CN114767785A - External medicine for treating scald and burn and preparation method thereof - Google Patents
External medicine for treating scald and burn and preparation method thereof Download PDFInfo
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Classifications
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G—PHYSICS
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- A61K2236/30—Extraction of the material
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses an external medicine for treating scalds and burns, which comprises the following raw material medicines in parts by weight: 55-75 parts of rhodiola rosea; 10-20 parts of bletilla striata; 8-13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica and hydrangea macrophylla; 7-12 parts of a mixture of at least two of Chinese lobelia, red peony and honeysuckle; wherein the weight ratio of the giant knotweed rhizome, the coptis root, the rhubarb, the coriaria sinica maxim and the inula tamarisk in the mixture of the giant knotweed rhizome, the coptis root, the rhubarb, the scutellaria root, the coriaria sinica maxim and the inula tamarisk is 1: 0.5-1:0.5-0.8:0.5-0.8:0.5-0.8: 0.5-0.8; the external medicine is powder, spray or ointment. The components of the invention are coordinated and matched to form the effects of stopping bleeding, cooling blood, resisting infection, resisting bacteria and viruses, disinfecting, healing wound, relieving swelling, removing necrotic tissue, promoting granulation and improving immunity, thereby accelerating recovery.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines and intelligent preparation, and particularly relates to an external medicine for treating scalds and burns and a preparation method thereof.
Background
Scalds and burns are injuries to the skin or muscles caused by external factors such as high temperature, strong light, radiation, etc. If the treatment cannot be carried out in time, the mild patients have erythema or blisters with different sizes, and the severe patients have symptoms of rot, suppuration and the like;
the existing medicine and method for treating burn or scald mainly comprise the following steps:
one type of treatment route mainly adopts western medicine, and comprises the steps of coating a plurality of chemically synthesized anti-inflammatory drugs and skin grafting operation, wherein the currently marketed drugs have simple efficacy, and scars are easy to leave after healing; the treatment method of the skin grafting operation can damage healthy subcutaneous tissues, and simultaneously has the problems of more times of dressing change of the wound surface, longer treatment course, high treatment cost and the like; the other type is a treatment route mainly based on traditional Chinese medicines, mainly based on internal medicines, and the wound surface is hardly directly treated by any medicine, so that the infection is easily caused, the growth and healing of a new organism are influenced, the treatment period is prolonged, the optimal treatment period is lost for a patient, the treatment cost of the patient is increased, and scars are easily left after the affected part is cured.
Disclosure of Invention
The invention mainly solves the technical problem of providing an external medicine for treating scalds and burns and a preparation method thereof, and various components are coordinated and matched to form the effects of stopping bleeding, cooling blood, resisting infection, resisting bacteria and viruses, disinfecting, healing wounds, reducing swelling, removing necrotic tissue, promoting granulation and improving immunity, thereby accelerating recovery.
In order to solve the technical problems, the invention adopts a technical scheme that: the external medicine for treating scalds and burns comprises the following raw material medicines in parts by weight: 55-75 parts of rhodiola rosea; 10-20 parts of bletilla striata; 8-13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica maxim and hydrangea strigosa; 7-12 parts of a mixture of at least two of Chinese lobelia, red peony and honeysuckle;
wherein the weight ratio of the giant knotweed rhizome, the coptis root, the rhubarb, the baikal skullcap root, the coriaria sinica diels to the white pouzolzia diels in the mixture of the giant knotweed rhizome, the coptis root, the rhubarb, the baikal skullcap root, the coriaria sinica diels and the white poultries is 1: 0.5-1:0.5-0.8:0.5-0.8:0.5-0.8: 0.5-0.8;
the external medicine is powder, spray or paste.
Further, the powder comprises the following components in percentage by weight:
75 parts of rhodiola rosea; 10 parts of common bletilla pseudobulb; 8 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea rhizome, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea rhizome are respectively 2 parts, 1 part and 1 part; and 7 parts of a mixture of Chinese lobelia, radix paeoniae rubra and honeysuckle, wherein the Chinese lobelia, the radix paeoniae rubra and the honeysuckle are respectively 2 parts, 3 parts and 2 parts.
Further, the spray comprises the following components in percentage by weight:
65 parts of rhodiola rosea; 15 parts of common bletilla pseudobulb; 10 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica diels and white pouce, wherein the giant knotweed, the coptis, the rhubarb, the scutellaria, the coriaria sinica diels and the white pouce are respectively 2 parts, 1.5 parts and 1.5 parts; 10 parts of mixture of radix paeoniae rubra and honeysuckle, wherein the radix paeoniae rubra and the honeysuckle are respectively 5 parts and 5 parts.
