CN114788858B

CN114788858B - Traditional Chinese medicine pill for treating nodules as well as preparation method and application thereof

Info

Publication number: CN114788858B
Application number: CN202210648995.7A
Authority: CN
Inventors: 张金波
Original assignee: Yantai Hospital Of Traditional Chinese Medicine
Current assignee: Yantai Hospital Of Traditional Chinese Medicine
Priority date: 2022-06-09
Filing date: 2022-06-09
Publication date: 2023-04-07
Anticipated expiration: 2042-06-09
Also published as: CN114788858A

Abstract

The invention discloses a traditional Chinese medicine pill for treating nodules as well as a preparation method and application thereof, and the traditional Chinese medicine pill is prepared from the following raw materials in parts by weight: 4 to 8 parts of mix-fried ephedra herb, 12 to 18 parts of weeping forsythia, 7 to 12 parts of thunberg fritillary bulb, 6 to 12 parts of ginger processed pinellia tuber, 26 to 32 parts of wild buckwheat rhizome, 4 to 8 parts of white mustard seed, 1 to 5 parts of asarum, 4 to 8 parts of dried ginger, 4 to 8 parts of Chinese magnoliavine fruit, 8 to 12 parts of baical skullcap root, 10 to 14 parts of pyrrosia lingua, 26 to 32 parts of plantain herb, 28 to 32 parts of spreading hedyotis herb, 4 to 8 parts of mix-fried sessile stemona root, 28 to 32 parts of common selfheal fruit-spike, 1 to 5 parts of mirabilite and 1 to 2 parts of hawthorn peptide. The traditional Chinese medicine pill prepared by the invention can realize targeted therapy of nodules on a microscopic scale, has quick response, has long drug action time as a pill, does not have gastrointestinal reaction and toxic or side effect after being taken for a long time, and is convenient to store and carry.

Description

Traditional Chinese medicine pill for treating nodules as well as preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine pill for treating nodules as well as a preparation method and application thereof.

Background

The nodular diseases are common diseases in human beings, and for treatment of the nodular diseases, the following observation is mostly adopted in clinical western medicine aiming at the nodular diseases, and the treatment by adopting medicines and operations is considered only when the nodular symptoms are serious and influence normal work and life. And the western medicine operation has large injury area, treats the symptoms, does not treat the root cause, and has easy relapse and more adverse reactions after the operation. The traditional Chinese medicine for treating sarcoidosis has the advantages of basically no side effect, no wound and no toxic or side effect due to weak physique of patients, long-term taking, restoration of physiological functions of human bodies by regulating the balance of qi, blood, yin and yang, and contribution to improving the immunity of organisms and regulating endocrine. Through traditional Chinese medicine conditioning, the balance of the body is achieved, the circulation of qi and blood is promoted, pathogenic qi in the body is removed, and the vital qi of the body is increased.

In terms of traditional Chinese medicine pathology, nodulation diseases belong to the category of traditional Chinese medicine accumulation, and the pathogenesis of the nodulation diseases is mainly caused by organ disharmony, qi stagnation, phlegm dampness and turbidity stasis caused by the factors such as feeling of exogenous pathogenic factors, emotional and food injury, and long-term unhealed diseases. The name of accumulation is first known in Ling Shu, five changes: "good accumulation in the intestine of human" \ 8230 \ 8230, thin and lusterless skin, not firm meat and glaring. Thus, the stomach and intestine are weak, and pathogenic qi is retained in the stomach and accumulated to cause injury. The interior of the book of Nei Jing is also named Fuliang, xicardia, fei Qi and Bengu, which are also included in the category of accumulation. In the treatment, the principles of "do you eliminate", "do you get away, leave you attack" and the like proposed in Su Wen & Zhi Zhen Yao Lun have a general guiding action. The book nan Jing clearly distinguishes the accumulation and describes the main symptoms of the accumulation of five zang organs. For malaria, it is called malaria mother and decocted in pill with Bie Jia in the formula jin Kui Yao, malaria syndrome and malaria syndrome. The etiology and pathogenesis of accumulation are discussed in more detail in the "theory of disease origin and disease accumulation", and it is thought that there is a process of gradual accumulation and disease formation in the accumulation, "all zang organs are affected by pathogenic factors, cannot accumulate at first, and stay in the accumulation, and become accumulation". The "treating diseases with the syndrome treating guideline and accumulation" is based on the summary of the experience of the predecessors, and proposes that the treatment is divided into the first, middle and last methods. The Jingyue quan Shu & Ju makes a good summary of the application of attack and tonification, and the key to treating excess is to know whether to attack or tonify, and to judge whether to attack or tonify when to know whether to attack or tonify. The 'Yi Zong Bi Yi Ji (medical records of books and accumulations)' organically combines the two methods of treatment of attack and supplement with the first, middle and last three stages of accumulation disease course, indicates that the treatment and accumulation can not be found quickly, and can 'attack and supplement frequently and use the average stage', which is rather valued by the doctors of the later generations. The 'Yi Lin correction' emphasizes the important role of blood stasis in the pathogenesis of accumulation and has outstanding contribution to the application of blood-activating and stasis-resolving medicines. The accumulation syndrome can regulate qi and the accumulation syndrome can promote blood circulation. The syndrome is mainly caused by qi system, and the basic treatment principle is to soothe liver, regulate qi, promote qi circulation and eliminate mass, and the emphasis is on regulating qi; the syndrome of stagnation is in the blood system, and the basic therapeutic principle is activating blood circulation to dissipate blood stasis, softening hardness to dissipate stagnation. Therefore, the generation of nodules is usually caused by the accumulation of phlegm-dampness and turbidity-stasis, and the treatment of traditional Chinese medicine is usually based on the above-mentioned pathology, and the prescription is selected.

