CN204017444U - A kind of efficient magnetic control disperses solid-phase extraction device - Google Patents
A kind of efficient magnetic control disperses solid-phase extraction device Download PDFInfo
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- CN204017444U CN204017444U CN201420403132.4U CN201420403132U CN204017444U CN 204017444 U CN204017444 U CN 204017444U CN 201420403132 U CN201420403132 U CN 201420403132U CN 204017444 U CN204017444 U CN 204017444U
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Abstract
A kind of efficient magnetic control disperses solid-phase extraction device, it is characterized in that: the extraction cartridge that can simultaneously carry out batch process sample that comprises several settings parallel with one another, the upper end of extraction cartridge is provided with injection port, lower end is provided with outlet, the in-built micron adsorbent that is magnetic of extraction cartridge, the bottom in extraction cartridge is provided with sieve plate, and sieve plate is provided with ultrasonic, extraction cartridge is around with coil, and the end line of coil and power supply, power switch and slide rheostat are in series.The utility model patent has overcome traditional dispersion solid phase extraction techniques complex operation, poor reproducibility, extraction is slow and extraction efficiency is low shortcoming, the ultrasonic absorption of the utility model collection, purification, wash-out and solid-liquid two-phase magnetic are located away from one, the single or multiple mass simultaneous processing samples of energy, have feature simple to operate, that rate of extraction is fast, efficiency is high.
Description
Technical field
The utility model belongs to solid phase extraction techniques field, relate to a kind of sample analysis pre-processing device, relate in particular to a kind of efficient magnetic control and disperse solid-phase extraction device, dispersed, the adsorption/desorption of magnetic adsorptive material and the quick separation of solid-liquid two-phase when disperseing SPE.
Background technology
Due to the complexity of analytic sample matrix, it is particularly important that the research of new and effective Sample Pretreatment Technique seems.Disperseing solid phase extraction techniques is fast-developing and a kind of enrichment of coming and the Sample Pretreatment Technique Used of purification in recent years, but because tradition disperses solid phase extraction techniques to have that operating process is loaded down with trivial details, the processing time is long and Separation of Solid and Liquid is difficult etc. that deficiency is restricted.The history that magnetic separates can be traced back to before more than 100 year the earliest, and within 1865, Porter applies it in large-scale water treatment facilities first.Be applied to gradually afterwards the fields such as microbiology, cell biology, molecular biology and biochemistry, analytical chemistry and biotechnology and green technology.Based on the difference of physical adsorption process, magnetic separates and is mainly divided into: directly magnetic separates, and adds the magnetic of flocculant to separate, the separation (being magnetic control SPE) of applied magnetic adsorbent, and four kinds of forms of magnetic separation of being combined with other process.The general principle of magnetic control SPE is to utilize the two-phase of object between magnetic adsorptive material and solution to distribute, in the time that sample solution contacts with magnetic adsorbent, by selective absorption, can realize enrichment to target analytes and with the separating of Coexisting component, then adopt magnetic control technology that solid-liquid two is separated.The pattern of magnetic SPE, according to the existence form of fixing phase, can be divided into distributing and fill two kinds of pillars.Wherein distributing is many carries out in beaker, after ultrasonic dispersing nanometer magnetic-particle, can make upper solution clarify rapidly by externally-applied magnetic field, and realize batch operation, in extraction process, in the time that magnetic material is added in the solution that contains target analytes, target analytes is just optionally adsorbed on magnetic material, after externally-applied magnetic field, the magnetic material that has adsorbed target analytes separates with original solution is quick.Subsequently, adopt suitable solvent that target analytes is eluted from nano magnetic material, thereby realize purifying and enrichment to target analytes, finally eluent is introduced to follow-up analytical instrument and detected.
Through looking into, the existing patent No. is the Chinese patent " magnetic control magnetic substrate solid-phase extraction device " of CN201220351885.6, cylinder upper end has suitable for reading, there is infundibulate end opening lower end, main body is cylindrical, cylinder overcoat has coil and coil rack, and the end line of coil is in series with dc source, switch and slide rheostat.Produce magnetic orientation migration by externally-applied magnetic field, make magnetic sample accelerate rate of extraction under paramagnetic direction, overcome in experimentation and extracted slow, incomplete shortcoming, saved the time.But its magnetic adsorbent is to be filled in cylinder by sieve plate as solid matrix, in the time of extraction, magnetic adsorbent is fixed, in sample solution, can not fully disperse, therefore there is the defect that extraction efficiency is low, require further improvement, make magnetic adsorbent in sample solution, can carry out dispersed and absorption, the quick magnetic of realizing solid-liquid two-phase separates, and improves extraction efficiency.
Utility model content
Technical problem to be solved in the utility model is to provide and a kind ofly collects the efficient magnetic control that ultrasonic absorption, purification, wash-out and solid-liquid two-phase magnetic is located away from one and disperse solid-phase extraction device, has feature simple to operate, extraction efficiency is high.
