CN114797174A - Extraction column placing device - Google Patents
Extraction column placing device Download PDFInfo
- Publication number
- CN114797174A CN114797174A CN202210519095.2A CN202210519095A CN114797174A CN 114797174 A CN114797174 A CN 114797174A CN 202210519095 A CN202210519095 A CN 202210519095A CN 114797174 A CN114797174 A CN 114797174A
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- column
- liquid
- pull rod
- liquid feeding
- extraction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
Abstract
The invention provides an extraction column placing device which is provided with a movable column frame, a sliding column pressing plate positioned above the movable column frame, a pull rod supporting plate fixed below the movable column frame, and a liquid adding column, wherein two ends of the liquid adding column are respectively fixed on the movable column frame and the pull rod supporting plate; the outlet end of the liquid feeding column is provided with a liquid dropping plug, the liquid dropping plug is provided with a linear gap which is kept sealed under a normal state, the liquid dropping plug is also provided with a radial flange which can open the linear gap, and the lower side of the radial flange is correspondingly contacted with the pull rod supporting plate; the entry end of liquid feeding column pass through sealing element with the downside sealing connection of traveller clamp plate, the traveller clamp plate can be controlled the downward application of force in the entry end of liquid feeding column makes and produces the relative motion trend between the radial flange of the dropping stopper of the exit end of liquid feeding column and the pull rod layer board. The liquid filling column can rapidly switch the sealing and circulating states of the outlet ends of all liquid filling columns, and the problem of cross contamination is avoided.
Description
Technical Field
The invention relates to an extraction column placing device capable of limiting reagent outflow, in particular to a simple, rapid and convenient sample pretreatment technology in laboratory application.
Background
Extraction is a unit operation in which the solvent is purified or concentrated by virtue of the difference in partition coefficient between two immiscible phases. Since the proper extractant and flow can be selected according to the separation object and requirement. Therefore, the method has the characteristics of high selectivity, good separation effect, strong adaptability and the like. The solvent extraction is usually carried out at normal temperature or low temperature, the energy consumption is low, the method is particularly suitable for separating heat-sensitive substances, and the large-scale continuous production is easy to realize. In recent years, extraction is more and more widely applied in industrial processes such as atomic energy, hydrometallurgy, petroleum, chemical engineering, medicine, environmental protection and the like, and high and new technical fields such as bioengineering, new materials and the like, and extraction equipment is continuously developed and updated along with the wide application of extraction in the industry.
The solid phase extraction is a sample pretreatment technology developed from the middle of eighties, and the solid phase extraction is to adsorb a target compound in a liquid sample by using a solid adsorbent, separate the target compound from a matrix and an interfering compound of the sample, and then elute or heat-desorb the target compound by using an eluent to achieve the purpose of separating and enriching the target compound. Compared with the traditional liquid-liquid extraction method, the solid-phase extraction method does not need a large amount of immiscible solvents, does not generate emulsification in the treatment process, can improve the recovery rate of analytes, can obviously reduce the using amount of the solvents, simplifies the sample in the treatment process, simultaneously reduces the required cost to a certain extent, reduces the sample pretreatment process, and has simple operation, time saving and labor saving. Solid phase extraction is used as a sample pretreatment technology, is more and more widely applied in laboratories, and is widely applied in the fields of medicines, foods, environments, commercial inspection, chemical engineering and the like.
As a simple, rapid and convenient sample pretreatment technology, the technology has been invented for over ten years, and has been generally concerned by domestic and foreign scholars in recent years and rapidly developed due to the unique balance mode and sampling thought. The small column for solid phase extraction has diversified forms, different application occasions and different requirements, the existing 5ml solid small column is easy to drain in the using process, liquid leakage can occur in the moving process, pipelines are disordered, the number of electromagnetic valves is large, the compactness degree of a solid adsorbent is different, and cross contamination and other problems are easily caused in the extraction process.
Disclosure of Invention
Therefore, the present invention is directed to an extraction column placing device capable of limiting the outflow of a reagent, so as to solve at least one of the above technical problems of the prior art.
In order to achieve the purpose, the invention adopts the technical scheme that:
the utility model provides an extraction post placer which characterized in that: the device is provided with a movable column frame, a sliding column pressing plate positioned above the movable column frame, a pull rod supporting plate fixed below the movable column frame, and a liquid adding column with two ends respectively fixed on the movable column frame and the pull rod supporting plate;
the outlet end of the liquid feeding column is provided with a liquid dropping plug, the liquid dropping plug is provided with a linear gap which is kept sealed under a normal state, the liquid dropping plug is also provided with a radial flange which can open the linear gap, and the lower side of the radial flange is correspondingly contacted with the pull rod supporting plate;
the entry end of liquid feeding column pass through sealing element with the downside sealing connection of traveller clamp plate, the traveller clamp plate can be controlled the downward application of force in the entry end of liquid feeding column makes and produces the relative motion trend between the radial flange of the dropping stopper of the exit end of liquid feeding column and the pull rod layer board.
