CN114767759A - Pharmaceutical composition for treating alopecia and application thereof - Google Patents

Pharmaceutical composition for treating alopecia and application thereof Download PDF

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Publication number
CN114767759A
CN114767759A CN202210440009.9A CN202210440009A CN114767759A CN 114767759 A CN114767759 A CN 114767759A CN 202210440009 A CN202210440009 A CN 202210440009A CN 114767759 A CN114767759 A CN 114767759A
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China
Prior art keywords
pharmaceutical composition
alopecia
scalp
treating alopecia
liquid medicine
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Pending
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CN202210440009.9A
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Chinese (zh)
Inventor
崔庆华
林晓
卢盈宇
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Peking University
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Peking University
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Publication of CN114767759A publication Critical patent/CN114767759A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Cosmetics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Animal Husbandry (AREA)

Abstract

The invention discloses a pharmaceutical composition for treating alopecia and application thereof, belonging to the field of medicines. The pharmaceutical composition comprises the content of the Suhuang cough-relieving capsule and pharmaceutically acceptable auxiliary agents. Taking the content of 1 granule of Suhuang cough relieving capsule as a raw material in parts by weight, adding 5ml of deionized water for full dissolution, and heating and stirring the dissolved liquid medicine for 30min to obtain the pharmaceutical composition for treating alopecia. When the scalp is in a dry state, the liquid medicine is dipped on the scalp by a cotton swab or a dropper and is cleaned when the liquid medicine is completely absorbed by the scalp. Can effectively prevent and treat alopecia, has short treatment course, quick response, no adverse reaction and toxic or side effect, and high safety.

Description

Pharmaceutical composition for treating alopecia and application thereof
Technical Field
The invention belongs to the field of medicines, and particularly relates to a pharmaceutical composition for treating alopecia and application thereof.
Background
Hair is a specially derived structure of the skin and is also a characteristic of mammals that plays an important role in aesthetics and maintenance of body temperature, among other things. Alopecia is a clinically common class of skin diseases characterized by hair loss, which affects up to 70% and 40% of the population in both men and women. The normal person drops 70-100 hairs every day, and meanwhile, the hairs are regenerated in an equivalent amount. If more than 100-120 hair drops per day, the hair is medically lost. The reasons for alopecia include heredity, aging, chemotherapy drugs, etc.; common pathological factors are immune system disorders and androgen-induced alopecia. At present, the means for treating alopecia mainly comprise oral medicines, external hair-increasing medicines, hair transplantation and the like, the oral medicines are sometimes accompanied with adverse reactions, the effect of the external medicine is very little, the hair transplantation is expensive and takes effect slowly, and certain risks exist. Thus, although various strategies have been applied to the treatment of alopecia, there is still a lack of effective and safe treatment methods.
Disclosure of Invention
The invention aims to disclose a pharmaceutical composition for treating alopecia, which has no chemical addition, no side effect, no toxicity or harm and can be used at ease.
The purpose of the invention is realized by the following technical scheme:
a pharmaceutical composition for treating alopecia, wherein:
the pharmaceutical composition comprises the content of the perilla yellow cough-relieving capsule.
Further, the pharmaceutical composition also comprises pharmaceutically acceptable auxiliary agents.
Further, the adjuvants include, but are not limited to: diluents, buffers, suspensions, emulsions, granules, encapsulating agents, excipients, fillers, adhesives, sprays, transdermal absorbents, wetting agents, disintegrants, absorption enhancers, surfactants, colorants, flavors, or adsorptive adjuvants.
The invention also discloses a shampoo added with the medicinal composition.
The invention also discloses a skin care product added with the pharmaceutical composition.
The invention also discloses application of any one of the pharmaceutical compositions in preparing a medicament for treating alopecia.
The invention also discloses a method for preparing the medicine for treating alopecia, which comprises the following steps:
taking a Su Huang cough relieving capsule (production enterprise: Beijing Haishi Yan pharmaceutical Co., Ltd., approved No. Z20103075 of Yangziang pharmaceutical industry group), removing the capsule shell, and taking the whole content as one part of the Su Huang cough relieving capsule content;
adding 5ml of deionized water into one part by weight of raw materials for fully dissolving;
heating and stirring the dissolved medicinal liquid for 30min, or directly dissolving in warm water.
The invention also discloses a medicine for treating alopecia, which is prepared by the preparation method.
The invention also discloses an application of the medicine in treating alopecia, which comprises the following steps:
when the scalp is in a dry state, the liquid medicine is dipped on the scalp by a cotton swab or a dropper, and the scalp is cleaned when the liquid medicine is completely absorbed by the scalp.
The invention has the beneficial effects that:
the medicinal Suhuang cough-relieving capsule disclosed by the invention is a known product and can be purchased from the market, and the raw materials are pure traditional Chinese medicine components, so that the capsule is non-toxic and harmless and has no stimulation effect on scalp. Simple preparation and use method, quick response and no relapse, and is a specific medicine for treating alopecia.
Detailed Description
In order that the invention may be more fully understood, the following description is included. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example 1
A Chinese medicinal capsule for treating alopecia, SUHUANGZHIKE Capsule, is prepared from brown particles, and has fragrant smell and slightly bitter taste.
The preparation method comprises the following steps:
1) taking one part of the content of the perilla yellow cough-relieving capsule by weight;
2) dissolving in 5mL warm water to obtain Suhuang cough relieving capsule content solution.
The using method comprises the following steps:
when scalp is dry, the content solution of SUHUANGZHIKE Capsule is dipped on scalp with cotton bud, and normal shampoo can be used after full exposure to scalp (more preferably more than 2 hr).
The treatment effect judgment standard is as follows:
the hair stops falling off, and the symptoms of greasiness, pruritus and desquamation disappear to be healed;
the alopecia phenomenon is improved, and the relieving symptoms of greasiness, pruritus and desquamation are judged to be effective;
the alopecia phenomenon is improved, and the symptoms of greasiness, pruritus and desquamation are relieved and the effect is judged to be effective;
the symptoms of alopecia, greasiness, pruritus and desquamation are not improved and judged to be ineffective.
The test result of the hair loss conditioning effect of the perilla yellow cough relieving capsule provided by the invention is as follows:
case 1: for the male. Seborrheic alopecia, after twice treatments with the contents of example 1, the symptoms were significantly improved without side effects, and the amount of alopecia was reduced by 80%.
Case 2: for the male. Androgenetic alopecia, treated once a week for a month using the contents of example 1, showed a significant improvement in symptoms without side effects.
Case 3: for the male. Androgenetic alopecia, treated once a week for a month with the contents of example 1, showed a better improvement in symptoms without side effects.
The results show that the content of the perilla yellow cough-relieving capsule is dissolved by warm water and then is smeared on scalp, thus effectively improving alopecia, having no toxic or side effect, simple and efficient method, no rebound phenomenon and good effect of treating alopecia.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is specific and detailed, but not to be understood as limiting the scope of the invention. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention.

Claims (9)

1. A pharmaceutical composition for treating alopecia, wherein:
the pharmaceutical composition comprises the content of the perilla yellow cough-relieving capsule.
2. The pharmaceutical composition of claim 1, wherein:
the pharmaceutical composition also comprises pharmaceutically acceptable auxiliary agents.
3. The pharmaceutical composition of claim 2, wherein:
the auxiliary agent comprises: diluents, buffers, suspensions, emulsions, granules, capsules, excipients, fillers, adhesives, sprays, transdermal absorbents, humectants, disintegrators, absorption promoters, surfactants, colorants, flavors, or adsorptive auxiliaries.
4. A shampoo containing the pharmaceutical composition as defined in any one of claims 1-3.
5. A skin care product to which the pharmaceutical composition according to any one of claims 1 to 3 is added.
6. Use of a pharmaceutical composition according to any one of claims 1 to 3 in the preparation of a medicament for the treatment of alopecia.
7. A method for preparing the agent for treating alopecia according to claim 6, comprising:
taking the content of 1 Suhuang cough-relieving capsule as a raw material in parts by weight for later use;
adding 5ml of deionized water into one part by weight of raw materials for fully dissolving;
heating and stirring the dissolved medicinal liquid for 30min to obtain the final product.
8. A medicament for treating alopecia prepared by the process according to claim 7.
9. Use of a medicament according to claim 8 for the treatment of alopecia, comprising:
when the scalp is in a dry state, the liquid medicine is dipped on the scalp by a cotton swab or a dropper and is cleaned when the liquid medicine is completely absorbed by the scalp.
CN202210440009.9A 2022-04-25 2022-04-25 Pharmaceutical composition for treating alopecia and application thereof Pending CN114767759A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210440009.9A CN114767759A (en) 2022-04-25 2022-04-25 Pharmaceutical composition for treating alopecia and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210440009.9A CN114767759A (en) 2022-04-25 2022-04-25 Pharmaceutical composition for treating alopecia and application thereof

Publications (1)

Publication Number Publication Date
CN114767759A true CN114767759A (en) 2022-07-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210440009.9A Pending CN114767759A (en) 2022-04-25 2022-04-25 Pharmaceutical composition for treating alopecia and application thereof

Country Status (1)

Country Link
CN (1) CN114767759A (en)

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Application publication date: 20220722