CN114681583B - Throat-clearing lung-benefiting smoking-stopping composition, and preparation method and application thereof - Google Patents

Throat-clearing lung-benefiting smoking-stopping composition, and preparation method and application thereof Download PDF

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CN114681583B
CN114681583B CN202210331776.6A CN202210331776A CN114681583B CN 114681583 B CN114681583 B CN 114681583B CN 202210331776 A CN202210331776 A CN 202210331776A CN 114681583 B CN114681583 B CN 114681583B
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parts
smoking
throat
benefiting
lung
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CN114681583A (en
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郭斌
芦涵琪
刘子仪
陈曼雨
郝玉婷
窦楠
杨家馨
张自瑶
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Chengde Daze Agricultural Technology Co.,Ltd.
Hebei university of traditional chinese medicine
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Hebei University of Chinese Medicine
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    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
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Abstract

The invention relates to the technical field of smoking cessation products, in particular to a composition for clearing throat, benefiting lung and stopping smoking as well as a preparation method and application thereof. The throat-clearing lung-benefiting smoking-stopping composition is prepared from coptis chinensis, bamboo shavings, aster, radix stemonae, snakegourd fruit, pinellia tuber, platycodon root, cynanchum atratum, dried orange peel, exocarpium citri rubrum and other raw materials, has the effects of clearing heat and benefiting lung, regulating qi and resolving phlegm, harmonizing stomach and benefiting gall, drying dampness and relieving depression, can improve common symptoms of smokers such as bitter taste, dry throat, itching throat, cough, uncomfortable phlegm, dry lung, yellow greasy tongue fur and the like caused by smoking through an inhalation mode, can relieve smoking addiction, has a pacifying effect when a long-term smoker is difficult to cut a cigarette product, and has mild smoking stopping process and no side effect. The composition does not contain nicotine or other addictive components, does not cause dependence due to long-term use, and can be used for preparing throat-clearing lung-benefiting smoking-stopping electronic cigarette.

Description

Throat-clearing lung-benefiting smoking-stopping composition, and preparation method and application thereof
Technical Field
The invention relates to the technical field of smoking cessation products, in particular to a composition for clearing throat, benefiting lung and stopping smoking as well as a preparation method and application thereof.
Background
Tobacco combustion can produce smoke containing more than 7000 substances and is mostly harmful to the human body. When smoking, smoke enters from the mouth, enters blood through the throat, the trachea and the bronchus, and various diseases such as laryngitis, tracheitis, emphysema and the like are easily caused by long-term smoking, so that the cigarette is extremely harmful to the health and has addiction. About 80% of smokers wish to quit smoking, but often fail to quit smoking because of difficulty in overcoming smoking addiction.
At present, the smoking cessation patch and the smoking cessation spray in the market are in direct contact with skin, skin anaphylactic reaction is easy to generate, and chemical components in the smoking cessation patch and the smoking cessation spray can possibly cause harm to a nervous system. In recent years, electronic cigarette series products are becoming popular, and substances such as nicotine and nicotine in tobacco tar can be artificially reduced to reduce harm, but various uncertain factors still exist, and some experiments show that when people use the electronic cigarettes, various toxic compounds besides nicotine can be inhaled into the body, and zero harm to human bodies cannot be realized.
Disclosure of Invention
Aiming at the technical problems that smokers are difficult to overcome, nicotine and other components can cause harm to human bodies and the like, the invention provides a composition for clearing heat from throat, benefiting lung and stopping smoking, a preparation method and application thereof. The composition can relieve tobacco addiction, and is helpful for stopping smoking, and can also reduce and relieve symptoms caused by smoking such as bitter taste, itching throat, cough, itching throat, and difficult expectoration.
In order to achieve the above purpose, the embodiment of the invention adopts the following technical scheme:
in a first aspect, the embodiment of the invention provides a composition for clearing heat from throat, benefiting lung and stopping smoking, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8-12 parts of coptis chinensis, 15-25 parts of bamboo shavings, 8-12 parts of immature bitter orange, 8-12 parts of pinellia ternate, 8-12 parts of exocarpium citri rubrum, 5-7 parts of liquorice, 5-7 parts of ginger, 8-12 parts of poria cocos, 8-12 parts of platycodon grandiflorum, 8-12 parts of aster, 15-25 parts of radix stemonae, 8-12 parts of cynanchum glaucescens, 8-12 parts of dried orange peel, 8-12 parts of mugwort leaf, 8-12 parts of perilla leaf, 8-12 parts of mint, 2-4 parts of borneol and 10-20 parts of snakegourd fruit.
The throat-clearing lung-benefiting smoking-stopping composition is prepared from the traditional Chinese medicine raw materials in the proportion, and the compatibility of the traditional Chinese medicines is as follows:
coptis chinensis has the effects of regulating stomach, relieving diarrhea, purging pathogenic fire, removing toxic substances, resisting bacteria and killing viruses; bamboo Ru Qing gallbladder harmonizes stomach, arrest vomiting and relieve restlessness; aster and Stemonae radix are sweet and bitter in taste and warm in nature, and are good at resolving phlegm and relieving cough, and are suitable for both new and prolonged cough; gua Lou is slightly cold in nature and has the actions of clearing heat, removing phlegm, relieving chest stuffiness and resolving masses. The five traditional Chinese medicines are monarch medicines in the composition.