Further, the paste comprises the following components in percentage by weight:
55 parts of rhodiola rosea; 20 parts of common bletilla pseudobulb; 13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica diels and white pouce, wherein the giant knotweed, the coptis, the rhubarb, the scutellaria, the coriaria sinica diels and the white pouce are respectively 3 parts, 2 parts and 2 parts; 12 parts of a mixture of Chinese lobelia and honeysuckle, wherein the Chinese lobelia and the honeysuckle respectively account for 4 parts and 8 parts.
A preparation method of an external medicine for treating scalds and burns comprises the following steps:
s100, weighing the following components in parts by weight for the external medicine: 55-75 parts of rhodiola rosea; 10-20 parts of bletilla striata; 8-13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica maxim and hydrangea strigosa; 7-12 parts of a mixture of at least two of Chinese lobelia, radix paeoniae rubra and honeysuckle;
wherein the weight ratio of the giant knotweed rhizome, the coptis root, the rhubarb, the coriaria sinica maxim and the inula tamarisk in the mixture of the giant knotweed rhizome, the coptis root, the rhubarb, the scutellaria root, the coriaria sinica maxim and the inula tamarisk is 1: 0.5-1:0.5-0.8:0.5-0.8:0.5-0.8: 0.5-0.8;
s200, detecting and treating harmful substance residues of the components of the external medicine;
and S300, after the detection treatment is qualified, preparing the powder into the powder through a powder preparation process, preparing the spray through a spray preparation process or preparing the ointment through an ointment preparation process respectively.
The S200 is used for detecting and treating harmful residues of the components of the external medicine, and comprises the following steps:
s201, randomly sampling a set amount of external medicine component samples; grinding the external medicine component sample by a nano grinder to obtain nano powder of the medicine sample to be detected; dividing the drug sample nanopowder to be detected into a first group of drug sample nanopowder and a second group of drug sample nanopowder;
s202, blowing and mixing the first group of drug sample nanopowder with a gas chromatography analysis carrier gas to form a first group of drug sample to-be-detected aerosol; mixing and dissolving the second group of drug sample nanopowder through a liquid chromatography analysis solution to form a second group of drug sample solution to be detected;
s203, carrying out gas chromatography on non-soluble harmful residual components in the nano powder of the drug sample to be detected; and (3) carrying out liquid chromatography analysis on easily soluble harmful residual components in the nano powder of the medicine sample to be detected, and identifying and detecting harmful residues contained in the components of the external medicine.
Further, the S203 includes the following steps:
s2031 gas chromatography of non-soluble harmful residue in nanometer powder of the sample to be tested comprises: enabling the aerosol to be detected of the first group of preprocessed drug samples to enter a sample component collection cavity through a clean gas path pipeline; the sample component collecting cavity collects components of substances to be detected in the first group of medicinal samples to be detected in the aerosol to be detected, and gas subjected to component collecting treatment is output to the gas chromatographic column; the gas chromatographic column separates the components of the sample to be detected from the gas sucked through the sample component collecting cavity to obtain the components of the aerosol to be detected by chromatographic separation; carrying out gas chromatography detection on the components to be detected after chromatographic separation; and the prepared chromatographic separation aerosol component to be detected and the standard reference aerosol component are contrasted and analyzed by matching with fluorescence detection; obtaining a reference comparative analysis gas chromatogram;
s2032, the liquid chromatography analysis of the soluble harmful residual components in the nanometer powder of the drug sample to be detected comprises: inputting the solution to be detected of the second group of medicine samples from the liquid sample into a liquid chromatographic column for separating liquid components of the sample to be detected; obtaining chromatographic separation liquid to be detected; carrying out gas chromatography detection on the components to be detected of the chromatographic separation liquid; and the prepared chromatographic separation liquid to-be-detected components and the standard reference solution are contrasted and analyzed by matching with fluorescence detection; obtaining a reference contrast analysis liquid chromatogram;
s2033, performing image recognition on the reference contrast analysis gas chromatogram and the reference contrast analysis liquid chromatogram, and recognizing and detecting harmful substance residues contained in the components of the external medicine.
Further, the preparation of the powder in S300 by the powder preparation process includes the following steps:
s311, weighing each component of the powder; and S312, respectively grinding and sieving by a sieve of 50-80 meshes, and uniformly mixing to obtain the powder.
Further, the preparation of the spray in S300 through the spray preparation process includes the steps of:
s321, weighing each component of the spray, adding water, soaking for 15-20 hours, extracting at high temperature, and concentrating to form an extract; the weight ratio of the extract to the weight of the raw material medicines is 1: 4-6;
s322, filling the mixture according to the weight ratio of 35-50 parts of the extract, 15-30 parts of ethanol and 30-50 parts of distilled water to obtain a spray;
in the step S321, the high-temperature extraction is to boil with strong fire and then keep the temperature with slow fire for 1-2 hours; the water addition, high-temperature extraction and concentration are continuously carried out for 3-5 times.
Further, the preparation of the paste by the paste preparation process of S300 comprises the steps of:
s331, weighing each component of the paste, adding water, soaking for 15-20 hours, extracting at high temperature, and concentrating to form an extract; the weight ratio of the extract to the weight of the raw material medicines is 1: 4-6;
s332, uniformly mixing 65-90 parts of the extract, 5-15 parts of radix paeoniae rubra and 5-15 parts of glycerol according to the weight ratio to obtain the paste.
Further, the high-temperature extraction in the step S331 is to boil with strong fire and then keep with slow fire for 1 to 2 hours; the water addition, high-temperature extraction and concentration are continuously carried out for 3-5 times.
The radix Rhodiolae has antiinflammatory, antibacterial, antiinflammatory, antitoxic, and wound surface protecting effects.
Rhizoma Bletillae has effects of astringing, stopping bleeding, subsiding swelling and promoting granulation.
Rhizoma Polygoni Cuspidati has effects of clearing away heat and toxic materials, promoting blood circulation, relieving swelling and pain;
the coptis, the rhubarb and the scutellaria have the effects of promoting blood circulation, stopping bleeding, clearing away heat and toxic materials, relieving swelling and pain, and clearing heat and drying dampness, so that the wound surface is promoted to be converged and healed, the blood vessels are restored to be smooth, and the swelling and pain disappear.
The coriaria sinica diels has the effects of relieving pain, tranquilizing, resisting toxin, expelling pus and promoting granulation.
The radix Aconiti Kusnezoffii has effects of clearing away heat and toxic materials, promoting blood circulation, and removing blood stasis.
Herba Lobeliae chinensis has effects of resisting snake venom, ulcer, bacteria, blood coagulation and cancer.
Radix Paeoniae Rubra has analgesic, tranquilizing, antiinflammatory, antiulcer, antibacterial, and antipyretic effects.
The flos Lonicerae has effects of clearing heat, relieving pain, resisting inflammation, and eliminating pus.
The invention has the beneficial effects that: according to the external medicine for treating scalds and burns and the preparation method, various components of the medicine are coordinated and matched to form the effects of stopping bleeding, cooling blood, resisting infection, resisting bacteria, resisting viruses, disinfecting, healing wound, relieving swelling, removing necrotic tissue, promoting granulation and improving immunity, so that the rehabilitation is accelerated; the composition is natural and safe, has no hormone component and no harmful residue, has various dosage forms, reliable preparation method, wide application range and good rehabilitation effect, is widely applicable to wounds, burns, scalds, pustules, sprains, frostbites and the like, and is suitable for household stock and various medical and first-aid treatments;
by calculating the concentration degree similarity factor value of the extract concentrated by the decompression tank, when the concentration degree similarity factor value of the extract concentrated by the decompression tank is larger, the proximity of the concentration degree of the extract concentrated by the decompression tank to the extract is higher, and the concentration proportion component is more accurately controlled; the concentration control precision of the extract concentrated by the decompression tank can be further improved;
the detection treatment of harmful substance residues is carried out on the component composition of the external medicament, so that pesticide residues, herbicide residues and pollutant residues in the storage and transportation process of the components contained in the component composition can be detected, and the medicament components are purer, and the medicament effect is safer and more reliable; the preparation in various forms can enable the application range of the medicine to be wider; by carrying out nano grinding on the external medicine component sample, various components in the medicine sample to be detected can be separated out and separated better; the harmful substance residue detection of the components of the external medicine can be more accurately carried out through gas chromatography analysis and liquid chromatography analysis;
the components to be detected can be collected and separated more thoroughly; carrying out gas chromatography detection on the components to be detected after chromatographic separation; the prepared chromatographic separation aerosol component to be detected and the standard reference aerosol component are contrastively analyzed by matching with fluorescence detection, so that the detection comprehensiveness can be further improved, and harmful substance residues contained in the external medicine component composition can be more comprehensively and accurately identified and detected;
can reduce harmful substance residue in the medicine components as far as possible, so that the medicine has less side effect, better efficacy, better application and rehabilitation in various aspects such as scald, burn and the like, and further expands the wide applicability of the medicine.
Detailed Description
The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention, and to clearly and unequivocally define the scope of the present invention.
Example 1
The preparation method of the externally applied medicine for treating scalds and burns comprises the following steps:
weighing 75 parts of rhodiola rosea by weight; 10 parts of common bletilla pseudobulb; 8 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea rhizome, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea rhizome are respectively 2 parts, 1 part and 1 part; and 7 parts of a mixture of the Chinese lobelia, the red peony and the honeysuckle, wherein the Chinese lobelia, the red peony and the honeysuckle are respectively 2 parts, 3 parts and 2 parts, the Chinese lobelia, the red peony and the honeysuckle are respectively ground and sieved by a sieve of 50-80 meshes, and the mixture is uniformly mixed to obtain the powder.
