.

The casein hydrolysate peptide is also rich in various proteins in milk, can effectively whiten skin and make skin compact, tender and smooth, and is rich in L-tryptophan, so that the casein hydrolysate peptide has the effects of soothing nerves and helping sleep.

Theanine is one of the characteristic components in tea leaves, and accounts for 1-2% of the total dry matter, and is higher in some tea leaves, such as Anji white tea. Theanine is non-protein amino acid, and accounts for more than 50% of total amount of free amino acids in tea. Theanine has effects of lowering blood pressure, tranquilizing, improving sleep, promoting brain function, activating inhibitory nerve of brain, tranquilizing and exciting nerve, improving sleep condition, and promoting sleep.

It was found that the main receptor for theanine is the brain. After theanine enters the brain through brain barriers, the intragranular neurotransmitter dopamine in brain cells is obviously increased, and the dopamine is an adrenaline and noradrenaline precursor and is an important substance for conveying the excitation degree of brain nerve cells, and the release of the dopamine can greatly influence the emotion of a human. In addition, theanine may have an effect on the synthesis and breakdown of serotonin in the brain. After taking theanine, the content of tryptophan in brain is obviously increased or tends to be increased, but the content of serotonin is reduced. Theanine may reduce serotonin synthesis and increase its breakdown, or inhibit serotonin release.

Human body research shows that the intake of theanine improves the relaxed feeling of a human body through two ways, firstly, the theanine directly stimulates the formation of alpha brain waves to form deep relaxation and mental alertness, and secondly, the theanine participates in the synthesis of gamma-aminobutyric acid, thereby helping the human body to improve sleep. Compared with the other substance caffeine which can refresh and refresh the brain, the caffeine has the refreshing and exciting effects, but the caffeine which is taken alone has certain harm to human bodies, and the equal amount of caffeine exciting effects can not be generated after the tea is drunk. This is because theanine has an antagonistic effect on the excitation of caffeine production. Theanine is caffeine antagonist, and has effects of tranquilizing, reducing tension and relaxing nerve.

Inulin is a reserve polysaccharide in plants, mainly comes from the plants, is contained in protoplasts of cells in a colloidal form, is different from starch, is easily dissolved in hot water, is separated out from the water by adding ethanol, and does not react with iodine. Inulin is also very easily hydrolyzed to fructose under dilute acid, which is characteristic of all fructans. Can also be hydrolyzed into fructose by inulase. Inulin has high hygroscopicity, and free water binding ability, and can reduce water activity. This can be fully used to delay the evaporation of water in food processing, prevent the product from becoming stale, and prolong the shelf life and quality guarantee period of food. Inulin is not digested but becomes a probiotic to enter the intestine. The probiotics are helpful for culturing and increasing the number of beneficial bacteria in the digestive system, controlling weight and digestive health, and improving and controlling blood sugar.

In some embodiments of the present application, the inulin is made from one or more of Jerusalem artichoke, chicory, dahlia. The inulin content in the jerusalem artichoke is highest, the contents of the inulin in the chicory and the inulin in the dahlia are also higher, and the inulin can be quickly extracted.

In some embodiments of the present application, the adjunct includes one or more of a filler, a lubricant, and a sweetener.

The filler is an auxiliary material used for increasing the weight and the volume of the tablet and facilitating tabletting. The filler is one or more of starch, dextrin and lactose. The starch is cheap but has poor compressibility, and the dextrin is a product obtained by partial hydrolysis of the starch, and has strong adhesion, high hardness and strong adsorbability. Lactose is an excellent tablet filler, and lactose particles prepared by a spray drying method are close to spherical, have good fluidity and compressibility, and can be used for directly tabletting powder.

The lubricant can smoothly feed and discharge the tablets during tabletting, reduce sticking and reduce the friction force between granules or tablets and the wall of a die hole, and ensure that the tablets have smooth and attractive appearance. The lubricant is one or more of magnesium stearate, hydrogenated vegetable oil, and silica gel micropowder.

