CN114795985A

CN114795985A - Gel hand sanitizer and preparation method thereof

Info

Publication number: CN114795985A
Application number: CN202210364054.0A
Authority: CN
Inventors: 余鑫; 刘芝兰; 胡方圆; 张玺
Original assignee: Minnesota Mining and Manufacturing Medical Equipment Shanghai Co Ltd
Current assignee: 3M Medical Devices and Materials Manufacturing Shanghai Co Ltd
Priority date: 2022-03-31
Filing date: 2022-03-31
Publication date: 2022-07-29

Abstract

The invention provides a gel hand sanitizer and a preparation method thereof. The gel hand sanitizer comprises the following components in percentage by weight based on the total weight of the gel hand sanitizer: 75-85% by weight of a monohydric alcohol; 0.05-1 wt% of hydrogen peroxide; 0.1-2 wt% of a thickener; 0.01-1 wt% of a neutralizing agent; and the balance water, wherein the neutralizing agent has the formula C _a H _b N _c O _d The structure is shown in the specification, wherein a is more than or equal to 6, b is more than or equal to 15, c is more than or equal to 1 and less than 3, and d is more than or equal to 1 and less than 6. According to the technical scheme of the invention, the gel hand sanitizer has good stability, moisture retention and good fungus and virus killing effect.

Description

Gel hand sanitizer and preparation method thereof

Technical Field

The invention relates to the technical field of cleaning, and particularly provides a gel hand sanitizer and a preparation method thereof.

Background

Hand washing is an important part of daily life to maintain personal hygiene. Also, hand washing is a frequently repetitive operation required by hospital care personnel, which is critical to preventing or reducing cross-contamination of related illnesses in hospitals. A wide variety of hand sanitizer products currently exist on the market, such as liquid hand sanitizers, foam hand sanitizers, and gel hand sanitizers. Compared with other formulations of hand sanitizer, the gel hand sanitizer is more convenient to use, has more stable liquid output and is not easy to splash and flow. At present, the requirements for gel hand-washing solutions are gradually increasing, and besides the requirement for providing good cleaning effect, the gel hand-washing solutions also need to have good stability, moisture retention, fungus killing and virus killing effects.

Therefore, the development of the gel hand sanitizer with good stability, moisture retention and good fungus and virus killing effect has important significance.

Disclosure of Invention

In view of the above-mentioned problems, it is an object of the present invention to provide a gel hand sanitizer with good stability, moisture retention and good fungus and virus killing effect, and a preparation method thereof. The present inventors have made intensive studies and completed the present invention.

In accordance with one aspect of the present invention, there is provided a gel hand sanitizer comprising, based on the total weight of the gel hand sanitizer:

75-85% by weight of a monohydric alcohol;

0.05-1 wt% of hydrogen peroxide;

0.1-2 wt% of a thickener;

0.01-1 wt% of a neutralizing agent; and

the balance of water is added into the mixture,

wherein the neutralizing agent has the formula C _a H _b N _c O _d The structure is shown in the specification, wherein a is more than or equal to 6, b is more than or equal to 15, l is more than or equal to c and less than 3, and l is more than or equal to d and less than 6.

According to another aspect of the invention, there is provided a method of preparing a gel hand cleanser, the method comprising mixing the components of the gel hand cleanser described above.

The gel hand sanitizer disclosed by the invention has good stability and moisture retention and also has an effective killing effect on fungi and viruses.

Detailed Description

It is to be understood that other various embodiments can be devised and modified by those skilled in the art in light of the teachings of this specification without departing from the scope or spirit of the disclosure. The following detailed description is, therefore, not to be taken in a limiting sense.

Unless otherwise indicated, all numbers expressing feature sizes, quantities, and physical and chemical characteristics used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the foregoing specification and attached claims are approximations that can be suitably varied by those skilled in the art in seeking to obtain the desired properties utilizing the teachings disclosed herein. The use of numerical ranges by endpoints includes all numbers within that range and any range within that range, for example, 1 to 5 includes 1, 1.1, 1.3, 1.5, 2, 2.75, 3, 3.80, 4, and 5, and the like.