Pinellia tuber, rhizoma Pinelliae, with effects of eliminating dampness and resolving phlegm, and lowering adverse qi and relieving vomiting; immature bitter orange regulates qi to resolve phlegm, and enables qi to guide qi and remove phlegm; radix Platycodi and rhizoma Cynanchi Stauntonii can be used for dispersing lung qi, eliminating phlegm, relieving cough, and guiding medicine upwards; dried orange peel can regulate qi and resolve phlegm; exocarpium Citri rubrum has effects of regulating qi-flowing, relieving middle energizer, eliminating dampness and resolving phlegm. The six traditional Chinese medicines are ministerial medicines in the composition.
Borneol has the effects of inducing resuscitation and refreshing mind, clearing heat and removing toxicity, and relieving swelling and pain; perilla leaf has effects of activating qi-flowing, regulating stomach, regulating qi-flowing, removing blood stasis, and removing toxic substances; poria has effects of invigorating spleen and eliminating dampness, and Du Shengtan; peppermint, herba Menthae, having effects of refreshing, relieving sore throat and relieving pain; mugwort leaf controls emotion, relieves anxiety, enhances the resistance of human body to diseases, and has good antioxidation effect. The five traditional Chinese medicines are adjuvant drugs in the composition.
Licorice root, radix Glycyrrhizae Praeparata has the effect of invigorating spleen and regulating stomach, and harmonizing the drugs, it is a guiding drug in the composition.
The throat-clearing lung-benefiting smoking-stopping composition has the effects of clearing heat and promoting lung, regulating qi and resolving phlegm, harmonizing stomach and promoting bile flow, drying dampness and relieving depression through reasonable compatibility of the traditional Chinese medicines, can improve common symptoms of smokers such as bitter taste, dry throat, itching throat, cough, uncomfortable expectoration, dry lung, yellow and greasy tongue fur and the like caused by smoking through an inhalation mode, can relieve smoking addiction, has a pacifying effect when a long-term smoker is difficult to cut a cigarette product, and has mild smoking stopping process and no side effect. Meanwhile, related experiments also prove that the prescription of the product has certain prevention and treatment effects on respiratory diseases such as rhinitis, pharyngitis and the like, can enhance immunity and is beneficial to improving the health level of smoking cessation people.
The composition for clearing throat, benefiting lung and stopping smoking does not contain nicotine or other addictive components, and does not cause dependence due to long-term use.
Preferably, the throat-clearing lung-benefiting smoking-stopping composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 9 to 11 parts of coptis chinensis, 18 to 22 parts of bamboo shavings, 9 to 11 parts of immature bitter orange, 9 to 11 parts of pinellia ternate, 9 to 11 parts of exocarpium citri rubrum, 5.5 to 6.5 parts of liquorice, 5.5 to 6.5 parts of ginger, 9 to 11 parts of poria cocos, 9 to 11 parts of platycodon grandiflorum, 9 to 11 parts of aster, 18 to 22 parts of radix stemonae, 9 to 11 parts of cynanchum atratum, 9 to 11 parts of dried orange peel, 9 to 11 parts of folium artemisiae argyi, 9 to 11 parts of perilla leaf, 9 to 11 parts of mint, 2.5 to 3.5 parts of borneol and 13 to 17 parts of snakegourd fruit.
Preferably, the throat-clearing lung-benefiting smoking-stopping composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of coptis chinensis, 20 parts of caulis bambusae in taeniam, 10 parts of immature bitter orange, 10 parts of pinellia ternate, 10 parts of exocarpium citri rubrum, 6 parts of liquorice, 6 parts of ginger, 10 parts of poria cocos, 10 parts of platycodon grandiflorum, 10 parts of aster, 20 parts of radix stemonae, 10 parts of cynanchum glaucescens, 10 parts of pericarpium citri reticulatae, 10 parts of folium artemisiae argyi, 10 parts of perilla leaf, 10 parts of mint, 3 parts of borneol and 15 parts of snakegourd fruit.
Under the preferable proportion, the throat-clearing lung-benefiting smoking-stopping composition can produce better effects of clearing throat, benefiting lung and reducing smoking addiction.
Preferably, the traditional Chinese medicine raw materials for preparing the throat-clearing lung-benefiting smoking-stopping composition also comprise 8-13 parts of radix scutellariae. After adding the baikal skullcap root, the composition also has the effects of clearing up Jiao Huore, relieving chest stuffiness and eliminating stagnation, can further relieve smoking addiction and eliminate symptoms such as cough caused by long-term smoking, and is also beneficial to eliminating chest distress caused by long-term smoking.
Preferably, the weight part of the baikal skullcap root is 9-11 parts, more preferably 10 parts.
In a second aspect, the embodiment of the invention also provides a preparation method of the composition for clearing throat, benefiting lung and stopping smoking, which comprises the following operations: extracting essential oil of the traditional Chinese medicine raw materials except borneol, uniformly mixing the essential oil according to the weight part ratio of the raw materials in the throat-clearing lung-benefiting smoking-stopping composition, adding the borneol and dissolving to obtain the throat-clearing lung-benefiting smoking-stopping composition. Namely, the mass ratio of each essential oil and borneol in the throat-clearing lung-benefiting smoking-stopping composition is calculated by the mass ratio of the corresponding traditional Chinese medicine raw materials.
The preparation method can also select the following operations: weighing the raw materials according to the weight portion ratio, extracting essential oil of the traditional Chinese medicine raw materials except borneol, uniformly mixing the obtained essential oil, adding the borneol and dissolving to obtain the throat-clearing lung-benefiting smoking-stopping composition.
The two preparation methods can be selected according to the production conditions in practical application. It is understood herein that other modes of operation which do not differ substantially from the above-described preparation methods are also within the scope of the present invention.