However, when the traditional Chinese medicine is used for treating the nodular diseases, the prescription is selected according to the pathogenesis of the nodular diseases macroscopically, namely, the target of the action of the medicine is the viscera and meridians of the body, so that the blood circulation is promoted to be removed, or the phlegm is reduced, the hardness is softened and the stagnation is dissipated, and the nodules are promoted to be absorbed by themselves.

Disclosure of Invention

Based on the defects of the prior art, the invention aims to provide a traditional Chinese medicine pill for treating nodules and a preparation method thereof, and summarizes the precise and micro dialectics of 'dredging the channels of the nodules and the striae, dissolving turbidity, removing stasis, softening hardness and dissipating stagnation' and the accurate positioning treatment principle according to the principle that phlegm-dampness and turbidity stasis are accumulated in the pores and the xuan fu are the basic pathogenesis of the nodular diseases, it is indicated in Su Wen & zang Qi Fang Lun that the pungent and sweet herbs are used to open the striae and open the skin and muscles to ventilate the body fluid, and in Shang He Ji, shang Han Zhi Ge, to open the striae and muscles of the surface of the nodule and to disperse the shell membrane of the nodule to release the exterior, relax the striae and expand the collaterals, resolve the stasis and soften the hardness and dissipate the stagnation. Induces the therapeutic principles of relieving exterior syndrome, dredging collaterals, dispelling phlegm, softening hardness and dissipating stagnation, and realizes the purposes of relieving exterior syndrome, dredging striae and dissipating stagnation. The invention provides a basic pathogenesis of 'nodus and striae and mysterious closure, phlegm dampness and turbidity and stasis mutual connection', determines a treatment method for relieving exterior syndrome, dredging striae and skin striae, dredging the mysorethorn, reducing phlegm, softening hardness and dissipating stagnation, and the prepared traditional Chinese medicine pill (Xuanqujie pill) has the advantages of accurate positioning and obvious curative effect, and can realize targeted treatment on the microscopic nodules. As pills, the medicine has long action time and is convenient to store and carry.

In order to realize the purposes, the adopted technical scheme is as follows:

the invention aims to provide a traditional Chinese medicine pill for treating nodules, which is prepared from the following raw materials in parts by weight: 4 to 8 parts of mix-fried ephedra herb, 12 to 18 parts of weeping forsythia capsule, 7 to 12 parts of thunberg fritillary bulb, 6 to 12 parts of ginger-processed pinellia tuber, 26 to 32 parts of golden buckwheat rhizome, 4 to 8 parts of white mustard seed, 1 to 5 parts of manchurian wildginger, 4 to 8 parts of dried ginger, 4 to 8 parts of Chinese magnoliavine fruit, 8 to 12 parts of baical skullcap root, 10 to 14 parts of pyrrosia lingua, 26 to 32 parts of plantain herb, 28 to 32 parts of spreading hedyotis herb, 4 to 8 parts of mix-fried sessile stemona root, 28 to 32 parts of common selfheal fruit-spike, 1 to 5 parts of mirabilite and 1 to 2 parts of hawthorn peptide.

Further, the traditional Chinese medicine pill for treating nodules is prepared from the following raw materials in parts by weight: 5 to 7 parts of mix-fried ephedra herb, 14 to 16 parts of weeping forsythia capsule, 8 to 10 parts of thunberg fritillary bulb, 8 to 10 parts of ginger-processed pinellia tuber, 28 to 32 parts of wild buckwheat rhizome, 5 to 7 parts of white mustard seed, 2 to 4 parts of manchurian wildginger, 5 to 7 parts of dried ginger, 5 to 7 parts of Chinese magnoliavine fruit, 9 to 11 parts of baical skullcap root, 11 to 13 parts of pyrrosia lingua, 28 to 30 parts of plantain herb, 29 to 30 parts of spreading hedyotis herb, 5 to 7 parts of mix-fried sessile stemona root, 28 to 30 parts of common selfheal fruit-spike, 2 to 4 parts of mirabilite and 1 part of hawthorn peptide.

Still further, the traditional Chinese medicine pill for treating nodules is prepared from the following raw materials in parts by weight: 6 parts of mix-fried ephedra herb, 15 parts of weeping forsythia capsule, 10 parts of thunberg fritillary bulb, 9 parts of ginger processed pinellia tuber, 30 parts of wild buckwheat rhizome, 6 parts of white mustard seed, 3 parts of asarum, 6 parts of dried ginger, 6 parts of Chinese magnoliavine fruit, 10 parts of baical skullcap root, 12 parts of pyrrosia lingua, 30 parts of plantain herb, 30 parts of spreading hedyotis herb, 6 parts of mix-fried sessile stemona root, 30 parts of common selfheal fruit-spike, 3 parts of mirabilite and 1 part of hawthorn peptide.

The invention also aims to provide a preparation method of the traditional Chinese medicine pill, which comprises the following steps:

(1) Cleaning herba Ephedrae preparata, fructus forsythiae, bulbus Fritillariae Thunbergii, ginger processed pinellia Tuber, rhizoma Fagopyri Dibotryis, semen Sinapis Albae, herba asari, zingiberis rhizoma, fructus Schisandrae chinensis, scutellariae radix, folium Pyrrosiae, herba plantaginis, herba Hedyotidis Diffusae, radix Stemonae preparata, and Prunellae Spica, sun drying, grinding, pulverizing, mixing at a certain ratio, and adding Natrii sulfas to obtain Chinese medicinal powder;

(2) Placing Mel in a pot, adding purified water, maintaining the temperature at 105-108 deg.C, removing superficial foam, filtering to remove impurities, heating and concentrating for 30-60 min to make it viscous and slightly wiredrawing.

(3) Putting the traditional Chinese medicine powder prepared in the step (1) into a pot, stir-frying until the color is deepened, adding the honey prepared in the step (2), quickly turning, adding the hawthorn peptide powder to uniformly stir the honey and the medicinal materials, taking out, and rolling into pills.