Currently, with the development and application of hand sanitizer products, the technical requirements on the hand sanitizer products are higher and higher, and it is desirable that the hand sanitizer products have good stability and moisture retention and effective killing effects on various common fungi and viruses while having good cleaning effects. Currently, the most common commercial gel hand sanitizer products typically contain components such as ethanol, thickeners, and humectants. The inventors of the present invention have found that these commercial gel hand sanitizer products comprising only the above components are not as desirable in terms of antifungal and virucidal effects, etc. For example, although these products have a certain killing effect on escherichia coli, staphylococcus aureus and pseudomonas aeruginosa, they have no significant killing effect on candida albicans, which are common in daily life, and have a poor killing effect on poliovirus. The inventor of the present invention found in research that by using a combination of a monohydric alcohol, hydrogen peroxide, a thickening agent, a specific neutralizing agent and water in specific amounts, a hand sanitizer can be provided which has good stability, moisture retention and a good fungicidal effect against a wide range of common fungi and viruses in life, including candida albicans and poliovirus.

Gel hand sanitizer

Certain aspects of the present invention provide a gel hand sanitizer comprising, based on the total weight of the gel hand sanitizer:

75-85% by weight of a monohydric alcohol;

0.05-1 wt% of hydrogen peroxide;

0.1-2 wt% of a thickener;

0.01-1 wt% of a neutralizing agent; and

the balance of water is added into the mixture,

The various components that may be included in a gel hand sanitizer according to the present invention, as well as methods of preparing a gel hand sanitizer, are described in detail below.

Monohydric alcohol

In some embodiments, the gel hand sanitizer may include a monohydric alcohol. The primary function of the monohydric alcohol is as a solvent and disinfectant. The monohydric alcohol may act synergistically with the hydrogen peroxide mentioned below to enhance the fungus and virus killing effect of the gel hand sanitizer. There is no particular limitation on the specific type of monohydric alcohol that may be used in the present invention, so long as it provides the proper solvent and disinfectant action. In some embodiments, the monohydric alcohol is selected from one or more of the group consisting of ethanol, n-propanol, and isopropanol. The monohydric alcohol is present in an amount of 75 to 85% by weight, based on the total weight of the gel hand lotion. Commercially available products of monohydric alcohols that may be used in the present invention include, for example: ethanol (product name: ethanol) produced by national pharmaceutical agents corporation.

Hydrogen peroxide

In some embodiments, the gel hand sanitizer may include hydrogen peroxide. The hydrogen peroxide acts as a disinfectant (acts to kill fungi and viruses). The hydrogen peroxide may act synergistically with the monohydric alcohols mentioned above to enhance the fungicidal and virucidal effect of the gel hand sanitizer. The content of the hydrogen peroxide is 0.05-1 wt% based on the total weight of the gel hand sanitizer. In some embodiments, the hydrogen peroxide is present in an amount of 0.05 to 0.5 wt.%, based on the total weight of the gel hand sanitizer. Commercially available products of hydrogen peroxide that can be used in the present invention include, for example: hydrogen peroxide (product name: hydrogen peroxide) produced by national pharmaceutical agents corporation.

Thickening agent

In some embodiments, the gel hand sanitizer may include a thickener. The thickening agent may cause the hand sanitizer of the present invention to form a gel system. In some embodiments, the thickener is selected from carbomer-based thickeners. In some embodiments, the carbomer-based thickener is a cross-linked copolymer of an acrylate and a C10-30 alkyl acrylate. In some embodiments, the viscosity of the carbomer-based thickener is 20000-. The viscosity of the carbomer-based thickener in the present invention was measured by adding the carbomer-based thickener to water to obtain a 0.5% by weight aqueous dispersion, and then subjecting the obtained 0.5% by weight aqueous dispersion to a viscosity test to characterize the viscosity of the carbomer-based thickener with respect to the viscosity of the 0.5% by weight aqueous dispersion. For the purposes of this patent application, viscosity is determined according to the test method of the examples section. The thickener is present in an amount of 0.1 to 2 wt% based on the total weight of the gel hand sanitizer. In some embodiments, the thickening agent is present in an amount of 0.1 to 1 wt%, based on the total weight of the gelled hand sanitizer. Commercially available products of the thickener which can be used in the present invention are, for example, U20 (product name: U20) and ETD2020 (product name: ETD2020) manufactured by Luborun.

