CN114755432B - Multi-channel fluorescence immunochromatographic assay system and method - Google Patents
Multi-channel fluorescence immunochromatographic assay system and method Download PDFInfo
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- CN114755432B CN114755432B CN202210660283.7A CN202210660283A CN114755432B CN 114755432 B CN114755432 B CN 114755432B CN 202210660283 A CN202210660283 A CN 202210660283A CN 114755432 B CN114755432 B CN 114755432B
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Abstract
The application discloses a multi-channel fluorescence immunochromatographic assay system and a method; the system comprises a master control center, an analysis and detection system and an access card system; the analysis and detection system comprises a controller, an analyzer body provided with N detection channels and N detection devices; the card access system comprises a driving device and a storage device, wherein each side of the storage device is provided with N cavities corresponding to the N detection channels; the chamber is internally provided with a lifting control device and a telescopic control device of which the end part is provided with an adsorption device; the lifting control device is used for adjusting the height of the telescopic control device; the telescopic control device is used for driving the adsorption device to convey the reagent card between the interior of the cavity and the interior of the detection channel; the master control center controls the storage device to rotate by a preset angle based on the detection completion signal received by the controller so as to automatically detect the reagent card on the other side; the method and the device have the advantages of high detection efficiency, diversified detection items and capability of independently detecting different items.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a multi-channel fluorescence immunochromatographic assay system and a multi-channel fluorescence immunochromatographic assay method.
Background
Generally, in a laboratory, when a liquid sample to be detected is sent to be detected, the liquid sample to be detected is placed in each sample reagent tube, an operator needs to manually suck sample liquid from the sample reagent tube, then the sample liquid is injected into a detection reagent card, the detection reagent card containing the liquid sample to be detected is placed into a fluorescence immunoassay analyzer one by one at a time to receive fluorescence immunoassay, after the analysis is completed, the old detection reagent card is manually taken out, a new detection reagent card is placed, mechanical manual operation is performed, the labor intensity of the detector is high, and the detection efficiency is low.
The existing fluorescence immunochromatographic analyzer comprises a single-channel instrument type and a multi-channel instrument type, but the single-channel instrument type cannot detect various different items simultaneously, the detection items are single, and the detection speed cannot be improved; the type of the multi-channel instrument is only provided with one inlet, and the multi-channel instrument needs to be queued for detection, so that the whole detection process is inconvenient, the reagent card to be detected and the detected reagent card are easy to be confused, and the detection period is long.
Disclosure of Invention
In order to solve the problems that the existing detection efficiency is low, the detection items are single, and different item detections cannot be independently carried out, the application provides a multi-channel fluorescence immunochromatographic assay system and a multi-channel fluorescence immunochromatographic assay method.
The multichannel fluorescence immunochromatographic assay system provided by the first aspect of the application adopts the following technical scheme:
a multi-channel fluorescence immunochromatographic assay system comprises a master control center, an analysis detection system and an access card system, wherein the analysis detection system and the access card system are both arranged on a bearing platform and are in signal connection with the master control center;
the analysis and detection system comprises a controller, an analyzer body and N detection devices, wherein the analyzer body is provided with N detection channels, and the N detection devices are matched with the N detection channels to perform fluorescence detection on N reagent cards;
the card access system comprises a driving device and a storage device, wherein each side of the storage device is provided with N cavities corresponding to the N detection channels;
a telescopic control device and a lifting control device are arranged in the chamber; the end part of the telescopic control device is provided with an adsorption device; the lifting control device is arranged at the bottom of the telescopic control device to bear the telescopic control device; in a first state, the telescopic control device drives the adsorption device to descend under the driving of the lifting control device so as to adsorb the reagent card to be detected in the chamber; in a second state, the adsorption device is driven by the lifting control device to ascend, driven by the telescopic control device to suspend to the interior of the detection channel, and the reagent card is loosened; in a third state, the adsorption device adsorbs the detected reagent card and recovers the reagent card into the chamber under the driving of the telescopic control device;
and the master control center controls the driving device to drive the storage device to rotate by a preset angle based on the detection completion signal received by the controller so as to automatically detect the reagent card to be detected in the N chambers on the other side.
