CN117959382A

CN117959382A - Traditional Chinese medicine composition for treating pulmonary nodules and application thereof

Info

Publication number: CN117959382A
Application number: CN202311769348.2A
Authority: CN
Inventors: 姚曼; 杜娟; 韩睿; 徐砚南; 冯妮然; 向爽; 崔恩泽; 严诏贤; 刘海亮
Original assignee: First Affiliated Hospital of Naval Military Medical University of PLA
Current assignee: First Affiliated Hospital of Naval Military Medical University of PLA
Priority date: 2023-12-21
Filing date: 2023-12-21
Publication date: 2024-05-03

Abstract

The invention discloses a traditional Chinese medicine composition for treating pulmonary nodules, which is prepared from the following components in parts by weight: 5-10 parts of tangerine pith, 10-30 parts of fritillaria thunbergii, 10-30 parts of semen trichosanthis, 10-30 parts of raw oyster and 5-15 parts of fructus forsythiae. The traditional Chinese medicine composition provided by the invention has the advantages of low cost of raw materials, simple and convenient preparation and convenient use. The traditional Chinese medicine composition is safe and nontoxic, and can be taken for a long time.

Description

Traditional Chinese medicine composition for treating pulmonary nodules and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating pulmonary nodules and application thereof.

Background

Pulmonary nodules (pulmonary nodule, PN) are a clinically common sign, meaning round-like or irregular lesions with an internal diameter of less than or equal to 3cm (i.e., 30 mm) in the lung, are imaged as shadows of increased density, can be single or multiple, and have clear or unclear boundaries. It is often found by accident that the symptoms of most patients are not obvious during physical examination or diagnosis of other diseases, and symptomatic patients often show symptoms such as dyspnea, chest pain, cough, hemoptysis and the like.

Etiology of lung nodules:

1. Basic etiology (1) malignant lesions ① primary lung cancer: mainly comprises lung adenocarcinoma, lung squamous cell carcinoma, lung large cell carcinoma and lung small cell carcinoma. ② Metastatic malignancy: such as malignant tumor of head and neck, melanoma, colon cancer, etc. (2) Benign lesions ① benign tumor: such as lung hamartoma, lung fibroma, lung lipoma, etc. ② infection: mycobacterium tuberculosis infection, pulmonary fungus (such as candida, aspergillus, mucor) infection, etc. ③ Inflammatory lesions: such as granulomatosis, sarcoidosis, etc. ④ Pulmonary vascular abnormalities: such as pulmonary arteriovenous malformations, pulmonary telangiectasis, etc. ⑤ Congenital diseases of the lung: such as bronchogenic cyst, pulmonary isolation, etc.

2. The high risk factor (1) is smoking or has a history of smoking. (2) the presence of a fungal or bacterial infection of the lung. (3) past malignant tumors or a family history of lung cancer. (4) There is a history of environmental or high risk occupational exposure, such as frequent exposure to asbestos, beryllium, uranium, radon, and the like. (5) Chronic obstructive pulmonary disease and diffuse pulmonary fibrosis are combined.

Typical manifestations of pulmonary nodule symptoms:

1. cough: persistent repetitive cough can occur when a pulmonary nodule affects pulmonary nerves. Lung nodules caused by infection are often accompanied by purulent sputum.

2. Chest pain: when a tumor or tuberculosis focus affects the pleura or chest wall, chest pain may develop, which may be exacerbated with respiratory movement and cough.

3. Dyspnea: if the nodule is continuously enlarged, chest distress, short breath, wheezing, dyspnea and other symptoms can occur when the bronchus is pressed.

4. Hemoptysis: when a nodule reaches a pulmonary vessel, a patient may develop hemoptysis symptoms.

5. Systemic manifestations: for lung nodules caused by malignant tumor or tuberculosis infection, nonspecific manifestations such as debilitation, low fever, weight loss, night sweat (night sleep sweating, sweat after waking and stopping) and the like can appear. High fever can occur if the tuberculosis focus spreads sharply.

Treatment of pulmonary nodules: it is expected that the treating physician will administer a personalized treatment regimen based on the cause of the pulmonary nodules. If a lung nodule is diagnosed as benign or malignant, surgical excision may be considered; anti-tuberculosis and antifungal treatments are respectively applied to the patients caused by the mycobacterium tuberculosis infection and the fungal infection. If the lung nodule is not qualitative, but the judgment can be made by an observer, a doctor can make a proper follow-up plan for the patient according to the malignancy probability of the nodule.

Drug treatment of lung nodules:

1. Antitubercular drugs are mainly used for pulmonary nodules caused by pulmonary tuberculosis. The common medicines are isoniazid, rifampicin and the like, which can kill tubercle bacillus and achieve the purpose of controlling illness state.

2. The common antibiotics include ofloxacin, norfloxacin, moxifloxacin, erythromycin, etc. Mainly aims at patients with infection symptoms and can prevent secondary infection.

3. The antifungal agent is mainly used for patients with fungal infection, and common medicines include itraconazole, fluconazole, terbinafine hydrochloride and the like. Related medicines such as isoniazid, rifampin, ofloxacin, norfloxacin, moxifloxacin, erythromycin, itraconazole, fluconazole and terbinafine hydrochloride.

Surgical treatment of lung nodules:

1. Surgical mode

(1) Television assisted thoracoscopic surgery (vat): the doctor makes a small incision in the patient's chest and inserts a tube with a camera and light source for surgery. Has the characteristics of wide visual field, small wound, light pain and quick postoperative rehabilitation. Meanwhile, more mediastinal lymph nodes can be cleaned, the incidence rate of lymph node residue is reduced, and the method is a main operation mode at present.

(2) Thoracotomy: for deeper lung nodules, open chest surgery may be required.

2. Surgical resection scope physicians may administer sub-lobe or lobe resections, wedge resections, lung segments or sub-lobe segment resections, regional lymph node cleaning, etc., depending on the size, nature, etc. of the nodule. Other treatments for highly malignant probability lung nodules that cannot tolerate surgery, ablation treatments may be considered after PET evaluation.

Lung nodules are often free of special symptoms at early stages, often found during physical examination of chest CT examinations, and their scientific management is important, focusing on distinguishing benign from malignant nodules, avoiding excessive invasive examination and treatment of benign nodules, while early detection of malignant nodules gives intervention, maintains or reduces benign lung nodule size to some extent, and improves patient quality of life. Western medicine often takes follow-up visit to lung nodules which do not reach the operation indication as the main part, treatment measures are limited, patients often cannot be effectively treated, and mental stress is high, so that malignant circulation is formed. At this time, the Chinese medicine can fully exert advantages, and can treat the pulmonary nodules in multiple targets, multiple ways and multiple directions.

The traditional Chinese medicine considers that the lung nodule is a pathogenic factor and is mainly formed by mutually blooding phlegm, blood stasis and toxin, and the nodule is enlarged when the nodule is developed to be combined with infection and shows some syndrome characteristics, and can be characterized by the syndrome of qi stagnation and phlegm obstruction, the syndrome of cold phlegm stagnation, the syndrome of damp-heat and phlegm stasis, the syndrome of yang deficiency and internal heat and the like of the traditional Chinese medicine. The traditional Chinese medicine has rich experience, rich treatment method and higher curative effect, combines the disease differentiation and syndrome differentiation of the modern traditional Chinese medicine, explores a plurality of new treatment schemes and prescription drugs, and clinically shows unique advantages.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating pulmonary nodules.

The invention also aims at providing an application of the traditional Chinese medicine composition in preparing medicines for treating pulmonary nodules.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

The invention provides a traditional Chinese medicine composition for treating pulmonary nodules, which is prepared from the following components in parts by weight: 5-10 parts of tangerine pith, 10-30 parts of fritillaria thunbergii, 10-30 parts of semen trichosanthis, 10-30 parts of raw oyster and 5-15 parts of fructus forsythiae.

The traditional Chinese medicine composition for treating lung nodules is prepared from the following components in parts by weight: 8 parts of tangerine pith, 25 parts of fritillaria thunbergii, 15 parts of semen trichosanthis, 15 parts of raw oyster and 10 parts of weeping forsythiae capsule.

The traditional Chinese medicine composition for treating lung nodules is prepared from the following components in parts by weight: 10 parts of tangerine pith, 30 parts of fritillaria thunbergii, 30 parts of semen trichosanthis, 20 parts of raw oyster and 9 parts of weeping forsythiae capsule.

The traditional Chinese medicine composition for treating lung nodules is prepared from the following components in parts by weight: 6 parts of tangerine pith, 20 parts of fritillaria thunbergii, 10 parts of semen trichosanthis, 10 parts of raw oyster and 7 parts of fructus forsythiae.

The traditional Chinese medicine composition for treating lung nodules is prepared from the following components in parts by weight: 7 parts of tangerine pith, 10 parts of fritillaria thunbergii, 20 parts of semen trichosanthis, 15 parts of raw oyster and 8 parts of fructus forsythiae.

The traditional Chinese medicine composition for treating lung nodules is prepared from the following components in parts by weight: 9 parts of tangerine pith, 15 parts of fritillaria thunbergii, 15 parts of semen trichosanthis, 30 parts of raw oyster and 12 parts of fructus forsythiae.

In a second aspect, the invention provides application of the traditional Chinese medicine composition in preparation of medicines for treating pulmonary nodules.

In a third aspect of the present invention, a Chinese medicinal preparation is provided, which is prepared from the above Chinese medicinal composition.

The Chinese medicinal preparation is in the form of decoction, tablet, mixture, oral liquid, granule, pill, capsule, navel patch, and suppository.

The invention takes tangerine pith and fritillary bulb as monarch drugs to play the role of regulating qi, resolving stagnation, resolving phlegm and resolving masses. Semen Trichosanthis is used as ministerial drug for clearing lung-heat and eliminating phlegm, oyster is used for suppressing yang and nourishing yin, descending the evil in chest, fructus forsythiae is used as conductant drug for guiding the drug into the channel and directly reaching the disease site, and is used for clearing lung-heat and eliminating phlegm, and detumescence and resolving masses together. Promoting qi circulation, resolving phlegm, resolving masses and strengthening body resistance, and can achieve the effects of eliminating pathogenic factors, strengthening body resistance and smoothing yin and yang.

The traditional Chinese medicine raw material medicine has the following main functions of taste, meridian tropism:

The invention takes the symptoms of upper energizer, obstruction of collaterals and qi obstruction, phlegm and qi obstruction, and heat transformation caused by depression as the symptoms, and treats the symptoms of regulating qi movement, dredging collaterals and resolving hard mass, clearing lung and moistening lung.

Orange collaterals are neutral in nature, sweet and bitter in taste, and enter lung and spleen meridians. The tangerine pith has the effects of relieving the nature of the medicine, regulating the flow of qi, strengthening the spleen, removing food retention and eliminating stagnation, and is especially good at dredging the channels and collaterals and eliminating phlegm; zhejiang fritillary bulb, bitter and cold, enters lung and heart meridians. Has effects of clearing heat, eliminating phlegm, descending qi, relieving cough, resolving hard mass, and detumescence, and is good at clearing lung heat from exterior and interior, resolving phlegm. The compendium of the eye to pick up the effect indicates: the tangerine pith can be used for dredging channels and collaterals, relieving qi stagnation and pulse distention, dispelling phlegm and promoting blood circulation. In Ben Cao gang mu Shi (compendium of materia Medica and its excessive body), zhe Bei mu can detoxify and promote phlegm, open and ventilate lung qi, so it is indicated for wind-fire with phlegm. The two are main medicines of the composition, and play roles of dredging collaterals, dispersing phlegm and clearing exterior and interior.

Fructus Trichosanthis is has sweet and bitter taste and cold nature, and has effects of clearing heat and eliminating phlegm, relieving chest stuffiness and resolving hard mass, moistening dryness and lubricating intestines when growing at Shen Yue, heptin and unitary month, unitary containing and unitary month corresponding to lung, stomach and large intestine channels. For upper heat in the lung, middle energizer is smoothened, lower intestine is smoothened, and qi movement of the whole body is smoothened; oyster is salty and slightly cold, enters liver and kidney meridians, and causes qi of human body to converge and descend. Has the effects of astringing yin, softening hardness and resolving hard mass, and can treat scrofula. Oyster is better at breaking and resolving phlegm. "Jingyue holly book": gua Lou ren is thick in flavor and is moist and descending in nature. Can reduce excessive heat phlegm and saliva, relieve depression, block qi, quench thirst, relieve distention and asthma, moisten lung and relieve cough. In Changsha Yaojie Jie (Changsha drug solution): all phlegm-blood symptoms, gall, scrofula and the like are treated. It can be seen that the two herbs are combined to have more special effect.

