CN114761383A - 磺酰胺衍生物及其用途 - Google Patents

磺酰胺衍生物及其用途 Download PDF

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Publication number
CN114761383A
CN114761383A CN202080057150.XA CN202080057150A CN114761383A CN 114761383 A CN114761383 A CN 114761383A CN 202080057150 A CN202080057150 A CN 202080057150A CN 114761383 A CN114761383 A CN 114761383A
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China
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compound
alkyl
alkyl radical
optionally substituted
substituted
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Pending
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CN202080057150.XA
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English (en)
Chinese (zh)
Inventor
M·G·波克
D·哈里森
J·E·斯坎伦
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Northera Ltd
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Northera Ltd
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Publication of CN114761383A publication Critical patent/CN114761383A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202080057150.XA 2019-06-12 2020-06-11 磺酰胺衍生物及其用途 Pending CN114761383A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962860661P 2019-06-12 2019-06-12
US62/860661 2019-06-12
PCT/EP2020/066196 WO2020249669A1 (en) 2019-06-12 2020-06-11 Sulfonamide derivatives and uses thereof

Publications (1)

Publication Number Publication Date
CN114761383A true CN114761383A (zh) 2022-07-15

Family

ID=71108564

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080057150.XA Pending CN114761383A (zh) 2019-06-12 2020-06-11 磺酰胺衍生物及其用途

Country Status (5)

Country Link
US (1) US20220267300A1 (enExample)
EP (1) EP3983388A1 (enExample)
JP (1) JP2022535955A (enExample)
CN (1) CN114761383A (enExample)
WO (1) WO2020249669A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
CN114641466B (zh) 2019-06-12 2025-09-30 诺瑟拉有限公司 磺酰脲衍生物及其用途
EP4559461A1 (en) * 2023-11-22 2025-05-28 Servicio Andaluz De Salud Dual nlrp1 and nlrp3 inhibitors for use as a medicament

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758500A (en) * 1970-02-03 1973-09-11 Merck Sharp & Dohme N-sulfonyl-indole-3-acetamides
CN1084515A (zh) * 1992-05-06 1994-03-30 E·R·斯奎布父子公司 苯基氨磺酰内皮(endothelin)拮抗药
CN1646509A (zh) * 2002-03-28 2005-07-27 诺瓦提斯公司 作为类固醇硫酸酯酶抑制剂的哌嗪基－或哌啶基胺─氨基磺酸酰胺
WO2016131098A1 (en) * 2015-02-16 2016-08-25 The University Of Queensland Sulfonylureas and related compounds and use of same
WO2017184604A1 (en) * 2016-04-18 2017-10-26 Ifm Therapeutics, Inc Compounds and compositions for treating conditions associated with nlrp activity
WO2018015445A1 (en) * 2016-07-20 2018-01-25 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
CN108513574A (zh) * 2015-10-09 2018-09-07 艾伯维公司 N-磺酰化吡唑并[3,4-b]吡啶-6-甲酰胺和使用方法
WO2018225018A1 (en) * 2017-06-09 2018-12-13 Cadila Healthcare Limited Novel substituted sulfoximine compounds
CN109071454A (zh) * 2016-02-16 2018-12-21 昆士兰大学 磺酰脲和相关化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
WO1993004045A1 (en) * 1991-08-19 1993-03-04 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
AU2494792A (en) * 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
AU7782694A (en) * 1993-09-28 1995-04-18 Ciba-Geigy Ag Acylated sulphonamides as insecticides and acaricides
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
GB201721185D0 (en) * 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
GB201902327D0 (en) * 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
US12187702B2 (en) * 2018-08-15 2025-01-07 Inflazome Limited Sulfonamideurea compounds

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758500A (en) * 1970-02-03 1973-09-11 Merck Sharp & Dohme N-sulfonyl-indole-3-acetamides
CN1084515A (zh) * 1992-05-06 1994-03-30 E·R·斯奎布父子公司 苯基氨磺酰内皮(endothelin)拮抗药
CN1646509A (zh) * 2002-03-28 2005-07-27 诺瓦提斯公司 作为类固醇硫酸酯酶抑制剂的哌嗪基－或哌啶基胺─氨基磺酸酰胺
WO2016131098A1 (en) * 2015-02-16 2016-08-25 The University Of Queensland Sulfonylureas and related compounds and use of same
CN108513574A (zh) * 2015-10-09 2018-09-07 艾伯维公司 N-磺酰化吡唑并[3,4-b]吡啶-6-甲酰胺和使用方法
CN109071454A (zh) * 2016-02-16 2018-12-21 昆士兰大学 磺酰脲和相关化合物及其用途
WO2017184604A1 (en) * 2016-04-18 2017-10-26 Ifm Therapeutics, Inc Compounds and compositions for treating conditions associated with nlrp activity
WO2018015445A1 (en) * 2016-07-20 2018-01-25 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
WO2018225018A1 (en) * 2017-06-09 2018-12-13 Cadila Healthcare Limited Novel substituted sulfoximine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FLAVIA IZZO, ET AL.: ""Exploration of Novel Chemical Space: Synthesis and in vitro Evaluation of N-Functionalized Tertiary Sulfonimidamides"", CHEMISTRY - A EUROPEAN JOURNAL, vol. 24, no. 37, pages 9295 - 9304, XP055626913, DOI: 10.1002/chem.201801557 *

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EP3983388A1 (en) 2022-04-20
US20220267300A1 (en) 2022-08-25
WO2020249669A1 (en) 2020-12-17
JP2022535955A (ja) 2022-08-10

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