While the powder is prepared, the powder is provided with comparative examples which are as follows:
comparative example 1: the rhodiola rosea in the raw material is replaced by the same amount of safflower, namely 75 parts of safflower; 10 parts of common bletilla pseudobulb; 8 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea rhizome, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea rhizome are respectively 2 parts, 1 part and 1 part; 7 parts of a mixture of Chinese lobelia, red peony and honeysuckle, wherein the Chinese lobelia, red peony and honeysuckle are respectively 2 parts, 3 parts and 2 parts;
comparative example 2: the rhodiola root single agent is ground and sieved to obtain the rhodiola root powder;
comparative example 3: different from the embodiment 1, the rhodiola rosea is not contained, namely 10 parts of bletilla striata; 8 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica maxim and white spiraea nuta, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica maxim and the white spiraea nuta are respectively 2 parts, 1 part and 1 part; and 7 parts of a mixture of Chinese lobelia, radix paeoniae rubra and honeysuckle, wherein the Chinese lobelia, the radix paeoniae rubra and the honeysuckle are respectively 2 parts, 3 parts and 2 parts.
The powders of example 1 and comparative examples 1 to 3 were applied to a site with a lesion with the same degree of clinical trauma, and then applied to a site with external tetanus and subcutaneous hemorrhage, respectively, wherein the powder prepared in example 1 stopped bleeding and stopped pain immediately after application, and the subcutaneous blood stasis was completely absorbed in 48 hours, and the wound was healed. The powder of comparative example 1 has a weak pain relieving effect, and about 30% of area can be remained visually when subcutaneous blood stasis is 48 h; the powder of comparative example 2 stops bleeding when being scattered, has weak pain relieving effect, and has about 40 percent of area remained when subcutaneous blood stasis reaches 72 hours; the blood still oozed slowly after the application of comparative example 3, the wound appeared dry after half an hour, and about 40% area of subcutaneous blood stasis was visible after 48 hours.
Example 2
The embodiment prepares an external spray for treating scalds and burns, and the method comprises the following steps:
(1) weighing 65 parts of rhodiola rosea according to parts by weight; 15 parts of common bletilla pseudobulb; 10 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea thunbergii, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea thunbergii are respectively 2 parts, 1.5 parts and 1.5 parts; 10 parts of mixture of radix paeoniae rubra and honeysuckle, wherein the radix paeoniae rubra and the honeysuckle are respectively 5 parts and 5 parts. Respectively soaking in water with the mass of 1.5 times of that of the mixture at the temperature of less than 40 ℃ for 15-20 hours, carrying out high-temperature water boiling extraction, heating to boiling by using strong fire, keeping the water temperature at 95-100 ℃ by using slow fire, filtering out filter residues, adding water, repeatedly boiling for one time, filtering out the filter residues, mixing liquid medicines obtained in the two times, and concentrating in a pressure reduction tank to obtain an extract;
(2) and (3) uniformly mixing 40 parts of extract, 20 parts of ethanol and 40 parts of distilled water in a ratio, and filling in an automatic process under an ultra-clean and pollution-free environment to obtain the spray.
The obtained spray is used for repairing clinical scalds such as boiling water, hot oil and the like, is sprayed on an affected part once every 10-20 minutes, is cool and comfortable after being sprayed, has an obvious pain relieving effect, effectively reduces secretions, and can heal moderate internal wounds within 72 hours generally.
Example 3
The preparation method of the externally-applied ointment for treating scalds and burns comprises the following steps:
(1) weighing 55 parts of rhodiola rosea according to parts by weight; 20 parts of common bletilla pseudobulb; 13 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea rhizome, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea rhizome are respectively 3 parts, 2 parts and 2 parts; 12 parts of a mixture of Chinese lobelia and honeysuckle, wherein the Chinese lobelia and the honeysuckle are respectively 4 parts and 8 parts, the Chinese lobelia and the honeysuckle are respectively soaked in water with the temperature of less than 40 ℃ and 2 times for 4-24 hours, boiled and extracted, the mixture is heated to boiling by using a sharp fire, the water temperature is kept at 95-100 ℃ by using a slow fire for 1-2 hours, filter residues are filtered, the same amount of water is added to repeat the extraction process for the residues, the two filtrates are combined, and the mixture is concentrated into an extract in a pressure reduction tank;
(2) and (3) fully stirring and uniformly mixing 80 parts of the extract, 10 parts of radix paeoniae rubra and 10 parts of glycerol in an ultraclean and pollution-free environment to obtain the paste.
The obtained paste can be used for clinical repair of suppurative cold injury and wound initiationArea of 2cm2The ointment is smeared to cover the wound surface once every 2-4 hours, the swelling is relieved in 24 hours, and the wound is healed in 72 hours.
In the process of concentrating the extract in the decompression tank, the concentration degree similarity factor value of the extract concentrated in the decompression tank is calculated, and the calculation formula is as follows:
wherein Rxsd is a concentration similarity factor value of the extract concentrated by the pressure reducing tank, Rt is a concentration contrast extract t-time average accumulated theoretical release degree, St is the t-time average accumulated theoretical release degree of the extract concentrated by the pressure reducing tank, Rzt is a concentration contrast extract t-time average accumulated actual release degree, Szt is the t-time average accumulated actual release degree of the extract concentrated by the pressure reducing tank, n is a sampling test point number, and lg is a logarithmic expression with 10 as a base number; by calculating the concentration degree similarity factor value of the extract concentrated by the decompression tank, when the concentration degree similarity factor value of the extract concentrated by the decompression tank is larger, the proximity of the concentration degree of the extract concentrated by the decompression tank to the extract is higher, and the control of the concentration proportion components is more accurate.
Example 4
The invention discloses a preparation method of an external medicine for treating scalds and burns, which comprises the following steps:
s100, weighing the following components in parts by weight for the external medicine: 55-75 parts of rhodiola rosea; 10-20 parts of bletilla striata; 8-13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica maxim and hydrangea strigosa; 7-12 parts of a mixture of at least two of Chinese lobelia, red peony and honeysuckle;
wherein the weight ratio of the giant knotweed rhizome, the coptis root, the rhubarb, the coriaria sinica maxim and the inula tamarisk in the mixture of the giant knotweed rhizome, the coptis root, the rhubarb, the scutellaria root, the coriaria sinica maxim and the inula tamarisk is 1: 0.5-1:0.5-0.8:0.5-0.8:0.5-0.8: 0.5-0.8;
s200, detecting and treating harmful substance residues of the components of the external medicine;
and S300, after the detection treatment is qualified, preparing the powder, the spray or the ointment respectively through a powder preparation process and a spray preparation process.
S200, carrying out harmful residue detection treatment on the components of the external medicine, wherein the harmful residue detection treatment comprises the following steps:
s201, randomly sampling a set amount of external medicine component samples; grinding the external medicine component sample by a nano grinder to obtain nano powder of the medicine sample to be detected; dividing the drug sample nanopowder to be detected into a first group of drug sample nanopowder and a second group of drug sample nanopowder;
s202, blowing and mixing the first group of drug sample nanopowder with a gas chromatography analysis carrier gas to form a first group of drug sample to-be-detected aerosol; mixing and dissolving the second group of nano powder of the drug sample through a liquid chromatography analysis solution to form a second group of solution to be detected of the drug sample;
s203, carrying out gas chromatography on non-soluble harmful residual components in the nano powder of the drug sample to be detected; and (3) performing liquid chromatography analysis on easily soluble harmful residual components in the nano powder of the medicine sample to be detected, and identifying and detecting harmful residues contained in the components of the externally applied medicine.
Harmful substance residue detection treatment is carried out on the component composition of the external medicine, so that pesticide residue, herbicide residue and pollutant residue in the component storage and transportation process can be detected, and the medicine components are purer, and the medicine effect is safer and more reliable; preparing into powder by a powder preparation process, preparing into spray by a spray preparation process or preparing into paste by a paste preparation process respectively; the preparation in various forms can enable the application range of the medicine to be wider; carrying out harmful residue detection treatment on the components of the external-use medicine, and randomly sampling a set amount of external-use medicine component samples; grinding the external medicine component sample by a nano grinder to obtain nano powder of the medicine sample to be detected; purging and mixing the first group of drug sample nanopowder with a gas chromatography analysis carrier gas to form a first group of drug sample to-be-detected aerosol; mixing and dissolving the second group of drug sample nanopowder through a liquid chromatography analysis solution to form a second group of drug sample solution to be detected; carrying out gas chromatography analysis on non-soluble harmful residual components in the nano powder of the drug sample to be detected; performing liquid chromatography analysis on easily soluble harmful residue components in the nano powder of the drug sample to be detected, and identifying and detecting harmful residues contained in the components of the external drug; by carrying out nano grinding on the external medicine component sample, various components in the medicine sample to be detected can be separated out and separated better; the harmful substance residue detection of the components of the externally applied medicine can be more accurately carried out through gas chromatography analysis and liquid chromatography analysis.
In one embodiment, the S203 includes the steps of:
s2031 gas chromatography of the non-soluble harmful residual components in the nanometer powder of the drug sample to be detected comprises: enabling the aerosol to be detected of the first group of preprocessed drug samples to enter a sample component collection cavity through a clean gas path pipeline; the sample component collecting cavity collects components of substances to be detected in the first group of medicine samples to be detected aerosol, and gas subjected to component collecting treatment is output to the gas chromatographic column; the gas chromatographic column separates the components of the sample to be detected from the gas sucked through the sample component collecting cavity to obtain the components of the aerosol to be detected by chromatographic separation; carrying out gas chromatography detection on the components to be detected after chromatographic separation; and comparing and analyzing the prepared chromatographic separation aerosol component to be detected and the standard reference aerosol component by matching with fluorescence detection; obtaining a reference contrast analysis gas chromatogram;
s2032, the liquid chromatography analysis of the soluble harmful residual components in the nanometer powder of the drug sample to be detected comprises: inputting the solution to be detected of the second group of medicine samples into a liquid chromatographic column from the liquid sample to perform liquid component separation on the sample to be detected; obtaining chromatographic separation liquid to be detected components; carrying out gas chromatography detection on the components to be detected in the chromatographic separation liquid; and the prepared chromatographic separation liquid to-be-detected component and the standard reference solution are contrasted and analyzed by matching with fluorescence detection; obtaining a reference contrast analysis liquid chromatogram;
s2033, performing image recognition on the reference contrast analysis gas chromatogram and the reference contrast analysis liquid chromatogram, and recognizing and detecting harmful substance residues contained in the components of the external medicine.
The components to be detected can be collected and separated more thoroughly; carrying out gas chromatography detection on the components to be detected after chromatographic separation; and the prepared chromatographic separation aerosol component to be detected and the standard reference aerosol component are contrastively analyzed by matching with fluorescence detection, so that the detection comprehensiveness can be further improved, and the harmful substance residues contained in the external medicine component can be more comprehensively and accurately identified and detected.
In one embodiment, the preparation of the powder in S300 by the powder preparation process comprises the following steps:
s311, weighing each component of the powder; and S312, respectively grinding, sieving by a 50-80-mesh sieve, and uniformly mixing to obtain the powder.
In one embodiment, the preparing of the spray through the spray preparation process in S300 includes the following steps:
s321, weighing each component of the spray, adding water, soaking for 15-20 hours, extracting at high temperature, and concentrating to form an extract; the weight ratio of the extract to the weight of the raw material medicines is 1: 4-6;
s322, filling the mixture according to the weight ratio of 35-50 parts of the extract, 15-30 parts of ethanol and 30-50 parts of distilled water to obtain a spray;
in the step S321, the high-temperature extraction is to boil with strong fire and then keep the temperature with slow fire for 1-2 hours; the water addition, high-temperature extraction and concentration are continuously carried out for 3-5 times.
In one embodiment, the preparation of the S300 into the paste through the paste preparation process includes the steps of:
s331, weighing each component of the paste, adding water, soaking for 15-20 hours, extracting at high temperature, and concentrating to form an extract; the weight ratio of the extract to the weight of the raw material medicines is 1: 4-6;
s332, uniformly mixing 65-90 parts of the extract, 5-15 parts of radix paeoniae rubra and 5-15 parts of glycerol according to the weight ratio to obtain the paste.
In one embodiment, the high-temperature extraction in step S331 is to boil with strong fire and then keep with slow fire for 1-2 hours; the water addition, high-temperature extraction and concentration are continuously carried out for 3-5 times.
In conclusion, the external medicine for treating scalds and burns provided by the invention has the advantages of natural and safe components, no hormone component, no harmful residue, various dosage forms, reliable preparation method, wide application range, good rehabilitation effect and the like, is widely applicable to wounds, burns, scalds, pustules, sprains, frostbites and the like, and is suitable for household stock and various medical and first-aid treatments;
by calculating the concentration degree similarity factor value of the extract concentrated by the decompression tank, when the concentration degree similarity factor value of the extract concentrated by the decompression tank is larger, the proximity of the concentration degree of the extract concentrated by the decompression tank to the extract is higher, and the concentration proportion component is more accurately controlled; the concentration control precision of the extract concentrated by the decompression tank can be further improved.
Harmful substance residue detection treatment is carried out on the component composition of the external medicine, so that pesticide residue, herbicide residue and pollutant residue in the component storage and transportation process can be detected, and the medicine components are purer, and the medicine effect is safer and more reliable; preparing into powder by a powder preparation process, preparing into spray by a spray preparation process or preparing into paste by a paste preparation process respectively; the preparation in various forms can enable the application range of the medicine to be wider; carrying out harmful substance residue detection treatment on the components of the externally applied medicine, and randomly sampling a set amount of externally applied medicine component samples; grinding the external medicine component sample by a nano grinder to obtain nano powder of the medicine sample to be detected; purging and mixing the first group of drug sample nanopowder with a gas chromatography analysis carrier gas to form a first group of drug sample to-be-detected aerosol; mixing and dissolving the second group of nano powder of the drug sample through a liquid chromatography analysis solution to form a second group of solution to be detected of the drug sample; carrying out gas chromatographic analysis on non-soluble harmful residual components in the nano powder of the drug sample to be detected; performing liquid chromatography analysis on easily soluble harmful residual components in the nano powder of the medicine sample to be detected, and identifying and detecting harmful residues contained in the components of the externally applied medicine; through nano grinding of the externally applied medicine component sample, various components in the medicine sample to be detected can be better separated out and separated; the harmful substance residue detection of the components of the external medicine can be more accurately carried out through gas chromatography analysis and liquid chromatography analysis;
the components to be detected can be collected and separated more thoroughly; carrying out gas chromatography detection on the components to be detected after chromatographic separation; the prepared chromatographic separation aerosol component to be detected and the standard reference aerosol component are contrastively analyzed by matching with fluorescence detection, so that the detection comprehensiveness can be further improved, and harmful substance residues contained in the external medicine component composition can be more comprehensively and accurately identified and detected;
can reduce harmful substance residue in the medicine components as much as possible, so that the medicine has less side effect, better efficacy, better application and rehabilitation in various aspects such as scald, burn and the like, and further expand the wide applicability of the medicine.