Further, the adding amount of the honey in the step (2) is 1/3 of the weight of the traditional Chinese medicine powder obtained in the step (1), and the adding amount of the purified water in the step (2) is 1/5 of the weight of the honey.

The invention also aims to provide application of the traditional Chinese medicine pill in the field of preparation of medicines for treating nodular diseases.

The medicine properties and pharmacology of the selected traditional Chinese medicines are respectively as follows:

ephedra and asarum are the principal drugs, ephedra is called the "first drug of release", the interior meridian-dredging action will dredge the joints of the hundred, the exterior orifices of the meridian-dredging action will penetrate the Xuan Fu, and the Ben Jing Shu Zheng (the syndrome of dredging the meridian) indicates that Ephedra is not specific for the exterior. The book Huang from Ben Jing Shu Zheng (the book is sparse in the symptoms and signs) states that the odor is light and clear, and can be thoroughly gone up and down, and can be thoroughly gone inside and inside, so essence, blood and body fluids can be circulated inside, the joint muscles and hair orifices can be kept on the surface, cough and headache can be eliminated in the upper part, and mass can be eliminated in the lower part. It is seen that the penetrating force of Ma Huang reaches the orifices of the head and eyes, the interior of the Ma Huang reaches the exterior of the five zang-organs and six fu-organs, and the collaterals of the Ma Huang open and penetrate the Xuan Fu, and the collaterals of the Ma Huang also expand and relax, so that the qi and blood are smooth, and the internal pathogenic factors can disperse; asarum herb is called ' Baijie contracture, rheumatism arthralgia and dead muscle ', so it is called ' Asarum herb, with the most fragrance, so it is good at resolving stagnation of qi, discharging stasis, and can reach the vertex, easing ear and eyes, and can reach wrestle without slight damage. The two medicines are used together to play the role of releasing and closing.

Fructus forsythiae has the effects of clearing away heat and toxic materials, resolving carbuncle, resolving hard mass, and dispelling wind and heat, is a common heat-clearing medicinal material, and has the effects of clearing away toxic materials, clearing away heart heat, resisting bacteria and viruses, diminishing inflammation and the like. The fritillary bulb is pungent, bitter, mild and slightly cold in taste and is non-toxic. Clearing heat, moistening lung, eliminating phlegm, relieving cough, resolving hard mass, and resolving carbuncle. It can be used for treating typhoid fever, dysphoria, stranguria, pathogenic qi, hernia, pharyngitis, and alum with sour taste, cold and no toxicity. Astringe to stop bleeding, astringe intestines to check diarrhea, dispel phlegm to induce resuscitation, dry dampness and remove toxicity. The ginger pinellia tuber, the wild buckwheat rhizome and the white mustard seed are used together to play the effects of softening hardness to dissipate stagnation, dissolving phlegm and inducing diuresis. Radix Stemonae has effects of moistening lung qi, relieving cough, and killing parasite, and can be used for treating pulmonary tuberculosis. The roasted radix stemonae is a processed traditional Chinese medicine obtained by adding honey or vinegar into a traditional Chinese medicine radix stemonae for moxibustion, and the traditional Chinese medicine is milder in property and better in effect than the radix stemonae. The selfheal has the effects of clearing heat, reducing internal heat, soothing liver, relieving depression, eliminating stagnation and reducing swelling, can clear liver, eliminate stagnation and induce diuresis, and has certain effects on scrofula, thyromegaly, scrofula, goiter, acute mastitis and phthisis. Seven ingredients are used together and are used as ministerial drugs.

Gan Jiang warms lung to resolve retained fluid, lian Qiao clears away heat and toxic material, dispels wind-heat. Wu Wei Zi can tonify qi and promote the production of body fluid, and resolve the dryness-fire property of pungent and dispersing herbs. The compatibility of the two components can widen the internal and external Xuanfu of human body, cause the collaterals of the whole body to be 'external and internal spread', and cause the circulation of qi, blood and semen to be smooth. Zhejiang fritillaria bulb, scutellaria baicalensis, plantain herb and spreading hedyotis herb are used together to clear heat and dry dampness and induce diuresis to treat stranguria, and the various medicines are used together as adjuvant medicines.

The herb of herba pyrrosiae, which reaches the canopy of china, passes through the three spring bodies from the top to the bottom, guides the herbs to the surface of the tuberous skin, softens the hard masses of mirabilite, and can smooth the collaterals, so that the tuberous can be dissipated and smoothly discharged.

According to the theory that yellow emperor's internal meridian middle coke such as retting and middle coke contains rotten water and cooked rice, hawthorn peptide powder is added into the prescription, the hawthorn peptide powder is used as a fermentation substrate, gastric acid is used as an environmental condition suitable for the growth of excellent microbial strains, the traditional Chinese medicines and the hawthorn peptide are fermented again under the action of the gastric acid, macromolecules of the traditional Chinese medicines are transferred into small molecules, the utilization rate and the absorption rate of the traditional Chinese medicines are increased, the stimulation to gastric mucosa is reduced, and the purpose of accelerating, increasing the efficiency and accurately treating the traditional Chinese medicines is achieved.

Compared with the prior art, the invention has the beneficial effects that:

the target of the action of the drugs in the prior art is usually the body or the viscera and meridians, and the drugs can activate blood and resolve stasis, or resolve phlegm and soften hard masses, improve blood circulation, and reduce swelling and dissipate stagnation on the basis of macroscopic dialectics. The treatment method has certain clinical curative effect, but has slow effect, long treatment course and difficult realization of precise positioning and targeted treatment. The invention provides a theory acting on relieving exterior syndrome, dredging the striae and expanding collaterals, and takes the epiphragma of visible substances such as viscera tissues of a body, even abdominal masses, accumulations, nodules and the like as the surface striae. The basic pathogenesis of the nodule is the closure of the sweat pores of the nodule and the stagnation of phlegm-dampness and stasis, the treatment method for relieving exterior syndrome, dredging the sweat pores, expanding the collaterals, penetrating the Xuan fu, reducing phlegm, softening hardness and dissipating stagnation is determined, and the prepared traditional Chinese medicine pill (Xuanguan Jie Wan) can realize the targeted treatment of the nodule on the microscopic level. Has the advantages of accurate positioning, quick absorption, obvious curative effect, lasting effect, no gastrointestinal reaction and toxic or side effect after long-term administration, and convenient storage and carrying.