The essential oil of each raw material can be purchased from commercial essential oil, and can also be prepared by adopting the following method: adding 3-7 times of purified water into the traditional Chinese medicine raw materials, distilling and extracting for 3-5 hours, and collecting the obtained oily components to obtain the traditional Chinese medicine. The commercial essential oil or the essential oil prepared by the method can be used for preparing the composition for clearing throat, benefiting lung and stopping smoking, and can produce similar effects.
In a third aspect, the embodiment of the invention also provides application of the throat-clearing lung-benefiting smoking cessation composition in preparation of throat-clearing lung-benefiting smoking cessation electronic cigarettes.
The electronic cigarette is a non-combustion type electronic atomization device, adopts a microelectronic technology and a physical atomization technology to atomize tobacco tar into smoke, and humanized simulation of smoking process is realized.
After the throat-clearing lung-benefiting smoking-quitting composition is prepared into the throat-clearing lung-benefiting smoking-quitting electronic cigarette, on one hand, the traditional Chinese medicine essential oil is atomized into smoke through a microelectronic technology and a physical atomization technology, and the effects of clearing throat, benefiting lung and reducing smoking addiction are produced in an inhalation mode; on the other hand, the appearance of the electronic cigarette is similar to that of a cigarette, so that the mind of a smoker, especially a smoker who smokes for a long time, for rejecting the mustard of the product can be reduced, the mind of anxiety without the cigarette can be relieved, and the difficulty of smoking cessation can be reduced. In addition, the electronic cigarette is convenient to carry and use, is not limited by time space, and is more easily accepted.
Preferably, the throat-clearing lung-benefiting smoking-cessation electronic cigarette is provided with a tobacco tar storage cavity, and the throat-clearing lung-benefiting smoking-cessation composition is placed in the tobacco tar storage cavity.
The invention does not limit the structure of the throat-clearing lung-benefiting smoking-stopping electronic cigarette, and all the electronic cigarettes sold in the market and containing the tobacco tar storage cavity can be used for preparing the throat-clearing lung-benefiting smoking-stopping electronic cigarette, and the throat-clearing lung-benefiting smoking-stopping composition is placed in the tobacco tar storage cavity to replace the conventional tobacco tar.
Drawings
Fig. 1 is a schematic cross-sectional view of an electronic cigarette for clearing throat, benefiting lung and stopping smoking in embodiment 11 of the present invention;
fig. 2 is a schematic perspective view of an electronic cigarette for clearing throat, benefiting lung and stopping smoking in embodiment 11 of the present invention;
FIG. 3 shows an experimental apparatus in experimental example 1 of the present invention.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The long-term smoker can produce a plurality of physical and psychological comprehensive reactions such as craving smoking, dysphoria, depression, headache, instability, mental difficulty concentration, drowsiness, gastrointestinal dysfunction and the like when smoking cigarettes, and the clinical symptoms of traditional Chinese medicine include yellow and greasy tongue coating, wiry and slippery pulse, epigastric fullness and chest distress, nausea, dizziness, neurasthenia and the like. In the invention, the Chinese herbal medicine is taken as the medicinal component for research, and the throat-clearing lung-benefiting smoking-stopping composition is prepared from the following raw materials in parts by weight: 8-12 parts of coptis chinensis, 15-25 parts of bamboo shavings, 8-12 parts of immature bitter orange, 8-12 parts of pinellia ternate, 8-12 parts of exocarpium citri rubrum, 5-7 parts of liquorice, 5-7 parts of ginger, 8-12 parts of poria cocos, 8-12 parts of platycodon grandiflorum, 8-12 parts of aster, 15-25 parts of radix stemonae, 8-12 parts of cynanchum glaucescens, 8-12 parts of dried orange peel, 8-12 parts of mugwort leaf, 8-12 parts of perilla leaf, 8-12 parts of mint, 2-4 parts of borneol and 10-20 parts of snakegourd fruit.
The throat-clearing lung-benefiting smoking-stopping composition has the effects of clearing heat and benefiting lung, regulating qi and resolving phlegm, harmonizing stomach and resolving depression through the compatibility of the raw materials in a specific dosage proportion.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition comprises the following operations: extracting essential oil of the traditional Chinese medicine raw materials except borneol, uniformly mixing the essential oil according to the weight part ratio of the raw materials in the throat-clearing lung-benefiting smoking-stopping composition, adding the borneol and dissolving to obtain the traditional Chinese medicine smoking-stopping composition, or weighing the raw materials according to the weight part ratio, extracting the essential oil of the traditional Chinese medicine raw materials except borneol, uniformly mixing the obtained essential oil, adding the borneol and dissolving to obtain the traditional Chinese medicine smoking-stopping composition.
The throat-clearing lung-benefiting smoking-stopping composition can be used for preparing throat-clearing lung-benefiting smoking-stopping electronic cigarettes, and the essential oil of the traditional Chinese medicine raw materials can be atomized into smoke fog through the microelectronic technology and the physical atomization technology of the electronic cigarettes to produce the effects of clearing throat, benefiting lung and reducing smoking addiction in an inhalation mode. And the electronic cigarette is convenient to carry and use and is easy to accept.
The electronic cigarette with the tobacco tar storage cavity can be used for preparing the electronic cigarette for clearing throat, benefiting lung and stopping smoking, and the tobacco tar can be replaced by the composition for clearing throat, benefiting lung and stopping smoking.
The following examples are provided to further illustrate embodiments of the invention.
The experimental methods used in the following examples are conventional in the art unless otherwise specified.
The following examples were prepared from Coptidis rhizoma, caulis Bambusae in Taenia, fructus Aurantii Immaturus, rhizoma Pinelliae, exocarpium Citri rubrum, glycyrrhrizae radix, rhizoma Zingiberis recens, poria, radix Platycodi, radix Asteris, radix Stemonae, rhizoma Cynanchi Stauntonii, pericarpium Citri Tangerinae, folium Artemisiae Argyi, folium Perillae, herba Menthae, borneolum Syntheticum, fructus Trichosanthis and Scutellariae radix, and are in accordance with the corresponding specifications of a part of the text of Chinese pharmacopoeia (2020 edition).
Other materials, reagents, etc. used in the examples below were obtained commercially unless otherwise specified.
Example 1
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of coptis chinensis, 20 parts of caulis bambusae in taeniam, 10 parts of immature bitter orange, 10 parts of pinellia ternate, 10 parts of exocarpium citri rubrum, 6 parts of liquorice, 6 parts of ginger, 10 parts of poria cocos, 10 parts of platycodon grandiflorum, 10 parts of aster, 20 parts of radix stemonae, 10 parts of cynanchum glaucescens, 10 parts of pericarpium citri reticulatae, 10 parts of folium artemisiae argyi, 10 parts of perilla leaf, 10 parts of mint, 3 parts of borneol and 15 parts of snakegourd fruit.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition comprises the following steps:
weighing the raw materials according to the weight portion;
distilling Coptidis rhizoma with 4 times of purified water for 4 hr, and collecting the oily component to obtain Coptidis rhizoma essential oil;
distilling caulis Bambusae in Taenia with 6 times of purified water for 4 hr, and collecting the oily component to obtain caulis Bambusae in Taenia essential oil;
distilling fructus Aurantii Immaturus with 4 times of purified water for 5 hr, and collecting the oily component to obtain fructus Aurantii Immaturus essential oil;
extracting rhizoma Pinelliae with 4 times of purified water for 5 hr, and collecting oily components to obtain rhizoma Pinelliae essential oil;
extracting exocarpium Citri rubrum with 4 times of purified water for 5 hr, and collecting oily components to obtain exocarpium Citri rubrum essential oil;
distilling Glycyrrhrizae radix with 6 times of purified water for 3 hr, and collecting oily component to obtain Glycyrrhrizae radix essential oil;
distilling rhizoma Zingiberis recens with 3 times of purified water for 4 hr, and collecting the oily component to obtain rhizoma Zingiberis recens essential oil;
extracting Poria with 5 times of purified water for 5 hr, and collecting oily components to obtain Poria essential oil;
distilling radix Platycodi with 5 times of purified water for 3 hr, and collecting the oily component to obtain radix Platycodi essential oil;
distilling radix Asteris with 6 times of purified water for 3 hr, and collecting the oily component to obtain radix Asteris essential oil;
extracting radix Stemonae with 5 times of purified water for 4 hr, and collecting the oily component to obtain radix Stemonae essential oil;
distilling and extracting rhizoma Cynanchi Stauntonii with 5 times of purified water for 4 hr, and collecting the oily component to obtain rhizoma Cynanchi Stauntonii essential oil;
extracting pericarpium Citri Tangerinae with 5 times of purified water for 3 hr, and collecting oily components to obtain pericarpium Citri Tangerinae essential oil;
distilling and extracting folium Artemisiae Argyi with 6 times of purified water for 3 hr, and collecting the oily component to obtain folium Artemisiae Argyi essential oil;
distilling folium Perillae with 6 times of purified water for 3 hr, and collecting the oily component to obtain folium Perillae essential oil;
extracting herba Menthae with 4 times of purified water for 3 hr, and collecting the oily component to obtain herba Menthae essential oil;
distilling fructus Trichosanthis with 7 times of purified water for 5 hr, and collecting the oily component to obtain fructus Trichosanthis essential oil;
mixing the essential oils, adding Borneolum Syntheticum, and dissolving to obtain the composition for clearing throat, benefiting lung and stopping smoking.
Example 2
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 9 parts of coptis chinensis, 18 parts of caulis bambusae in taeniam, 9 parts of immature bitter orange, 9 parts of pinellia ternate, 9 parts of exocarpium citri rubrum, 5.5 parts of liquorice, 5.5 parts of ginger, 9 parts of poria cocos, 9 parts of platycodon grandiflorum, 9 parts of aster, 18 parts of radix stemonae, 9-11 parts of cynanchum atratum, 9 parts of pericarpium citri reticulatae, 9 parts of folium artemisiae argyi, 9 parts of perilla leaf, 9 parts of mint, 2.5 parts of borneol and 13 parts of snakegourd fruit.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition is the same as that of example 1.
Example 3
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 11 parts of coptis chinensis, 22 parts of bamboo shavings, 11 parts of immature bitter orange, 11 parts of pinellia ternate, 11 parts of exocarpium citri rubrum, 6.5 parts of liquorice, 6.5 parts of ginger, 11 parts of poria cocos, 11 parts of platycodon grandiflorum, 11 parts of aster, 22 parts of radix stemonae, 11 parts of cynanchum atratum, 11 parts of pericarpium citri reticulatae, 11 parts of folium artemisiae argyi, 11 parts of perilla leaves, 11 parts of mint, 3.5 parts of borneol and 17 parts of snakegourd fruit.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition is the same as that of example 1.