Neutralizing agent

In some embodiments, the gel hand sanitizer may include a neutralizing agent. The neutralizing agent in the invention can play a stabilizing role on hydrogen peroxide so as to ensure the virus killing function of the gel hand sanitizer. The neutralizing agent has a structure represented by the following general formula: c _a H _b N _c O _d Wherein a is more than or equal to 6, b is more than or equal to 15, l is more than or equal to c and less than 3, and l is more than or equal to d and less than 6. In some embodiments, 6. ltoreq. a < 30, 15. ltoreq. b < 40, 1. ltoreq. c < 3, 1. ltoreq. d.ltoreq.4. In some embodiments, 6. ltoreq. a < 15, 15. ltoreq. b < 35, 1. ltoreq. c < 3, 1. ltoreq. d.ltoreq.4. In some embodiments, the neutralizing agent is selected from one or more of the group consisting of triethanolamine, tetrahydroxypropylethylenediamine, and dimethylaminomethylpropanol. The neutralizing agent is present in an amount of 0.01 to 1 wt.% based on the total weight of the gel hand sanitizer. In some embodiments, the neutralizing agent is present in an amount of 0.01 to 0.1 wt.%, based on the total weight of the gelled hand sanitizer. Commercially available products of the neutralizing agent which can be used in the present invention are, for example, dimethylaminopropylalcohol (product name: DMAMP) manufactured by Angus chemical company, tetrahydroxyethylenediamine (product name Quadrol L) manufactured by Pasteur company.

Other Components

One or more additional components may also optionally be included in the gelled hand sanitizers according to the present invention to perform different functions. In some embodiments, the gel hand sanitizer further comprises one or more of the group consisting of caprylyl glycol, humectants, and the like. There are no particular restrictions on the amount of caprylyl glycol that can be used in the present invention, and the addition of caprylyl glycol can further enhance the fungal kill (particularly Candida albicans kill) properties of the gel hand sanitizer. The specific type and content of the moisturizer that can be used in the present invention are not particularly limited, and can be appropriately selected to be added without affecting the antibacterial, antiviral, etc. effects of the gel hand sanitizer according to the present invention. In some embodiments, the humectant is selected from one or more of glycerin and ceramide.

Water (W)

In the gel hand sanitizer according to the present invention, the water is a solvent in the gel hand sanitizer. The specific content of water is not particularly limited as long as the monohydric alcohol, hydrogen peroxide, the thickener, the neutralizer and optionally other components mentioned above can be sufficiently dissolved or dispersed and adjusted to a degree suitable for hand washing applications in a gel state.

Method for preparing gel hand sanitizer

The particular method of preparing the gelled hand sanitizers according to the present invention is not particularly limited and mixing methods commonly employed in the art may be employed. In particular, the individual components of the gel hand sanitizer described above may be dissolved or dispersed together in a solvent, depending on their particular amounts.

For the description of the components of the gel hand sanitizer, see the section "gel hand sanitizer" of this specification.

The following detailed description is intended to illustrate the disclosure by way of example and not by way of limitation.

Embodiment 1 is a gel hand sanitizer comprising, based on the total weight of the gel hand sanitizer:

75-85% by weight of a monohydric alcohol;

0.05-1 wt% of hydrogen peroxide;

0.1-2 wt% of a thickener;

0.01-1 wt% of a neutralizing agent; and

the balance of water is added into the mixture,

Embodiment 2 is a gel hand sanitizer according to embodiment 1, wherein the monohydric alcohol is selected from one or more of the group consisting of ethanol, n-propanol, and isopropanol.

Embodiment 3 is a gel hand sanitizer according to embodiment 1, wherein the thickener is selected from carbomers.

Embodiment 4 is a gel hand sanitizer according to embodiment 3, wherein the carbomer-based thickener is a cross-linked copolymer of an acrylate and a C10-30 alkyl acrylate.

Embodiment 5 is the gel hand sanitizer of embodiment 3 wherein the carbomer-based thickener has a viscosity of 20000-90000 mPa-s.

Embodiment 6 is a gel hand sanitizer according to embodiment 1, wherein the neutralizing agent is selected from one or more of the group consisting of triethanolamine, tetrahydroxypropylethylenediamine, and dimethylaminomethylpropanol.

Embodiment 7 is the gel hand sanitizer of embodiment 1, wherein the gel hand sanitizer further comprises caprylyl glycol.

Embodiment 8 is a gel hand sanitizer according to embodiment 1, wherein the gel hand sanitizer further comprises a humectant.