The invention relates to a Chinese ephedra, asarum and pyrrosia leaf combination preparation, in particular to a preparation method of the Chinese ephedra, asarum, mirabilite and pyrrosia leaf combination preparation, which can achieve the effects of relieving exterior, dredging skin striae, dispelling phlegm, dissipating stasis, softening hard masses and resolving masses. The compatibility of the whole ingredients has the effects of relieving exterior syndrome, dredging striae, expanding collaterals, penetrating the xuan fu, dispersing blood stasis, softening hardness and dissipating stagnation so as to achieve the purposes of dissipating nodules and smoothing the skin.

The invention combines the observation of clinical curative effect and the improvement of symptoms of patients after taking the medicine, and based on the understanding of the theory of the medicine for dredging the river to the disease mechanism and the treatment principle, aiming at difficult and complicated diseases in internal medicine, the invention continuously improves the prescription, increases and decreases the medicine flavor and changes the dosage form according to the basic pathogenesis of skin, surface, striae, interstitial space and closure, and the medicine composition of the invention can relieve the pain of most patients and improve the clinical curative effect.

The pill of the invention is prepared by grinding the drugs into fine powder or extracts of the drugs, adding proper adhesive and fermentation substrate into the fine powder or extracts of the drugs to prepare a spherical solid dosage form, and the spherical solid dosage form is digested, decomposed and absorbed when entering the stomach, thereby overcoming the defects of slow dissolution and drug release of the pill. Through processing, during the process of preparing the traditional Chinese medicine decoction pieces into fine powder or extracting the medicinal materials, the pollution residues in pesticides, chemical fertilizers and soil in the traditional Chinese medicine decoction pieces are removed, and the toxic and side effects of the medicines are corrected to a certain extent, so compared with decoction, the traditional Chinese medicine decoction piece can reduce toxicity, reduce irritation, reduce adverse reaction and improve taste, and after the decoction piece is prepared into pills, the problems of difficult storage, inconvenient carrying and low compliance of the decoction are effectively solved, and the advantages of simplicity, convenience, low cost and effectiveness of the traditional Chinese medicine are revealed to a certain extent.

The pill prepared by the invention is mainly applied to nodular diseases in clinic, such as thyroid nodule, pulmonary nodule and breast nodule, and symptoms such as expectoration, fullness and asthma, chest pain and the like, can provide intervention measures in the follow-up visit and reexamination process of a nodular patient, improves symptoms and prevents the development of diseases by dredging the skin, the striae and the channels of the nodule, eliminating turbidity, removing blood stasis, softening hardness and dissipating, can remarkably reduce or even disappear the size of the nodule in clinic, and has no obvious adverse reaction.

Drawings

Figure 1 is an ultrasound diagnostic report of case 1 patient before treatment;

figure 2 is an ultrasound image of an ultrasound diagnostic report of case 1 patient before treatment;

fig. 3 is an ultrasound diagnostic report of case 1 after the patient took the traditional Chinese medicine pill of the present invention;

fig. 4 is an ultrasound image of an ultrasound diagnostic report after the patient of case 1 took the traditional Chinese medicine pill of the present invention;

figure 5 is an ultrasound diagnostic report of case 2 patient prior to treatment;

figure 6 is an ultrasound image of an ultrasound diagnostic report of case 2 patient prior to treatment;

fig. 7 is an ultrasonic diagnostic report of case 2 patients after taking the traditional Chinese medicine pill of the present invention;

fig. 8 is an ultrasound image of an ultrasound diagnostic report after the patient of case 2 took the traditional Chinese medicine pill of the present invention;

figure 9 is an ultrasound diagnostic report of case 3 patient before treatment;

FIG. 10 is an ultrasound image of an ultrasound diagnostic report of case 3 patient prior to treatment;

figure 11 is an ultrasonic diagnostic report of case 3 patients after taking a traditional Chinese medicine pill of the present invention;

figure 12 is an ultrasound image of an ultrasound diagnostic report after the patient of case 3 had taken a traditional Chinese medicine pill of the present invention;

figure 13 is an ultrasound diagnostic report of case 4 patient prior to treatment;

figure 14 is an ultrasound image of an ultrasound diagnostic report of case 4 patient before treatment;

figure 15 is an ultrasonic diagnostic report of case 4 patients after taking the traditional Chinese medicine pill of the present invention;

fig. 16 is an ultrasound image of an ultrasound diagnostic report after the patient of case 4 took the traditional Chinese medicine pill of the present invention;

FIG. 17 is a CT diagnosis report of case 5 patient prior to treatment;

figure 18 is an ultrasonic diagnostic report of case 5 patients after taking a traditional Chinese medicine pill of the present invention;

figure 19 is an ultrasound diagnostic report of case 6 patient prior to treatment;

figure 20 is an ultrasonic diagnostic report of case 6 patients after taking a traditional Chinese medicine pill of the present invention;

figure 21 is a CT diagnostic report of case 7 patient before treatment;

FIG. 22 is a CT diagnostic report of case 7 patients after taking the Chinese medicinal pill of the present invention;

FIG. 23 is a pre-treatment X-ray diagnostic report of case 8 patients;

fig. 24 is a CT diagnosis report of case 8 patients after taking the traditional Chinese medicine pill of the present invention.