Example 4
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8 parts of coptis chinensis, 15 parts of bamboo shavings, 8 parts of immature bitter orange, 8 parts of pinellia ternate, 8 parts of exocarpium citri rubrum, 5 parts of liquorice, 5 parts of ginger, 8 parts of poria cocos, 8 parts of platycodon grandiflorum, 8 parts of aster, 15 parts of radix stemonae, 8 parts of cynanchum glaucescens, 8 parts of pericarpium citri reticulatae, 8 parts of folium artemisiae argyi, 8 parts of perilla leaf, 8 parts of mint, 2 parts of borneol and 10 parts of snakegourd fruit.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition comprises the following steps:
weighing commercially available coptis chinensis essential oil, bamboo shavings essential oil, immature bitter orange essential oil, pinellia tuber essential oil, exocarpium citri rubrum essential oil, liquorice essential oil, ginger essential oil, poria cocos essential oil, platycodon grandiflorum essential oil, aster essential oil, radix stemonae essential oil, cynanchum atratum essential oil, dried orange peel essential oil, mugwort leaf essential oil, perilla leaf essential oil, peppermint essential oil and snakegourd essential oil according to the weight ratio of the raw materials, mixing uniformly, adding borneol and dissolving.
Example 5
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12 parts of coptis chinensis, 25 parts of caulis bambusae in taeniam, 12 parts of immature bitter orange, 12 parts of pinellia ternate, 12 parts of exocarpium citri rubrum, 7 parts of liquorice, 7 parts of ginger, 12 parts of poria cocos, 12 parts of platycodon grandiflorum, 12 parts of aster, 25 parts of radix stemonae, 12 parts of cynanchum glaucescens, 12 parts of pericarpium citri reticulatae, 12 parts of folium artemisiae argyi, 12 parts of perilla leaf, 12 parts of mint, 4 parts of borneol and 20 parts of snakegourd fruit.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition is the same as that of example 4.
Example 6
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of coptis chinensis, 20 parts of caulis bambusae in taeniam, 10 parts of immature bitter orange, 10 parts of pinellia ternate, 10 parts of exocarpium citri rubrum, 6 parts of liquorice, 6 parts of ginger, 10 parts of poria cocos, 10 parts of platycodon grandiflorum, 10 parts of aster, 20 parts of radix stemonae, 10 parts of cynanchum glaucescens, 10 parts of pericarpium citri reticulatae, 10 parts of folium artemisiae argyi, 10 parts of perilla leaf, 10 parts of mint, 3 parts of borneol, 15 parts of snakegourd fruit and 10 parts of radix scutellariae.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition comprises the following steps:
the preparation method of example 1 comprises preparing Coptidis rhizoma essential oil, caulis Bambusae in Taenia essential oil, fructus Aurantii Immaturus essential oil, rhizoma Pinelliae essential oil, exocarpium Citri rubrum essential oil, glycyrrhrizae radix essential oil, rhizoma Zingiberis recens essential oil, poria essential oil, radix Platycodi essential oil, radix Asteris essential oil, radix Stemonae essential oil, rhizoma Cynanchi Stauntonii essential oil, pericarpium Citri Tangerinae essential oil, folium Artemisiae Argyi essential oil, folium Perillae essential oil, herba Menthae essential oil, and fructus Trichosanthis essential oil;
extracting Scutellariae radix with 7 times of purified water for 5 hr, and collecting the oily component to obtain Scutellariae radix essential oil.
Mixing the above essential oils, adding Borneolum Syntheticum, and dissolving to obtain the composition for clearing throat, benefiting lung and stopping smoking.
Example 7
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 9 parts of coptis chinensis, 18 parts of bamboo shavings, 9 parts of immature bitter orange, 9 parts of pinellia ternate, 9 parts of exocarpium citri rubrum, 5.5 parts of liquorice, 5.5 parts of ginger, 9 parts of poria cocos, 9 parts of platycodon grandiflorum, 9 parts of aster, 18 parts of radix stemonae, 9-11 parts of cynanchum atratum, 9 parts of pericarpium citri reticulatae, 9 parts of folium artemisiae argyi, 9 parts of perilla leaves, 9 parts of mint, 2.5 parts of borneol, 13 parts of snakegourd fruit and 9 parts of radix scutellariae.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition is the same as that of example 6.
Example 8
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 11 parts of coptis chinensis, 22 parts of bamboo shavings, 11 parts of immature bitter orange, 11 parts of pinellia ternate, 11 parts of exocarpium citri rubrum, 6.5 parts of liquorice, 6.5 parts of ginger, 11 parts of poria cocos, 11 parts of platycodon grandiflorum, 11 parts of aster, 22 parts of radix stemonae, 11 parts of cynanchum atratum, 11 parts of pericarpium citri reticulatae, 11 parts of folium artemisiae argyi, 11 parts of perilla leaves, 11 parts of mint, 3.5 parts of borneol, 17 parts of snakegourd fruit and 11 parts of radix scutellariae.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition is the same as that of example 6.
Example 9
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8 parts of coptis chinensis, 15 parts of bamboo shavings, 8 parts of immature bitter orange, 8 parts of pinellia ternate, 8 parts of exocarpium citri rubrum, 5 parts of liquorice, 5 parts of ginger, 8 parts of poria cocos, 8 parts of platycodon grandiflorum, 8 parts of aster, 15 parts of radix stemonae, 8 parts of cynanchum glaucescens, 8 parts of dried orange peel, 8 parts of folium artemisiae argyi, 8 parts of perilla leaf, 8 parts of mint, 2 parts of borneol, 10 parts of snakegourd fruit and 8 parts of radix scutellariae.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition comprises the following steps:
weighing commercially available coptis chinensis essential oil, bamboo shavings essential oil, immature bitter orange essential oil, pinellia tuber essential oil, exocarpium citri rubrum essential oil, liquorice essential oil, ginger essential oil, poria cocos essential oil, platycodon root essential oil, aster essential oil, stemona essential oil, cynanchum atratum essential oil, dried orange peel essential oil, mugwort leaf essential oil, perilla leaf essential oil, peppermint essential oil, snakegourd essential oil and baical skullcap root essential oil according to the weight ratio of the raw materials, mixing uniformly, adding borneol and dissolving.