By adopting the technical scheme, a plurality of detection channels can be provided and are arranged independently, so that not only can the batch quick detection of the same item be carried out, but also the batch detection of different items can be realized, and the detection efficiency is high; in addition, through the cavity that storage device and test passage match the setting, guarantee that the inside reagent card of each test passage does not obscure each other, the testing process is swift accurate, and artifical intensity is low, and degree of automation is high.
Preferably, the lifting control device comprises a lifting driving motor and a bearing plate, and the bearing plate is fixedly arranged at the power output end of the lifting driving motor.
By adopting the technical scheme, the position of the reagent card to be detected can be flexibly controlled.
Preferably, the telescopic control device comprises a first motor and a first telescopic rod, and the first telescopic rod is arranged at the power output end of the first motor; the first motor is fixedly arranged on the bearing plate;
the number of the telescopic control devices is two, and the two telescopic control devices are arranged in parallel;
the distance between the two telescopic control devices is smaller than the width of the reagent card.
By adopting the technical scheme, the reagent card can be effectively controlled, and can be effectively adsorbed without damaging the reagent card when the position of the reagent card is moved; after the reagent card is moved into position, the reagent card can be moved to a position where the detection of the reagent card is not affected.
Preferably, the adsorption device comprises a vacuumizing power motor and a sucker, and the sucker is connected with the vacuumizing power motor through a hose; and the vacuumizing power motor is used for controlling the adsorption or release of the sucker and the reagent card.
By adopting the technical scheme, the reagent card can be fixed without being damaged.
Preferably, the number of the storage devices is M, and the M storage devices are arranged in parallel in the vertical direction; two adjacent storage devices are fixedly connected through a bearing column.
By adopting the technical scheme, the storage capacity of the reagent card of the system is greatly improved.
Preferably, a recovery device is arranged below each storage device;
the bottom of the cavity is provided with an opening and closing door in signal connection with the master control center;
and the master control center opens the opening and closing door based on the information that the detected reagent card is a waste card so as to control the corresponding adsorption device to loosen the detected reagent card and the recovery device to carry and recover the reagent card.
By adopting the technical scheme, automatic waste card collection can be realized, the storage of a new reagent card to be detected is not influenced, the storage efficiency is high, and the efficient uninterrupted detection of an analysis detection system can be ensured.
Preferably, the analysis and detection system further comprises a power device, wherein the power device is arranged at the bottom of the analyzer body to bear the analyzer body;
the power device is used for controlling the height adjustment of the analyzer body so as to be matched with the storage device with the corresponding height.
By adopting the technical scheme, the accommodating capacity and flexibility of the system are improved, and the detection efficiency of the reagent cards in batches is effectively improved.
Preferably, N of the detection channels are independently provided.
By adopting the technical scheme, the detection of different items can be simultaneously carried out.
Preferably, the drive means is a rotary platform.
Through adopting above-mentioned technical scheme, not only can carry out accurate rotation control to storage device, can also guarantee a plurality of storage device's the bearing strength.
The multichannel fluorescence immunochromatographic assay provided by the second aspect of the application adopts the following technical scheme:
a multi-channel fluorescence immunochromatographic assay method based on the multi-channel fluorescence immunochromatographic assay system of any one of the above, comprising the steps of:
controlling the adsorption device to descend so as to adsorb the reagent card to be detected in the chamber;
controlling the adsorption device to ascend, controlling the adsorption device to suspend in the detection channel, and loosening the reagent card; controlling the adsorption device to move to a preset position, wherein the adsorption device and the detection device are not interfered with each other;
starting a detection device to detect the reagent card;
the adsorption device adsorbs the detected reagent card and recovers the reagent card to the inside of the chamber;
based on the received detection completion signal of the controller, the driving device is controlled to drive the storage device to rotate by a preset angle so as to automatically detect the reagent card to be detected in the N chambers on the other side of the storage device.
By adopting the technical scheme, batch simultaneous detection of the reagent cards can be realized, the detection efficiency is high, the reagent cards to be detected and the detected reagent cards cannot be confused, and the automation degree is high.