Detailed Description

The present invention is described below with reference to examples, which are provided for illustration only and are not intended to limit the scope of the present invention.

In the examples, parts are parts by weight.

Example 1

A traditional Chinese medicine pill for treating nodules is prepared from the following raw materials in parts by weight: 6 parts of mix-fried ephedra herb, 15 parts of weeping forsythia capsule, 10 parts of thunberg fritillary bulb, 9 parts of ginger processed pinellia tuber, 30 parts of wild buckwheat rhizome, 6 parts of white mustard seed, 3 parts of asarum, 6 parts of dried ginger, 6 parts of Chinese magnoliavine fruit, 10 parts of baical skullcap root, 12 parts of pyrrosia lingua, 30 parts of plantain herb, 30 parts of spreading hedyotis herb, 6 parts of mix-fried sessile stemona root, 30 parts of common selfheal fruit-spike, 3 parts of mirabilite and 1 part of hawthorn peptide.

Example 2

A traditional Chinese medicine pill for treating nodules is prepared from the following raw materials in parts by weight: 4 parts of mix-fried ephedra herb, 12 parts of weeping forsythia capsule, 7 parts of thunberg fritillary bulb, 6 parts of ginger processed pinellia tuber, 26 parts of wild buckwheat rhizome, 4 parts of white mustard seed, 1 part of asarum, 4 parts of dried ginger, 4 parts of Chinese magnoliavine fruit, 8 parts of baical skullcap root, 10 parts of pyrrosia lingua, 26 parts of plantain herb, 28 parts of spreading hedyotis herb, 4 parts of mix-fried radix stemonae, 28 parts of common selfheal fruit-spike, 1 part of mirabilite and 1 part of hawthorn peptide.

Example 3

A traditional Chinese medicine pill for treating nodules is prepared from the following raw materials in parts by weight: 8 parts of mix-fried ephedra herb, 18 parts of weeping forsythia capsule, 12 parts of thunberg fritillary bulb, 12 parts of ginger processed pinellia tuber, 32 parts of wild buckwheat rhizome, 8 parts of white mustard seed, 5 parts of manchurian wildginger, 8 parts of dried ginger, 8 parts of Chinese magnoliavine fruit, 12 parts of baical skullcap root, 14 parts of pyrrosia lingua, 32 parts of plantain herb, 32 parts of spreading hedyotis herb, 8 parts of mix-fried sessile stemona root, 32 parts of common selfheal fruit-spike, 5 parts of mirabilite and 2 parts of hawthorn peptide.

The preparation method of the traditional Chinese medicine pill for treating nodules in the above embodiments 1 to 3 comprises the following steps:

(2) Putting 1/3 of the honey into a pot, adding 1/5 of purified water, heating, removing superficial foam, filtering to remove impurities, heating and concentrating for 50 min to make the honey viscous and slightly drawn to be held for later use.

(3) Putting the traditional Chinese medicine powder prepared in the step (1) into a pot, stir-frying until the color is deepened, adding the honey prepared in the step (2), quickly turning over, adding the hawthorn peptide powder, uniformly stirring the honey and the medicinal materials, taking out, and rubbing into pills.

Clinical data

1. Case selection

The pills developed by the invention are clinically applied, and in order to show the treatment effect of the traditional Chinese medicine pills for treating nodules, 320 patients suffering from thyroid nodules, lung nodules and breast nodules are clinically observed and treated, wherein the age of each half of the patients is between 20 and 70 years old, 116 patients suffering from thyroid nodules, 138 patients suffering from lung nodules and 66 patients suffering from breast nodules. The patient with the largest nodule with 16X 14mm and the smallest nodule with 5X 6mm was recorded with the medical history, disease condition, age and curative effect during the clinical observation.

2. Judgment criteria

The nodules are visible in the hospital ultrasound results, or palpated and palpated, and judged in combination with the clinical symptoms of the nodules.

3. Method of treatment

The traditional Chinese medicine pill for treating the nodules is taken by a patient in an oral mode, and the using method and the using amount are as follows: the medicine is taken 2 times a day, 9 g once, and 3 months are a treatment course.

4. Standard of therapeutic effect

Pulmonary nodule

According to the 2017 pulmonary nodule Fleischner guideline measurement requirement, a proper position is selected at an axial position and the like, measurement is carried out at the maximum level of the position, and the long axis and the short axis of the nodule are averaged and then taken as the average value. Partial solidity nodule measurement referring to the above method, the diameters of the solidity component and the hyposolidity component are measured respectively, and the change of the diameter of the solidity component is used as the reference basis of density change.

(1) And (4) complete alleviation: pulmonary nodules are completely absorbed or dissipated;

(2) local relief: the pulmonary nodule shrinkage is more than or equal to 2mm; the solidity part of the mixed nodule is reduced by more than or equal to 2mm;

(3) and (3) stabilizing: the size and the solid components of pulmonary nodules are unchanged; or nodule and solid component variation <2mm;

(4) the process comprises the following steps: the growth of the nodule is more than or equal to 2mm; the solidity part of the mixed nodule is increased by more than or equal to 2mm; new solid components appear on the pure ground glass nodules; newly added nodules appeared.

II, thyroid nodule

The sizes of the nodules are measured by color Doppler ultrasound before and after treatment, and are recorded in a book respectively for comparison. The standard for judging the size of the nodule is according to thyroid and parathyroid ultrasonography.

(1) The clinical recovery is that nodules disappear;

(2) has significant effect that the volume of the nodule is reduced by more than or equal to 50 percent;

(3) the volume of nodules is reduced by 30% to 49%;

(4) ineffective, the volume of the nodule is reduced by less than 30% or increased.

Thyroid function was measured before and after treatment, recorded separately and compared.