The extraction column placer, wherein: the inlet end of the liquid feeding column is provided with a column adapter, and the column adapter is cylindrical and is matched with the inlet end of the liquid feeding column in shape to form sealing connection; a sliding plunger piston is connected on the column adapter in a sealing way, and the sliding plunger piston can form a sealing connection with the gun head.
The extraction column placer, wherein: the dropping stopper has a pipe body, one end of the pipe body is opened and can be sealed and sheathed on the outlet end of the liquid feeding column, the other end of the pipe body is integrally formed with a sealing sheet, a linear gap is formed on the sealing sheet, and the relative outer side of the pipe body is integrally formed with a radial flange.
The extraction column placer, wherein: the dropping plug is made of silicon rubber.
The extraction column placer, wherein: the drip plug has two radial flanges which are rectangular in plan view.
The extraction column placer, wherein: remove to be formed with a plurality of last ladder holes on the pillar stand, every goes up the ladder hole and can supply one the upper end of liquid feeding column is inserted fixedly, be formed with a plurality of lower ladder holes on the pull rod layer board, every lower ladder hole can supply one the dropping liquid stopper that the cover was established on the outlet end of liquid feeding column puts into, moreover two radial flanges of dropping liquid stopper with the step face of lower ladder hole forms the contact.
The extraction column placer, wherein: the sliding column pressing plate is connected with the movable column frame through a pressing plate screw.
The extraction column placer, wherein: the sliding column pressing plate is provided with a bell mouth corresponding to the opening end of each liquid adding column, and the opening end of each liquid adding column, the column adapter, the sliding column plunger and the lower surface of the bell mouth are sequentially connected in a sealing mode.
The extraction column placer, wherein: the movable column frame is provided with a plurality of upper counter bores from top to bottom, the pull rod supporting plate is provided with a plurality of lower counter bores from bottom to top, upper screws inserted into the upper counter bores and lower screws inserted into the lower counter bores are respectively in threaded connection with two ends of a sliding column pull rod, and the movable column frame is connected with the pull rod supporting plate together.
The extraction column placer, wherein: and two ends of the movable column frame are respectively provided with a sliding column stop block.
The invention has the advantages that:
1. the liquid adding column can solve the problems that small columns are easy to flow dry in the using process, liquid leakage is caused in the moving process, pipelines are disordered, the number of electromagnetic valves is large, the density degrees of solid adsorbents are different, cross contamination is easy to cause in the extraction process and the like.
2. The movable column frame is designed to be convenient to slide stably under the action of external force and reduce friction force, two ends of the movable column frame are designed to be parallel to the sliding rod as far as possible, the size of an arc is the same as the diameter of the sliding rod, the sliding process is ensured to be stable, in addition, no additional friction force is added, the installation is convenient, under the condition of ensuring the stable sliding process, the contact surface of the movable column frame and the sliding rod is reduced as far as possible, the part of the lower end of the movable column frame except the contact surface is specially processed into a certain contraction angle to be used as a guide in the installation process and slide into equipment along the angle so as to be convenient to better install and reduce the corresponding friction force, the material is selected from acid-resistant PP materials, the whole column frame can be conveniently and quickly moved in the equipment, the device is designed in a floating installation mode, can be installed without any tool, and the aim is to meet the simple operation of the movable column frame 1, convenient change can effectively avoid the maintenance, improve sample treatment effeciency by a wide margin.
3. According to the invention, a plurality of liquid adding columns are assembled together, so that the sample treatment efficiency is greatly improved, the operation is simple, the replacement is convenient, the experiment precision is high, and the labor intensity of experimenters is reduced.
Drawings
Fig. 1 is a perspective view of the present invention.
Fig. 2 is a cross-sectional assembly view of a charge column assembly of the present invention.
FIG. 3 is a diagram of a single 5ml cartridge assembly of the invention.
Fig. 4 is an assembly view of the tie bar of the present invention.
Fig. 5 and 6 are a longitudinal sectional view and a bottom view of the dropping plug of the present invention, respectively.
Description of reference numerals: 1-moving the column frame; 2-a strut stop; 3-a strut pull rod; 4-a pull rod supporting plate; 5-screwing; 6-lower screw; 7-liquid adding column; 8-a column adapter; 9-a sliding plunger; 10-a strut press plate; 11-drip plugs; 12-a platen screw; 13-sealing piece; 14-linear slits; 15-a radial flange; 16-step surface; 17-bell mouth.
Detailed Description
The invention will be further elucidated with reference to the drawings and the detailed description.