Example 10
The embodiment of the invention provides a throat-clearing lung-benefiting smoking-stopping composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 12 parts of coptis chinensis, 25 parts of bamboo shavings, 12 parts of immature bitter orange, 12 parts of pinellia ternate, 12 parts of exocarpium citri rubrum, 7 parts of liquorice, 7 parts of ginger, 12 parts of poria cocos, 12 parts of platycodon grandiflorum, 12 parts of aster, 25 parts of radix stemonae, 12 parts of cynanchum glaucescens, 12 parts of dried orange peel, 12 parts of folium artemisiae argyi, 12 parts of perilla leaf, 12 parts of mint, 4 parts of borneol, 20 parts of snakegourd fruit and 13 parts of radix scutellariae.
The preparation method of the throat-clearing lung-benefiting smoking-stopping composition is the same as that of example 9.
Example 11
The embodiment of the invention provides application of the throat-clearing lung-benefiting smoking-cessation composition prepared in the embodiment in preparation of throat-clearing lung-benefiting smoking-cessation electronic cigarettes.
The structure of the throat-clearing lung-benefiting smoking-cessation electronic cigarette is shown in fig. 1 and 2, and the electronic cigarette consists of 6 components, namely a USB rechargeable battery, a Typ-C interface, an integrated circuit, an electronic airflow sensor, a tobacco tar storage cavity and an atomizer. Wherein the tobacco tar storage chamber is used for placing the throat-clearing lung-benefiting smoking-stopping composition in any one of embodiments 1-10.
In the using process, a user generates air flow through inspiration, and activates the switch under the action of the electronic airflow sensor, so that the throat-clearing lung-benefiting smoking-stopping composition is atomized through the atomizer and then enters the air pipe to reach the lung by the user, and the effects of clearing throat, benefiting lung, reducing phlegm, concentrating spirit and calming the mind, reducing smoking and the like are exerted.
Test example 1
The test example provides the abstinence effect of the throat-clearing lung-benefiting smoking-cessation composition prepared in the above examples 1-10 on nicotine-dependent rats.
1. Experimental materials
1.1 animals
SD rats (180-220 g), 6-8 weeks old, 60 males. Raising in clean animal house with temperature of 22-25 deg.c and humidity of 40-70% and with 12 hr light and 12 hr dark turning alternately. Rats were kept for approximately 1 week prior to the experiment to accommodate the environment, free-standing diet. Animal experiments are carried out according to the requirements of the national guidelines for welfare and ethical examination of experimental animals (GB/T35892-2018), and the welfare and ethical of experimental animals are standardized and implemented.
1.2 Experimental reagents
The compositions for clearing heat from throat, benefiting lung and stopping smoking obtained in examples 1 to 3 and 6 to 8.
Nicotine: analytically pure, pale yellow oily liquid, supplied by Chongqing Zhongyan industry Limited liability company laboratory, was prepared into nicotine solution by dissolving nicotine with physiological saline before modeling.
2. Experimental method
2.1 establishing a rat nicotine dependency model and dosing intervention:
the rats were subcutaneously injected with 1mg/ml of nicotine at a dose of 0.4mg/kg twice daily for 7 consecutive days; 10 rats from the same batch were also used as a blank group, and physiological saline was subcutaneously injected at a dose of 0.4 ml/kg.
On day 8, rats injected with nicotine were randomly grouped into 10 groups, and each example group was administered with the respective throat-clearing lung-benefiting smoking-stopping compositions prepared in examples 1 to 3 and 6 to 8, and the positive drug group was given positive drug. The groups and the administration doses are respectively as follows:
example 1 low dose group: the dosage is 3.2mg/kg;
dose group in example 1: the dosage is 4.8mg/kg;
example 1 high dose group: the dosage is 6.4mg/kg;
example 2 group: the dosage is 4.8mg/kg;
example 3 group: the dosage is 4.8mg/kg;
example 6 group: the dosage is 4.8mg/kg;
example 7 group: the dosage is 4.8mg/kg;
example 8 group: the dosage is 4.8mg/kg;
positive drug group: the dosage is 4.8mg/kg;
model group: an equal amount of physiological saline was administered.