Magnesium stearate, an organic compound, is a white, non-gritty fine powder that has a greasy feel on contact with the skin. Insoluble in water, ethanol and diethyl ether, and can be used as lubricant, antisticking agent and glidant.

Hydrogenated vegetable oil is an artificial fat and includes well-known non-dairy creamer (creamer), margarine, cocoa butter replacer, and the like. It is made up by adding hydrogen into ordinary vegetable oil under a certain temp. and pressure and making it undergo the process of catalysis. In addition to lubricants, hydrogenated vegetable oils can be used as co-binders in tablets, as viscosity modifiers in oily liquid and semisolid formulations, to reduce sedimentation of suspended components and improve the solidification process in the preparation of suppositories, as liquid and semisolid fillings for hard gelatin capsules.

Colloidal silica, also known as colloidal silica, is very fine in particle size, difficult to measure, often expressed as specific surface area, and functions well as a glidant, typically used in an amount of about 0.1% to about 0.5%. Can be used as flow aid, catalyst carrier, etc. in the production of medicine.

The addition of a sweetening agent imparts a palatable feel to the tablet and also acts as a flavoring agent. The sweetener is one or more of sorbitol, maltitol, and erythritol.

Sorbitol, also known as sorbitol, is the major photosynthetic product of plants of the Rosaceae family. Is white hygroscopic powder or crystalline powder, tablet or granule, and has no odor. Has cool sweet taste, sweetness about half of that of cane sugar, calorific value similar to that of cane sugar, and no dental caries when used as a sweetening agent. After eating, the food is not converted into glucose in blood and is not influenced by insulin.

Maltitol is a novel sweetener, and the sweeteners eaten by people in the past are basically sugars with high heat and sweetness, and are easy to cause diseases such as diabetes, obesity, arteriosclerosis, heart failure and the like. The maltitol has high sweetness, low calorie, good safety, more sufficient raw materials, simple manufacturing process and unique performance which is not possessed by other sweeteners. The maltitol can be used in oral preparation, candy, and food, and has no caries, toxicity, allergy or irritation.

Erythritol, a bulk sweetener. Erythritol is widely present in nature, such as fungus mushroom, lichen, melon and fruit, grape, pear, eyeball crystal of animal, plasma, fetal fluid, semen, urine, and fermented food such as wine, beer, soy sauce, and Japanese sake. Has refreshing sweet taste, is not easy to absorb moisture, is stable at high temperature, is stable in a wide pH range, has mild cool feeling when dissolved in the mouth, and is suitable for various foods. It has low hygroscopicity, and can prolong the shelf life of tablet.

In some embodiments of the present application, the weight ratio of the bulking agent, the lubricant, and the sweetener is (10-20): (1-2): (20-70). Under the proportion, the tablet can be well molded, has good taste and flavor and is more palatable.

In some embodiments of the present application, the above-mentioned sleep quality improving tablet further comprises less than 1% by weight of a flavorant.

The edible spice can improve the flavor of the tablet, and is convenient for people to accept the tablet. The dosage is less, and the health is generally not harmed.

In another aspect, the present application provides a method for preparing a tablet for improving sleep quality, which comprises:

s1, extraction of casein hydrolysate peptides: carrying out enzymolysis, enzyme deactivation, separation, concentration, sterilization and spray drying on a milk casein aqueous solution to obtain casein hydrolysate peptide; the extraction method is simple and has high extraction efficiency.

S2, extracting theanine from tea leaves: pulverizing folium Camelliae sinensis, extracting with water for several times, mixing filtrates, concentrating, precipitating with 95% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine; thus, the theanine in the tea can be effectively extracted.

In some embodiments of the present application, at S3, after tableting, further comprising a coating material, the coating material being one or more of sucrose powder, gelatin, acacia, zein ethanol solution, and cellulose acetate phthalate ethanol solution.