The invention provides an extraction column placing device capable of limiting reagent outflow, which is provided with a movable column frame 1, a sliding column pressing plate 10 positioned above the movable column frame 1, a pull rod supporting plate 4 positioned below the movable column frame 1, a liquid adding column 7 with two ends respectively fixed on the movable column frame 1 and the pull rod supporting plate 4, and a sliding column pull rod 3 connected with the movable column frame 1 and the pull rod supporting plate 4, as shown in figures 1, 2 and 4.
As shown in fig. 3, in the present application, a column adapter 8 is disposed at an inlet end of the liquid feeding column 7 (represented by a 5ml standard liquid feeding column 7), and the column adapter 8 is cylindrical and is matched with the inlet end of the liquid feeding column 7 in shape to form a sealing connection; a sliding plunger piston 9 is hermetically connected to the column adapter 8, and the sliding plunger piston 9 can be hermetically connected with the gun head;
as shown in fig. 5 and 6, the dropping plug 11 has a tube body, one end of the tube body is open and can be sealed and connected to the outlet end of the liquid feeding column 7, a sealing sheet 13 is integrally formed at the other end of the tube body, and a linear slit 14 is formed on the sealing sheet 13, the linear slit 14 can keep the outlet end of the liquid feeding column 7 sealed under normal pressure in a normal state, in addition, a radial flange 15 (including a circular radial flange of course) is integrally formed on the opposite outer side of the tube body, the dropping plug 11 is integrally made of an elastic material, when two radial flanges 15 are subjected to an axial force, the sealing sheet 13 is deformed, and the linear slit 14 is deformed to no longer keep the sealing of the outlet end of the liquid feeding column 7.
Referring to fig. 1 and 2 again, a plurality of upper stepped holes are formed in the movable column frame 1, each upper stepped hole is used for inserting and fixing the upper end of one of the feeding columns 7, a plurality of lower stepped holes are formed in the pull rod support plate 4, each lower stepped hole is used for placing a dropping plug 11 sleeved on the outlet end of one of the feeding columns 7, and a radial flange 15 of the dropping plug 11 is in contact with a stepped surface 16 of the lower stepped hole;
a sliding column pressing plate 10 is further arranged on the movable column frame 1, the sliding column pressing plate 10 is connected with the movable column frame 1 through pressing plate screws 12, a bell mouth 17 is arranged at the opening end of each liquid adding column 7, corresponding to each sliding column pressing plate 10, and the opening end of each liquid adding column 7, the column adapter 8, the sliding column piston 9 and the lower surface of the bell mouth 17 are sequentially in sealing connection;
referring to fig. 1 and 4 again, a plurality of upper counter bores are formed in the movable column frame 1 from top to bottom, a plurality of lower counter bores are formed in the pull rod supporting plate 4 from bottom to top, upper screws 5 inserted into the upper counter bores and lower screws 6 inserted into the lower counter bores are respectively in threaded connection with two ends of the sliding column pull rod 3, and the movable column frame 1 and the pull rod supporting plate 4 are connected together; through adjusting the falling depth of the upper screw 5 and the lower screw 6, the distance between the movable column frame 1 and the pull rod supporting plate 4 can be consistent with the length of the liquid feeding column 7, the radial flange 15 of the liquid dropping plug 11 is normally not opposite to the step surface 16 of the lower stepped hole, the linear gap 14 of the sealing sheet 13 of the liquid dropping plug 11 is in a sealing state, and liquid in the liquid feeding column 7 cannot flow out.
Once the module brings the gun head to apply an external force to the sliding column plug 9 at the sliding column pressing plate 10, the sliding column plug 9 is firstly sealed with the gun head, then the external force applied by the module enables the column adapter 8 to extrude the liquid feeding column 7, the whole liquid feeding column 7 is displaced downwards, the radial flange 15 of the liquid dropping plug 11 is blocked by the step surface 16 of the lower stepped hole, the sealing sheet 13 is deformed, the linear gap 14 is deformed along with the deformation, the sealing is not kept, and the liquid in the liquid feeding column 7 flows out from the outlet end.
It can be seen that through adopting above-mentioned structure, the sealed and circulation state of the exit end of all liquid feeding columns 7 can be switched rapidly to this application, and the exit end of liquid feeding column 7 does not have any pipeline or valve moreover, can avoid removing the cross contamination that the in-process caused to and too much hindrance operation, pleasing to the eye scheduling problem of pipeline.
As shown in figure 1, two ends of the movable column frame 1 are respectively provided with a sliding column stopper 2, so that the whole equipment can integrally move while keeping the whole equipment intact, and the whole equipment can not independently move in operation and can only slide to a collection bottle, an elution tank, a waste liquid tank and the like under the driving of external power.
