CN114711336A - 避免抗微生物剂抗性的抗腹泻制剂 - Google Patents

避免抗微生物剂抗性的抗腹泻制剂 Download PDF

Info

Publication number
CN114711336A
CN114711336A CN202111584816.XA CN202111584816A CN114711336A CN 114711336 A CN114711336 A CN 114711336A CN 202111584816 A CN202111584816 A CN 202111584816A CN 114711336 A CN114711336 A CN 114711336A
Authority
CN
China
Prior art keywords
formulation
bromelain
piglets
diarrhea
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202111584816.XA
Other languages
English (en)
Chinese (zh)
Inventor
特蕾西·L·迈诺特
约翰·沃尔什
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anatara Lifesciences Ltd
Original Assignee
Anatara Lifesciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anatara Lifesciences Ltd filed Critical Anatara Lifesciences Ltd
Publication of CN114711336A publication Critical patent/CN114711336A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22032—Stem bromelain (3.4.22.32)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22033—Fruit bromelain (3.4.22.33), i.e. juice bromelain
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Insects & Arthropods (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202111584816.XA 2014-08-25 2015-08-24 避免抗微生物剂抗性的抗腹泻制剂 Pending CN114711336A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462041175P 2014-08-25 2014-08-25
US62/041,175 2014-08-25
CN201580045389.4A CN106998749A (zh) 2014-08-25 2015-08-24 避免抗微生物剂抗性的抗腹泻制剂
PCT/US2015/046509 WO2016032944A1 (en) 2014-08-25 2015-08-24 Anti-diarrhea formulation which avoids antimicrobial resistance

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580045389.4A Division CN106998749A (zh) 2014-08-25 2015-08-24 避免抗微生物剂抗性的抗腹泻制剂

Publications (1)

Publication Number Publication Date
CN114711336A true CN114711336A (zh) 2022-07-08

Family

ID=55400400

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202111584816.XA Pending CN114711336A (zh) 2014-08-25 2015-08-24 避免抗微生物剂抗性的抗腹泻制剂
CN201580045389.4A Pending CN106998749A (zh) 2014-08-25 2015-08-24 避免抗微生物剂抗性的抗腹泻制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201580045389.4A Pending CN106998749A (zh) 2014-08-25 2015-08-24 避免抗微生物剂抗性的抗腹泻制剂

Country Status (11)

Country Link
US (1) US20170239334A1 (https=)
EP (1) EP3193629B1 (https=)
JP (1) JP6920199B2 (https=)
KR (1) KR102382930B1 (https=)
CN (2) CN114711336A (https=)
AU (2) AU2015306904A1 (https=)
CA (1) CA2959361A1 (https=)
DK (1) DK3193629T3 (https=)
ES (1) ES2938347T3 (https=)
PH (1) PH12017500338B1 (https=)
WO (1) WO2016032944A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4041285B1 (en) * 2019-10-11 2024-09-18 Anatara Lifesciences Limited Gastrointestinal health composition
MX2022011112A (es) * 2020-03-12 2022-10-07 Abbott Lab Metodos para tratar la diarrea o afecciones inflamatorias del intestino.
CN112618579B (zh) * 2020-12-24 2022-02-15 南京农业大学 一种防治仔猪腹泻复合益生菌制剂和制备方法及应用
EP4294426A1 (en) * 2021-02-16 2023-12-27 DSM IP Assets B.V. Methods for reducing pathogenic e coli by selective feed additive intervention comprising enzymes such as muramidase
PL246387B1 (pl) * 2022-08-16 2025-01-20 Nutropharma Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja doustna i jej zastosowanie
KR102592953B1 (ko) * 2023-01-30 2023-10-20 박예성 휴지기 없이 급여 가능한 반려동물용 영양제 제조공법
CN116889261B (zh) * 2023-07-22 2025-07-04 广东加大实业有限公司 一种防治腹泻乳猪饲料及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054261A (en) * 1998-05-20 2000-04-25 Q-Pharma, Inc. Coenzyme Q10 compositions for organ protection during perfusion
US6080403A (en) * 1998-06-18 2000-06-27 Star-Kist Foods, Inc. Protease containing hairball remedy and use thereof
CN1633245A (zh) * 2002-02-14 2005-06-29 Dsmip资产有限公司 水可分散的辅酶q10干粉
US20060052438A1 (en) * 2004-04-30 2006-03-09 Chi-Tang Ho Bioactive compounds and methods of uses thereof
WO2009009879A1 (en) * 2007-07-13 2009-01-22 Aquience Inc. Beverage composition for non-human animals