The coating is that sugar or other materials capable of forming films are coated on the outer surface of the solid pharmaceutical preparation in a specific device according to a specific process, and the solid pharmaceutical preparation becomes a layer or a plurality of layers of multifunctional protective layers with different thicknesses and different elasticity and is tightly adhered to the surface after being dried. The coating can improve the appearance of the tablet, increase the stability of the drug, mask the unpleasant odor of the drug, control the site of drug release, etc. The coating material is generally sucrose powder, gelatin, acacia, zein ethanol solution, cellulose acetate phthalate ethanol solution, cellulose derivative, etc.

The features and properties of the present application are described in further detail below with reference to examples.

Examples

The raw materials were prepared according to the ingredients in table 1.

TABLE 1 compounding ratio of raw materials in examples 1 to 8 (%)

The preparation method of the tablet for improving sleep quality of example 1-2 is as follows:

extraction of casein hydrolysate peptides: carrying out enzymolysis, enzyme deactivation, separation, concentration, sterilization and spray drying on the milk casein aqueous solution to obtain the casein hydrolysate peptide.

Extracting theanine: pulverizing folium Camelliae sinensis, extracting with deionized water for several times (at 100 deg.C) at a ratio of material to liquid of 30g/ml, mixing filtrates, concentrating, precipitating with 95% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine;

pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide and theanine, granulating, drying, mixing, tabletting, and coating to obtain tablet. The coating material is sucrose powder.

The preparation method of the tablets for improving sleep quality of examples 3 to 4 is as follows:

Extracting theanine: pulverizing folium Camelliae sinensis, extracting with deionized water for several times (at 100 deg.C) at a ratio of material to liquid of 30g/ml, mixing filtrates, concentrating, precipitating with 90% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine;

pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide and theanine, granulating, drying, mixing, tabletting, and coating to obtain tablet. The coating material used was gelatin.

The preparation method of the tablets for improving sleep quality of examples 5 to 6 is as follows:

Extracting theanine: pulverizing folium Camelliae sinensis, extracting with deionized water for multiple times (at 100 deg.C) at a ratio of materials to liquid of 20g/ml, mixing filtrates, concentrating, precipitating with 95% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine;

pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide and theanine, granulating, drying, mixing, tabletting, and coating to obtain tablet. The coating material used was gum arabic.

The preparation method of the tablet for improving sleep quality of example 7 comprises the following steps:

pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide and theanine, granulating, drying, mixing, tabletting, and coating to obtain tablet. The coating material used was a zein ethanol solution.

The preparation method of the tablet for improving sleep quality of example 8 is substantially the same as that of example 1-2 except that the coating material used is a cellulose acetate phthalate alcohol solution.

Examples of the experiments

To verify the effect of the tablets for improving sleep quality provided in the examples, a total of 44 patients were enrolled in the volunteer experiment. The subjects are 25-40 years old, have high work pressure, and have sleep disorder, and the Pittsburgh sleep quality index is 16-21 points. The trial is intended to preserve the personal rights of the subject as well as the safety and reliability of the test data. All subjects gave oral and written informed consent for participation.

The patients were randomly divided into three groups, and the experimental example was administered with the tablet prepared in example 2, and the comparative example was administered with melatonin. Each subject took 1 tablet (each containing 200mg of casein hydrolysate peptide) or one melatonin tablet as provided in example 2 before sleep. Subjects reacted to their sleep condition by filling out the pittsburgh sleep quality index table. Their sleep index data were collected on day 0 and day 30 of dosing, respectively, and the results are shown in tables 2 and 3.

The rating standard of Pittsburgh sleep quality index is as follows:

the quality of the sleep is good in 0-5 minutes, the quality of the sleep is still in 6-10 minutes, the quality of the sleep is general in 11-15 minutes, and the quality of the sleep is poor in 16-21 minutes.

TABLE 2 Pittsburgh sleep quality index average score

TABLE 3 score of subjects after 30 days of drug administration

The test results are shown in tables 2 and 3, and the mean score of pittsburgh sleep quality index of the subjects decreased from 16.35 to 11 on day 0 after taking the tablets provided in example 2 for 30 days, wherein the sleep quality of 22.7% of the patients was significantly improved, the sleep time was increased, the number of night awakenings was significantly reduced, and the subjects felt good mental status without significant side effects; the sleep quality index score of Pittsburgh of 72.7% of patients is reduced, but the sleep quality condition is improved and the daytime mental condition is good; the score of the pittsburgh sleep quality index of 18 percent of patients is still maintained between 16 and 21 points, and the sleep quality is not obviously improved.