The above description is only an embodiment of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structural changes made by using the content of the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. An external medicine for treating scalds and burns is characterized in that: the raw material medicine for the external use consists of the following components in parts by weight: 55-75 parts of rhodiola rosea; 10-20 parts of bletilla striata; 8-13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica maxim and hydrangea strigosa; 7-12 parts of a mixture of at least two of Chinese lobelia, red peony and honeysuckle;
wherein the weight ratio of the giant knotweed rhizome, the coptis root, the rhubarb, the coriaria sinica maxim and the inula tamarisk in the mixture of the giant knotweed rhizome, the coptis root, the rhubarb, the scutellaria root, the coriaria sinica maxim and the inula tamarisk is 1: 0.5-1:0.5-0.8:0.5-0.8:0.5-0.8: 0.5-0.8;
the external medicine is powder, spray or ointment.
2. The external medicine for treating scalds and burns as claimed in claim 1, which is characterized in that: the powder comprises the following components in percentage by weight:
75 parts of rhodiola rosea; 10 parts of common bletilla pseudobulb; 8 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica maxim and white spiraea nuta, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica maxim and the white spiraea nuta are respectively 2 parts, 1 part and 1 part; and 7 parts of a mixture of Chinese lobelia, radix paeoniae rubra and honeysuckle, wherein the Chinese lobelia, the radix paeoniae rubra and the honeysuckle are respectively 2 parts, 3 parts and 2 parts.
3. The external medicine for treating scalds and burns as claimed in claim 1, which is characterized in that: the spray comprises the following components in percentage by weight:
65 parts of rhodiola rosea; 15 parts of common bletilla pseudobulb; 10 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea thunbergii, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea thunbergii are respectively 2 parts, 1.5 parts and 1.5 parts; 10 parts of mixture of radix paeoniae rubra and honeysuckle, wherein the radix paeoniae rubra and the honeysuckle are respectively 5 parts and 5 parts.
4. The external medicine for treating scalds and burns as claimed in claim 1, characterized in that: the paste comprises the following components in percentage by weight:
55 parts of rhodiola rosea; 20 parts of common bletilla pseudobulb; 13 parts of a mixture of giant knotweed rhizome, coptis root, rhubarb, baical skullcap root, coriaria sinica and white spiraea rhizome, wherein the giant knotweed rhizome, the coptis root, the rhubarb, the baical skullcap root, the coriaria sinica and the white spiraea rhizome are respectively 3 parts, 2 parts and 2 parts; 12 parts of a mixture of Chinese lobelia and honeysuckle, wherein the Chinese lobelia and the honeysuckle respectively account for 4 parts and 8 parts.
5. A preparation method of an external medicine for treating scalds and burns is characterized by comprising the following steps: the method comprises the following steps:
s100, weighing the following components in parts by weight for the external medicine: 55-75 parts of rhodiola rosea; 10-20 parts of bletilla striata; 8-13 parts of a mixture of giant knotweed, coptis, rhubarb, scutellaria, coriaria sinica and hydrangea macrophylla; 7-12 parts of a mixture of at least two of Chinese lobelia, red peony and honeysuckle;
wherein the weight ratio of the giant knotweed rhizome, the coptis root, the rhubarb, the coriaria sinica maxim and the inula tamarisk in the mixture of the giant knotweed rhizome, the coptis root, the rhubarb, the scutellaria root, the coriaria sinica maxim and the inula tamarisk is 1: 0.5-1:0.5-0.8:0.5-0.8:0.5-0.8: 0.5-0.8;
s200, detecting and treating harmful substance residues of the components of the external medicine;
and S300, after the detection treatment is qualified, preparing the powder, the spray or the ointment respectively through a powder preparation process and a spray preparation process.
