CN114681326A - Multi-gene multi-factor dosing system for colorectal cancer patients and use method thereof - Google Patents
Multi-gene multi-factor dosing system for colorectal cancer patients and use method thereof Download PDFInfo
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- CN114681326A CN114681326A CN202210164867.5A CN202210164867A CN114681326A CN 114681326 A CN114681326 A CN 114681326A CN 202210164867 A CN202210164867 A CN 202210164867A CN 114681326 A CN114681326 A CN 114681326A
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- 206010009944 Colon cancer Diseases 0.000 title claims abstract description 45
- 208000001333 Colorectal Neoplasms Diseases 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 379
- 229940079593 drug Drugs 0.000 claims abstract description 40
- 238000012377 drug delivery Methods 0.000 claims abstract description 12
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- 238000007599 discharging Methods 0.000 claims description 19
- 241001411320 Eriogonum inflatum Species 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 8
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- KVUAALJSMIVURS-ZEDZUCNESA-L calcium folinate Chemical compound [Ca+2].C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 KVUAALJSMIVURS-ZEDZUCNESA-L 0.000 description 2
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- 201000002313 intestinal cancer Diseases 0.000 description 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0076—Medicament distribution means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0076—Medicament distribution means
- A61J7/0084—Medicament distribution means for multiple medicaments
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- Pharmacology & Pharmacy (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a polygene multifactor quantitative drug delivery system for colorectal cancer patients and a using method thereof, belonging to the technical field of medical equipment. The polygene multifactor quantitative drug delivery system for the colorectal cancer patients comprises a base, wherein a drug box is arranged on the base, a drug outlet cylinder is rotatably arranged at the bottom of the drug box and connected with a handle through a connecting rod, a plurality of drug bottles for storing drugs are arranged on the inner wall of the drug box, anti-loosening mechanisms are arranged in the drug bottles, a drug outlet groove for containing the drugs in the drug bottles is formed in the drug outlet cylinder, an adjusting component for adjusting the dosage of the drugs is arranged in the drug outlet groove, and through holes for communicating the drug bottles with the drug outlet groove are formed in the drug box; the invention can accurately and quantitatively take the medicine, is suitable for pill-shaped medicines and granular medicines with different sizes, realizes individual and accurate medicine taking for the patient with colorectal cancer, and can effectively remind the patient when the medicine amount is insufficient.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a polygene multifactor quantitative drug delivery system for colorectal cancer patients and a using method thereof.
Background
Colorectal cancer is generally referred to as large bowel cancer. Large bowel cancer is a common malignancy, including colon and rectal cancers. The incidence of colon cancer is, in order from high to low, rectal, sigmoid, cecum, ascending colon, descending colon, and transverse colon, and recently, the development of colon cancer tends to be toward the proximal end (right-half colon). The conventional treatment regimen for colorectal cancer patients is FOLFIRI (fluorouracil, calcium folinate, irinotecan), and the dosage of fluorouracil, calcium folinate and irinotecan in FOLFIRI dosing regimens is currently calculated based on the patient's Body Surface Area (BSA).
The existing colorectal cancer administration method has great disadvantages, on one hand, the differences of patients such as individual organ functions, disease development conditions and differences of drug absorption, metabolism and excretion caused by individual gene regulation cannot be considered, so that the patients have great safety and curative effect differences, most of the patients do not receive the optimal drug dosage, and individual precise administration cannot be realized; simultaneously because some medicines are unstable to light, make the medicine effect change easily, the medicine bottle generally does not set up transparent visual, can not remind the patient when the dose is not enough, influences the patient and uses medicine time.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a polygene multifactorial quantitative drug delivery system for colorectal cancer patients and a using method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
colorectal cancer patient polygenic factor multifactor ration drug delivery system, which comprises a base, be provided with the medical kit on the base, the bottom of medical kit is rotated and is provided with out the cartridge case, it is connected with the handle through the connecting rod to go out the cartridge case, the medical kit inner wall is provided with a plurality of medicine bottles that are used for depositing the medicine, be provided with locking mechanism in the medicine bottle, go out and be equipped with the play medicine groove that is used for the splendid attire medicine bottle interior medicine in the medicine bottle, it is provided with the adjusting part who is used for adjusting the medicine quantity to go out the medicine inslot, offer the through-hole that is used for communicateing the medicine bottle and goes out the medicine groove on the medical kit.
Preferably, the outer wall of the medicine outlet barrel is connected with a sliding block, an arc sliding groove matched with the sliding block is formed in the medicine box, and an arc spring is arranged between the sliding block and the arc sliding groove.
