CN114746086A - 大麻二酚型大麻素化合物 - Google Patents

大麻二酚型大麻素化合物 Download PDF

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Publication number
CN114746086A
CN114746086A CN202080080992.7A CN202080080992A CN114746086A CN 114746086 A CN114746086 A CN 114746086A CN 202080080992 A CN202080080992 A CN 202080080992A CN 114746086 A CN114746086 A CN 114746086A
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CN
China
Prior art keywords
cbdv
cbd
cannabidiol
cannabis
cannabinoids
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Pending
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CN202080080992.7A
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English (en)
Chinese (zh)
Inventor
杰弗里·盖伊
沃尔克·纳珀兹
本杰明·惠利
玛丽·伍利-罗伯茨
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Jiwei Research Co ltd
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Jiwei Research Co ltd
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Publication date
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Publication of CN114746086A publication Critical patent/CN114746086A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/70—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
    • C07C37/82—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202080080992.7A 2019-11-21 2020-11-18 大麻二酚型大麻素化合物 Pending CN114746086A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1916977.0A GB201916977D0 (en) 2019-11-21 2019-11-21 Cannibidol-type cannabinoid compound
GB1916977.0 2019-11-21
PCT/GB2020/052944 WO2021099783A1 (en) 2019-11-21 2020-11-18 Cannabidiol-type cannabinoid compound

Publications (1)

Publication Number Publication Date
CN114746086A true CN114746086A (zh) 2022-07-12

Family

ID=69137226

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080080992.7A Pending CN114746086A (zh) 2019-11-21 2020-11-18 大麻二酚型大麻素化合物

Country Status (15)

Country Link
US (1) US11590087B2 (https=)
EP (1) EP4061345A1 (https=)
JP (1) JP2023503309A (https=)
KR (1) KR20220103998A (https=)
CN (1) CN114746086A (https=)
AU (1) AU2020388278A1 (https=)
BR (1) BR112022009580A2 (https=)
CA (1) CA3158192A1 (https=)
GB (2) GB201916977D0 (https=)
IL (1) IL293035A (https=)
MX (1) MX2022006046A (https=)
PY (1) PY2076931A (https=)
TW (1) TW202132250A (https=)
WO (1) WO2021099783A1 (https=)
ZA (1) ZA202206386B (https=)

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GB2597321A (en) 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
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GB2606334A (en) * 2021-02-12 2022-11-09 Gw Res Ltd Use of cannabidivarin in the treatment of seizures associated with canine epilepsy
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KR20220103998A (ko) 2022-07-25
US20220265573A1 (en) 2022-08-25
US11590087B2 (en) 2023-02-28
EP4061345A1 (en) 2022-09-28
GB201916977D0 (en) 2020-01-08
WO2021099783A1 (en) 2021-05-27
GB2590187A9 (en) 2023-05-17
TW202132250A (zh) 2021-09-01
CA3158192A1 (en) 2021-05-27
JP2023503309A (ja) 2023-01-27
PY2076931A (es) 2021-07-15
GB2590187A (en) 2021-06-23
MX2022006046A (es) 2022-06-24
ZA202206386B (en) 2023-12-20
BR112022009580A2 (pt) 2022-08-02
GB2590187B (en) 2024-07-31
IL293035A (en) 2022-07-01
AU2020388278A1 (en) 2022-06-16
GB202018139D0 (en) 2020-12-30

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Application publication date: 20220712