S200, carrying out harmful residue detection treatment on the components of the external medicine, wherein the harmful residue detection treatment comprises the following steps:
s201, randomly sampling a set amount of external medicine component samples; grinding the external medicine component sample by a nano grinder to obtain nano powder of the medicine sample to be detected; dividing the drug sample nanopowder to be detected into a first group of drug sample nanopowder and a second group of drug sample nanopowder;
s202, blowing and mixing the first group of medicine sample nano powder by gas chromatography analysis carrier gas to form a first group of medicine sample to-be-detected aerosol; mixing and dissolving the second group of drug sample nanopowder through a liquid chromatography analysis solution to form a second group of drug sample solution to be detected;
s203, carrying out gas chromatography analysis on non-soluble harmful residual components in the nano powder of the drug sample to be detected; and (3) carrying out liquid chromatography analysis on easily soluble harmful residual components in the nano powder of the medicine sample to be detected, and identifying and detecting harmful residues contained in the components of the external medicine.
6. The method for preparing an external medicine for treating scalds and burns as claimed in claim 5, wherein: the step S203 includes the steps of:
s2031 gas chromatography of non-soluble harmful residue in nanometer powder of the sample to be tested comprises: enabling the pretreated first group of drug samples to be detected aerosol to enter a sample component collection cavity through a clean gas circuit pipeline; the sample component collecting cavity collects components of substances to be detected in the first group of medicinal samples to be detected in the aerosol to be detected, and gas subjected to component collecting treatment is output to the gas chromatographic column; the gas chromatographic column separates the components of the sample to be detected from the gas sucked through the sample component collecting cavity to obtain the components of the aerosol to be detected by chromatographic separation; carrying out gas chromatography detection on the components to be detected after chromatographic separation; and comparing and analyzing the prepared chromatographic separation aerosol component to be detected and the standard reference aerosol component by matching with fluorescence detection; obtaining a reference comparative analysis gas chromatogram;
s2032, the liquid chromatography analysis of the soluble harmful residual components in the nanometer powder of the drug sample to be detected comprises: inputting the solution to be detected of the second group of medicine samples into a liquid chromatographic column from the liquid sample to perform liquid component separation on the sample to be detected; obtaining chromatographic separation liquid to be detected; carrying out gas chromatography detection on the components to be detected of the chromatographic separation liquid; and the prepared chromatographic separation liquid to-be-detected components and the standard reference solution are contrasted and analyzed by matching with fluorescence detection; obtaining a reference contrast analysis liquid chromatogram;
s2033, performing image recognition on the reference contrast analysis gas chromatogram and the reference contrast analysis liquid chromatogram, and recognizing and detecting harmful substance residues contained in the components of the external medicine.
7. The preparation method of the externally applied powder for treating scalds and burns as claimed in claim 5, which is characterized in that: the preparation of the powder in the S300 by the powder preparation process comprises the following steps:
s311, weighing each component of the powder; and S312, respectively grinding and sieving by a sieve of 50-80 meshes, and uniformly mixing to obtain the powder.
8. The method for preparing the spray of the external medicine for treating the scalds and the burns as claimed in claim 5, which is characterized in that: the preparation of the spray in the S300 through the spray preparation process comprises the following steps:
s321, weighing each component of the spray, adding water, soaking for 15-20 hours, extracting at high temperature, and concentrating to form an extract; the weight ratio of the extract to the raw material medicines is 1: 4-6;
s322, filling according to the weight proportion of 35-50 parts of the extract, 15-30 parts of ethanol and 30-50 parts of distilled water to obtain a spray;
in the step S321, the high-temperature extraction is to boil with strong fire and then keep the temperature with slow fire for 1-2 hours; soaking for 15-20 hours after adding water, and continuously carrying out 3-5 times of circulation for high-temperature extraction and concentration.
9. The method for preparing an ointment for external use for treating scalds and burns as claimed in claim 5, wherein: the preparation of the S300 into the paste through the paste preparation process comprises the following steps:
s331, weighing each component of the paste, adding water, soaking for 15-20 hours, extracting at high temperature, and concentrating to form an extract; the weight ratio of the extract to the weight of the raw material medicines is 1: 4-6;
s332, uniformly mixing 65-90 parts of the extract, 5-15 parts of radix paeoniae rubra and 5-15 parts of glycerol according to the weight ratio to obtain the ointment.
10. The method for producing according to claim 9, characterized in that: in the step S331, the high-temperature extraction is to boil with strong fire and then keep the temperature with slow fire for 1-2 hours; soaking for 15-20 hours after adding water, and continuously carrying out 3-5 times of circulation for high-temperature extraction and concentration.
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| CN202210365903.4A CN114767785A (en) | 2022-04-08 | 2022-04-08 | External medicine for treating scald and burn and preparation method thereof |
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| CN202210365903.4A CN114767785A (en) | 2022-04-08 | 2022-04-08 | External medicine for treating scald and burn and preparation method thereof |
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