CN114729296A - 一种脂肪碎解器械及方法 - Google Patents
一种脂肪碎解器械及方法 Download PDFInfo
- Publication number
- CN114729296A CN114729296A CN202080052202.4A CN202080052202A CN114729296A CN 114729296 A CN114729296 A CN 114729296A CN 202080052202 A CN202080052202 A CN 202080052202A CN 114729296 A CN114729296 A CN 114729296A
- Authority
- CN
- China
- Prior art keywords
- filter
- adipose tissue
- filter stack
- combined
- pores
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 69
- 210000000577 adipose tissue Anatomy 0.000 claims abstract description 78
- 230000002792 vascular Effects 0.000 claims abstract description 34
- 210000000130 stem cell Anatomy 0.000 claims abstract description 21
- 238000002955 isolation Methods 0.000 claims abstract description 7
- 238000001531 micro-dissection Methods 0.000 claims abstract description 5
- 239000011148 porous material Substances 0.000 claims description 64
- 210000004027 cell Anatomy 0.000 claims description 32
- 238000000926 separation method Methods 0.000 claims description 23
- 229910001220 stainless steel Inorganic materials 0.000 claims description 14
- 239000010935 stainless steel Substances 0.000 claims description 14
- 239000011159 matrix material Substances 0.000 claims description 13
- 239000004417 polycarbonate Substances 0.000 claims description 12
- 229920000515 polycarbonate Polymers 0.000 claims description 12
- 238000003466 welding Methods 0.000 claims description 9
- 230000002708 enhancing effect Effects 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 239000007943 implant Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000013467 fragmentation Methods 0.000 description 7
- 238000006062 fragmentation reaction Methods 0.000 description 7
- 238000007789 sealing Methods 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 231100000241 scar Toxicity 0.000 description 3
- 230000035899 viability Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000002659 cell therapy Methods 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/05—Means for pre-treatment of biological substances by centrifugation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2020/060324 WO2022096917A1 (en) | 2020-11-03 | 2020-11-03 | Fat fragmentation device and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114729296A true CN114729296A (zh) | 2022-07-08 |
Family
ID=81457578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080052202.4A Pending CN114729296A (zh) | 2020-11-03 | 2020-11-03 | 一种脂肪碎解器械及方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4021466A4 (ko) |
| KR (1) | KR20230103754A (ko) |
| CN (1) | CN114729296A (ko) |
| WO (1) | WO2022096917A1 (ko) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100112695A1 (en) * | 2008-11-03 | 2010-05-06 | Kyungyoon Min | Apparatus And Methods For Processing Tissue to Release Cells |
| IT1400069B1 (it) * | 2010-05-20 | 2013-05-17 | Tremolada | Dispositivo e metodo per la preparazione di tessuto, in particolare tessuto adiposo per trapianto ottenuto da materiale adiposo lobulare estratto tramite liposuzione |
| DE102013209718B4 (de) * | 2012-06-22 | 2015-09-10 | Human Med Ag | Vorrichtung zum Separieren von adulten Stammzellen |
| US10772997B2 (en) | 2014-05-15 | 2020-09-15 | Ronald D. Shippert | Tissue parcelization method and apparatus |
| WO2016134132A1 (en) | 2015-02-19 | 2016-08-25 | Lifecell Corporation | Tissue processing device and associated systems and methods |
| FR3068986B1 (fr) * | 2017-07-12 | 2019-08-09 | Stemcis | Dispositif de fragmentation mecanique de tissus destine a la preparation d'une composition de cellules isolees, procede correspondant |
| EP3743508B1 (en) | 2018-01-25 | 2021-10-20 | Theralip SA | Device for producing globules of adipose tissue |
| WO2020008805A1 (ja) * | 2018-07-05 | 2020-01-09 | 富士フイルム株式会社 | 細胞分割装置 |
| JP7450600B2 (ja) * | 2018-07-24 | 2024-03-15 | ヒーレオン メディカル， インコーポレイテッド | 移植用脂肪及び他の組織をサイズ変更するための装置及び方法 |
-
2020
- 2020-11-03 WO PCT/IB2020/060324 patent/WO2022096917A1/en unknown
- 2020-11-03 CN CN202080052202.4A patent/CN114729296A/zh active Pending
- 2020-11-03 EP EP20938505.3A patent/EP4021466A4/en active Pending
- 2020-11-03 KR KR1020217043371A patent/KR20230103754A/ko unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4021466A1 (en) | 2022-07-06 |
| EP4021466A4 (en) | 2023-07-19 |
| WO2022096917A1 (en) | 2022-05-12 |
| KR20230103754A (ko) | 2023-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |