CN114699342A - 一种具有保湿、修复及防治脱屑功效的唇膏及其制备方法 - Google Patents
一种具有保湿、修复及防治脱屑功效的唇膏及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种具有保湿、修复及防治脱屑功效的唇膏及其制备方法。所述唇膏由活性成分、蜡类、油脂类和添加剂制成,其中,活性成分在唇膏中所占的质量百分比为1%~10%;蜡类在唇膏中所占的质量百分比为12%~50%;油脂类在唇膏中所占的质量百分比为47%~85%,添加剂在唇膏中所占的质量百分比为2%~5%;所述活性成分为纳米氧化锌、氢氧化镁、水解胶原和尿囊素。本发明唇膏除具有保湿功能,还能促进创伤表皮愈合,减轻炎症反应,预防唇黏膜脱屑,且成分相对简单、稳定,安全无刺激,使用方便,对唇黏膜具有良好的保护作用,适合日常唇部保湿或伴有脱屑、干裂等慢性唇炎的防护。
Description
技术领域
本发明属于日用化妆品技术领域,具体涉及一种具有保湿、修复及防治脱屑功效的唇膏,还涉及该唇膏的制备方法。
背景技术
唇部黏膜位于口腔黏膜与皮肤的交界处,上皮薄,主要由数层表皮细胞组成,固有层内乳头狭长,乳头中含有许多毛细血管袢,使唇部呈粉红色。与皮肤相比,唇黏膜缺乏分泌油脂的皮下脂肪及皮脂腺等附属器,与口腔黏膜相比,唇红部黏膜缺乏唾液的滋润,黏膜下缺乏黏液腺,因此娇嫩敏感,防御能力差,易受外界环境,如季节、温度、海拔、紫外线等影响,出现唇红干燥、皲裂、脱屑等现象;同时,口腔黏膜或皮肤的其他慢性疾病会导致口唇黏膜表皮萎缩、充血、渗出等炎症反应;除此之外,舔唇、咬唇等不良习惯也会引发唇红部裂口、烧灼、脱屑等。
唇部组织的干燥,脱屑、皲裂,渗出等异常不仅影响说话、进食等口腔功能,也会造成社交障碍、容貌焦虑等心理负担。目前,市售唇膏大多仅有保湿功能,无明确的促修复、抑制炎症和防治脱屑的作用。
发明内容
针对现有技术的缺陷不足,本发明提供了一种具有保湿、修复和防治脱屑功效的唇膏。
为此,本发明所提供的唇膏由活性成分、蜡类、油脂类和添加剂制成,其中,活性成分在唇膏中所占的质量百分比为1%~10%;蜡类在唇膏中所占的质量百分比为12%~50%;油脂类在唇膏中所占的质量百分比为47%~85%,添加剂在唇膏中所占的质量百分比为2%~5%;
所述活性成分以质量份数计包括,纳米氧化锌0.1-0.5份、氢氧化镁0.1-0.5份、水解胶原0.2-5份和尿囊素0.2-5份。
可选的,所述蜡类选自巴西棕榈蜡、聚乙烯蜡、地蜡、微晶蜡、蜂蜡、小烛树蜡和石蜡中的两种的混合物或三种的混合物。
可选的,所述油脂类包括固态油脂和液态油脂,其中固态油脂选自氢化椰油甘油酯、羊毛脂和双-二甘油多酰基己二酸酯-2中的一种或两种的混合物;液态油脂选自霍霍巴油、蓖麻油、辛酸/癸酸甘油三酯、液体石蜡和棕榈酸异丙酯中的两种以上的混合物。
可选的,所述的添加剂为司盘80、苯氧乙醇、维生素E乙酸酯和香精中的一种或两种以上的混合物。
本发明还提供了上述唇膏的制备方法。
为此,所提供的制备方法包括:
称取处方量的活性成分,研细,混合,再加入处方量的不包括香精的添加剂和固态油脂继续研匀,之后加入部分液态油脂研匀,得到色浆备用;
将处方量的蜡类和剩余的液态油脂加热熔融混匀,制得唇膏基质;
在唇膏基质中加入色浆,继续加热搅拌得均一膏体,最后加入香精搅匀;灌装、脱模即得。
本发明唇膏除具有保湿功能,还能促进创伤表皮愈合,减轻炎症反应,预防唇黏膜脱屑,且成分相对简单、稳定,安全无刺激,使用方便,对唇黏膜具有良好的保护作用,适合日常唇部保湿或伴有脱屑、干裂等慢性唇炎的防护。
进一步方案中尿囊素、霍霍巴油、蓖麻、辛酸/癸酸甘油三酯等油脂类成分易于渗透,不仅具有良好的保湿效果,而且益于维持表皮细胞活力,有效促进愈合修复,恢复黏膜屏障功能;维生素E具有抗氧化作用。该唇膏安全无刺激,对唇部干燥、脱屑和炎症反应有明显的缓解功效,见效快,制备工艺简单、使用感觉舒适。
附图说明
图1为本发明实施例和相关对比例兔耳皮肤创伤组织HE染色结果;
图2为本发明实施例和相关对比例唇黏膜脱屑程度测试,上一行图为评分标准,下面附图为实施例和对比例的测试结果。
具体实施方式
除非有特殊说明,本文中的术语根据相关领域普通技术人员的认识理解。
以下结合具体的实施例对本发明作进一步的说明,阐述本发明所采取的技术手段及其效果,但本发明并非局限在实施例范围内。以下实施例所用的组分及实验用动物和材料均为市售产品。
实施例1:
本实施例制备的唇膏,组分及各组分的比例如下:
制备方法为:
称取处方量的尿囊素、纳米氧化锌、氢氧化镁和水解胶原,研细,混合,再加入处方量的司盘80、苯氧乙醇、维生素E乙酸酯和双-二甘油多酰基己二酸酯-2继续研匀,之后加入辛酸/癸酸甘油三酯研匀,得到色浆备用;
称取处方量的蜂蜡、地蜡、氢化椰油甘油酯和霍霍巴油,85℃加热熔融混匀,制得唇膏基质,冷却至65℃保温备用;
在唇膏基质中加入上述预热至65℃的色浆,继续加热搅拌得均一膏体,盛色浆的容器用剩余量的辛酸/癸酸甘油三酯分三次涮洗,合并入膏体中,最后加入甜橙香精搅匀;灌装、脱模即得。
对比例1:
该对比例与实施例1不同的是不添加氢氧化镁。
对比例2:
该对比例与实施例1不同的是不添加纳米氧化锌。
发明人对上述实施例和对比例所制备的唇膏分别进行动物皮肤刺激试验、动物皮肤糜烂促愈合试验及炎症反应检测,对慢性脱屑性唇炎患者进行唇黏膜保湿、防治脱屑功效性测试,具体方法如下:
(1)动物皮肤刺激试验
观察上述实施例和对比例所制产品对家兔皮肤的局部刺激反应,试验方法如下:
取3只成年家兔,在试验前剃除背部脊柱两侧3cm×3cm范围的毛,不得损伤皮肤。两侧涂敷1g实施例产品,以医用凡士林作对照,用保鲜膜覆盖,再用故纱布包扎固定。贴敷4小时后,用温水去除残留受试物,分别在1小时、24小时记录皮肤的红斑、水肿、出血、粗糙等情况的发生,并进行刺激反应评分(评分标准参照中华人民共和国卫生部,化妆品卫生规范2007年版,皮肤刺激性试验),试验结果见表1。
表1家兔皮肤刺激试验
(2)动物皮肤糜烂促愈合试验及炎症反应检测
观察上述实施例和对比例所制产品和医用凡士林进行比较,对动物皮肤糜烂促愈合作用和炎症反应的影响。试验方法如下:
家兔3只,体重2-3kg,用10%的水合氯醛腹腔注射麻醉;每只兔耳腹侧在直径1cm的范围撕脱全层皮肤,造成创伤面;24小时后在创伤面涂敷唇膏,每天2次;1周后获取创面组织标本,甲醛固定,切片,HE染色,行组织病理观察创面愈合情况,和组织内炎症细胞浸润程度。结果如图1,除医用凡士林组兔耳皮肤未完全愈合,其余组创伤面均愈合,组织内炎症细胞浸润情况见表2。
表2兔耳皮肤创面愈合试验
(3)唇黏膜保湿功效测试
采用随机、平行对照试验方法,对上述实施例和对比例所制的产品和医用凡士林进行比较,测试保湿功效,为临床应用提供依据。试验方法如下:
选择20-40岁,男女不限,经临床医生诊断患有慢性脱屑性唇炎的患者。试验前至少1天内未接受过糖皮质激素或其他免疫相关制剂的口服或局部药物治疗,也未涂抹其他保湿用品,并志愿签署知情同意书。测试前用生理盐水擦拭下唇黏膜,去除鳞屑或其他附着物,在室温环境中等待30分钟,用水分量测量器(CM 825检测仪器)和水分流失检测仪器(TM300)检测下唇黏膜的含水量和经皮肤水分流失量,并记录。嘱受试者唇部涂抹测试品,早、中、晚各一次,24小时后,重复上述测试过程,比较两个时间点的平均黏膜含水量和平均经皮水分流失量(表3)。
表3唇黏膜平均水分含量及经皮水分流失量数据
(4)防治唇黏膜脱屑功效测试
采用随机、平行对照试验方法,对上述实施例和对比例所制的产品和医用凡士林进行比较,测试防治唇黏膜脱屑的功效,为临床应用提供依据。试验方法如下:
选择20-40岁,男女不限,经临床医生诊断患有慢性脱屑性唇炎的患者。试验前至少1天内未接受过糖皮质激素或其他免疫相关制剂的口服或局部药物治疗,也未涂抹其他保湿用品,并志愿签署知情同意书。使用唇膏前、使用唇膏24小时后,按照以下标准进行唇黏膜脱屑程度打分,测试结果如图2。
上述结果显示,本发明的唇膏有显著的保湿功能,还能促进创伤表皮愈合,减轻炎症反应,预防唇黏膜脱屑,对唇黏膜具有良好的保护作用。
以上所述仅是本发明的优选实施方式,不能依此来限定本发明保护的范围,对于本技术领域的普通技术人员,在本发明的基础上所做的任何改进和补充均属于本发明所要求的保护范围。
Claims (5)
1.一种具有保湿、修复和防治脱屑功效的唇膏,其特征在于,所述唇膏由活性成分、蜡类、油脂类和添加剂制成,其中,活性成分在唇膏中所占的质量百分比为1%~10%;蜡类在唇膏中所占的质量百分比为12%~50%;油脂类在唇膏中所占的质量百分比为47%~85%,添加剂在唇膏中所占的质量百分比为2%~5%;
所述活性成分以质量份数计包括,纳米氧化锌0.1-0.5份、氢氧化镁0.1-0.5份、水解胶原0.2-5份和尿囊素0.2-5份。
2.如权利要求1所述的唇膏,其特征在于,所述蜡类选自巴西棕榈蜡、聚乙烯蜡、地蜡、微晶蜡、蜂蜡、小烛树蜡和石蜡中的两种的混合物或三种的混合物。
3.如权利要求1所述的唇膏,其特征在于,所述油脂类包括固态油脂和液态油脂,其中固态油脂选自氢化椰油甘油酯、羊毛脂和双-二甘油多酰基己二酸酯-2中的一种或两种的混合物;液态油脂选自霍霍巴油、蓖麻油、辛酸/癸酸甘油三酯、液体石蜡和棕榈酸异丙酯中的两种以上的混合物。
4.如权利要求1所述的唇膏,其特征在于,所述的添加剂为司盘80、苯氧乙醇、维生素E乙酸酯和香精中的一种或两种以上的混合物。
5.权利要求1所述唇膏的制备方法,其特征在于,所述制备方法包括:
称取处方量的活性成分,研细,混合,再加入处方量的不包括香精的添加剂和固态油脂继续研匀,之后加入部分液态油脂研匀,得到色浆备用;
将处方量的蜡类和剩余的液态油脂加热熔融混匀,制得唇膏基质;
在唇膏基质中加入色浆,继续加热搅拌得均一膏体,最后加入香精搅匀;灌装、脱模即得。
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