CN114716387B - 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂 - Google Patents

用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂 Download PDF

Info

Publication number
CN114716387B
CN114716387B CN202210306552.XA CN202210306552A CN114716387B CN 114716387 B CN114716387 B CN 114716387B CN 202210306552 A CN202210306552 A CN 202210306552A CN 114716387 B CN114716387 B CN 114716387B
Authority
CN
China
Prior art keywords
group
compound
substituted
groups
tumors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202210306552.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN114716387A (zh
Inventor
S·雷
M·G·庞珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CN114716387A publication Critical patent/CN114716387A/zh
Application granted granted Critical
Publication of CN114716387B publication Critical patent/CN114716387B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN202210306552.XA 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂 Active CN114716387B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662311697P 2016-03-22 2016-03-22
US62/311,697 2016-03-22
CN201780031580.2A CN109311827B (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
PCT/US2017/023508 WO2017165473A1 (en) 2016-03-22 2017-03-22 Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780031580.2A Division CN109311827B (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂

Publications (2)

Publication Number Publication Date
CN114716387A CN114716387A (zh) 2022-07-08
CN114716387B true CN114716387B (zh) 2025-04-01

Family

ID=59899817

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202210306552.XA Active CN114716387B (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
CN202510305793.6A Pending CN120172884A (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
CN201780031580.2A Active CN109311827B (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202510305793.6A Pending CN120172884A (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
CN201780031580.2A Active CN109311827B (zh) 2016-03-22 2017-03-22 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂

Country Status (27)