Fructus forsythiae is a key herb for treating heat in upper jiao, especially for resolving toxin and carbuncle and resolving hard mass, and is bitter in flavor, and is effective in clearing lung heat, resolving phlegm, relieving swelling and resolving hard mass. Overall, fructus forsythiae and fritillariae thunbergii have the effect of dispersing and smoothing, and cooperate with the subsidence of semen trichosanthis and raw oyster to regulate the qi movement of a human body, so that qi flow is along with phlegm and the raw oyster and tangerine pith walk through viscera and channels as special medicines, and the functions of promoting qi circulation, reducing phlegm and resolving masses are combined, and both symptoms and root causes are treated, so that the effects of eliminating pathogenic factors, strengthening body resistance and smoothing yin and yang are achieved.

By adopting the technical scheme, the invention has the following advantages and beneficial effects:

the traditional Chinese medicine composition provided by the invention has the advantages of low cost of raw materials, simple and convenient preparation and convenient use. The traditional Chinese medicine composition is safe and nontoxic, and can be taken for a long time.

Detailed Description

In order to more clearly illustrate the present invention, the present invention will be further described with reference to preferred embodiments. It is to be understood by persons skilled in the art that the following detailed description is illustrative and not restrictive, and that this invention is not limited to the details given herein.

Example 1

A Chinese medicinal composition for treating pulmonary nodule:

mixing tangerine pith 8g, fritillaria thunbergii 25g, snakegourd fruit 15g, raw oyster 15g and weeping forsythiae capsule 10 g; reflux-extracting with water for 3 times (1000 ml,1 hr; 1000ml,1 hr), mixing extractive solutions, concentrating, oven drying, and pulverizing.

Example 2

A Chinese medicinal composition for treating pulmonary nodule:

mixing and grinding 10g of tangerine pith, 30g of fritillaria thunbergii, 30g of semen trichosanthis, 20g of raw oyster and 9g of fructus forsythiae; reflux-extracting with water for 3 times (1000 ml,1 hr; 1000ml,1 hr), mixing extractive solutions, and concentrating to obtain extract; adding proper pharmaceutical adjuvants (white sugar, mel, benzoic acid or ethyl hydroxy benzoate, etc.), and making into pill, mixture, oral liquid or syrup.

Example 3

A Chinese medicinal composition for treating pulmonary nodule:

Mixing 6g of tangerine pith, 20g of fritillaria thunbergii, 10g of semen trichosanthis, 10g of raw oyster and 7g of fructus forsythiae; reflux-extracting with water for 3 times (1000 ml,1 hr; 1000ml,1 hr), mixing extractive solutions, concentrating to obtain extract, drying, pulverizing, and making into granule.

Example 4

Mixing pericarpium Citri Tangerinae 7g, bulbus Fritillariae Thunbergii 10g, semen Trichosanthis 20g, concha Ostreae 15g, and fructus forsythiae 8 g; reflux-extracting with water for 3 times (1000 ml,1 hr; 1000ml,1 hr), mixing extractive solutions, concentrating to obtain extract, drying, pulverizing into granule, adding adjuvant, and making into tablet or capsule.

Example 5

Mixing 9g of tangerine pith, 15g of fritillaria thunbergii, 15g of semen trichosanthis, 30g of raw oyster and 12g of fructus forsythiae; reflux-extracting with water for 3 times (1000 ml,1 hr; 1000ml,1 hr), mixing the extractive solutions, and concentrating to obtain decoction.

Example 6

1. Case selection and grouping

(1) Case selection: refer to the "Chinese lung nodule classification, diagnosis and treatment guide (2016 edition)" formulated by the Chinese lung nodule diagnosis and treatment expert group 2016 in the "Chinese expert consensus for diagnosis and treatment of lung nodule (2018 edition)".

① Quantity: individual lesions are isolated, and 2 or more lesions are defined as multiple lesions.

② Density: the solid nodules, the ground glass nodules, and the partially solid nodules are classified into 3 categories based on the density and the degree of mixing.

③ Degree of risk: the solid nodule refers to the result of a Mayo malignancy probability prediction formula, and the lung cancer risk factors are divided into <5% (low risk), 5% -65% (medium risk) and >65% (high risk); the partial solid nodules are bounded by 8mm, >8mm (high risk), <8mm (medium risk); the pure ground glass nodules were bounded by 5mm, >5mm (medium risk), <5mm (low risk). Multiple nodules were ranked by the most dangerous nodules.

(2) Case grouping: the treatment groups and the control groups were randomized according to a random table.