The utility model for solving the problems of the technologies described above adopted technical scheme is: a kind of efficient magnetic control disperses solid-phase extraction device, it is characterized in that: the extraction cartridge that can simultaneously carry out batch process sample that comprises several settings parallel with one another, the upper end of extraction cartridge is provided with injection port, lower end is provided with outlet, the in-built micron adsorbent that is magnetic of extraction cartridge, bottom in extraction cartridge is provided with sieve plate, sieve plate is provided with ultrasonic, extraction cartridge is around with coil, and the end line of coil and power supply, power switch and slide rheostat are in series.
As improvement, described coil is doroid, on coil rack outside extraction cartridge, extraction cartridge is transparence or on extraction cartridge, is provided with longitudinal transparency window, on the outer surface of extraction cartridge or transparency window, is provided with the scale that can show liquor capacity.
As improvement, the lower end outlet of described extraction cartridge is funnel-form and is provided with control valve.
As improvement, described extraction cartridge is 1～36.
Improve, described extraction cartridge is 1,6 or 12 again.
Compared with prior art, the utility model has the advantage of: be provided with multiple extraction cartridges, can single or multiple mass simultaneous processing samples, the scale on extraction cartridge surface can accurately measure the volume of pending sample, ultrasonic of bottom can ensure magnetic adsorbent dispersed and absorption in sample solution, and the control valve of sample outlet position can be controlled the time of contact of magnetic adsorbent and sample solution easily; When work, the magnetic field that hot-wire coil produces makes absorption in each cylinder have the magnetic micrometer adsorbent of target analytes to show certain intensity of magnetization under this externally-applied magnetic field effect, produces magnetic field force, thereby realizes the quick magnetic separation of solid-liquid two-phase; The doroid number of turn can increase and decrease according to actual needs, and the large I of magnetic field force is by regulating slide rheostat to realize to control size of current.The utility model has overcome traditional dispersion solid phase extraction techniques complex operation, poor reproducibility, extraction is slow and extraction efficiency is low shortcoming, the ultrasonic absorption of the utility model collection, purification, wash-out and solid-liquid two-phase magnetic are located away from one, have feature simple to operate, that rate of extraction is fast, efficiency is high.
Brief description of the drawings
Fig. 1 is the structural representation of the related device of the utility model patent;
Fig. 2 is the structural representation of single extraction column in Fig. 1.
Detailed description of the invention
Below in conjunction with accompanying drawing embodiment, the utility model patent is described in further detail.
As shown in Figure 1, 2, the efficient magnetic control of the present embodiment disperses solid-phase extraction device, comprise the extraction cartridge 1 that can simultaneously carry out batch process sample of 6 settings parallel with one another, the upper end of extraction cartridge 1 is provided with injection port 11, lower end is provided with outlet, and extraction cartridge 1 peripheral hardware has coil rack 6, is wound with coil 3 on coil rack 6, coil 3 outside each extraction cartridge 1 is connected mutually, the end line of coil 3 and power supply 9, power switch 10 and the slide rheostat 8 formation control loop that is in series; The in-built micron adsorbent 7 that is magnetic of extraction cartridge 1, bottom in extraction cartridge 1 is provided with sieve plate 5, sieve plate 5 is provided with ultrasonic 4, it is ultrasonic auxiliary dispersed that the existence of ultrasonic 4 can make magnetic micrometer adsorbent 7 realize in sample solution, coil 3 is doroid, extraction cartridge 1 is transparence, is provided with the scale that can show liquor capacity at the outer surface of extraction cartridge 1, can accurately measure like this volume of fluid sample; The lower end outlet of extraction cartridge 1 is funnel-form and is provided with control valve 2, can conveniently control the time of contact of magnetic adsorbent and sample solution.
Below by embodiment, the duty of the utility model patent is described further.
Embodiment 1
1, disperse and absorption: power switch 10 is in disconnecting, and coil 3 is not switched on, and sample outlet position control valve 2 closures are moved ultrasonic 4 now magnetic adsorbent 7 fully dispersion in sample solution, and impurity in adsorbent solution.
2, magnetic separates: after fully adsorbing, closed electrical source switch 10, now coil 3 starts to switch on and produce magnetic field, opens outlet control valve 2, collect the fluid sample after absorption impurity, magnetic micrometer adsorbent 7 is realized effective solid-liquid two-phase magnetic and is separated under magnetic field force effect.
3, object is concentrated: collect solution, nitrogen blows concentrated, after constant volume, carries out qualitative and quantitative analysis by demand.
Embodiment 2
1, disperse and adsorb: power switch 10 is in disconnecting, and coil 3 is not switched on, and sample outlet position control valve 2 closures are moved ultrasonic 4, and now magnetic adsorbent 7 fully disperses in sample solution, and adsorbs object.
2, magnetic separates: after fully adsorbing, closed electrical source switch 10, now coil 3 starts to switch on and produce magnetic field, opens outlet control valve 2, abandon the fluid sample after absorption, magnetic micrometer adsorbent 7 is realized effective solid-liquid two-phase magnetic and is separated under magnetic field force effect.
