CN114685655B - Pd-1结合分子及其应用 - Google Patents

Pd-1结合分子及其应用 Download PDF

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Publication number
CN114685655B
CN114685655B CN202011582908.XA CN202011582908A CN114685655B CN 114685655 B CN114685655 B CN 114685655B CN 202011582908 A CN202011582908 A CN 202011582908A CN 114685655 B CN114685655 B CN 114685655B
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CN114685655A (zh
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李加国
于海翔
刘祥箴
朱伟民
孙艳
丁娜
钱其军
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Zhejiang Nano Antibody Technology Center Co ltd
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Zhejiang Nano Antibody Technology Center Co ltd
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Priority to CN202410342939.XA priority Critical patent/CN118240082A/zh
Priority to CN202011582908.XA priority patent/CN114685655B/zh
Priority to IL304096A priority patent/IL304096B1/en
Priority to CN202180088155.3A priority patent/CN116829718A/zh
Priority to EP21914288.2A priority patent/EP4269437A4/en
Priority to CA3206838A priority patent/CA3206838A1/en
Priority to JP2023540715A priority patent/JP2024502091A/ja
Priority to AU2021416127A priority patent/AU2021416127A1/en
Priority to PCT/CN2021/141740 priority patent/WO2022143552A1/zh
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Wood Science & Technology (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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CN202011582908.XA 2020-12-28 2020-12-28 Pd-1结合分子及其应用 Active CN114685655B (zh)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CN202410342939.XA CN118240082A (zh) 2020-12-28 2020-12-28 Pd-1结合分子及其应用
CN202011582908.XA CN114685655B (zh) 2020-12-28 2020-12-28 Pd-1结合分子及其应用
IL304096A IL304096B1 (en) 2020-12-28 2021-12-26 PD-1 binding molecule and its application
EP21914288.2A EP4269437A4 (en) 2020-12-28 2021-12-27 Pd-1 binding molecule and application thereof
CN202180088155.3A CN116829718A (zh) 2020-12-28 2021-12-27 Pd-1结合分子及其应用
CA3206838A CA3206838A1 (en) 2020-12-28 2021-12-27 Pd-1 binding molecule and application thereof
JP2023540715A JP2024502091A (ja) 2020-12-28 2021-12-27 Ｐｄ－１結合分子およびその使用
AU2021416127A AU2021416127A1 (en) 2020-12-28 2021-12-27 Pd-1 binding molecule and application thereof
PCT/CN2021/141740 WO2022143552A1 (zh) 2020-12-28 2021-12-27 Pd-1结合分子及其应用

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CN114685655B true CN114685655B (zh) 2024-04-12

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EP (1) EP4269437A4 (https=)
JP (1) JP2024502091A (https=)
CN (3) CN114685655B (https=)
AU (1) AU2021416127A1 (https=)
CA (1) CA3206838A1 (https=)
IL (1) IL304096B1 (https=)
WO (1) WO2022143552A1 (https=)

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JP7694922B2 (ja) * 2021-01-29 2025-06-18 ミンフィ ファーマシューティカル （ハンチョウ） リミテッド 抗原結合タンパク質およびその使用
CN121219403A (zh) * 2023-03-31 2025-12-26 上海细胞治疗集团股份有限公司 双特异性抗体及自分泌双特异性抗体的工程化免疫细胞
CN121511096A (zh) * 2023-06-29 2026-02-10 上海细胞治疗集团股份有限公司 药物组合物及其应用
WO2025016011A1 (en) * 2023-07-14 2025-01-23 Genor Biopharma Co., Ltd. Anti-PD-1/CTLA-4/VEGF ANTIBODIES AND USE THEREOF
CN118745227A (zh) * 2024-06-06 2024-10-08 北京磊顿生物科技有限公司 一种包含免疫细胞的药物组合物及其在制备治疗肿瘤药物中的应用
CN120518767B (zh) * 2025-05-30 2025-11-11 中国人民解放军军事科学院军事医学研究院 一种pd-1单克隆抗体及其应用

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CN107814845A (zh) * 2016-09-14 2018-03-20 浙江特瑞思药业股份有限公司 新的抗pd‑1纳米抗体及其应用
CN110950956A (zh) * 2019-12-12 2020-04-03 源道隆（苏州）医学科技有限公司 可结合pd1的多肽及其应用

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CN106046152A (zh) 2016-07-07 2016-10-26 南昌大学 特异性识别组氨酸标签的纳米抗体
NL2017267B1 (en) * 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
EP3565841A1 (en) * 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
TW202417517A (zh) * 2017-06-02 2024-05-01 德商麥克專利有限公司 與ｍｍｐ１３結合之免疫球蛋白
CN111699200B (zh) * 2018-01-15 2023-05-26 南京传奇生物科技有限公司 针对pd-1的单域抗体和其变体
CN110144010B9 (zh) * 2018-02-14 2021-01-05 上海洛启生物医药技术有限公司 阻断型pd-l1驼源单域抗体及其用途
EP3768724A4 (en) * 2018-03-20 2022-04-13 Wuxi Biologics Ireland Limited. NEW ANTI-PD-1 ANTIBODIES
CN120623346A (zh) * 2018-10-11 2025-09-12 因荷布瑞克斯生物科学公司 Pd-1单结构域抗体及其治疗组合物
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CN111892655B (zh) * 2019-05-06 2022-10-28 四川大学 抗pd-1纳米抗体的筛选及应用
CN116064397A (zh) * 2021-11-02 2023-05-05 上海细胞治疗集团有限公司 表达免疫检查点抑制剂的超级dc及其用途

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CN107814845A (zh) * 2016-09-14 2018-03-20 浙江特瑞思药业股份有限公司 新的抗pd‑1纳米抗体及其应用
CN110950956A (zh) * 2019-12-12 2020-04-03 源道隆（苏州）医学科技有限公司 可结合pd1的多肽及其应用

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Publication number Publication date
WO2022143552A1 (zh) 2022-07-07
CN114685655A (zh) 2022-07-01
CA3206838A1 (en) 2022-07-07
EP4269437A4 (en) 2024-11-20
IL304096A (en) 2023-08-01
IL304096B1 (en) 2026-04-01
AU2021416127A1 (en) 2023-08-10
JP2024502091A (ja) 2024-01-17
CN118240082A (zh) 2024-06-25
CN116829718A (zh) 2023-09-29
EP4269437A1 (en) 2023-11-01

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