① Treatment group (administration of the formulation prepared in example 5 of the invention + follow-up): 105 cases.

② Control group (follow-up only): 105 cases.

The two groups of patients were comparable with no significant differences in age, sex, course of disease and severity of disease (P > 0.05).

2. Method of observation and treatment

① The observation method comprises the following steps: the morphology of lung CT lung nodules was observed before and after treatment of group 2.

② The treatment method comprises the following steps: 150ml of the medicine is taken twice a day, each time in the morning and evening, and 3 months is a treatment course.

3. Standard of efficacy: reference is made to the guidelines of clinical research on new Chinese medicine.

(1) Clinical recovery: the lung nodules disappeared;

(2) The effect is shown: lung nodules were reduced by more than 60%;

(3) The method is effective: the lung nodule is reduced by 30 to 59 percent;

(4) Invalidation: pulmonary nodules do not change or turn into high risk nodules;

The total effective rate is the sum of healing, obvious effect and effective rate.

4. Therapeutic results and analysis

① Treatment group 105 cases, effects are shown in table 1:

TABLE 1

30 Cases are clinically cured, 12 cases are obvious, 32 cases are effective, 31 cases are ineffective, and the total effective rate is 70.50%.

② The effect of 105 cases of control group is shown in Table 2:

TABLE 2

6 Cases of clinical recovery, 7 cases of obvious effect, 15 cases of effective and 77 cases of ineffective, and the total effective rate is 26.67%.

Compared with the control group, the total effective rate of the patients in the treatment group is obviously higher than that of the patients in the control group, the difference is obvious, and the statistical significance is achieved (P < 0.05).

Example 7

The patient had a yellow spot, and had a first visit in year 2021, month 5 and 25, with a 41 year old male. Patients on day 19, 1, 2021 were examined in local hospitals and chest CT: the basal segment nodule behind the inferior lobe of the right lung is approximately 6mm in diameter and is clearly defined. Tumor markers such as carcinoembryonic antigen are not abnormal, related treatment is not carried out temporarily, and the patient suffers from stay overnight from insomnia and even anxiety after finding out the nodule.

The diagnosis is as follows: sleep, dry mouth, anorexia, dry stool, urine, red tongue, thin and yellow coating, dark red lip surface, red eyes, and deep and thready pulse.

Western diagnosis: insomnia, lung nodules. Diagnosis of traditional Chinese medicine: insomnia (pattern of hyperactivity of fire due to yin deficiency).

Prescription: 15g of fritillary bulb, 9g of tangerine pith, 15g of snakegourd fruit, 15g of peach seed and 15g of raw oyster; fructus forsythiae 12g, radix glehniae 15g, radix ophiopogonis 15g, spina date seed 15g, poria with hostwood 15g, mother-of-pearl 30g, fried chicken's gizzard-skin 12g and fried liquorice 9g. A total of 28 doses, 1 dose/day, 150ml each time, are decocted with water.

Two diagnoses: re-diagnosis in 2021 at 6 and 23 days, patients complain of sleep gradually, no dry mouth and inconvenient adjustment, but slightly sour after eating, go to Zhu Fu Shen and Zhenzhu Ping, add calcined flute 30g and take for 2 months.

Three diagnoses: the symptoms of complaints are healed in the 8 th year of 2021 and 18 th year, the upper part is calcined, the flute is calcined, the spine date seed, the glehnia root and the dwarf lilyturf tuber are removed, the chest CT is checked after 3 months of taking, the telephone is followed in the 11 th month of 2021, and the two lungs are not obviously abnormal when the chest CT is checked in the local hospital in the 11 th month of 2021.