3, drip washing: close outlet control valve 2, disconnecting power switch 10, add impurity leacheate from extraction cartridge 1 upper end injection port 11, move ultrasonic 4, leacheate is fully contacted, with magnetic micrometer adsorbent 7 after a period of time, closed electrical source switch 10, system produces magnetic field, opens outlet control valve 2, gives up impurity leacheate by outlet.
4, the wash-out of object is with concentrated: close outlet control valve 2, disconnecting power switch 10, adds object eluent from extraction cartridge 1 upper end injection port 11, moves ultrasonic 4, object eluent is fully contacted with magnetic micrometer adsorbent 7, target analytes is by wash-out, now closed electrical source switch 10, and system produces magnetic field, open outlet control valve 2, collect eluent, nitrogen blows concentrated, after constant volume, carries out qualitative and quantitative analysis by demand.
Claims (5)
1. an efficient magnetic control disperses solid-phase extraction device, it is characterized in that: the extraction cartridge that can simultaneously carry out batch process sample that comprises several settings parallel with one another, the upper end of extraction cartridge is provided with injection port, lower end is provided with outlet, the in-built micron adsorbent that is magnetic of extraction cartridge, the bottom in extraction cartridge is provided with sieve plate, and sieve plate is provided with ultrasonic, extraction cartridge is around with coil, and the end line of coil and power supply, power switch and slide rheostat are in series.
2. efficient magnetic control according to claim 1 disperses solid-phase extraction device, it is characterized in that: described coil is doroid, on coil rack outside extraction cartridge, extraction cartridge is transparence or on extraction cartridge, is provided with longitudinal transparency window, on the outer surface of extraction cartridge or transparency window, is provided with the scale that can show liquor capacity.
3. efficient magnetic control according to claim 1 disperses solid-phase extraction device, it is characterized in that: the lower end outlet of described extraction cartridge is funnel-form and is provided with control valve.
4. efficient magnetic control according to claim 1 disperses solid-phase extraction device, it is characterized in that: described extraction cartridge is 1～36.
5. efficient magnetic control according to claim 4 disperses solid-phase extraction device, it is characterized in that: described extraction cartridge is 1,6 or 12.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420403132.4U CN204017444U (en) | 2014-07-21 | 2014-07-21 | A kind of efficient magnetic control disperses solid-phase extraction device |
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| CN201420403132.4U CN204017444U (en) | 2014-07-21 | 2014-07-21 | A kind of efficient magnetic control disperses solid-phase extraction device |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018129789A1 (en) * | 2017-01-11 | 2018-07-19 | 中国科学院过程工程研究所 | Whole-process continuous gas-assisted magnetic separation system |
| CN108760425A (en) * | 2018-05-30 | 2018-11-06 | 重庆第二师范学院 | A kind of graphite oxide alkenyl pretreating device and its application in food inspection |
| CN108939613A (en) * | 2018-07-19 | 2018-12-07 | 贵州省人民医院 | Eucommia ulmoides extracts high-efficiency device for extracting and method for Prevention of cardiovascular disease |
| CN109073518A (en) * | 2016-04-01 | 2018-12-21 | 多伦多大学管理委员会 | The DMF method and system being concentrated into analyte from large volume using magnetic particle in smaller size smaller |
| CN110508030A (en) * | 2019-09-18 | 2019-11-29 | 深圳市易瑞生物技术股份有限公司 | A kind of Magnetic solid phases extraction column and its application method |
-
2014
- 2014-07-21 CN CN201420403132.4U patent/CN204017444U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109073518A (en) * | 2016-04-01 | 2018-12-21 | 多伦多大学管理委员会 | The DMF method and system being concentrated into analyte from large volume using magnetic particle in smaller size smaller |
| CN109073518B (en) * | 2016-04-01 | 2020-02-28 | 多伦多大学管理委员会 | DMF method and system for concentrating analytes from large volumes to smaller volumes using magnetic particles |
| US10976225B2 (en) | 2016-04-01 | 2021-04-13 | The Governing Council Of The University Of Toronto | DMF method and system for concentrating analyte from large volumes into smaller volumes using magnetic microparticles |
| WO2018129789A1 (en) * | 2017-01-11 | 2018-07-19 | 中国科学院过程工程研究所 | Whole-process continuous gas-assisted magnetic separation system |
| CN108760425A (en) * | 2018-05-30 | 2018-11-06 | 重庆第二师范学院 | A kind of graphite oxide alkenyl pretreating device and its application in food inspection |
| CN108939613A (en) * | 2018-07-19 | 2018-12-07 | 贵州省人民医院 | Eucommia ulmoides extracts high-efficiency device for extracting and method for Prevention of cardiovascular disease |
| CN108939613B (en) * | 2018-07-19 | 2020-08-11 | 贵州省人民医院 | Eucommia ulmoides extract efficient extraction device and method for preventing and treating cardiovascular diseases |
| CN110508030A (en) * | 2019-09-18 | 2019-11-29 | 深圳市易瑞生物技术股份有限公司 | A kind of Magnetic solid phases extraction column and its application method |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141217 Termination date: 20160721 |