The preparation method of the positive medicine comprises the following steps: according to the formula of the lung-heat clearing and toxin expelling decoction, the traditional Chinese medicines (9 parts of ephedra herb, 6 parts of honey-fried licorice root, 9 parts of almond, 15-30 parts of gypsum, 9 parts of cassia twig, 9 parts of rhizoma alismatis, 9 parts of grifola, 9 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 16 parts of radix bupleuri, 6 parts of radix scutellariae, 9 parts of rhizoma pinelliae preparata, 9 parts of ginger, 9 parts of aster, 9 parts of flos farfarae, 9 parts of blackberry lily, 6 parts of asarum, 12 parts of Chinese yam, 6 parts of immature bitter orange, 6 parts of dried orange peel and 9 parts of wrinkled gianthyssop) are taken, the essential oils of poria cocos, radix scutellariae, ginger, aster and dried orange peel are respectively prepared according to the method of the embodiment 6, and the essential oils are extracted from the other traditional Chinese medicines according to the following method:
distilling herba Ephedrae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, bupleuri radix, rhizoma Pinelliae Preparatum, and herba Pogostemonis with 4 times of purified water for 4 hr, and collecting the oily components to obtain herba Ephedrae essential oil, radix Glycyrrhizae Preparata essential oil, ramulus Cinnamomi essential oil, bupleuri radix essential oil, rhizoma Pinelliae Preparatum essential oil, and herba Pogostemonis essential oil; extracting semen Armeniacae amarum, alismatis rhizoma, polyporus, atractylodis rhizoma, flos Farfarae, rhizoma Belamcandae, herba asari, rhizoma Dioscoreae, and fructus Aurantii Immaturus with 5 times of purified water respectively by distillation for 5 hr, collecting oily components, and respectively obtaining semen Armeniacae amarum essential oil, alismatis rhizoma essential oil, polyporus essential oil, atractylodis rhizoma essential oil, flos Farfarae essential oil, rhizoma Belamcandae essential oil, herba asari essential oil, rhizoma Dioscoreae essential oil, and fructus Aurantii Immaturus essential oil.
Mixing the above essential oils, and adding Gypsum Fibrosum to obtain the final product.
Blank, dosing (distilled water) 4.8mg/kg.
The administration mode is as follows: inhalation, experiments were performed using the apparatus shown in fig. 3: the throat-clearing lung-benefiting smoking-stopping composition, the positive medicine or distilled water with the corresponding weight are measured according to the corresponding administration dose of each group, the throat-clearing lung-benefiting smoking-stopping composition, the positive medicine or distilled water are placed in a sample bottle, a heater (simulating the use state of the electronic cigarette in the embodiment 11) is started, the object to be measured is diffused into a glass jar in which a rat is placed, and an exhaust port is closed in the experimental process so as to prevent essential oil loss. And removing the sample bottle after 20min, introducing air, simultaneously opening the air outlet, and finishing ventilation in the glass cylinder to finish one-time administration.
The dosing was performed once daily at 9:00, 12:00, 21:00, respectively, and the rest of the time kept the air in the glass jar normally circulated. The administration is carried out for 3 days.
3. Observation index
3.1 open field experiment
The method is characterized in that an open field experiment box with the length of 50cm multiplied by 50cm is taken, the periphery and the bottom of the box are black, the box cover is made of white organic glass, and a ventilating fan and an infrared camera device are arranged and used for tracking and recording the movement track and movement time of a rat in the experiment box. After the end of the administration for 60min on day 3, the rats were placed at the center of the experimental box, and each rat was oriented to the same angle as the box body when placed, the box cover was closed, and the movement distance and movement time of the rats within 5min were recorded. Room temperature was maintained at 22 ℃ ± 1 ℃ during recording and room silence was maintained. The results are shown below:
table 1 open field test results
Figure SMS_1
Figure SMS_2
Figure SMS_3
* Represents P < 0.05 compared to model group; # indicates that P < 0.05 compared to the positive drug group.
3.2 elevated plus maze
At 60min after the end of the 3 rd day dosing, rats were placed into the maze from the central lattice towards the closed arms, and activity was recorded within 5 min. The open arm entry times (two melons must enter the arm), open arm dwell time, closed arm entry times, closed arm dwell time were observed. And calculating the residence time proportion of the open arms and the entering frequency proportion of the open arms. After the experiment is completed, the rats are taken out, the two arms are cleaned up, alcohol is sprayed to remove smell, and data analysis is performed by Xeye animal behavioural software.
The results are shown below:
table 2 elevated plus maze test results
Figure SMS_4
Figure SMS_5
Figure SMS_6
* Represents P < 0.05 compared to model group; # indicates that P < 0.05 compared to the positive drug group.
3.3 respiratory frequency
Rats were tested for respiratory rate 60min after the end of day 3 dosing.
The results are shown below:
table 3 respiratory rate test results
Figure SMS_7
Respiratory rate
Blank group 95.3±5.28*#
Model group 112.9±3.26
Example 1 Low dose group 110.2±4.22
Dose group in example 1 103.7±4.39*#
Example 1 high dose group 95.2±5.17*#
Example 2 group 106.7±4.82*
Example 3 group 105.9±4.69*#
Example 6 group 98.2±3.97*#
Example 7 group 99.8±4.28*#
Example 8 group 101.7±4.57*#
Positive medicine group 109.9±5.24
* Represents P < 0.05 compared to model group; # indicates that P < 0.05 compared to the positive drug group.
3.4 quantitative analysis index
And (3) observing the indexes: chewing/staggering; twist/wheezing; tremor/tremors; and other symptoms (licking feet, scratching, and yawning) are divided by 10 by 1 score, respectively; eyelid prolapse is measured as light, medium and heavy 1, 2 and 3 points respectively.
The results are shown below:
TABLE 4 quantitative analysis of index results
Figure SMS_8
Figure SMS_9
Figure SMS_10
* Represents P < 0.05 compared to model group; # indicates that P < 0.05 compared to the positive drug group.
The throat-clearing lung-benefiting smoking-stopping compositions of the groups 4, 5, 9 and 10 are tested according to the method, and the effect of relieving the nicotine withdrawal symptoms can be achieved, and the data in all aspects are obviously different from that in the model group.
The results prove that the throat-clearing lung-benefiting smoking-stopping composition provided by the invention has a remarkable effect of relieving nicotine withdrawal symptoms.