The preparation method comprises the following steps: the patient has plain character, is prone to have a frequent check, has serious anxiety in the recent times, has poor qi activity, and has the effects of fluid resistance, phlegm generation, blood stagnation, stasis and phlegm stasis; yin-fluid deficiency failing to nourish the body and deficient heat is generated internally. Considering the basic pathogenesis in conjunction with tongue pulse is: phlegm and blood stasis are mutually combined, and fire is excessive due to yin deficiency. The recipe is effective in activating qi-flowing, resolving phlegm, resolving stagnation, nourishing yin and tranquilizing mind. Modified by taking the traditional Chinese medicine composition as the basis for temporary symptoms. In the formula, fritillary bulb, tangerine pith, and tangerine pith have the functions of regulating qi, resolving stagnation, resolving phlegm and resolving masses; radix glehniae, radix ophiopogonis, capable of nourishing yin, moisturizing lung, benefiting stomach and promoting fluid production; semen Ziziphi Spinosae, poria and Concha Margaritifera can calm heart and tranquilize mind; semen Persicae and semen Trichosanthis have effects of loosening bowel to relieve constipation, removing blood stasis and resolving hard mass; oyster can be used for resolving masses and eliminating mass, and green fructus forsythiae can be introduced into the channels to directly reach the disease sites; the whole formula plays the roles of eliminating symptoms, resolving hard mass and harmonizing yin and yang together. The patients with the second diagnosis all have reduced symptoms, but are slightly sour after eating, so Zhu Fu Shen and Zhu mu are removed, and 30g of calcined concha arcae are added, so that the effects of inhibiting acid, eliminating phlegm, softening hardness and resolving hard mass are enhanced. The three patients with all symptoms are cured, the bellyband is pathogenic, the disease condition is lingering, frequent review is not suitable, the special traditional Chinese medicine composition of the invention is taken for three months for observing the curative effect, and then the pulmonary nodule disappears.

Example 8

The patient had a certain, male, 61 years old, 2021, 4 months, 13 days first visit. The patient is going to local hospital for diagnosis and treatment for cough of 1 month or more due to cold, 2021, 4 months and 9 days, and chest CT examination shows: the upper She Duofa nodules of the left lung, approximately 8mm. Tumor markers were not abnormal. Related treatments were not performed. The diagnosis is as follows: cough, expectoration, debilitation, shortness of breath, loose stool, urine, pale tongue with white and thin coating, pale lips, pale complexion and thready pulse.

Western diagnosis: cough, lung nodules. Diagnosis of traditional Chinese medicine: cough (qi deficiency of lung and spleen).

Prescription: 15g of fritillary bulb, 9g of tangerine pith, 15g of snakegourd fruit, 15g of peach seed and 15g of raw oyster; 12g of fructus forsythiae; 15g of astragalus; 15g of raw white atractylodes rhizome; 30g of radix pseudostellariae; 30g of cordate houttuynia; 15g of coltsfoot flower; 9g of costustoot; 12g of fried chicken's gizzard-membrane; radix Glycyrrhizae Preparata 9g. A total of 28 doses, 1 dose/day, 150ml each time, are decocted with water.

Two diagnoses: re-diagnosis in 2021, 5 and 11 days, cough, expectoration, hypodynamia, shortness of breath and constipation. Herba Houttuyniae, flos Farfarae and radix aucklandiae are removed from the upper part, and the mixture is taken for 2 months.

Three diagnoses: re-diagnosis is performed in 7 th year and 6 th year of 2021, complaints are all healed, astragalus root, raw atractylodes macrocephala koidz and radix pseudostellariae are removed from the upper part, and chest CT is re-checked after taking three months.

Four diagnostic methods: re-examination at 28 days of 10 months of 2021, re-examination at 27 days of 10 months of 2021 chest distress CT shows: the upper left lung is a tiny nodule, about 3mm, smaller than 2021-4-9 tablets. Patients have no special discomfort, stop taking the traditional Chinese medicine, and review chest CT every half year with the help of diagnosis.

The preparation method comprises the following steps: the patients are diagnosed with cough after one month, the symptoms are as follows: phlegm, weakness, shortness of breath, loose stool, pale and fat tongue with tooth marks, thin and white coating and thin pulse, which are considered as the symptoms of qi deficiency of lung and spleen, qi deficiency of other viscera, weak promotion of qi deficiency, unsmooth blood circulation and stasis; spleen deficiency causes insufficient transportation and transformation, and phlegm-dampness is self-generated. The pathogenesis of the disease is as follows: qi deficiency of the lung and spleen, and blood stasis due to phlegm coagulation. The traditional Chinese medicine composition disclosed by the invention is materialized and cut for tonifying qi and resolving phlegm, and relieving cough and removing blood stasis, radix pseudostellariae, astragalus and raw bighead atractylodes rhizome in the formula have the effects of tonifying qi and strengthening spleen, promoting the production of body fluid and moistening lung, and radix aucklandiae has the effects of warming middle-jiao and harmonizing stomach and relieving diarrhea with astringents, and herba houttuyniae, flos farfarae and radix glycyrrhizae preparata are added to increase the effects of relieving cough and resolving phlegm, so that radix glycyrrhizae preparata has the effects of harmonizing various medicines. Cough and expectoration of patients with secondary diagnosis are healed, and the cough and expectoration of patients with secondary diagnosis still have weak and shortness of breath, so the cordate houttuynia, the coltsfoot flower and the elecampane are removed, and the traditional Chinese medicine composition is taken for 2 months. Three patients have no symptoms, and the breast CT is rechecked to reduce the nodule to 3mm after taking the traditional Chinese medicine composition of the invention for 3 months. The prescription for clinical symptoms is not more than ten digits, but the prescription is seemingly concise and practical, and has the advantages of simplified and high effect when the prescription is used for treating the symptom.