Preferably, the anti-loosening mechanism comprises a pressing component and a lifting component, the pressing component comprises a bottle stopper in threaded connection with the medicine bottle, a first elastic element is arranged on the bottom wall of the bottle stopper, and a pressing plate used for pressing the medicine is connected to one end, far away from the bottle stopper, of the first elastic element.
Preferably, lift up the subassembly include with clamp plate fixed connection's connecting rod, the one end that the clamp plate was kept away from to the connecting rod passes the bottle plug and is connected with the limiting plate, limiting plate outer wall cover is equipped with the sleeve pipe, limiting plate sliding connection is in the sleeve pipe, sheathed tube top is connected with the atress board, be provided with the elastic telescopic rod between atress board and the medical kit, lift up the subassembly still include with play cartridge fixed connection's lug, the lug offsets with the atress board activity.
Preferably, the lug includes and goes out a explosive cartridge fixed connection's fixed block, set up the cavity of mutual intercommunication in fixed block and the explosive cartridge, cavity inner wall is provided with second elastic element, the one end that cavity inner wall was kept away from to second elastic element is provided with the movable block, movable block sliding connection is in the cavity, just the movable block offsets with the atress board activity, the base includes supporting seat and rather than fixed connection's arc seat, the arc seat passes through bolt and explosive cartridge fixed connection, the movable block offsets with the inner wall activity of arc seat.
Preferably, the movable block and the arc seat are both provided with a groove, the inner wall of the groove is provided with a rotating shaft, and the rotating shaft is connected with an auxiliary wheel.
Preferably, the adjusting part is including setting firmly the fixed plate in a medicine groove, fixed plate female connection has the screw rod, be connected with the knob on the screw rod, the one end that the knob was kept away from to the screw rod passes the fixed plate and is connected with the regulating plate, regulating plate sliding connection is in a medicine inslot.
Preferably, be provided with third elastic element on the regulating plate, the one end that the regulating plate was kept away from to third elastic element is connected with the fly leaf, fixedly connected with movable rod on the fly leaf, the one end that the fly leaf was kept away from to the movable rod passes regulating plate and screw rod in proper order and outwards extends.
Preferably, the bottom of the pressure plate and the top of the movable plate are both bonded with sponge pads.
The invention also discloses a use method of the polygene multifactor quantitative drug delivery system for the colorectal cancer patient, which comprises the following steps:
s1: the patient respectively places a plurality of medicines for treating colorectal cancer in different medicine bottles in the medicine chest, the dosage of the medicines suitable for the patient each time is adjusted according to the examination report of the patient, the knob drives the screw rod to rotate by rotating the knob, the screw rod is in threaded connection with the fixed plate, the screw rod drives the adjusting plate to move up and down relative to the fixed plate, and the medicine taking capacity in the medicine outlet groove is adjusted;
s2: when a patient needs to take medicine, the medicine outlet barrel is rotated relative to the medicine box by rotating the handle at the medicine outlet barrel, the medicine outlet barrel rotates initially, the medicine outlet groove is not opposite to the through hole at the medicine box, the through hole is abutted against the side wall of the medicine outlet barrel, the medicine outlet groove is opposite to the through hole along with the rotation of the medicine outlet barrel, the convex block connected to the outer side of the medicine outlet barrel is abutted against the stress plate, the stress plate drives the limiting plate and the connecting rod and the pressing plate connected with the limiting plate to move upwards through the sleeve when moving upwards, so that the pressing plate does not abut against the medicine in the medicine bottle any more, and the medicine in the medicine bottle can move freely and falls into the medicine outlet groove through the through hole;
s3: after the medicine discharging groove is filled with the medicines, the medicine discharging barrel continues to rotate, the medicine discharging groove is driven to be far away from the through hole when the medicine discharging barrel rotates, the through hole abuts against the side wall of the medicine discharging barrel again, the medicine discharging groove leaks out of the medicine box along with the rotation of the medicine discharging barrel, and at the moment, the patients can collect the medicines;
s4: then, the acting force applied to the handle is cancelled, the arc-shaped spring recovers and the sliding block slides in the arc-shaped sliding groove, the sliding block drives the medicine outlet barrel to rotate, the medicine outlet groove which leaks out of the medicine box recovers to the position of the medicine box again, the medicine outlet groove passes through the through hole again in the rotation process, the medicine in the medicine bottle enters the medicine outlet groove again through the through hole, in the process, the protruding block abuts against the stress plate again, when the movable block in the protruding block rotates along with the medicine outlet barrel, the movable block abuts against the arc-shaped seat, the movable block is stressed and transmitted to the second elastic element, the elastic force of the second elastic element is smaller than that of the arc-shaped spring, the medicine outlet barrel rotates slowly when the medicine in the medicine outlet groove falls down from the through hole, the medicine in the medicine outlet groove can be filled completely, and the medicine outlet groove continues to rotate after being filled with the medicine under the elastic force of the arc-shaped spring until the medicine outlet groove moves to the initial position;
s5: the medicine box can be shaken, if the medicine box sends out the medicine shaking sound, and the medicine in the medicine box is pressed by the pressing plate, the medicine outlet groove is not filled with the medicine, and the medicine in the medicine box is not enough to meet the dosage of a patient at the next time; if the sound of the medicine shaking is not transmitted from the medicine box, the medicine in the medicine box is indicated to meet the medicine taking requirement of the next patient.
Compared with the prior art, the invention provides a polygene multifactor quantitative drug delivery system for colorectal cancer patients and a use method thereof, and the system has the following beneficial effects:
1. this polygenic factor multifactor quantitative drug delivery system of colorectal cancer patient and application method thereof can adjust the patient dosage of the different state of an illness through adjusting part, and ration that can be accurate is got it filled, realizes the individualized accurate medicine of colorectal cancer patient, and cooperates with the medicine outlet groove through locking mechanism, can effectively remind the patient when the dosage is not enough, makes the patient can in time mend medicine, avoids influencing the treatment of the state of an illness.
2. This polygenic multi-factor ration dosing system of colorectal cancer patient and application method thereof through rotating the knob, makes the knob drive the screw rod and rotates, screw rod and fixed plate threaded connection, and the screw rod drives the relative fixed plate of regulating plate and reciprocates, and then adjusts out the inside medicine capacity of taking medicine of medicine inslot, realizes the accurate medicine of colorectal cancer patient individuation.
3. This polygenic multi-factor ration drug delivery system of colorectal cancer patient and application method thereof, through rotating the handle of play cartridge case department, make out the cartridge case rotate for the medical kit, at this in-process, it is relative with the through-hole to go out the medicine groove, the medicine fills out the medicine groove that finishes, continue to rotate out the cartridge case, it keeps away from the through-hole to drive out the medicine groove when making out the cartridge case rotation, the through-hole offsets with the lateral wall that goes out the cartridge case once more, it spills the medical kit along with the rotation of going out the cartridge case to go out the medicine groove, the patient can collect the medicine this moment, the realization is got the medicine to the convenience of medicine.
4. This polygenic multifactor dosing system of colorectal cancer patient and application method thereof, through the recovery of arc spring and make the slider slide in the arc spout, when the movable block in the lug rotates along with a medicine section of thick bamboo, the movable block offsets with the arc seat, and the movable block atress is transmitted to second elastic element, and although second elastic element's elasticity is less than the arc spring, nevertheless makes to draw the medicine groove and go out the medicine section of thick bamboo rotation slowly when connecing the medicine that the through-hole department fell, guarantees to go out the medicine groove and can fill the medicine that finishes.
5. This polygene multifactor dosing system of colorectal cancer patient and application method thereof through set up deformable foam-rubber cushion on clamp plate and fly leaf, makes clamp plate or fly leaf when the medicine contact, and the foam-rubber cushion can effectively fill the space between medicine and clamp plate or the fly leaf, avoids when rocking the medical kit, even if the medicine quantity satisfies the patient demand, still has the medicine in the medical kit to rock the sound.
Drawings
FIG. 1 is a first schematic structural diagram of the present invention;
FIG. 2 is a second schematic structural view of the present invention;
FIG. 3 is a schematic structural view of the arc chute of the present invention;
fig. 4 is a first sectional view of the medicine box and the medicine discharge cartridge according to the present invention;
fig. 5 is a second schematic sectional view of the medicine chest and the medicine discharge case according to the present invention;
FIG. 6 is a schematic view of the pressing assembly of the present invention;
FIG. 7 is a schematic structural view of an adjustment assembly of the present invention;
FIG. 8 is a schematic cross-sectional view of the screw of the present invention;
FIG. 9 is a schematic cross-sectional view of a vial of the present invention;
FIG. 10 is a schematic cross-sectional view of a bump according to the present invention;
fig. 11 is a schematic structural view of the arc seat of the present invention.
In the figure: 1. a base; 101. a supporting seat; 102. an arc-shaped seat; 2. a medicine chest; 201. a through hole; 202. an arc-shaped chute; 3. discharging the medicine barrel; 301. a handle; 4. a medicine bottle; 5. a medicine outlet groove; 6. a bottle stopper; 601. a first elastic element; 602. pressing a plate; 7. a connecting rod; 701. a limiting plate; 702. a sleeve; 703. a stress plate; 7031. an elastic telescopic rod; 8. a bump; 9. a slider; 901. an arc spring; 10. a fixed block; 11. a cavity; 111. a second elastic element; 112. a movable block; 12. a groove; 121. a rotating shaft; 122. an auxiliary wheel; 13. a fixing plate; 131. a screw; 132. a knob; 133. an adjusting plate; 14. a third elastic element; 141. a movable plate; 15. a movable rod; 16. a spongy cushion.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are used only for convenience in describing the present invention and for simplification of description, and do not indicate or imply that the system or element being referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
Example 1:
referring to fig. 1, fig. 2, fig. 4 and fig. 5, polygenic multi-factor ration dosing system of colorectal cancer patient, including base 1, be provided with medical kit 2 on the base 1, the bottom of medical kit 2 is rotated and is provided with out cartridge case 3, it is connected with handle 301 through the connecting rod to go out cartridge case 3, 2 inner walls of medical kit are provided with a plurality of medicine bottles 4 that are used for depositing the medicine, be provided with locking mechanism in the medicine bottle 4, it has the play medicine groove 5 that is used for splendid attire medicine bottle 4 medicine to go out to have seted up in the cartridge case 3, it is provided with the adjusting part that is used for adjusting the medicine quantity in the medicine groove 5 to go out, set up the through-hole 201 that is used for communicateing medicine bottle 4 and play medicine groove 5 on medical kit 2.
It is specific, the patient will treat the multiple medicine of colorectal cancer and place respectively in different medicine bottle 4 in medical kit 2, according to patient's inspection report, adjust out the medicine capacity of 5 inside medicine grooves through adjusting part, the adjustment is fit for the patient at every turn to the quantity of medicine, realize the individualized accurate medicine of colorectal cancer patient, and cooperate with play medicine groove 5 through locking moving mechanism, can effectively remind the patient when the quantity is not enough, make the patient can in time mend the medicine, avoid influencing the treatment of the state of an illness.
Example 2:
referring to fig. 3, 4 and 6, the multi-gene multi-factor quantitative drug delivery system for colorectal cancer patients is the same as that in embodiment 1, further, the outer wall of the drug outlet barrel 3 is connected with a slide block 9, the medicine chest 2 is provided with an arc-shaped chute 202 matched with the slide block 9, and an arc-shaped spring 901 is arranged between the slide block 9 and the arc-shaped chute 202; when the medicine discharge barrel 3 rotates relative to the medicine chest 2, the slider 9 slides in the arc-shaped sliding groove 202, and the arc-shaped spring 901 can automatically reset the medicine discharge barrel 3.
As a preferred technical scheme of the present invention, the anti-loosening mechanism comprises a pressing component and a lifting component, the pressing component comprises a bottle stopper 6 in threaded connection with the medicine bottle 4, a first elastic element 601 is arranged on the bottom wall of the bottle stopper 6, and a pressing plate 602 for pressing the medicine is connected to one end of the first elastic element 601 away from the bottle stopper 6; can fill medicine in the medicine bottle 4 through rotatory bottle stopper 6, first elastic element 601 can promote clamp plate 602 and extrude the medicine in the medicine bottle 4, prevents that the medicine from rocking in medicine bottle 4.
Example 3:
referring to fig. 1, 4, 5, 9, 10 and 11, the multi-gene multi-factor dosing system for colorectal cancer patients is the same as that of embodiment 2, further, the lifting assembly includes a connecting rod 7 fixedly connected with the pressing plate 602, one end of the connecting rod 7 far away from the pressing plate 602 penetrates through the bottle stopper 6 and is connected with a limiting plate 701, a sleeve 702 is sleeved on the outer wall of the limiting plate 701, the limiting plate 701 is slidably connected in the sleeve 702, a stressed plate 703 is connected to the top of the sleeve 702, an elastic telescopic rod 7031 is arranged between the stressed plate 703 and the medicine box 2, the lifting assembly further includes a bump 8 fixedly connected with the medicine outlet barrel 3, and the bump 8 is movably abutted against the stressed plate 703; when the patient need use medicine, handle 301 through rotating out 3 departments of cartridge case, make out 3 cartridges for the medical kit 2 rotation, it is initial to go out 3 cartridges, it is relative not with the through-hole 201 of 2 departments of medical kit not to go out medicine groove 5, through-hole 201 and 3 lateral walls looks butt of a cartridge case, along with the rotation of going out 3 cartridges, it is relative with through-hole 201 to go out medicine groove 5, and the lug 8 that 3 outside of a cartridge case was connected were gone out this moment offsets with atress board 703, connecting rod 7 and clamp plate 602 that the atress board 703 was connected through sleeve pipe 702 drive limiting plate 701 and with limiting plate 701 shift up when shifting up, make clamp plate 602 no longer to the medicine in the medicine bottle 4 support the pressure, medicine in the medicine bottle 4 can free activity and drop in a medicine groove 5 through-hole 201, the bottom of medicine bottle 4 can set up to be equipped with open-ended back taper, be convenient for pouring out of medicine.
As a preferred technical solution of the present invention, the bump 8 includes a fixed block 10 fixedly connected to the medicine output barrel 3, a cavity 11 communicated with each other is formed in the fixed block 10 and the medicine output barrel 3, a second elastic element 111 is disposed on an inner wall of the cavity 11, a movable block 112 is disposed at an end of the second elastic element 111 away from the inner wall of the cavity 11, the movable block 112 is slidably connected in the cavity 11, and the movable block 112 movably abuts against the stress plate 703, the base 1 includes a support seat 101 and an arc seat 102 fixedly connected thereto, the arc seat 102 is fixedly connected to the medicine box 2 through a bolt, and the movable block 112 movably abuts against an inner wall of the arc seat 102; in the rotation process of the medicine outlet barrel 3, the convex block 8 at the outer side of the medicine outlet barrel 3 abuts against the inner wall of the arc-shaped seat 102, the movable block 112 is contracted in the fixed block 10, but when the medicine outlet groove 5 is opposite to the through hole 201, the movable block 112 is not pressed by the arc-shaped seat 102, the second elastic element 111 pushes the movable block 112 to move out of the fixed block 10 and abut against the stress plate 703, the elastic telescopic rod 7031 is stretched, the stress plate 703 moves upwards to drive the limiting plate 701, the connecting rod 7 connected with the limiting plate 701 and the pressing plate 602 to move upwards through the sleeve 702, so that the pressing plate 602 does not press the medicine in the medicine bottle 4 any more, the medicine in the medicine bottle 4 can freely move and fall into the medicine outlet groove 5 through the through hole 201, along with the rotation of the convex block 8 along with the medicine outlet barrel 3, the movable block 112 abuts against the side wall of the arc-shaped seat 102, the movable block 112 is pressed and transferred to the second elastic element 111, the elasticity of the second elastic element 111 is smaller than the arc-shaped spring 901, but the medicine outlet barrel 3 rotates slowly when the medicine outlet groove 5 receives the medicine falling from the through hole 201, so that the medicine outlet groove 5 can be completely filled with the medicine.
As the preferred technical scheme of the invention, the movable block 112 and the arc seat 102 are both provided with a groove 12, the inner wall of the groove 12 is provided with a rotating shaft 121, and the rotating shaft 121 is connected with an auxiliary wheel 122; avoid the serious abrasion between the movable block 112 and the arc seat 102.
Example 4:
referring to fig. 4, 7 and 8, the multi-gene multi-factor dosing system for colorectal cancer patients is the same as that of embodiment 2, and further, the adjusting assembly comprises a fixing plate 13 fixedly arranged in the drug discharge groove 5, a screw 131 is connected to the fixing plate 13 through an internal thread, a knob 132 is connected to the screw 131, one end of the screw 131 far away from the knob 132 penetrates through the fixing plate 13 and is connected with an adjusting plate 133, and the adjusting plate 133 is slidably connected in the drug discharge groove 5.
Concretely, through rotating knob 132, make knob 132 drive screw rod 131 rotate, screw rod 131 and 13 threaded connection of fixed plate, screw rod 131 drives adjusting plate 133 and reciprocates relatively fixed plate 13, and then adjusts out the inside capacity of using medicine of medicine groove 5, realizes the accurate medicine of colorectal cancer patient individuation.
Example 5:
referring to fig. 7 and 8, a multi-gene multi-factor dosing system for colorectal cancer patients is similar to that of embodiment 3, and further, a third elastic element 14 is disposed on the adjusting plate 133, a movable plate 141 is connected to an end of the third elastic element 14 away from the adjusting plate 133, a movable rod 15 is fixedly connected to the movable plate 141, and an end of the movable rod 15 away from the movable plate 141 sequentially passes through the adjusting plate 133 and the screw 131 and extends outward.
Specifically, after the medicine is taken out, the acting force applied to the handle 301 is cancelled, the arc-shaped spring 901 is restored, the sliding block 9 slides in the arc-shaped sliding groove 202, the sliding block 9 drives the medicine outlet cylinder 3 to rotate, in the process, the medicine outlet groove 5 is filled with the medicine through the through hole 201, then the medicine outlet cylinder 3 continues to rotate until the medicine outlet cylinder moves to the initial position, at this time, the medicine box 2 can be shaken, if the sound of shaking of the medicine is sent out from the medicine box 2, under the condition that the medicine in the medicine box 4 is pressed by the pressing plate 602, it is indicated that the medicine in the medicine outlet groove 5 is not filled with the medicine, the medicine in the medicine box 2 is not enough to meet the dosage of the next patient, and when the medicine is not filled, the shaking of the medicine can exert force on the movable plate 141, the movable plate 141 extrudes the third elastic element 14, the movable plate 141 drives the movable rod 15 to move up and down, so that the patient can know which medicine dosage is insufficient, and can accurately add the medicine, the medicine bottles 4 are not required to be opened one by one to check the medicine amount of each medicine; if the medicine box 2 does not emit the sound of the medicine shaking, it indicates that the medicine in the medicine box 2 satisfies the demand for the next patient.
Example 6:
referring to fig. 6, the multi-gene multi-factor dosing system for colorectal cancer patients, like in example 3, further comprises a sponge pad 16 adhered to the bottom of the pressing plate 602 and the top of the movable plate 141; through set up deformable foam-rubber cushion 16 on clamp plate 602 and fly leaf 141, when making clamp plate 602 or fly leaf 141 lie in the medicine contact, foam-rubber cushion 16 can effectively fill the space between medicine and clamp plate 602 or fly leaf 141, avoids when rocking medical kit 2, even if the medicine quantity satisfies the patient's demand, still has the medicine in the medical kit 2 to rock the sound.
The invention also discloses a use method of the polygene multifactor quantitative drug delivery system for the colorectal cancer patient, which comprises the following steps:
s1: a patient places various medicines for treating colorectal cancer in different medicine bottles 4 in the medicine box 2 respectively, the dosage of the medicines suitable for the patient each time is adjusted according to the examination report of the patient, the knob 132 is rotated to drive the screw 131 to rotate, the screw 131 is in threaded connection with the fixed plate 13, the screw 131 drives the adjusting plate 133 to move up and down relative to the fixed plate 13, and then the medicine taking capacity in the medicine outlet groove 5 is adjusted;
s2: when a patient needs to take medicine, the medicine outlet barrel 3 is rotated relative to the medicine box 2 by rotating the handle 301 at the position of the medicine outlet barrel 3, the medicine outlet barrel 3 rotates initially, the medicine outlet groove 5 is not opposite to the through hole 201 at the position of the medicine box 2, the through hole 201 is abutted against the side wall of the medicine outlet barrel 3, the medicine outlet groove 5 is opposite to the through hole 201 along with the rotation of the medicine outlet barrel 3, the lug 8 connected to the outer side of the medicine outlet barrel 3 abuts against the stress plate 703, the stress plate 703 moves upwards and drives the limiting plate 701, the connecting rod 7 connected with the limiting plate 701 and the pressing plate 602 to move upwards through the sleeve 702, so that the pressing plate 602 does not abut against the medicine in the medicine bottle 4 any more, and the medicine in the medicine bottle 4 can move freely and falls into the medicine outlet groove 5 through the through hole 201;
s3: after the medicine discharging groove 5 is filled with the medicines, the medicine discharging barrel 3 continues to rotate, the medicine discharging groove 5 is driven to be far away from the through hole 201 when the medicine discharging barrel 3 rotates, the through hole 201 abuts against the side wall of the medicine discharging barrel 3 again, the medicine discharging groove 5 leaks out of the medicine box 2 along with the rotation of the medicine discharging barrel 3, and at the moment, the patients can collect the medicines;
s4: then, the acting force applied to the handle 301 is cancelled, the arc-shaped spring 901 is restored, the slide block 9 slides in the arc-shaped sliding groove 202, the slide block 9 drives the medicine outlet tank 3 to rotate, the medicine outlet groove 5 leaking out of the medicine boxes 2 is retracted to the medicine boxes 2 again, the medicine outlet groove 5 passes through the through hole 201 again in the rotation process, the medicine in the medicine bottle 4 enters the medicine outlet groove 5 again through the through hole 201, in the process, the lug 8 abuts against the stress plate 703 again, the movable block 112 abuts against the arc-shaped seat 102 when the movable block 112 in the lug 8 rotates along with the medicine outlet tank 3, the stress of the movable block 112 is transferred to the second elastic element 111, although the elastic force of the second elastic element 111 is smaller than that of the arc-shaped spring 901, the medicine outlet tank 5 rotates slowly when the medicine falling from the through hole 201 is received, the medicine outlet tank 5 can be filled with the medicine, and under the elastic force of the arc-shaped spring 901, the medicine outlet tank 5 continues to rotate after the medicine is filled, until the initial position is moved;
s5: at this time, the medicine box 2 can be shaken, and when the medicine shaking sound is transmitted from the medicine box 2 and the medicine in the medicine bottle 4 is pressed by the pressing plate 602, the medicine discharging groove 5 is not filled with the medicine, and the medicine in the medicine box 2 is insufficient to satisfy the dosage of the next patient; if the medicine box 2 does not emit the sound of the medicine shaking, it indicates that the medicine in the medicine box 2 satisfies the demand for the next patient.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. Colorectal cancer patient polygenic factor multifactor ration drug delivery system, including base (1), its characterized in that, be provided with medical kit (2) on base (1), the bottom of medical kit (2) is rotated and is provided with out cartridge case (3), it is connected with handle (301) through the connecting rod to go out cartridge case (3), medical kit (2) inner wall is provided with a plurality of medicine bottles (4) that are used for depositing the medicine, be provided with locking mechanism in medicine bottle (4), it is used for splendid attire medicine bottle (4) interior medicine groove (5) to have seted up in cartridge case (3), be provided with the adjusting part who is used for adjusting the medicine quantity in medicine groove (5), offer through-hole (201) that are used for communicateing medicine bottle (4) and play medicine groove (5) on medical kit (2).