Test example 2
The test example provides the effect of the throat-clearing lung-benefiting smoking-stopping compositions prepared in the above examples 1-10 on the saturation of blood samples.
Test example 1 after each group of rats was subjected to each test, heart blood was collected using a heparinized syringe, and the saturation of the blood sample was measured. The results were as follows:
TABLE 5 blood oxygen saturation detection results
Figure SMS_11
Figure SMS_12
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Figure SMS_13
* Represents P < 0.05 compared to model group; # indicates that P < 0.05 compared to the positive drug group.
It can be seen that each example group was able to significantly increase the blood oxygen saturation of rats.
The throat-clearing lung-benefiting smoking-stopping compositions of the examples 4, 5, 9 and 10 are tested according to the method, and the effect of improving the blood oxygen saturation can be achieved, and the data in all aspects are obviously different from that in the model group.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, or alternatives falling within the spirit and principles of the invention.

Claims (10)

1. The throat-clearing lung-benefiting smoking-stopping composition is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 8-12 parts of coptis chinensis, 15-25 parts of bamboo shavings, 8-12 parts of immature bitter orange, 8-12 parts of pinellia ternate, 8-12 parts of exocarpium citri rubrum, 5-7 parts of liquorice, 5-7 parts of ginger, 8-12 parts of poria cocos, 8-12 parts of platycodon grandiflorum, 8-12 parts of aster, 15-25 parts of radix stemonae, 8-12 parts of cynanchum glaucescens, 8-12 parts of dried orange peel, 8-12 parts of mugwort leaf, 8-12 parts of perilla leaf, 8-12 parts of mint, 2-4 parts of borneol and 10-20 parts of snakegourd fruit.
2. The composition for clearing heat from throat, benefiting lung and stopping smoking according to claim 1 is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 9 to 11 parts of coptis chinensis, 18 to 22 parts of bamboo shavings, 9 to 11 parts of immature bitter orange, 9 to 11 parts of pinellia ternate, 9 to 11 parts of exocarpium citri rubrum, 5.5 to 6.5 parts of liquorice, 5.5 to 6.5 parts of ginger, 9 to 11 parts of poria cocos, 9 to 11 parts of platycodon grandiflorum, 9 to 11 parts of aster, 18 to 22 parts of radix stemonae, 9 to 11 parts of cynanchum atratum, 9 to 11 parts of dried orange peel, 9 to 11 parts of folium artemisiae argyi, 9 to 11 parts of perilla leaf, 9 to 11 parts of mint, 2.5 to 3.5 parts of borneol and 13 to 17 parts of snakegourd fruit.
3. The composition for clearing heat from throat, benefiting lung and stopping smoking according to claim 2 is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of coptis chinensis, 20 parts of caulis bambusae in taeniam, 10 parts of immature bitter orange, 10 parts of pinellia ternate, 10 parts of exocarpium citri rubrum, 6 parts of liquorice, 6 parts of ginger, 10 parts of poria cocos, 10 parts of platycodon grandiflorum, 10 parts of aster, 20 parts of radix stemonae, 10 parts of cynanchum glaucescens, 10 parts of pericarpium citri reticulatae, 10 parts of folium artemisiae argyi, 10 parts of perilla leaf, 10 parts of mint, 3 parts of borneol and 15 parts of snakegourd fruit.
4. The composition for clearing heat from throat, benefiting lung and stopping smoking according to any one of claims 1 to 3, wherein the traditional Chinese medicine raw materials further comprise 8 to 13 parts of baikal skullcap root.
5. The composition for clearing heat from throat, benefiting lung and stopping smoking according to claim 4, wherein the weight portion of the baikal skullcap root is 9-11 portions.
6. The composition for clearing heat from throat, benefiting lung and stopping smoking according to claim 5, wherein the weight part of the scutellaria baicalensis is 10 parts.
7. The method for preparing the composition for clearing throat, benefiting lung and stopping smoking according to any one of claims 1 to 6, which is characterized by comprising the following operations: extracting essential oil of the traditional Chinese medicine raw materials except borneol, uniformly mixing the essential oil according to the weight part ratio of the raw materials in the throat-clearing lung-benefiting smoking-stopping composition, adding the borneol and dissolving to obtain the throat-clearing lung-benefiting smoking-stopping composition; or (b)
Weighing the raw materials according to the weight portion ratio, extracting essential oil of the traditional Chinese medicine raw materials except borneol, uniformly mixing the obtained essential oil, adding the borneol and dissolving to obtain the throat-clearing lung-benefiting smoking-stopping composition.
8. The method for preparing the throat-clearing lung-benefiting smoking cessation composition according to claim 7, wherein the preparation method of the essential oil of the traditional Chinese medicine raw materials is as follows: adding 3-7 times of purified water into the traditional Chinese medicine raw materials, distilling and extracting for 3-5 hours, and collecting the obtained oily components to obtain the traditional Chinese medicine.
9. Use of a composition for clearing throat, benefiting lung and stopping smoking prepared by the preparation method of claim 7 or 8 in preparing an electronic cigarette for clearing throat, benefiting lung and stopping smoking.
10. The use according to claim 9, wherein the throat-clearing lung-benefiting smoking cessation electronic cigarette is provided with a tobacco tar storage cavity, and the throat-clearing lung-benefiting smoking cessation composition is placed in the tobacco tar storage cavity.
CN202210331776.6A 2022-03-30 2022-03-30 Throat-clearing lung-benefiting smoking-stopping composition, and preparation method and application thereof Active CN114681583B (en)

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