III, mammary nodule

The BI-RADS rating is as follows according to American society of radiology ultrasound second edition diagnostic criteria:

stage 0: if the data is not complete or the examination is not ideal, the condition should be evaluated by combining with other imaging examinations. Level 1: no obvious abnormality was seen in the ultrasound examination. Stage 2: ultrasound results showed the tumor to be a benign sign. And 3, level: the breast lesions may be benign with a malignancy rate of less than or equal to 2%, and patients are advised to follow-up for 3-6 months. And 4, stage 4: suspected malignancy (3% -94% malignancy potential), a needle biopsy is recommended for definitive diagnosis. Grade 4 is divided into 3 sub-grades according to the size of the malignant risk, and the possibility of grade 4a is 3% -10%; class 4b possibilities are 10% -50%; the class 4c probability is 50% -94%. Stage 5: malignancy is highly suspected (malignancy may be > 95%) and the treatment regimen should be determined in time. And 6, level: the pathology has been confirmed as a malignant lesion, but has not been treated. The division point between 4a and 4b is defined as the benign and malignant lesion.

(1) The clinical cure is as follows: the nodule disappears;

(2) the method has the following advantages: nodule BI-RADS grade reduction;

(3) and (4) invalidation: nodal BI-RADS scores were unchanged or increased.

5. Therapeutic results

The prescription has a treatment course of three months, and after a patient with small nodules uses the prescription for 1 treatment course, the original symptoms are obviously relieved, and the nodules disappear after the rechecking; after 2-3 treatment courses, the original symptoms of the patients with the middle-stage nodules are obviously relieved, and the nodules of the patients become smaller obviously after the patients are rechecked; after 4-6 treatment courses, the original symptoms of the patients with advanced nodules are obviously relieved, and the nodules are obviously reduced or kept stable after the reexamination. Through statistics, 32 patients with lung nodules are completely relieved, 74 patients with lung nodules are partially relieved, 18 patients with lung nodules are kept stable, 4 patients with lung nodules are invalid, and the effective rate reaches 97.1%; 28 patients with thyroid nodule are cured clinically, 62 patients with obvious effect, 23 patients with effective effect and 3 patients with ineffective effect have the effective rate of 97.4 percent; the breast nodules cure 20 patients clinically, 43 effective patients and 3 ineffective patients, and the effective rate reaches 95.5%. The total effective rate of the nodular diseases reaches over 96 percent, and a great effect is achieved.

6. Typical cases

A list of 8 typical cases is as follows:

(1) Case 1: a certain grandchild, a woman, age 53

The main complaints are: left thyroid nodule after right thyroidectomy

The current medical history is as follows: patient, female, 53 years old, was seen in our clinic for "after right thyroidectomy, left thyroid nodule" seen in the present case: swollen and uncomfortable pharynx, pharyngalgia, pharynx itch, chest distress, palpitation, temporary dysphagia, dizziness and headache, easy sleep, convenient adjustment, pale tongue with thick coating, and wiry and unsmooth pulse.

The past history: the patient is healthy.

Four diagnostic methods of traditional Chinese medicine: the patient has a clear mind, a clear spirit, a dark and dark complexion, a pale tongue with thick coating and a wiry and unsmooth pulse.

Physical examination: neck: the neck is normal in shape and free to move, the jugular vein is not full, the carotid artery has no abnormal pulsation, the thyroid palpation can touch the small node, and the trachea is centered.

Auxiliary inspection: (hospital 2021-7-17) thyroid color ultrasonography: after partial excision of right thyroid lobe and isthmus, there are multiple hypoechoic nodules in the bilateral thyroid lobes, the larger one is about: 1.3 × 1.4cm, left 1.5 × 0.3cm, see fig. 1, 2.

After the traditional Chinese medicine pill provided by the invention is taken for 30 days, nodules are obviously reduced, after two treatment courses, the nodules disappear, the symptoms are obviously improved, and a patient reviews the B ultrasonic mode in a hospital from 2021-12-01: the pouch and parenchymal mass were not seen in the left thyroid lobe, see fig. 2 and 3.

(2) Case 2: one certain piece, woman, age 55

The main complaints are: discovery of thyroid nodule more than 1 month

The current medical history: patients, women, 55 years old, have a diagnosis in our clinic for "finding thyroid nodule for more than 1 month", and the symptoms are as follows: the pharynx is still distended and discomfortable, the feeling of swallowing obstruction, chest distress and palpitation, dizziness and headache, pharyngalgia, pharynx itch, sleep reception, convenient adjustment, pale tongue with thick coating, and wiry and unsmooth pulse.

History of the past: the patient is healthy.

Four diagnostic methods of traditional Chinese medicine: the patient has clear mind, spiritual, dark and gloomy complexion, pale tongue with thick coating and wiry and unsmooth pulse.

Physical examination: neck: the neck is normal in shape and free in movement, the jugular vein is not full, the carotid artery is not abnormally pulsating, the thyroid palpation can touch the nodule, and the trachea is centered.

Auxiliary inspection: (hospital 2018-4-10) color thyroid ultrasonography: thyroid left lobe nodule (aspect ratio > 1), TI-RDAS classification 4, suggesting further examination; bilateral thyroid nodules, TI-RDAS class 3, 3.1 × 1.9cm hypoechoic nodules were visible in the middle of the right lobe, and hypoechoic nodules were visible in the left lobe, approximately 2.1 × 3.2cm in size (see FIGS. 5 and 6).

After taking the traditional Chinese medicine pill provided by the invention for 30 days, nodules are reduced, symptoms are obviously improved after two treatment courses, and a patient reviews the type-B ultrasonic diagnosis in a hospital in 2018-6-4: heterogeneous changes in thyroid; thyroid left-lobe solid nodule, TI-RADS classification 3, and it can be seen that thyroid left and right lobes are about 1.3 × 1.0cm,1.3 × 1.5cm in size, respectively (see fig. 7, 8).