2. The system for multi-gene multi-factor dosing of colorectal cancer patients according to claim 1, wherein a slide block (9) is connected to the outer wall of the drug outlet cylinder (3), an arc-shaped chute (202) matched with the slide block (9) is formed in the drug box (2), and an arc-shaped spring (901) is arranged between the slide block (9) and the arc-shaped chute (202).
3. A multi-gene multi-factor dosing system for colorectal cancer patients according to claim 2, wherein the anti-loosening mechanism comprises a pressing component and a lifting component, the pressing component comprises a bottle stopper (6) in threaded connection with the medicine bottle (4), the bottom wall of the bottle stopper (6) is provided with a first elastic element (601), and one end of the first elastic element (601) far away from the bottle stopper (6) is connected with a pressing plate (602) for pressing the medicine.
4. The system for multi-gene multi-factor dosing of colorectal cancer patients according to claim 3, wherein the lifting assembly comprises a connecting rod (7) fixedly connected with a pressing plate (602), one end of the connecting rod (7) far away from the pressing plate (602) penetrates through a bottle stopper (6) and is connected with a limiting plate (701), a sleeve (702) is sleeved on the outer wall of the limiting plate (701), the limiting plate (701) is slidably connected in the sleeve (702), a stress plate (703) is connected to the top of the sleeve (702), an elastic telescopic rod (7031) is arranged between the stress plate (703) and the medicine box (2), the lifting assembly further comprises a projection (8) fixedly connected with the medicine outlet box (3), and the projection (8) is movably abutted against the stress plate (703).
5. The multi-gene, multi-factor dosing system for colorectal cancer patients according to claim 4, it is characterized in that the lug (8) comprises a fixed block (10) fixedly connected with the medicine outlet cylinder (3), cavities (11) which are communicated with each other are arranged in the fixed block (10) and the medicine outlet cylinder (3), a second elastic element (111) is arranged on the inner wall of the cavity (11), a movable block (112) is arranged at one end, far away from the inner wall of the cavity (11), of the second elastic element (111), the movable block (112) is connected in the cavity (11) in a sliding manner, the movable block (112) is movably propped against the stress plate (703), the base (1) comprises a supporting seat (101) and an arc-shaped seat (102) fixedly connected with the supporting seat, the arc-shaped seat (102) is fixedly connected with the medicine chest (2) through bolts, and the movable block (112) is movably abutted against the inner wall of the arc-shaped seat (102).
6. The system for multi-gene multi-factor dosing of colorectal cancer patients according to claim 5, wherein the movable block (112) and the arc-shaped seat (102) are both provided with a groove (12), the inner wall of the groove (12) is provided with a rotating shaft (121), and the rotating shaft (121) is connected with an auxiliary wheel (122).
7. The system for multi-gene multi-factor dosing of colorectal cancer patients according to claim 2, wherein the adjusting assembly comprises a fixing plate (13) fixedly arranged in the drug discharge groove (5), a screw rod (131) is connected to the fixing plate (13) in a threaded manner, a knob (132) is connected to the screw rod (131), one end of the screw rod (131) far away from the knob (132) penetrates through the fixing plate (13) and is connected with an adjusting plate (133), and the adjusting plate (133) is slidably connected in the drug discharge groove (5).
8. The system for multi-gene multi-factor dosing of colorectal cancer patients according to claim 7, wherein a third elastic element (14) is disposed on the adjustment plate (133), a movable plate (141) is connected to one end of the third elastic element (14) away from the adjustment plate (133), a movable rod (15) is fixedly connected to the movable plate (141), and one end of the movable rod (15) away from the movable plate (141) sequentially passes through the adjustment plate (133) and the screw (131) and extends outwards.