In summary, the present application includes at least one of the following beneficial technical effects:
1. by the multi-channel fluorescence immunochromatographic assay system disclosed by the first aspect of the application, simultaneous detection of a plurality of reagent cards of the same project and simultaneous detection of a plurality of actual cards of different projects can be realized; through the setting of the card access system, the large-capacity storage of the reagent cards to be detected can be carried out, the simultaneous transmission of the reagent cards to be detected in batches can be realized, the simultaneous output of the reagent cards to be detected in batches can be realized, the detection efficiency is high, the period is short, and the automation degree is high.
2. Through the independent setting of N detection channel, provide N import, can carry out the reagent card that corresponds the project and detect, effectively prevent to detect reagent card and the confusion of having detected the reagent card.
3. The memory space of the reagent card to be detected is greatly improved by setting M memory devices; through the setting of power device, can carry out nimble regulation to the height of analysis appearance body to match with the storage device who corresponds the height and detect.
4. This application simple structure, degree of automation are high.
Drawings
FIG. 1 is a schematic perspective view of a first embodiment of a multi-channel fluorescence immunochromatographic assay system of the present application.
FIG. 2 is a schematic diagram of the analytical test system of FIG. 1.
Fig. 3 is a schematic view of the structure of the center subassembly of fig. 2.
Fig. 4 is a schematic structural diagram of the detection apparatus in fig. 3.
Fig. 5 is a schematic cross-sectional view of the storage device of fig. 1.
Fig. 6 is a schematic configuration diagram of the expansion and contraction control device, the elevation control device, and the suction device in fig. 5.
FIG. 7 is a schematic perspective view of a second embodiment of the multi-channel fluorescence immunochromatographic assay system of the present application.
FIG. 8 is a schematic perspective view of a third embodiment of the multi-channel fluorescence immunochromatographic assay system of the present application.
Description of reference numerals: 100. an analytical detection system; 110. an analyzer body; 111. a detection channel; 112. a control panel; 113. a positioning assembly; 114. a limiting component; 115. a transmission assembly; 116. a base; 117. a power source; 118. a fan; 121. a scanning assembly; 122. an optical path component; 130. a power plant; 200. an access card system; 210. a drive device; 220. a storage device; 221. a chamber; 230. a telescoping control device; 240. a lift control device; 250. an adsorption device; 260. a recovery device; 300. a load-bearing platform; 400. and (4) reagent cards.
Detailed Description
The present application is described in further detail below with reference to fig. 1-8.
A first aspect of the application discloses a multi-channel fluorescence immunochromatographic assay system.
Example one
Referring to fig. 1 and fig. 2, the multichannel fluorescence immunochromatographic assay system disclosed in the present application includes a master control center, an assay detection system 100 and an access card system 200, wherein the assay detection system 100 and the access card system 200 are both installed on a bearing platform 300 and are both in signal connection with the master control center; wherein, the analysis and detection system 100 is used for detecting the reagent card 400; the access card system 200 is used to store a batch of reagent cards 400 to be tested in an initial test state and automatically recover the tested reagent cards 400.
When the reagent cards 400 are of the same item, the access card system 200 can simultaneously convey the same batch of reagent cards 400 to be tested, and the analysis and detection system 100 can simultaneously detect the same batch of reagent cards 400 to be tested; after the test is completed, the card access system 200 recovers the same tested reagent cards 400 in a corresponding batch at the same time.
When the reagent cards 400 are different types of items, the access card system 200 can simultaneously convey different types of the reagent cards 400 to be tested in batches, simultaneously detect the different types of the reagent cards 400 to be tested in batches through the analysis and detection system 100, and after the detection is finished, when the detection time requirements of the different types of the reagent cards 400 to be tested are different, the access card system 200 can carry out the in-situ recovery of the detected reagent cards 400 of the corresponding channels according to the detected completion condition in the corresponding detection channels 111.
Specifically, the analysis and detection system 100 includes a controller, an analyzer body 110 and N detection devices, wherein the analyzer body 110 is provided with N detection channels 111, and the N detection devices are arranged in a matching manner with the N detection channels 111 to perform fluorescence detection on the N reagent cards 400; the card access system 200 includes a driving device 210 and a storage device 220, wherein each side of the storage device 220 is opened with N chambers 221 corresponding to the N detection channels 111.
The analyzer body 110 includes a base 116 and a control panel 112 covering the base 116.