(3) Case 3: wangzhi, female, 38 years old

A chief complaint: thyroid nodule for more than 1 month

The current medical history is as follows: the patient, female, 38 years old, was diagnosed in our clinic for "finding thyroid nodule for 1 month later", and the symptoms are: fullness and discomfort of the throat, swallowing obstruction, chest distress and palpitation, dizziness and headache, sore throat and itching throat, easy sleep, convenient adjustment, pale tongue with thick coating, and wiry and unsmooth pulse.

History of the past: the patient is healthy.

Auxiliary inspection: (hospital 2021-4-25) color thyroid ultrasonography: nodules were added to the right side of the thyroid gland at approximately 1.2 x 0.9mm in size and the internal echoes were not uniform, as shown in fig. 9 and 10.

After the traditional Chinese medicine pill provided by the invention is taken for 30 days, the nodules are reduced to some extent, the nodules are obviously relieved after two treatment courses, the symptoms are obviously improved, and a patient reviews the B-mode ultrasonography in a hospital at 2022-3-25: greater thyroid bilateral lobe tubercle (1.0 × 0.8 × 0.7cm) as shown in fig. 11 and 12.

(4) Case 4: zhangyi, a certain woman, 39 years old

The main complaints are: dull pain in the bilateral breasts for more than one month. The current medical history: patients, women, 55 years old, have a diagnosis in our clinic for "dull pain in both breasts at both sides for more than one month", and the symptoms are as follows: dull pain in the breast, yellow and thick leucorrhea, slow sleep, pale tongue with thick coating, wiry and unsmooth pulse.

History of the past: the patient is healthy.

Auxiliary inspection: (hospital 2021-1-27) color breast ultrasound: 1. bilateral hyperplasia of mammary glands; 2. right mammary hypoechoic nodules, BI-RADS class 3; about 11 points of right breast 4.5 x 3.6mm;3. low echo of left milk, 18 × 6 × 8mm at 12 points, bi-RADS 4 type; bilateral axillary lymph nodes are visible, see fig. 13, 14.

After taking the traditional Chinese medicine pill provided by the invention for 30 days, nodules are reduced, symptoms are obviously improved after two treatment courses, and a patient reviews the type-B ultrasonic examination in a hospital by 2021-4-8: bilateral mammary gland multidirectional scanning, glandular tissue thickness is still enough, echoes are enhanced and uneven, flaky low echoes and spot-shaped strong echoes are alternated, a low echo area is visible at about 12 points of left mammary gland, the range is about 16 x 5mm, the boundary is clear, the shape is irregular, internal echoes are uneven, spot-shaped strong echoes are visible in the low echo area, and branch blood flow signals are visible at the periphery of the CDFI. Bilateral axilla had no visible enlarged lymph nodes. Ultrasonic prompting: left mammary hypoechoic area, BI-RADS class 4a, see FIGS. 15, 16.

(5) Case 5: liu's certain herb, woman, age 57

The main complaints are: discovery of pulmonary nodules for more than 2 months

The current medical history: the patient, female, 57 years old, was diagnosed in our clinic for "finding lung nodules for 2 months", and the symptoms are: chest distress and breath holding, chest stabbing pain, occasional palpitation, no dizziness and headache, no pharyngalgia, pharynx itch, sleep regulation, pale tongue with thick coating, wiry and unsmooth pulse.

The past history: the patient is healthy.

Auxiliary inspection: low dose CT scan of lungs (hospital 2021-12-22) showed: the posterior segment of the left superior lobe of the lung, pure ground vitreous nodules approximately 5.5 x 4.7mm in size, and the inferior segment of the right lung, pure ground vitreous nodules approximately 6.3mm x 5.09mm in size, as shown in fig. 17.

After the traditional Chinese medicine pill provided by the invention is taken for 30 days, nodules are obviously reduced, the nodules disappear after two treatment courses, the symptoms are obviously improved, and a patient reviews the type-B ultrasonic examination in a hospital at 2022-4-1: the two lungs were ground to vitreous nodules and the remaining two lung nodules, see fig. 18.

(6) Case 6: somehow Cao, woman, age 53

The main complaints are: discovery of pulmonary nodules more than 1 month

The current medical history: the patients, women, 55 years old, have a diagnosis in our clinic because "lung nodules are found for more than 1 month", and the symptoms are as follows: cough, chest distress, lung fullness and discomfort, occasional chest distress and palpitation, no dizziness and headache, no sore throat and itching throat, easy sleep, pale tongue with thick coating, wiry and unsmooth pulse.

History of the past: the patient is healthy.

Auxiliary inspection: lung nodule color ultrasound (hospital 2021-10-22): 1. the posterior end of the superior lobe tip of the left lung (pacs 302-164) can be seen with a mixed frosted nodule focus, the size of the border is about 5mm, and a nodule-like higher density focus can be seen in the center, which indicates the precursor lesion of the gland and is combined with the clinic. 2. The anterior tip of the superior lobe of the left lung (pacs 302-264) is visible with ground glass nodules, blurred borders, a size of about 6mm, and recommended to follow the diagnosis and review for 6 months. 3. The remaining two lung bodies are scattered in the nodulation of the chestnut granules, as shown in fig. 19.

After taking the traditional Chinese medicine pill provided by the invention for 30 days, nodules are reduced, symptoms are obviously improved after two treatment courses, and a patient reviews the type-B ultrasonic examination in a hospital by 2022-5-4: the double lung milling vitreous nodules and the double lung millet nodule are shown in FIG. 20.

(7) Case 7: qu Zhi, woman, age 54

The main complaints are: finding lung nodules more than 1 month

The current medical history is as follows: the patient, woman, 54 years old, is in the clinic because "find lung nodule more than 1 month", now the disease is seen: cough, chest distress, lung fullness and discomfort, amnesia, dry mouth, bitter taste, dry throat, spontaneous perspiration, palpitation and tiredness.

History of the past: the patient is healthy.