Example 9

The patient is a female, 54 years old, and Han nationality. Breast CT at outer hospital, 5 months, 18 days 2021: the upper lobe solid nodules (lamellar, im30,4 mm) of the left lung were followed; the medial lobe of the right lung has a few fibroproliferative lesions. Tumor markers are not abnormal, and the diagnosis is from 6 th month 5 th year 2021 to the clinic, and the diagnosis is carved: the symptoms of debilitation, cough, phlegm, chest distress, and short breath are not obvious, the symptoms of anorexia, insomnia, constipation, pale red tongue with thin and white coating, and deep and thready pulse are not obvious.

Prescription: 9g of tangerine pith, 15g of fritillaria thunbergii, 15g of snakegourd fruit, 30g of raw oyster and 12g of weeping forsythia. The medicines are decocted for 1 dose/day, 150ml each time, and the medicines are orally taken in the morning and evening.

Chest CT was reviewed at the outer hospital at 12 months 3 of 2021: no obvious abnormalities were seen.

The foregoing description is only illustrative of the preferred embodiment of the present invention, and is not to be construed as limiting the invention, but is to be construed as limiting the invention to any and all simple modifications, equivalent variations and adaptations of the embodiments described above, which are within the scope of the invention, may be made by those skilled in the art without departing from the scope of the invention.

Claims

1. The traditional Chinese medicine composition for treating lung nodules is characterized by being prepared from the following components in parts by weight: 5-10 parts of tangerine pith, 10-30 parts of fritillaria thunbergii, 10-30 parts of semen trichosanthis, 10-30 parts of raw oyster and 5-15 parts of fructus forsythiae.

2. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, wherein the traditional Chinese medicine composition for treating pulmonary nodules is prepared from the following components in parts by weight: 8 parts of tangerine pith, 25 parts of fritillaria thunbergii, 15 parts of semen trichosanthis, 15 parts of raw oyster and 10 parts of weeping forsythiae capsule.

3. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, wherein the traditional Chinese medicine composition for treating pulmonary nodules is prepared from the following components in parts by weight: 10 parts of tangerine pith, 30 parts of fritillaria thunbergii, 30 parts of semen trichosanthis, 20 parts of raw oyster and 9 parts of weeping forsythiae capsule.

4. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, wherein the traditional Chinese medicine composition for treating pulmonary nodules is prepared from the following components in parts by weight: 6 parts of tangerine pith, 20 parts of fritillaria thunbergii, 10 parts of semen trichosanthis, 10 parts of raw oyster and 7 parts of fructus forsythiae.

5. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, wherein the traditional Chinese medicine composition for treating pulmonary nodules is prepared from the following components in parts by weight: 7 parts of tangerine pith, 10 parts of fritillaria thunbergii, 20 parts of semen trichosanthis, 15 parts of raw oyster and 8 parts of fructus forsythiae.

6. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, wherein the traditional Chinese medicine composition for treating pulmonary nodules is prepared from the following components in parts by weight: 9 parts of tangerine pith, 15 parts of fritillaria thunbergii, 15 parts of semen trichosanthis, 30 parts of raw oyster and 12 parts of fructus forsythiae.

7. Use of a traditional Chinese medicine composition according to any one of claims 1 to 6 for preparing a medicament for treating pulmonary nodules.

8. A Chinese medicinal preparation prepared from the Chinese medicinal composition according to any one of claims 1 to 6.

9. The traditional Chinese medicine preparation according to claim 8, wherein the dosage form of the traditional Chinese medicine preparation is selected from decoction, tablets, mixture, oral liquid, granules, pills, capsules, navel patches and suppositories.