After the detection and recovery of the reagent cards 400 to be detected on one side of the storage device 220 are completed, the storage device 220 is driven by the driving device 210 to rotate by a preset angle, so as to perform automatic detection of the reagent cards 400 to be detected in the N chambers 221 on the other side.
Preferably, the N detection channels 111 are independently provided.
Referring to fig. 3 and 4, in the present embodiment, N is 3; the detection channel 111 is provided with a positioning assembly 113 inside for carrying the fed reagent card 400 to be detected.
The upper parts of the three detection channels 111 are provided with three optical path assemblies 122 for fluorescence excitation inside the corresponding detection channels 111.
The bottom of the three detection channels 111 is correspondingly provided with three transmission assemblies 115 for adjusting the position of the positioning assembly 113 arranged therein.
Further, three scanning assemblies 121 are disposed, and the three scanning assemblies 121 are disposed inside the top plate of the control panel 112 and are disposed corresponding to the three detection channels 111 for performing detection processing of corresponding fluorescence signals.
The inner ends of the three detection channels 111 are also correspondingly provided with three limiting components 114 for limiting the three light path components 122 respectively; it should be noted that, in this embodiment, the scanning component 121 and the optical path component 122 are disposed in a staggered manner, so that after the reagent card 400 to be detected is placed on the detection channel 111, the optical path component 122 disposed thereon is used for exciting fluorescence, the moving device drives the reagent card 400 to move to a preset position, and the scanning component 121 scans to obtain corresponding information.
Specifically, the detection channel 111 in this embodiment is a through cavity formed by a structure provided on the base 116 and the top surface of the base 116, and the through cavity is opened outward.
Referring to fig. 5 and 6, a telescopic control device 230 and a lifting control device 240 are provided inside the chamber 221; the end of the telescopic control device 230 is provided with an adsorption device 250; the lifting control device 240 is disposed at the bottom of the telescoping control device 230 to carry the telescoping control device 230.
In the first working state, the expansion control device 230 drives the adsorption device 250 to descend under the driving of the lifting control device 240, so as to adsorb the reagent card 400 to be detected in the chamber 221.
In the second operating state, the adsorption device 250 is driven by the elevation control device 240 to ascend, and driven by the expansion control device 230 to suspend inside the detection channel 111, and the reagent card 400 is released.
In the third operating state, the adsorption device 250 adsorbs the detected reagent card 400 and recovers it into the chamber 221 by the driving of the expansion control device 230.
Further, the lifting control device 240 includes a lifting driving motor and a bearing plate, wherein the bearing plate is fixedly disposed at a power output end of the lifting driving motor.
Further, the telescopic control device 230 includes a first motor and a first telescopic rod, the first telescopic rod is disposed at the power output end of the first motor; the first motor is fixedly arranged on the bearing plate.
Two telescopic control devices 230 are arranged, and the two telescopic control devices 230 are arranged in parallel; the distance between the two telescoping control devices 230 is less than the width of the reagent card 400.
Further, the adsorption device 250 comprises a vacuum-pumping power motor and a suction cup, and the suction cup is connected with the vacuum-pumping power motor through a hose; the vacuumizing power motor is used for controlling the suction or the release of the suction cup and the reagent card 400.
Preferably, the driving means 210 is a rotating platform.
The embodiment of the application discloses a multichannel fluorescence immunochromatographic assay system, which has the implementation principle that: in an initial state, storing the reagent cards 400 to be detected in batches through the card access system 200; when detection is needed, the reagent card 400 to be detected is adsorbed and fixed through the telescopic control device 230, the lifting control device 240 and the adsorption device 250 which are arranged in the storage device 220, and then the reagent card is suspended to the corresponding detection channel 111 in the analyzer body 110, so that the corresponding detection devices can conveniently detect one by one. After the reagent card 400 inside the corresponding detection channel 111 is detected, the detected reagent card 400 is adsorbed and fixed through the telescopic control device 230, the lifting control device 240 and the adsorption device 250 and is brought back to the corresponding chamber 221 for placing, so that the detection efficiency is greatly improved, the detection period of the reagent cards 400 in batches is shortened, and the labor intensity is effectively reduced.