Auxiliary inspection: (Hospital 2019-4-11) the thorax is symmetrical, and the mediastinum is centered. Multiple nodule shadows (202/190, 194, 269 and 301) can be seen in the two lungs, the larger one is located in the upper right lung lobe, the diameter is about 0.8cm, the adjacent bronchus is narrowed, and the surrounding points can be seen as flaky fuzzy shadows; multiple striae of the lungs were visible in fig. 21.

After the traditional Chinese medicine pill provided by the invention is taken for 30 days, the nodules are reduced, the nodules are relieved after two treatment courses, the symptoms are obviously improved, and a patient reviews the B-mode ultrasonic examination in a hospital in 2019-10-18: double lung fibrous foci, the minor induration focus of the right inferior lung, see fig. 22.

(8) Case 8: ju Shi, woman, 56 years old

A chief complaint: mammary nodules were found for 10 days.

The current medical history is as follows: the patients, women, 55 years old, have a diagnosis in our clinic because of "finding mammary nodules for 10 days", and the symptoms are as follows: occasionally, the breast is stabbing and painful, the leucorrhea is normal, the patient can take the medicine, the sleep is poor, and the patient can adjust the medicine conveniently. There was no significant change in body weight recently. Regulating sleep, regulating the flow of qi and blood, pale tongue with thick coating, wiry and unsmooth pulse.

History of the past: the patient is healthy.

Auxiliary inspection: (hospital 2018-4-10) color Doppler ultrasound for mammary glands:

1. left mammary gland BI-RADS classification 4B left mammary outer superior gland showed nodular high density shadows with less distinct borders of about 1.2cm in size, with left mammary scattered in nodular calcifications. 2. The right mammary gland BI-RADS classification 1, no obvious nodules or lump shadows were seen, see fig. 23.

After taking the traditional Chinese medicine pill provided by the invention for 30 days, nodules are reduced, symptoms are obviously improved after two treatment courses, and a patient reviews the type-B ultrasonic examination in a hospital in 2018-6-4: 1. lung fibrofoci, 2. Left mammary punctate calcification, see fig. 24.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the present invention, which is intended to cover any modifications, equivalents, improvements, etc. within the spirit and scope of the present invention.

Claims

1. A traditional Chinese medicine pill for treating nodules is characterized by being prepared from the following raw materials in parts by weight: 4 to 8 parts of mix-fried ephedra herb, 12 to 18 parts of weeping forsythia, 7 to 12 parts of thunberg fritillary bulb, 6 to 12 parts of ginger processed pinellia tuber, 26 to 32 parts of wild buckwheat rhizome, 4 to 8 parts of white mustard seed, 1 to 5 parts of asarum, 4 to 8 parts of dried ginger, 4 to 8 parts of Chinese magnoliavine fruit, 8 to 12 parts of baical skullcap root, 10 to 14 parts of pyrrosia lingua, 26 to 32 parts of plantain herb, 28 to 32 parts of spreading hedyotis herb, 4 to 8 parts of mix-fried sessile stemona root, 28 to 32 parts of common selfheal fruit-spike, 1 to 5 parts of mirabilite and 1 to 2 parts of hawthorn peptide.

2. The traditional Chinese medicine pill according to claim 1, which is prepared from the following raw materials in parts by weight: 5-7 parts of mix-fried ephedra herb, 14-16 parts of weeping forsythia, 8-10 parts of thunberg fritillary bulb, 8-10 parts of ginger processed pinellia tuber, 28-32 parts of wild buckwheat rhizome, 5-7 parts of white mustard seed, 2-4 parts of asarum, 5-7 parts of dried ginger, 5-7 parts of Chinese magnoliavine fruit, 9-11 parts of baical skullcap root, 11-13 parts of pyrrosia lingua, 28-30 parts of plantain herb, 29-30 parts of spreading hedyotis herb, 5-7 parts of mix-fried sessile stemona root, 28-30 parts of common selfheal fruit-spike, 2-4 parts of mirabilite and 1 part of hawthorn peptide.

3. The traditional Chinese medicine pill according to claim 1, which is prepared from the following raw materials in parts by weight: 6 parts of mix-fried ephedra herb, 15 parts of weeping forsythia capsule, 10 parts of thunberg fritillary bulb, 9 parts of ginger processed pinellia tuber, 30 parts of wild buckwheat rhizome, 6 parts of white mustard seed, 3 parts of asarum, 6 parts of dried ginger, 6 parts of Chinese magnoliavine fruit, 10 parts of baical skullcap root, 12 parts of pyrrosia lingua, 30 parts of plantain herb, 30 parts of spreading hedyotis herb, 6 parts of mix-fried sessile stemona root, 30 parts of common selfheal fruit-spike, 3 parts of mirabilite and 1 part of hawthorn peptide.

4. A method of preparing a traditional Chinese medicine pill according to any of claims 1 to 3, comprising the steps of:

(2) Placing Mel in a pot, adding purified water, maintaining the temperature at 105-108 deg.C, removing superficial foam, filtering to remove impurities, heating and concentrating for 30-60 min to make it viscous and slightly wiredrawing;

(3) And (2) putting the traditional Chinese medicine powder prepared in the step (1) into a pot, stir-frying until the color is deepened, adding the honey prepared in the step (2), quickly turning, adding the hawthorn peptide to uniformly stir the honey and the traditional Chinese medicine powder, taking out, and rolling into pills.

5. The method for preparing a traditional Chinese medicine pill according to claim 4, wherein the honey of step (2) is added in an amount of 1/3 of the weight of the traditional Chinese medicine powder obtained in step (1), and the purified water of step (2) is added in an amount of 1/5 of the weight of the honey.

6. Use of a Chinese medicinal pill according to any one of claims 1 to 3 in the manufacture of a medicament for the treatment of nodules, such as thyroid nodules, breast nodules or lung nodules.