Embodiment 9 is a gel hand sanitizer according to embodiment 8, wherein the humectant is selected from glycerin and/or ceramide.

Embodiment 10 is a method of preparing a gel hand sanitizer comprising mixing the components of a gel hand sanitizer according to any one of the preceding embodiments 1-9.

The present invention will be described in more detail with reference to examples. It should be noted that the description and examples are intended to facilitate the understanding of the invention, and are not intended to limit the invention. The scope of the invention is to be determined by the claims appended hereto.

Examples

In the present invention, unless otherwise indicated, all reagents used were commercially available products and were used without further purification treatment.

Test method

In the present disclosure, the gel hand sanitizers obtained in the following examples and comparative examples were tested for stability, moisture retention, fungus killing performance, and virus killing performance. Specific test methods are described below.

Stability of

The stability of the gel hand sanitizer was evaluated as the rate of decrease (%) in hydrogen peroxide content. After the gel hand sanitizer sample is prepared, the gel hand sanitizer sample is sealed and placed at room temperature for 1 day, and then the hydrogen peroxide content is tested. The sample was then resealed and placed in a 37 degree celsius oven for 90 days. The sample was removed and the hydrogen peroxide content was again tested after the temperature had returned to room temperature. The rate of decrease of the hydrogen peroxide content measured twice was calculated and recorded. When the reduction rate of the hydrogen peroxide content is less than or equal to 2%, the stability of the gel hand sanitizer is excellent; when the reduction rate of the hydrogen peroxide content is more than 2% and less than or equal to 10%, the stability of the gel hand sanitizer is qualified; when the reduction rate of the hydrogen peroxide content is more than 10%, the stability of the gel hand sanitizer is unqualified.

The hydrogen peroxide content was tested according to disinfection specification 2002, 2.2.1.2.4.

2.2.1.2.4 Hydrogen peroxide (H) ₂ O ₂ ) Determination of the content

(1) Preparing 2mol/L sulfuric acid and 100g/L manganese sulfate solution. A0.02 mol/L potassium permanganate titration solution (see 2.2.1.3.3) was prepared and calibrated additionally.

(2) Precisely sucking a proper amount of sample to make the sample equal to about 0.3g of hydrogen peroxide, diluting the sample to a scale mark in a 100ml volumetric flask with distilled water, and uniformly mixing.

(3) Taking 10.0ml of hydrogen peroxide diluent, putting the hydrogen peroxide diluent into a 100ml iodine measuring flask, adding 20ml of 2mol/L sulfuric acid and 3 drops of 100g/L manganese sulfate, and shaking up. Titrating with 0.02mol/L potassium permanganate titration solution (filled in a 25ml burette) until the solution is pink, and recording the dosage of the potassium permanganate titration solution. The measurement was repeated 2 times, and the average value of 2 times was calculated as follows.

(4) Since 1ml of 1mol/L potassium permanganate titrant corresponds to 0.08505g of hydrogen peroxide, the hydrogen peroxide content can be calculated according to the following formula

In the formula: x is the content of hydrogen peroxide, g/L; c is the concentration of potassium permanganate titration solution, mol/L; v _pp The volume of potassium permanganate titration solution is ml; v is the volume of the hydrogen peroxide sample liquid contained in the iodine measuring flask, and is ml.

Moisture retention

Preparation before testing:

any product (cosmetics or medicines) cannot be used for 2-3 days before the test of the tested part, and water cannot be contacted for 1-3 h. Before the experiment, the subjects need to uniformly clean the inner forearms of both hands. The cleaning method is to wipe the dry facial tissue clean. Before formal test, the patient should sit still in a standard room for at least 20min, no water or beverage can be drunk, the forearm is exposed, and the patient is placed in a test state and kept relaxed.

Testing equipment:

Corneometer CM 825

the test method comprises the following steps:

1. the product application area and the blank control area should be randomly distributed in the left and right arm calibration areas to ensure that all product and blank area positions are statistically balanced.

2. The test sample is (2.0 +/-0.1) mg/cm ² The amount of the coating is used for single coating, a latex finger sleeve is used for uniformly coating the sample in a test area, and the actual sample coating amount is recorded.

3. After adjusting the instrument according to Corneometer tester instructions, measurements were taken of the product and control areas, each area being measured in parallel at least 3 times. The initial values for each test area (before sample application) were measured, and then the skin moisture content of the test and control areas was measured after the use of the cleaning composition. The set time remains consistent.

The results of the 3 tests on the test area were averaged to obtain the skin moisture content test result for the test area. If the test result is less than or equal to 20g/hm ² If so, the moisture retention test is qualified; if the test result is more than 20g/hm ² Then testing for moisture retentionIs not qualified.

Fungicidal property

Fungal kill Performance the gel hand cleansers obtained in the following examples and comparative examples were tested for bactericidal performance against Candida albicans according to the fungal kill test recorded in section 2.1.1.9 of Disinfection Specification 2002.

When the Candida albicans killing rate is more than or equal to 99.990% and less than 99.999%, the fungus killing performance is qualified; when the Candida albicans killing rate is more than or equal to 99.999 percent, the fungus killing performance is excellent; when the candida albicans killing rate is less than 99.990%, the fungus killing performance is unqualified.

Virucidal properties

Virus-killing performance test the gel hand sanitizers obtained in the following examples and comparative examples were tested for their poliovirus-killing performance according to the poliovirus-inactivation test recorded in section 2.1.1.10.7 of disinfection specification 2002.

If the average inactivation log value is more than or equal to 3.00 and less than 4.00, the poliovirus killing performance is judged to be qualified; if the average inactivation log value is more than or equal to 4.00, the poliovirus can be judged to have excellent killing performance; if the average inactivation log value is less than 3.00, the poliovirus killing performance is judged to be unqualified.

Viscosity measurement

The viscosities of the gelled hand sanitizers obtained in the following examples and comparative examples were tested according to the Brookfield viscosity test method. The amount of gel hand sanitizer is sufficient to immerse the rotor above 1/2 deg.f at room temperature. The corresponding rotor and speed should first be selected with reference to the following table, and its viscosity can be estimated by stirring it in the solution with a fixed doctor blade.

And when the viscosity is measured, the rotor is inserted into the liquid to be measured until the sample submerges the groove on the rotor. For a disc type rotor, the rotor is tilted slightly to avoid entrainment of air bubbles. When the rotor is installed, the viscometer joint is held tightly by one hand and slightly supported, and the rotor is screwed by the other hand. The rotor is then inserted into the sample to the appropriate depth. Then, the viscosity is measured by selecting a proper rotor and rotating speed, and reading after the numerical value is stabilized. To obtain maximum measurement accuracy,% (induction moment) reading is greater than 10%. If the rotor or the sample is replaced, the motor is turned OFF by pressing a MOTORON/OFF key. The rotor is cleaned. And after the viscosity value reading is stable, recording the result displayed by the instrument.

When the viscosity is greater than or equal to 5000cps, the viscosity is qualified in the viscosity test; when the viscosity is less than 5000cps, the viscosity test is failed.

The reagents used in the following examples and comparative examples are specifically listed in table 1 below:

TABLE 1

Example 1(E1)

75g of ethanol, 0.1g of hydrogen peroxide, 0.5g of thickener U20, 0.04g of neutralizing agent TE0A, 1g of caprylyl glycol, 0.5g of glycerol and 1g of ceramide are dissolved in 21.86g of deionized water at a temperature of 25-30 ℃ and sufficiently stirred to prepare gel hand sanitizer 1.

The resulting gel hand sanitizer 1 was tested for stability, moisture retention, fungus-kill performance, virus-kill performance, and viscosity according to the test methods described above, and the specific test results are shown in table 5 below, respectively.

Examples 2-20(E2-E20) and comparative examples 1-7(C1-C7)

Examples 2 to 20(E2 to E20) and comparative examples 1 to 7(C1 to C7) were prepared in a similar manner to example 1, except that the amounts of the respective components were changed according to the compounding ratios shown in the following tables 2, 3 and 4, to obtain gel hand lotions.

The gel hand cleaners obtained in examples 2-20(E2-E20) and comparative examples 1-7(C1-C7) were tested for stability, moisture retention, fungus-killing properties, virus-killing properties and viscosity, respectively, according to the test methods described above, and the specific test results are shown in Table 5 below.