In addition, through the multichannel fluorescence immunochromatographic assay system disclosed in the first aspect of the present application, batch detection of reagent cards 400 of different projects can be performed, and by the chambers 221 arranged in one-to-one correspondence to the plurality of detection channels 111, co-location recovery of a single reagent card 400 is ensured, confusion between the detected reagent card 400 and the undetected reagent card 400 is prevented, and the multichannel fluorescence immunochromatographic assay system is high in accuracy and automation degree.
Example two
Referring to fig. 7, M storage devices 220 are provided, and the M storage devices 220 are arranged in parallel in the vertical direction; two adjacent storage devices 220 are fixedly connected through a bearing column. In the embodiment, M is 3, it should be noted that the present embodiment does not limit the protection scope of the present application, and therefore, descriptions of other numbers of the storage devices 220 are not repeated herein.
The storage capacity of the reagent card 400 is effectively improved by the arranged multilayer storage device 220; each side of each layer is correspondingly arranged with the detection channel 111, and synchronous conveying and recovery are realized.
In the fourth working state, the master control center controls the driving device 210 to drive the storage device 220 to rotate by a preset angle based on the detection completion signal received by the controller, so as to automatically detect the reagent card 400 to be detected in the N chambers 221 on the other side.
The analysis and detection system 100 further includes a power device 130, wherein the power device 130 is disposed at the bottom of the analyzer body 110 to support the analyzer body 110; the power device 130 is used to control the height adjustment of the analyzer body 110 to match with the storage device 220 with the corresponding height, so as to further improve the synchronization rate between the access card system 200 and the analysis and detection system 100.
EXAMPLE III
Referring to fig. 8, a recovery device 260 is provided below each storage device 220; the bottom of the cavity 221 is provided with an opening and closing door in signal connection with the master control center; the master control center opens the opening and closing door based on the information that the detected reagent card 400 is a waste card, so as to control the corresponding adsorption device 250 to release the detected reagent card 400, and the recovery device 260 carries the information for recovery.
Specifically, the recovery device 260 is a recovery tray.
The second aspect of the present application discloses a multichannel fluorescence immunochromatographic assay method based on the multichannel fluorescence immunochromatographic assay system, comprising the following steps:
controlling the adsorption device 250 to descend so as to adsorb the reagent card 400 to be detected in the chamber 221;
controlling the adsorption device 250 to ascend, controlling the adsorption device to suspend to the interior of the detection channel 111, and loosening the reagent card 400; controlling the adsorption device 250 to move to a preset position without interfering with the detection device;
starting the detection device to detect the reagent card 400;
the adsorption device 250 adsorbs the detected reagent card 400 and recovers the reagent card into the chamber 221;
based on the detection completion signal received by the controller, the driving device 210 is controlled to drive the storage device 220 to rotate by a preset angle, so as to automatically detect the reagent cards 400 to be detected in the N chambers 221 on the other side of the storage device 220.
The implementation principle of the above embodiment is as follows: the reagent card automatic conveying and recovery of the analysis and detection system are realized through the card access system, the batch detection of the reagent cards is realized, the detection efficiency is high, the reagent cards to be detected and the detected reagent cards cannot be confused, and the automation degree is high.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (10)
1. A multi-channel fluorescence immunochromatographic assay system is characterized in that: the system comprises a master control center, an analysis and detection system (100) and an access card system (200), wherein the analysis and detection system (100) and the access card system (200) are both arranged on a bearing platform (300) and are in signal connection with the master control center;
the analysis and detection system (100) comprises a controller, an analyzer body (110) and N detection devices, wherein the analyzer body (110) is provided with N detection channels (111), and the N detection devices are matched with the N detection channels (111) to perform fluorescence detection on N reagent cards (400);
the access card system (200) comprises a driving device (210) and a storage device (220), wherein each side of the storage device (220) is provided with N chambers (221) corresponding to the N detection channels (111);
a telescopic control device (230) and a lifting control device (240) are arranged in the chamber (221); the end part of the telescopic control device (230) is provided with an adsorption device (250); the lifting control device (240) is arranged at the bottom of the telescopic control device (230) to bear the telescopic control device (230); in a first state, the telescopic control device (230) drives the adsorption device (250) to descend under the driving of the lifting control device (240) so as to adsorb the reagent card (400) to be detected in the chamber (221); in a second state, the adsorption device (250) is driven by the lifting control device (240) to ascend, driven by the telescopic control device (230) to overhang into the detection channel (111), and releases the reagent card (400); in a third state, the adsorption device (250) adsorbs the detected reagent card (400) and recovers the reagent card into the chamber (221) under the driving of the expansion control device (230);
the master control center controls the driving device (210) to drive the storage device (220) to rotate by a preset angle based on the detection completion signal received by the controller so as to automatically detect the reagent cards (400) to be detected in the N chambers (221) on the other side.
