CN114788823A - 用于治疗肾脏疾病或病症的联苯磺酰胺化合物 - Google Patents
用于治疗肾脏疾病或病症的联苯磺酰胺化合物 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- Plural Heterocyclic Compounds (AREA)
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| CN201780076280.6A Pending CN110049764A (zh) | 2016-10-13 | 2017-10-13 | 用于治疗肾脏疾病或病症的联苯磺酰胺化合物 |
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| BR112021012226A2 (pt) | 2018-12-21 | 2021-09-08 | Travere Therapeutics, Inc. | Composições de esparsentano amorfo |
| US20220304979A1 (en) * | 2019-12-17 | 2022-09-29 | Chinook Therapeutics, Inc. | Methods of reducing disease flares |
| HRP20260121T1 (hr) * | 2019-12-17 | 2026-03-13 | Chinook Therapeutics, Inc. | Farmaceutski prihvatljiva sol atrasentana za uporabu u postupku za liječenje iga nefropatije |
| US20230270718A1 (en) * | 2020-04-10 | 2023-08-31 | Chinook Therapeutics, Inc. | Methods of treating diabetic kidney disease |
| WO2022246200A1 (en) | 2021-05-21 | 2022-11-24 | Travere Therapeutics, Inc. | Methods of treating kidney diseases or disorders |
| KR20240051999A (ko) * | 2021-08-26 | 2024-04-22 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 방향족 고리 함유 생물학적 길항제, 이의 제조 방법 및 용도 |
| WO2023127853A1 (ja) * | 2021-12-28 | 2023-07-06 | 株式会社アークメディスン | 化合物、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物 |
| WO2024073672A1 (en) | 2022-09-30 | 2024-04-04 | Travere Therapeutics, Inc. | Combination therapy with sparsentan and a sglt2 inhibitor for treating kidney diseases or disorders |
| JP2025183466A (ja) * | 2022-11-11 | 2025-12-17 | 株式会社アークメディスン | 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物 |
| EP4719402A1 (en) | 2023-05-31 | 2026-04-08 | Travere Therapeutics, Inc. | Sparsentan for use in a method of treating iga-mediated diseases |
| KR20260089488A (ko) | 2023-09-20 | 2026-06-15 | 트래비어 테라퓨틱스, 인코포레이티드 | 면역글로불린 A 신장병증(IgAN)의 치료를 위한 스파르센탄 |
| CN118666826A (zh) * | 2024-08-23 | 2024-09-20 | 成都臻拓医药科技有限公司 | 一种司帕生坦原料药的重结晶纯化方法 |
| WO2026165438A1 (en) | 2025-01-31 | 2026-08-06 | Travere Therapeutics, Inc. | Sparsentan for the treatment of patients post kidney transplantation with proteinuric iga nephropathy or fsgs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107176A (zh) * | 2009-03-31 | 2014-10-22 | 利亘制药公司 | 治疗高血压和糖尿病肾病的二苯基磺酰胺内皮素和血管紧张素ii受体激动剂的口服制剂 |
| US20150175695A1 (en) * | 2012-08-17 | 2015-06-25 | Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital | Rac1 inhibitors for the treatment of alport glomerular disease |
| US20150284405A1 (en) * | 2014-04-04 | 2015-10-08 | Pfizer Inc. | Bicyclic-Fused Heteroaryl or Aryl Compounds |
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| ID26984A (id) * | 1998-07-06 | 2001-02-22 | Bristol Myers Squibb Co | Senyawa-senyawa sulfonamida sebagai antagonis reseptor angiotensin endotelin ganda |
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| WO2001044239A2 (en) | 1999-12-15 | 2001-06-21 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| GB0513553D0 (en) * | 2005-07-01 | 2005-08-10 | Fond D Amico Per La Ricerca Su | Rab3a |
| WO2010135350A2 (en) | 2009-05-20 | 2010-11-25 | Pharmacopeia, Llc | Biphenyl intermediate compounds and methods for the preparation of a dual angiotensin ii and endothelin a receptor antagonist |
| JP7524167B2 (ja) | 2018-10-04 | 2024-07-29 | トラビア セラピューティクス， インコーポレイテッド | Ｉｖ型コラーゲン疾患の処置のためのビフェニルスルホンアミド化合物 |
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2020
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2022
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2023
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| CN104107176A (zh) * | 2009-03-31 | 2014-10-22 | 利亘制药公司 | 治疗高血压和糖尿病肾病的二苯基磺酰胺内皮素和血管紧张素ii受体激动剂的口服制剂 |
| US20150175695A1 (en) * | 2012-08-17 | 2015-06-25 | Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital | Rac1 inhibitors for the treatment of alport glomerular disease |
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