TABLE 5 test results of stability, moisturizing, fungus-killing, virus-killing, and viscosity of gel hand sanitizers prepared in examples 1-20(E1-E20) and comparative examples 1-7(C1-C7)

As can be seen from the test results shown in table 5 above, when a gel hand sanitizer was prepared by selecting specific amounts of monohydric alcohol, hydrogen peroxide, thickener, specific neutralizer, and water within the scope of the present invention, the resulting gel hand sanitizer had good stability, moisture retention, and excellent killing effects against both candida albicans and poliovirus.

As can be seen from comparison between example 1 and comparative example 1, when the content (65 wt%) of the monohydric alcohol in the gel hand washing solution is less than the lower limit value (75 wt%) defined in the present invention, the resulting gel hand washing solution has a poor virus-killing effect.

As can be seen from comparison of example 15 with comparative example 2, the gel hand sanitizer obtained had a poor virus-killing effect when no hydrogen peroxide was contained therein.

As can be seen from comparison of example 6 with comparative example 3, when the content of the thickener (0.01 wt%) in the gel hand soap is less than the lower limit value (0.1 wt%) specified in the present invention, the viscosity of the obtained hand soap is too low to form a gel system.

Comparing example 1 with comparative example 4, it can be seen that when the thickening agent in the gelled hand sanitizer is a cellulosic thickening agent (non-carbomer thickening agent), the resulting hand sanitizer has too low a viscosity to form a gel system.

When the content of the neutralizer (0.001 wt%) in the gel hand soap is less than the lower limit value (0.01 wt%) defined in the present invention, it is found that the viscosity of the obtained hand soap is too low to form a gel system, as compared with example 9 and comparative example 5, and example 7 and comparative example 6.

Comparing example 2 with comparative example 7, it can be seen that the neutralizing agent in the gel hand sanitizer is aminomethyl propanol (not having the general formula C) _a H _b N _c O _d (wherein a is more than or equal to 6, b is more than or equal to 15, l is more than or equal to c and less than 3, and l is more than or equal to d and less than 6)), the content of the hydrogen peroxide in the obtained hand sanitizer is greatly reduced (reduced by 11%) and the viscosity is too low, so that the obtained hand sanitizer has poor stability and cannot form a gel system.

Although specific embodiments have been illustrated and described herein, it will be appreciated by those of ordinary skill in the art that a variety of alternate and/or equivalent implementations may be substituted for the specific embodiments shown and described without departing from the scope of the present invention. This application is intended to cover any adaptations or variations of the specific embodiments discussed in the present disclosure. Accordingly, it is intended that this invention be limited only by the claims and the equivalents thereof.

It will be understood by those skilled in the art that various changes and modifications may be made without departing from the scope of the invention. Such modifications and variations are intended to fall within the scope of the invention as defined in the appended claims.

Claims

1. A gel hand sanitizer comprising, based on the total weight of the gel hand sanitizer:

75-85% by weight of a monohydric alcohol;

0.05-1 wt% of hydrogen peroxide;

0.1-2 wt% of a thickener;

0.01-1 wt% of a neutralizing agent; and

the balance of water is added into the mixture,

wherein the neutralizing agent has the formula C _a H _b N _c O _d The structure is shown in the specification, wherein a is more than or equal to 6, b is more than or equal to 15, c is more than or equal to 1 and less than 3, and d is more than or equal to 1 and less than 6.

2. The gel hand sanitizer of claim 1 wherein the monohydric alcohol is selected from one or more of the group consisting of ethanol, n-propanol, and isopropanol.

3. The gelled hand sanitizer of claim 1 wherein the thickener is selected from carbomer-based thickeners.

4. The gelled hand sanitizer of claim 3 wherein the carbomer-based thickener is a cross-linked copolymer of an acrylate and a C10-30 alkyl acrylate.

5. The gelled hand sanitizer of claim 3 wherein the carbomer-based thickener has a viscosity of 20000-.

6. The gelled hand sanitizer of claim 1 wherein the neutralizing agent is selected from one or more of the group consisting of triethanolamine, tetrahydroxypropylethylenediamine, and dimethylaminomethylpropanol.

7. The gel hand sanitizer of claim 1 further comprising caprylyl glycol.

8. The gel hand sanitizer of claim 1 further comprising a moisturizer.

9. The gel hand sanitizer of claim 8 wherein the humectant is selected from glycerin and/or ceramide.

10. A method for preparing a gelled hand sanitizer comprising mixing the components of the gelled hand sanitizer according to any one of claims 1-9.