2. The multi-channel fluorescence immunochromatographic assay system according to claim 1, wherein: the lifting control device (240) comprises a lifting driving motor and a bearing plate, and the bearing plate is fixedly arranged at the power output end of the lifting driving motor.
3. The multi-channel fluorescence immunochromatographic assay system according to claim 2, wherein: the telescopic control device (230) comprises a first motor and a first telescopic rod, and the first telescopic rod is arranged at the power output end of the first motor; the first motor is fixedly arranged on the bearing plate;
two telescopic control devices (230) are arranged, and the two telescopic control devices (230) are arranged in parallel;
the distance between the two telescopic control devices (230) is smaller than the width of the reagent card (400).
4. The multi-channel fluorescence immunochromatographic assay system according to claim 3, wherein: the adsorption device (250) comprises a vacuumizing power motor and a sucker, and the sucker is connected with the vacuumizing power motor through a hose; the vacuumizing power motor is used for controlling the suction disc to be adsorbed or loosened with the reagent card (400).
5. The multi-channel fluorescence immunochromatographic assay system according to claim 1, wherein: the number of the storage devices (220) is M, and the M storage devices (220) are arranged in parallel in the vertical direction; two adjacent storage devices (220) are fixedly connected through a bearing column.
6. The multi-channel fluorescence immunochromatographic assay system according to claim 5, wherein: a recovery device (260) is arranged below each storage device (220);
the bottom of the cavity (221) is provided with a starting and closing door in signal connection with the master control center;
and the master control center opens the opening and closing door based on the information that the detected reagent card (400) is a waste card so as to control the corresponding adsorption device (250) to release the detected reagent card (400), and the recovery device (260) carries the recovery.
7. The multi-channel fluorescence immunochromatographic assay system according to claim 5, wherein: the analysis and detection system (100) further comprises a power device, wherein the power device is arranged at the bottom of the analyzer body (110) to bear the analyzer body (110);
the power device is used for controlling the height adjustment of the analyzer body (110) so as to be matched with the storage device (220) with the corresponding height.
8. The multi-channel fluorescence immunochromatographic assay system according to claim 1, wherein: the N detection channels (111) are independently arranged.
9. The multi-channel fluorescence immunochromatographic assay system according to claim 1, wherein: the driving device (210) is a rotary platform.
10. A multi-channel fluorescence immunochromatographic assay method is characterized in that: the method is based on a multi-channel fluorescence immunochromatographic assay system according to any one of claims 1 to 9, comprising the steps of:
controlling the adsorption device (250) to descend so as to adsorb the reagent card (400) to be detected in the chamber (221);
controlling the adsorption device (250) to ascend, controlling the adsorption device to suspend to the interior of the detection channel (111), and loosening the reagent card (400); controlling the adsorption device (250) to move to a preset position, wherein the adsorption device and the detection device are not interfered with each other;
starting the detection device to detect the reagent card (400);
the adsorption device (250) adsorbs the detected reagent card (400) and recovers the reagent card into the chamber (221);
based on the detection completion signal received by the controller, the driving device (210) is controlled to drive the storage device (220) to rotate by a preset angle so as to automatically detect the reagent cards (400) to be detected in the N chambers (221) on the other side of the storage device (220).
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| CN114217087A (en) * | 2021-12-23 | 2022-03-22 | 安图实验仪器(郑州)有限公司 | Chemiluminescence immunity analyzer |
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| CN208497068U (en) * | 2018-06-06 | 2019-02-15 | 广东昭信智能装备有限公司 | A kind of reagent strip cutting device |
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| CN114217087A (en) * | 2021-12-23 | 2022-03-22 | 安图实验仪器(郑州)有限公司 | Chemiluminescence immunity analyzer |
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| CN114755432A (en) | 2022-07-15 |
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