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2798248B2 (ja) * 1986-08-28 1998-09-17 コーテックス リミテッド 生物学的活性物質の動物の腸管部位へのデリバリーに有効なマイクロ顆粒状製剤
HUT67007A (en) * 1991-07-24 1995-01-30 Enzacor Pty Ltd Preparations containing biologically activ agent wich are absorbed in the superior intestinal tract of animals
CN1548154A (zh) * 2003-05-22 2004-11-24 维奥（四川）生物技术有限公司 用于治疗哺乳动物腹泻的菠萝蛋白酶微胶囊化药物组合物
WO2008049437A1 (en) * 2006-10-26 2008-05-02 Biofiber-Damino A/S Composition comprising lignin and antidi arrheal component
AT506095A1 (de) * 2007-12-03 2009-06-15 Volopharm Gmbh Verwendung von proteasen
CN102300989B (zh) * 2009-01-06 2015-12-09 柯尔朗恩有限责任公司 用于治疗或预防金黄色葡萄球菌感染以及用于根除或减少表面上金黄色葡萄球菌的组合物和方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054261A (en) * 1998-05-20 2000-04-25 Q-Pharma, Inc. Coenzyme Q10 compositions for organ protection during perfusion
US6080403A (en) * 1998-06-18 2000-06-27 Star-Kist Foods, Inc. Protease containing hairball remedy and use thereof
CN1633245A (zh) * 2002-02-14 2005-06-29 Dsmip资产有限公司 水可分散的辅酶q10干粉
US20060052438A1 (en) * 2004-04-30 2006-03-09 Chi-Tang Ho Bioactive compounds and methods of uses thereof
WO2009009879A1 (en) * 2007-07-13 2009-01-22 Aquience Inc. Beverage composition for non-human animals

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
《中国药物大全》编委会: "中国药物大全：西药卷", vol. 2, 31 January 1998, 人民卫生出版社, pages: 509 *
赵力超等: "多糖和添加剂对菠萝茎蛋白酶活力的影响", 《食品科学》, vol. 32, no. 15, 31 December 2011 (2011-12-31), pages 225 - 229 *
韩琦等: "立泻止对仔猪腹泻的预防效果", 《今日养猪业》, no. 1, 28 February 2014 (2014-02-28), pages 39 - 41 *

Also Published As

Publication number Publication date
CA2959361A1 (en) 2016-03-03
EP3193629A4 (en) 2018-07-11
JP2017532369A (ja) 2017-11-02
DK3193629T3 (da) 2023-03-13
KR20170082149A (ko) 2017-07-13
PH12017500338B1 (en) 2023-01-13
AU2019204496A1 (en) 2019-07-18
US20170239334A1 (en) 2017-08-24
AU2015306904A1 (en) 2017-04-06
JP6920199B2 (ja) 2021-08-18
PH12017500338A1 (en) 2017-07-17
AU2019204496B2 (en) 2020-12-24
WO2016032944A4 (en) 2016-04-28
CN106998749A (zh) 2017-08-01
ES2938347T3 (es) 2023-04-10
KR102382930B1 (ko) 2022-04-04
WO2016032944A1 (en) 2016-03-03
EP3193629B1 (en) 2023-01-25
EP3193629A1 (en) 2017-07-26

Similar Documents

Publication Publication Date Title
AU2019204496B2 (en) Anti-diarrhea formulation which avoids antimicrobial resistance
US20240033287A1 (en) Antimicrobial clay compositions and methods of using
Hassan et al. Innovative drugs, chemicals, and enzymes within the animal production chain
TWI568360B (zh) The use of cashew nut shell oil
JP6822734B2 (ja) 経口補水組成物とその方法
DK2224918T3 (en) The use of EDTA and its salts for the prevention and treatment of bacterial intestinal diseases of pigs
CN103690952A (zh) 治疗畜禽大肠杆菌感染疾病的复方药物
CN103989725A (zh) 一种含有含珠草和阿米卡星的畜禽用复方药物
CN107373130A (zh) 一种缓解仔猪断奶应激的替抗饲料添加剂
EP2668849A1 (en) Feed additive of plant origin
CA3198493A1 (en) Clay compositions and methods for improving animal performance
JP4809225B2 (ja) 獣医学および医学用途のための組成物
CN101757069A (zh) 治疗鸡混合感染的药物口服液及其制备方法、应用
US20250082732A1 (en) Anti-microbial and anti-inflammatory compositions and methods for treating enteric diseases in animals
JP2008285431A (ja) 養殖魚のウイルス感染症の予防・治療組成物
JP4665082B2 (ja) 抗エンドトキシン剤
TWI569732B (zh) 植物源動物飼料添加劑
CN106983771B (zh) 防治海马头部溃烂病的药物及组合物
CN117244002A (zh) 治腹泻兽用制剂
CN102114032A (zh) 一种用于改善家禽免疫机能的营养组合物
HK1155383A (en) Compositions for veterinary and medical applications
HK1096586B (en) Compositions for veterinary and medical applications

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20220708