In the subjects taking melatonin, 9% of the patients also had a significant improvement in sleep quality, but only 45.4% of the patients had a certain improvement in sleep quality, some of the subjects had a feeling of listlessness during the day, and 45.4% of the subjects considered to have no significant sleep-promoting effect when they were taken melatonin.

The improvement of sleep quality by taking the tablets of example 2 is better than the comparative example, and most importantly, no significant side effects are observed in the subjects of example 1.

In summary, the embodiments of the present application provide a tablet for improving sleep quality, which includes, by weight: 10-65% of casein hydrolysate peptide, 1-30% of theanine, 1-5% of inulin and 21-82% of auxiliary material. The casein hydrolysate peptide contains decapeptide, can effectively relieve symptoms of insomnia, dreaminess and the like caused by stress, has the functions of relaxing people, soothing nerves and helping sleep, and the theanine has the effects of lowering blood pressure, soothing nerves, improving sleep, promoting brain functions and the like, activates inhibitory nerves of brain, calms excitatory nerves, improves sleep condition and promotes people to sleep well. The casein hydrolysate peptide is matched with theanine, so that the sleep quality problems of insomnia, night awakening, difficulty in falling asleep and the like caused by stress, anxiety and the like can be effectively improved, and no side effect is caused. The tablet provided by the application is beneficial to improving the sleep problems such as insomnia, night awakening and difficulty in falling asleep caused by anxiety stress, promoting deep sleep, improving sleep quality, relieving nerve excitation, improving anxiety and facilitating promotion of physical and mental health.

The embodiment of the application also provides a preparation method of the tablet for improving sleep quality, which comprises the following steps: extraction of casein hydrolysate peptides: mixing and hydrolyzing milk casein water solution and compound hydrolase, ultrafiltering and drying to obtain casein hydrolysate peptide; extracting theanine: pulverizing folium Camelliae sinensis, extracting with water for several times, mixing filtrates, concentrating, precipitating with 95% ethanol, filtering, concentrating, ultrafiltering, purifying, and drying to obtain powdered theanine; pulverizing the rest materials, sieving, mixing with casein hydrolysate peptide and theanine, granulating, drying, mixing, and tabletting to obtain tablet. The method has high extraction efficiency, and the obtained tablet is convenient for carrying and administration.

The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

Claims

1. A tablet for improving sleep quality is characterized by comprising the following components in percentage by weight: 10-65% of casein hydrolysate peptide, 1-30% of theanine, 1-5% of inulin and 21-82% of auxiliary material.

2. The tablet for improving sleep quality as claimed in claim 1, wherein the adjuvant includes one or more of a filler, a lubricant and a sweetener.

3. The tablet for improving sleep quality according to claim 2, wherein the filler is one or more of starch, dextrin and lactose.

4. The tablet for improving sleep quality according to claim 2, wherein the lubricant is one or more of magnesium stearate, hydrogenated vegetable oil, and aerosil.

5. The tablet for improving sleep quality according to claim 2, wherein the sweetener is one or more of sorbitol, maltitol, erythritol.

6. The tablet for improving sleep quality according to claim 2, wherein the weight ratio of the filler, the lubricant and the sweetener is (10-20): (1-2): (20-70).

7. The tablet for improving sleep quality according to claim 1, further comprising less than 1% by weight of a flavorant.

8. Tablet for improving sleep quality according to claim 1, characterized in that the inulin is made from one or more of Jerusalem artichoke, chicory, dahlia.

9. A method for preparing a tablet for improving sleep quality as claimed in any one of claims 1 to 8, which comprises:

10. The method of claim 9, further comprising a coating after the tabletting in the step S3, wherein the coating material is one or more selected from sucrose powder, gelatin, acacia, zein ethanol solution and cellulose acetate phthalate ethanol solution.