9. The system for multi-gene multi-factor dosing of patients with colorectal cancer according to claim 8, wherein the bottom of the pressure plate (602) and the top of the movable plate (141) are both adhered with sponge pads (16).
10. A method of using the multi-gene, multi-factor dosing system of colorectal cancer patients according to any of claims 1-9, comprising the steps of:
s1: the patient places a plurality of medicines for treating colorectal cancer in different medicine bottles (4) in a medicine box (2) respectively, the dosage of the medicines suitable for the patient each time is adjusted according to the examination report of the patient, the knob (132) is rotated to drive the screw rod (131) to rotate, the screw rod (131) is in threaded connection with the fixing plate (13), the screw rod (131) drives the adjusting plate (133) to move up and down relative to the fixing plate (13), and the medicine consumption capacity in the medicine outlet groove (5) is adjusted;
s2: when a patient needs to take medicine, the medicine outlet barrel (3) is rotated relative to the medicine box (2) by rotating the handle (301) at the position of the medicine outlet barrel (3), the medicine outlet groove (5) is not opposite to the through hole (201) at the position of the medicine box (2) at the beginning of the rotation of the medicine outlet barrel (3), the through hole (201) is abutted against the side wall of the medicine outlet barrel (3), the medicine outlet groove (5) is opposite to the through hole (201) along with the rotation of the medicine outlet barrel (3), at the moment, the convex block (8) connected with the outer side of the medicine outlet cylinder (3) abuts against the stress plate (703), when the stress plate (703) moves upwards, the limiting plate (701), the connecting rod (7) connected with the limiting plate (701) and the pressing plate (602) are driven to move upwards through the sleeve (702), so that the pressing plate (602) does not press the medicine in the medicine bottle (4) any more, and the medicine in the medicine bottle (4) can move freely and fall into the medicine outlet groove (5) through the through hole (201);
s3: after the medicine outlet groove (5) is filled with the medicines, the medicine outlet cylinder (3) continues to rotate, the medicine outlet groove (5) is driven to be far away from the through hole (201) when the medicine outlet cylinder (3) rotates, the through hole (201) is propped against the side wall of the medicine outlet cylinder (3) again, the medicine outlet groove (5) leaks out of the medicine box (2) along with the rotation of the medicine outlet cylinder (3), and at the moment, a patient can collect the medicines;
s4: then, the acting force applied to the handle (301) is cancelled, the arc-shaped spring (901) recovers and the sliding block (9) slides in the arc-shaped sliding groove (202), the sliding block (9) drives the medicine box (3) to rotate, so that the medicine outlet groove (5) leaking out of the medicine box (2) is retracted to the medicine box (2) again, the medicine outlet groove (5) passes through the through hole (201) again in the rotating process, the medicine in the medicine bottle (4) enters the medicine outlet groove (5) again through the through hole (201), in the process, the bump (8) is propped against the stress plate (703) again, the movable block (112) in the bump (8) props against the arc-shaped seat (102) when the movable block (112) rotates along with the medicine box (3), the movable block (112) bears the force and is transmitted to the second elastic element (111), the elasticity of the second elastic element (111) is smaller than that of the arc-shaped spring (901), but the medicine box (3) is slowly rotated when the medicine falling from the through hole (201) is taken out of the medicine groove (5), the medicine discharging groove (5) can be filled with the medicine, and under the action of the elastic force of the arc-shaped spring (901), the medicine discharging groove (5) continues to rotate after being filled with the medicine until the medicine discharging groove moves to the initial position;
s5: at the moment, the medicine box (2) can be shaken, and if the medicine shaking sound is transmitted from the medicine box (2), and the medicine in the medicine bottle (4) is pressed by the pressing plate (602), the medicine outlet groove (5) is not filled with the medicine, and the medicine in the medicine box (2) is not enough to meet the dosage of a patient at the next time; if the medicine box (2) does not transmit the sound of shaking the medicine, the medicine in the medicine box (2) is indicated to meet the medicine taking demand of the next patient.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210164867.5A CN114681326A (en) | 2022-02-23 | 2022-02-23 | Multi-gene multi-factor dosing system for colorectal cancer patients and use method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210164867.5A CN114681326A (en) | 2022-02-23 | 2022-02-23 | Multi-gene multi-factor dosing system for colorectal cancer patients and use method thereof |
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| CN202210164867.5A Pending CN114681326A (en) | 2022-02-23 | 2022-02-23 | Multi-gene multi-factor dosing system for colorectal cancer patients and use method thereof |
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Inventor after: Zong Yi Inventor after: Liu Yang Inventor after: Tao Fengying Inventor after: Luo Wenyue Inventor before: Luo Wenyue |