Wherein, the movable column frame 1 is designed to be convenient to slide stably under the action of external force and reduce friction force, two ends of the movable column frame are designed to be parallel to the sliding rod as far as possible, so that the size of an arc is the same as the diameter of the sliding rod, the sliding process is ensured to be stable, in addition, no extra friction force is added and the installation is convenient, under the condition of ensuring the stable sliding process, the contact surface of the movable column frame 1 and the sliding rod is reduced as far as possible, the lower end of the movable column frame 1 except the contact surface is specially processed into a certain contraction angle to be used as a guide in the installation process and slide into equipment along the angle, so that the better installation and the corresponding friction force are reduced, the material is selected from acid-resistant PP materials, the whole column frame can be conveniently and rapidly moved in the equipment, the device is designed to adopt a floating installation mode and can be installed without any tool, and the aim is to meet the simple operation of the movable column frame 1, convenient change can effectively avoid the maintenance, improve sample treatment effeciency by a wide margin.
The dropping plug 11 is preferably made of silicon rubber, which has good elasticity and can perform multiple opening and closing operations, and the two radial flanges 15 are preferably rectangular in plan view to ensure the rotation prevention in the left and right directions.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. The utility model provides an extraction post placer which characterized in that: the device is provided with a movable column frame, a sliding column pressing plate positioned above the movable column frame, a pull rod supporting plate fixed below the movable column frame, and a liquid adding column with two ends respectively fixed on the movable column frame and the pull rod supporting plate;
the outlet end of the liquid feeding column is provided with a liquid dropping plug, the liquid dropping plug is provided with a linear gap which is kept sealed under a normal state, the liquid dropping plug is also provided with a radial flange which can open the linear gap, and the lower side of the radial flange is correspondingly contacted with the pull rod supporting plate;
the entry end of liquid feeding column pass through sealing element with the downside sealing connection of traveller clamp plate, the traveller clamp plate can be controlled the downward application of force in the entry end of liquid feeding column makes and produces the relative motion trend between the radial flange of the dropping stopper of the exit end of liquid feeding column and the pull rod layer board.
2. The extraction column placement device of claim 1, wherein: the inlet end of the liquid feeding column is provided with a column adapter, and the column adapter is cylindrical and is matched with the inlet end of the liquid feeding column in shape to form sealing connection; a sliding plunger piston is connected on the column adapter in a sealing way, and the sliding plunger piston can form a sealing connection with the gun head.
3. The extraction column placement device of claim 1, wherein: the dropping stopper has a pipe body, one end of the pipe body is opened and can be sealed and sheathed on the outlet end of the liquid feeding column, the other end of the pipe body is integrally formed with a sealing sheet, a linear gap is formed on the sealing sheet, and the relative outer side of the pipe body is integrally formed with a radial flange.
4. The extraction column placement device of claim 3, wherein: the dropping plug is made of silicon rubber.
5. The extraction column placement device of claim 3, wherein: the drip plug has two radial flanges which are rectangular in plan view.
6. The extraction column placement device of claim 5, wherein: remove to be formed with a plurality of last ladder holes on the pillar stand, every goes up the ladder hole and can supply one the upper end of liquid feeding column is inserted fixedly, be formed with a plurality of lower ladder holes on the pull rod layer board, every lower ladder hole can supply one the dropping liquid stopper that the cover was established on the outlet end of liquid feeding column puts into, moreover two radial flanges of dropping liquid stopper with the step face of lower ladder hole forms the contact.
7. The extraction column placement device of claim 1, wherein: the sliding column pressing plate is connected with the movable column frame through a pressing plate screw.
8. The extraction column placement device of claim 2, wherein: the sliding column pressing plate is provided with a bell mouth corresponding to the opening end of each liquid adding column, and the opening end of each liquid adding column, the column adapter, the sliding column plunger and the lower surface of the bell mouth are sequentially connected in a sealing mode.
9. The extraction column placing device according to claim 1, wherein: the movable column frame is provided with a plurality of upper counter bores from top to bottom, the pull rod supporting plate is provided with a plurality of lower counter bores from bottom to top, upper screws inserted into the upper counter bores and lower screws inserted into the lower counter bores are respectively in threaded connection with two ends of a sliding column pull rod, and the movable column frame is connected with the pull rod supporting plate together.
10. The extraction column placement device of claim 1, wherein: and two ends of the movable column frame are respectively provided with a sliding column stop block.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210519095.2A CN114797174A (en) | 2022-05-12 | 2022-05-12 | Extraction column placing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210519095.2A CN114797174A (en) | 2022-05-12 | 2022-05-12 | Extraction column placing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114797174A true CN114797174A (en) | 2022-07-29 |
Family
ID=82514133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210519095.2A Pending CN114797174A (en) | 2022-05-12 | 2022-05-12 | Extraction column placing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114797174A (en) |
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2022
- 2022-05-12 CN CN202210519095.2A patent/CN114797174A/en active Pending
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