CN114788823A - 用于治疗肾脏疾病或病症的联苯磺酰胺化合物 - Google Patents
用于治疗肾脏疾病或病症的联苯磺酰胺化合物 Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- Plural Heterocyclic Compounds (AREA)
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| CN201780076280.6A CN110049764A (zh) | 2016-10-13 | 2017-10-13 | 用于治疗肾脏疾病或病症的联苯磺酰胺化合物 |
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| MA53817A (fr) * | 2018-10-04 | 2021-08-11 | Travere Therapeutics Inc | Composés biphényl-sulfonamide destinés au traitement de maladies du collagène de type iv |
| EP3897834A1 (en) * | 2018-12-21 | 2021-10-27 | Travere Therapeutics, Inc. | Amorphous sparsentan compositions |
| CN116173014A (zh) | 2019-12-17 | 2023-05-30 | 奇努克医疗公司 | 用阿曲生坦治疗IgA肾病的方法 |
| US20220304979A1 (en) * | 2019-12-17 | 2022-09-29 | Chinook Therapeutics, Inc. | Methods of reducing disease flares |
| CN115768421A (zh) * | 2020-04-10 | 2023-03-07 | 切诺克治疗公司 | 治疗糖尿病肾病的方法 |
| WO2022246200A1 (en) | 2021-05-21 | 2022-11-24 | Travere Therapeutics, Inc. | Methods of treating kidney diseases or disorders |
| WO2023025277A1 (zh) | 2021-08-26 | 2023-03-02 | 上海翰森生物医药科技有限公司 | 含芳环类生物拮抗剂、其制备方法和应用 |
| AR128112A1 (es) * | 2021-12-28 | 2024-03-27 | Alchemedicine Inc | Compuesto, antagonista del receptor de angiotensina ii tipo 1 y composición farmacéutica |
| WO2024073672A1 (en) | 2022-09-30 | 2024-04-04 | Travere Therapeutics, Inc. | Combination therapy with sparsentan and a sglt2 inhibitor for treating kidney diseases or disorders |
| JP2025183466A (ja) * | 2022-11-11 | 2025-12-17 | 株式会社アークメディスン | 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物 |
| WO2024249509A1 (en) | 2023-05-31 | 2024-12-05 | Travere Therapeutics, Inc. | Sparsentan for use in a method of treating iga-mediated diseases |
| WO2025064688A1 (en) | 2023-09-20 | 2025-03-27 | Travere Therapeutics, Inc. | Sparsentan for treating immunoglobulin a nephropathy (igan) |
| CN118666826A (zh) * | 2024-08-23 | 2024-09-20 | 成都臻拓医药科技有限公司 | 一种司帕生坦原料药的重结晶纯化方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107176A (zh) * | 2009-03-31 | 2014-10-22 | 利亘制药公司 | 治疗高血压和糖尿病肾病的二苯基磺酰胺内皮素和血管紧张素ii受体激动剂的口服制剂 |
| US20150175695A1 (en) * | 2012-08-17 | 2015-06-25 | Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital | Rac1 inhibitors for the treatment of alport glomerular disease |
| US20150284405A1 (en) * | 2014-04-04 | 2015-10-08 | Pfizer Inc. | Bicyclic-Fused Heteroaryl or Aryl Compounds |
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| CN1149196C (zh) | 1998-07-06 | 2004-05-12 | 布里斯托尔-迈尔斯斯奎布公司 | 作为血管紧张肽和内皮肽受体双重拮抗剂的联苯基磺酰胺 |
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| EP1741713A3 (en) | 1999-12-15 | 2009-09-09 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| GB0513553D0 (en) * | 2005-07-01 | 2005-08-10 | Fond D Amico Per La Ricerca Su | Rab3a |
| WO2010135350A2 (en) | 2009-05-20 | 2010-11-25 | Pharmacopeia, Llc | Biphenyl intermediate compounds and methods for the preparation of a dual angiotensin ii and endothelin a receptor antagonist |
| MA53817A (fr) | 2018-10-04 | 2021-08-11 | Travere Therapeutics Inc | Composés biphényl-sulfonamide destinés au traitement de maladies du collagène de type iv |
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2017
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| CN104107176A (zh) * | 2009-03-31 | 2014-10-22 | 利亘制药公司 | 治疗高血压和糖尿病肾病的二苯基磺酰胺内皮素和血管紧张素ii受体激动剂的口服制剂 |
| US20150175695A1 (en) * | 2012-08-17 | 2015-06-25 | Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital | Rac1 inhibitors for the treatment of alport glomerular disease |
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| US20200281901A1 (en) | 2020-09-10 |
| KR20230066644A (ko) | 2023-05-16 |
| BR112019007576A2 (pt) | 2019-07-02 |
| CA3039819A1 (en) | 2018-04-19 |
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| US20190262317A1 (en) | 2019-08-29 |
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| US10864197B2 (en) | 2020-12-15 |
| US20250325523A1 (en) | 2025-10-23 |
| KR20220132030A (ko) | 2022-09-29 |
| KR102528435B1 (ko) | 2023-05-03 |
| JP2022137245A (ja) | 2022-09-21 |
| AU2023219839A1 (en) | 2023-09-07 |
| MA46524A (fr) | 2019-08-21 |
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| US20250325522A1 (en) | 2025-10-23 |
| JP2022141802A (ja) | 2022-09-29 |
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| CN117085013A (zh) | 2023-11-21 |
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