Country Link
US (3) US11458213B2 (enExample)
EP (3) EP3925952B1 (enExample)
JP (3) JP7073270B2 (enExample)
KR (4) KR20230147751A (enExample)
CN (3) CN114716387B (enExample)
AU (1) AU2017238181B2 (enExample)
BR (1) BR112018069507A2 (enExample)
CA (1) CA3018709A1 (enExample)
CL (1) CL2018002683A1 (enExample)
CY (1) CY1124487T1 (enExample)
DK (2) DK3925952T3 (enExample)
ES (2) ES2972148T3 (enExample)
FI (1) FI3925952T3 (enExample)
HR (2) HRP20240215T1 (enExample)
HU (2) HUE055607T2 (enExample)
LT (2) LT3925952T (enExample)
MX (1) MX384823B (enExample)
PH (1) PH12018502048A1 (enExample)
PL (2) PL3433238T3 (enExample)
PT (2) PT3925952T (enExample)
RS (2) RS65188B1 (enExample)
RU (2) RU2021115958A (enExample)
SA (1) SA518400103B1 (enExample)
SI (2) SI3433238T1 (enExample)
TR (1) TR201813644T1 (enExample)
WO (1) WO2017165473A1 (enExample)
ZA (1) ZA201806389B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018031809A1 (en) 2016-08-10 2018-02-15 Cancer Targeted Technology Llc Chelated psma inhibitors
EP3544960A1 (en) * 2016-11-23 2019-10-02 Cancer Targeted Technology LLC Albumin-binding psma inhibitors
CN110291401B (zh) 2016-12-14 2023-04-11 普渡研究基金会 成纤维细胞活化蛋白(fap)-靶向成像和治疗
US11491247B2 (en) 2017-05-02 2022-11-08 Cornell University Methods and reagents for tumor targeting with greater efficacy and less toxicity
WO2018222778A1 (en) * 2017-05-30 2018-12-06 The Johns Hopkins University Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
WO2019115547A1 (en) * 2017-12-11 2019-06-20 Technische Universität München Psma ligands for imaging and endoradiotherapy
EP3494999A1 (en) * 2017-12-11 2019-06-12 Technische Universität München Psma ligands for imaging and endoradiotherapy
EP3494998A1 (en) * 2017-12-11 2019-06-12 Technische Universität München Glycosylated psma inhibitors for imaging and endoradiotherapy
PL3498308T3 (pl) * 2017-12-13 2025-03-31 Sciencons AS Kompleks zawierający związek celujący w PSMA połączony z radionuklidem ołowiu lub toru
KR20250021601A (ko) * 2018-02-06 2025-02-13 우니베르시타트 하이델베르크 Fap 억제제
BR112020016040A2 (pt) * 2018-02-06 2020-12-08 The Johns Hopkins University Ureia-poliaminocarboxilatos radiohalogenados que utilizam psma como alvo para radioterapia contra câncer
SG11202009649RA (en) 2018-03-30 2020-10-29 Futurechem Co Ltd Psma-targeted radiopharmaceutical for diagnosing and treating prostate cancer
AU2019287595B2 (en) * 2018-04-27 2024-10-31 University Of Iowa Research Foundation Compositions for chelating metals at low temperatures
BR112021005931A2 (pt) * 2018-09-28 2021-06-29 Universität Heidelberg composto, complexo e composição farmacêutica
RU2697519C1 (ru) * 2018-10-15 2019-08-15 Общество с ограниченной ответственностью "Изварино Фарма" Средство пептидной природы, включающее псма-связывающий лиганд на основе производного мочевины, способ его получения и применение для получения конъюгата с лекарственным и диагностическим агентом
WO2020139012A1 (ko) * 2018-12-27 2020-07-02 (주)퓨쳐켐 카르복시산이 도입된 psma-표적 화합물 및 그의 용도
JP7608378B2 (ja) * 2019-07-02 2025-01-06 ノバルティス アーゲー 前立腺特異的膜抗原（ｐｓｍａ）リガンド及びその使用
CN120441497A (zh) * 2019-07-02 2025-08-08 先进加速器应用意大利公司 前列腺特异性膜抗原（psma）配体及其用途
RU2713151C1 (ru) * 2019-07-02 2020-02-04 Общество с ограниченной ответственностью "Изварино Фарма" Конъюгат флуоресцентного красителя с веществом пептидной природы, включающим псма-связывающий лиганд на основе производного мочевины для визуализации клеток, экспрессирующих псма, способ его получения и применения
RU2730507C1 (ru) * 2019-08-27 2020-08-24 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Соединение для диагностики опухолей, экспрессирующих псма, и композиция на его основе
WO2021219719A1 (en) 2020-04-29 2021-11-04 Advanced Accelerator Applications (Italy) Srl Methods for radiolabelling psma binding ligands and their kits
WO2022043557A1 (en) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
EP4204020A1 (en) 2020-08-31 2023-07-05 Advanced Accelerator Applications International S.A. Method of treating psma-expressing cancers
WO2022043556A1 (en) 2020-08-31 2022-03-03 Novartis Ag Stable radiopharmaceutical composition
WO2022101352A1 (en) 2020-11-12 2022-05-19 Abx Advanced Biochemical Compounds Gmbh Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks
EP4247798B1 (en) * 2020-11-19 2025-08-27 Novartis AG Synthesis of prostate specific membrane antigen (psma) ligands
MX2021005089A (es) * 2021-04-30 2022-11-01 Instituto Nac De Investigaciones Nucleares Radiofarmacos basados en el acido ((r)-1-((6-hidrazinilnicotinoil) d-alanil)pirrolidin-2-il)boronico (hynic-ifap) para la deteccion de la sobreexpresion de la proteina de activacion de fibrolastos.
WO2022266499A1 (en) * 2021-06-17 2022-12-22 Mayo Foundation For Medical Education And Research Methods and materials for combining biologics with multiple chelators
KR20230050552A (ko) * 2021-10-07 2023-04-17 (주)퓨쳐켐 가돌리늄 화합물 및 이를 포함하는 전립선암의 진단 및 치료용 약학적 조성물
JP2025506001A (ja) 2022-02-09 2025-03-05 ノバルティス アーゲー ２２５－アクチニウム標識錯体及びビスマス封鎖剤を含む医薬組成物
EP4637843A2 (en) * 2022-12-21 2025-10-29 Mayo Foundation for Medical Education and Research Methods and materials for combining biologics with multiple chelators
WO2025022285A2 (en) 2023-07-21 2025-01-30 Novartis Ag Psma-targeting radioligand treatment regimen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2862857A1 (en) * 2013-10-18 2015-04-22 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
CN105025933A (zh) * 2013-01-14 2015-11-04 分子制药洞察公司 三嗪类放射性药物和放射性显影剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5680409B2 (ja) * 2007-06-26 2015-03-04 ザ ジョンズ ホプキンス ユニバーシティ 前立腺特異膜抗原（ｐｓｍａ）の標識阻害剤、生物学的評価およびイメージング剤としての使用
WO2009070302A1 (en) 2007-11-30 2009-06-04 The Johns Hopkins University Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer
AU2009322171A1 (en) * 2008-12-05 2011-06-30 Molecular Insight Pharmaceuticals, Inc. CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer
CA3257131A1 (en) * 2009-03-19 2025-04-15 The Johns Hopkins University PSMA-TARGETING COMPOUNDS AND RELATED USES
ES2732060T3 (es) * 2011-08-05 2019-11-20 Molecular Insight Pharm Inc Inhibidores radiomarcados del antígeno de membrana específico de la próstata
CN113149921B (zh) * 2011-11-30 2024-11-29 约翰霍普金斯大学 前列腺特异性膜抗原(psma)的同源多价抑制剂和异源多价抑制剂以及其用途
AU2014336638C1 (en) * 2013-10-18 2020-09-17 Novartis Ag Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
CN111285918B (zh) * 2014-05-06 2024-05-31 约翰霍普金斯大学 用于psma靶向的成像和放射疗法的金属/放射性金属标记的psma抑制物
WO2016030329A1 (en) * 2014-08-24 2016-03-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the production of 18f-labeled active esters and their application exemplified by the preparation of a psma-specific pet-tracer
EP3212610B1 (en) * 2014-10-30 2020-10-28 Katholieke Universiteit Leuven Methods for low temperature fluorine-18 radiolabeling of biomolecules
US11520472B2 (en) * 2015-09-24 2022-12-06 Mitutoyo Corporation Inspection program editing environment including integrated alignment program planning and editing features
US10688200B2 (en) * 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105025933A (zh) * 2013-01-14 2015-11-04 分子制药洞察公司 三嗪类放射性药物和放射性显影剂
EP2862857A1 (en) * 2013-10-18 2015-04-22 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer

Also Published As

Publication number Publication date
US20230015736A1 (en) 2023-01-19
PT3433238T (pt) 2021-07-28
PL3925952T3 (pl) 2024-04-22
RU2018133693A3 (enExample) 2020-04-22
HUE065327T2 (hu) 2024-05-28
JP2019519467A (ja) 2019-07-11
US11458213B2 (en) 2022-10-04
SI3433238T1 (sl) 2021-11-30
BR112018069507A2 (pt) 2019-01-29
WO2017165473A1 (en) 2017-09-28
CY1124487T1 (el) 2022-07-22
LT3433238T (lt) 2021-09-27
PL3433238T3 (pl) 2021-12-13
RS62274B1 (sr) 2021-09-30
KR20220063298A (ko) 2022-05-17
JP2022116028A (ja) 2022-08-09
ES2972148T3 (es) 2024-06-11
RS65188B1 (sr) 2024-03-29
PT3925952T (pt) 2023-12-13
DK3925952T3 (da) 2024-02-05
CN114716387A (zh) 2022-07-08
EP4385981A1 (en) 2024-06-19
EP3925952B1 (en) 2023-11-29
CN120172884A (zh) 2025-06-20
SA518400103B1 (ar) 2022-03-20
HRP20211386T1 (hr) 2021-12-10
JP7073270B2 (ja) 2022-05-23
LT3925952T (lt) 2024-01-25
US20200155713A1 (en) 2020-05-21
EP3925952A1 (en) 2021-12-22
EP3433238B1 (en) 2021-06-16
US20250195700A1 (en) 2025-06-19
KR20230147751A (ko) 2023-10-23
CA3018709A1 (en) 2017-09-28
RU2018133693A (ru) 2020-04-22
MX2018011519A (es) 2019-01-28
KR102396307B1 (ko) 2022-05-09
NZ786380A (en) 2025-05-02
CN109311827A (zh) 2019-02-05
ZA201806389B (en) 2024-01-31
HUE055607T2 (hu) 2021-12-28
CL2018002683A1 (es) 2019-04-22
AU2017238181A1 (en) 2018-10-18
KR20250057132A (ko) 2025-04-28
AU2017238181B2 (en) 2021-05-27
RU2749399C2 (ru) 2021-06-09
EP3433238A4 (en) 2019-09-11
HRP20240215T1 (hr) 2024-04-26
DK3433238T3 (da) 2021-09-06
SI3925952T1 (sl) 2024-03-29
TR201813644T1 (tr) 2018-11-21
ES2877572T3 (es) 2021-11-17
NZ746701A (en) 2024-12-20
RU2021115958A (ru) 2021-07-12
PH12018502048A1 (en) 2019-07-01
MX384823B (es) 2025-03-14
KR20180134918A (ko) 2018-12-19
FI3925952T3 (fi) 2024-02-13
JP2024050608A (ja) 2024-04-10
EP3433238A1 (en) 2019-01-30
CN109311827B (zh) 2022-04-12

Similar Documents

Publication Publication Date Title
CN114716387B (zh) 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
CN111032632B (zh) 用于前列腺癌的腔内放射疗法的前列腺特异性膜抗原靶向的高亲和力剂
US20240140971A1 (en) Psma targeted radiohalogenated ureas for cancer radiotherapy
JP7503495B2 (ja) がん放射線治療法のための、ｐｓｍａをターゲットとした放射性ハロゲン化した尿素‐ポリアミノカルボン酸塩
KR102531494B1 (ko) 탄산 탈수효소 ix를 표적으로 하는 핵 영상화 및 방사선치료 제제 및 이의 용도
HK1259764B (en) Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
BR122025009780A2 (pt) Compostos, método para tratar uma ou mais células ou tumores que expressam psma in vitro ou ex vivo que utiliza os ditos compostos e uso dos mesmos para tratar tumores ou células que expressam psma

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant