CN114645988B - Heat exchange mechanism for preparing lipid drugs - Google Patents

Heat exchange mechanism for preparing lipid drugs Download PDF

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Publication number
CN114645988B
CN114645988B CN202210566266.7A CN202210566266A CN114645988B CN 114645988 B CN114645988 B CN 114645988B CN 202210566266 A CN202210566266 A CN 202210566266A CN 114645988 B CN114645988 B CN 114645988B
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China
Prior art keywords
air
pipeline
grease
heat exchange
air supply
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Active
Application number
CN202210566266.7A
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Chinese (zh)
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CN114645988A (en
Inventor
孙毅毅
谢来宾
陈梨花
甘红星
羊向新
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Jiangxi Chundi Biotechnology Co ltd
Chengdu Kejian Biomedical Co ltd
Original Assignee
Jiangxi Chundi Biotechnology Co ltd
Chengdu Kejian Biomedical Co ltd
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Priority to CN202210566266.7A priority Critical patent/CN114645988B/en
Publication of CN114645988A publication Critical patent/CN114645988A/en
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L53/00Heating of pipes or pipe systems; Cooling of pipes or pipe systems
    • F16L53/30Heating of pipes or pipe systems
    • F16L53/32Heating of pipes or pipe systems using hot fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D29/00Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • B01D29/03Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements self-supporting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D35/00Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/02Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L55/00Devices or appurtenances for use in, or in connection with, pipes or pipe systems
    • F16L55/24Preventing accumulation of dirt or other matter in the pipes, e.g. by traps, by strainers

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  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)

Abstract

The invention provides a heat exchange mechanism for preparing lipid drugs, relates to the technical field of heat exchange, and aims to solve the problem that in the prior art, grease molecules are changed into gel from a liquid crystal state due to temperature in the process of phospholipid delivery. There is provided a heat exchange mechanism for the production of lipid drugs, the heat exchange mechanism being installed within a lipid delivery tubing, the heat exchange mechanism comprising: the air supply pipeline is arranged in the grease conveying pipeline, and an air inlet of the air supply pipeline is positioned at one end of a liquid outlet of the grease conveying pipeline; the air outlet of the hot air blower is connected with the air inlet of the air supply pipeline; the air inlet of the air return pipeline is connected with the air outlet of the air supply pipeline, and the air outlet of the air return pipeline is arranged at the air inlet of the air heater; and the plurality of slitting nets are sequentially arranged along the conveying direction of the grease conveying pipeline. According to the invention, the heat exchange mechanism is used for carrying out heat exchange on the oil, so that the temperature of the oil in the oil conveying pipeline is ensured.

Description

Heat exchange mechanism for preparing lipid medicine
Technical Field
The invention relates to the technical field of heat exchange, in particular to a heat exchange mechanism for preparing lipid medicines.
Background
In the preparation of lipid drugs, grease is required to be used, and the grease gradually changes from a liquid crystal state (a state capable of flowing and having a certain shape and volume) to a gel state (non-flowing) along with the reduction of the ambient temperature. The grease conveying pipeline of the existing conveying equipment cannot exchange heat for grease in the pipeline, so that phospholipid molecules are quickly changed into gel from a liquid crystal state in the conveying process, and the grease cannot quickly enter a subsequent processing mechanism for processing.
Disclosure of Invention
The invention aims to solve the problem that phospholipid molecules are changed into gel from a liquid crystal state due to the fact that an existing grease conveying pipeline cannot exchange heat in the process of conveying the phospholipid in the prior art, and provides a heat exchange mechanism for preparing lipid medicines.
The technical scheme adopted by the invention is as follows:
a heat exchange mechanism for use in the preparation of lipid based drugs, the heat exchange mechanism being mounted within a lipid delivery conduit, the heat exchange mechanism comprising:
the air supply pipeline is arranged in the grease conveying pipeline, and an air inlet of the air supply pipeline is positioned at one end of a liquid outlet of the grease conveying pipeline;
the air outlet of the hot air blower is connected with the air inlet of the air supply pipeline;
the air inlet of the air return pipeline is connected with the air outlet of the air supply pipeline, and the air outlet of the air return pipeline is arranged at the air inlet of the air heater; and
the plurality of cutting nets are sequentially arranged along the conveying direction of the grease conveying pipeline;
wherein, grease pipeline's the inside installation cavity that is equipped with of pipe wall, the return air pipeline sets up in the installation cavity, be equipped with along its axis direction on grease pipeline's the inside wall with a plurality of through-holes of installation cavity intercommunication, two the through-hole is a set of, and is adjacent two sets of the through-hole sets up on grease pipeline's the relative lateral wall, the one end of supply air pipeline stretches into in the installation cavity, then follow grease pipeline's axis direction passes in proper order the through-hole.
Optionally, the heat exchange mechanism further comprises:
and the heat insulation felt is wrapped on the outer side of the grease conveying pipeline.
Optionally, the joint of the air supply pipeline and the inner wall of the grease conveying pipeline is in smooth transition connection.
Optionally, the grease conveying pipeline, the air supply pipeline and the air return pipeline are of an integrally formed structure.
Optionally, the heat blower is an electromagnetic heat blower.
Optionally, the slitting wire is a mesh structure formed by a plurality of wires.
Optionally, the cutting net is arranged coaxially with the grease conveying pipeline, but one end of the cutting net is arranged obliquely along the conveying direction of the oil.
Optionally, the mesh sizes of the slitting nets are sequentially increased along the liquid inlet end of the grease conveying pipeline towards the liquid outlet end.
Optionally, the wire is drawn from pure gold.
Optionally, the heat exchange mechanism further comprises:
one end of the auxiliary air supply pipeline is communicated with an air inlet of the air heater, and the other end of the auxiliary air supply pipeline is connected into the installation cavity;
and one end of the auxiliary air return pipeline is communicated with the mounting cavity at the other end of the grease conveying pipeline, and the other end of the auxiliary air return pipeline extends to the air inlet of the air heater.
Compared with the prior art, the invention has the beneficial effects that:
1. through set up the supply air duct in the grease pipeline of grease, carry out the heat exchange through wind circulation and the interior fluid of grease pipeline, improve the fluidity of grease.
2. In order to conveniently cut flaky grease in the hot air circulation process, a cutting net is arranged in a grease conveying pipeline to cut blocky grease, and the cut blocky grease is quickly dissolved in the heat exchange process.
3. The air supply pipeline is arranged in the grease conveying pipeline in a penetrating mode, the contact area of grease and the air supply pipeline is increased, and the heat exchange efficiency is improved.
4. The heat insulation felt sleeve is arranged on the outer side of the grease conveying pipeline in order to avoid overhigh heat of the outer wall of the grease conveying pipeline and cause accidental scalding of workers in a workshop.
5. In order to avoid grease accumulation at the joint of the air supply pipeline and the grease conveying pipeline, the joint is in smooth transition connection.
6. In order to increase the contact area between the slitting net and the grease, the slitting net is obliquely arranged in the grease conveying pipeline and is in contact with the air supply pipeline.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic diagram of the overall structure of a heat exchange mechanism for the preparation of lipid drugs.
FIG. 2 is a partial schematic diagram of a heat exchange mechanism for the preparation of lipid drugs.
FIG. 3 is a schematic cross-sectional view of a heat exchange mechanism for the preparation of lipid drugs.
FIG. 4 is a schematic end view of a heat exchange mechanism for the preparation of lipid drugs.
Fig. 5 is a schematic structural view of a heat exchange mechanism for preparing lipid drugs, which has an auxiliary air supply duct and an auxiliary air return duct.
Reference numerals:
1. an air supply duct; 2. a hot air blower; 3. a return air duct; 4. cutting the net; 5. heat insulation felt; 6. an auxiliary air supply duct; 7. an auxiliary return air duct; 8. a grease delivery conduit; 81. installing a chamber; 82. and a through hole.
Detailed Description
In the following, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate orientations and positional relationships that are based on the orientations and positional relationships shown in the drawings, or the orientations and positional relationships that the products of the present invention conventionally place when in use, or the orientations and positional relationships that are conventionally understood by those skilled in the art, are used for convenience in describing and simplifying the present invention, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore, should not be construed as limiting the present invention.
In the present invention, unless otherwise explicitly stated or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly, e.g., as being permanently connected, detachably connected, or integral; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
The following disclosure provides many different embodiments or examples for implementing different features of the invention. To simplify the disclosure of the present invention, specific example components and arrangements are described below. Of course, they are merely examples and are not intended to limit the present invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, such repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
As shown in fig. 1, 2 and 3, the embodiment of the present invention provides a heat exchange mechanism for preparing lipid drugs, which is installed in a lipid delivery tube 8, and comprises: the air supply pipeline 1 is arranged in the grease conveying pipeline 8, and an air inlet of the air supply pipeline 1 is positioned at one end of a liquid outlet of the grease conveying pipeline 8; the air outlet of the air heater 2 is connected with the air inlet of the air supply pipeline 1; an air inlet of the return air pipeline 3 is connected with an air outlet of the air supply pipeline 1, and an air outlet of the return air pipeline is arranged at an air inlet of the hot air blower 2; the plurality of cutting nets 4 are sequentially arranged along the conveying direction of the grease conveying pipeline 8;
wherein, the inside installation cavity 81 that is equipped with of pipe wall of grease conveying pipeline 8, return air duct 3 sets up in the installation cavity 81, be equipped with along its axis direction on grease conveying pipeline's the inside wall with a plurality of through-holes 82, two of installation cavity 81 intercommunication through-hole 82 is a set of, and is adjacent two sets of through-hole 82 sets up on grease conveying pipeline's the relative lateral wall, the one end of supply air duct 1 stretches into in the installation cavity 81, then follow grease conveying pipeline's axis direction passes in proper order through-hole 82.
In the use, hot-blast air blower 2 work is to the delivery of air supply pipe 1 in hot-blast, because the import of hot-blast pipeline is located grease conveying pipe 8's export one end, makes things convenient for hot-blast quick preheating grease conveying pipe 8's the other end, because the grease that just got into in grease conveying pipe 8 does not solidify its required heat still less, consequently with hot-blast import setting in grease conveying pipe 8's export one end. In order to improve the contact surface of grease in the air supply pipeline 1 and the grease conveying pipeline 8, an installation cavity 81 is arranged in the pipe wall of the grease conveying pipeline 8, then through holes 82 are formed in the inner side wall of the grease conveying pipeline 8, two through holes 82 form a group, one end of an air inlet pipeline penetrates out of the side wall of the installation cavity 81, then the air inlet pipeline returns to the installation cavity 81 through the through hole 82 on the other side, then the air inlet pipeline penetrates out through the adjacent through holes 82, the steps are repeated until the air supply pipeline 1 is installed, the outlet of the air supply pipeline 1 is located in the installation cavity 81 and connected with an air return pipeline 3, air with certain heat is sent to the air inlet of the air heater 2 through the air return pipeline 3, and the energy loss of the air heater 2 is reduced.
For the convenience of cutting the caked grease in the conveying process, a cutting net 4 is arranged in the grease conveying pipeline 8, the cutting net 4 cuts the coagulated massive grease into small grease blocks, and the cut grease carries out heat exchange through the air supply pipeline 1 in the conveying process so that the cut massive grease is quickly dissolved.
In another embodiment, as shown in fig. 4, in order to avoid the temperature of the grease conveying pipe 8 being too high during the use process and causing accidental scalding of workers, the outer side wall of the grease conveying pipe 8 is wrapped with a heat insulation felt 5.
In another embodiment, in order to avoid the dead angle at the joint of the air supply pipeline 1 and the grease conveying pipeline 8, which is inconvenient to clean, the joint of the air supply pipeline 1 and the inner wall of the grease conveying pipeline 8 is in smooth transition connection, so that the inconvenience of cleaning after the grease is solidified is avoided.
In another embodiment, in order to facilitate the processing and enhance the overall strength of the grease conveying pipe 8, the air supply pipe 1 and the air return pipe 3 are integrally formed by casting.
In another embodiment, the heat blower 2 is an electromagnetic heat blower 2. The electromagnetic heating air heater 2 has the advantages of high conversion rate, long service life, convenient temperature control and good insulating property.
In another embodiment, as shown in fig. 3, the slitting mesh 4 is a mesh structure formed by a plurality of metal wires, so as to facilitate the circulation of grease and simultaneously slit grease blocks. The metal wire carries out the stripping and slicing to cubic grease and handles, because it has the part that contacts to divide cutting net 4 and supply air duct 1, the metal has the heat conduction effect, on the mode through the heat transfer absorbs the heat on the supply air duct 1 to the metal wire, then cuts cubic grease through the metal wire.
In another embodiment, as shown in fig. 3, in order to increase the contact surface of the dividing net 4 with the grease, the dividing net 4 is disposed coaxially with the grease carrying pipe 8, but one end thereof is disposed obliquely in the carrying direction of the oil.
In other embodiments, the two adjacent dicing nets 4 are inclined in opposite directions or at a certain angle difference, so that the possibility of contact between the lumpy grease and the dicing net 4 is increased.
In another embodiment, as shown in fig. 3, since the grease is gradually cooled during the transportation process, the grease which just enters the grease transportation pipe 8 can quickly form small blocky grease due to temperature, but after a period of flowing, the temperature can gradually form large blocky grease, so the mesh size of the cutting net 4 is gradually increased from the liquid inlet end to the liquid outlet end of the grease transportation pipe 8, so that the blocky grease which is preliminarily formed is quickly cut, and the formation of large blocky grease is avoided. After the massive grease is cut, heat exchange is carried out through the heat exchange mechanism, so that the massive grease is quickly dissolved.
In order to further improve the cutting efficiency of the cutting net 4, one end of the cutting net 4 facing the liquid inlet is provided with a cutting edge, so that the massive grease is rapidly blocked after touching the cutting edge.
It should be explained that, can form cubic grease fast because of the difference in temperature reason after the grease gets into in the grease conveying pipeline 8, consequently will install the mesh size of cutting net 4 at the 8 feed liquor ends of grease conveying pipeline and set up to minimum, conveniently will just form cubic grease and cut, the grease that flows to 8 middle parts of grease conveying pipeline or go out the liquid end is owing to carried out the heat exchange through hot-blast, reduce the massive structure in the grease, consequently, in order to avoid influencing the flow property of grease, the mesh size that is located the middle part of grease conveying pipeline 8 or goes out the mesh size that cuts net 4 of liquid end is greater than the mesh size that is located the cutting net 4 of 8 feed liquor ends of grease conveying pipeline.
In another embodiment, the metal wires constituting the cut net 4 are drawn from pure gold in order to improve the heat-conducting property of the cut net 4. Because the metal property of the gold is inactive, the chemical property is stable, and the gold has extremely high corrosion resistance and excellent heat conduction and electric conductivity.
In another embodiment, as shown in fig. 5, in order to further increase the heat exchange speed, an auxiliary air supply duct 6 is further disposed at the air outlet of the air heater 2, one end of the auxiliary air supply duct 6 is communicated with the air inlet of the air heater 2, and the other end is connected to the inside of the mounting chamber 81; the other end of the grease conveying pipeline 8 is provided with an auxiliary return air pipeline 7 communicated with the mounting cavity 81, and the other end of the auxiliary return air pipeline 7 extends to the air inlet of the air heater 2. The circulation of the heated air in the installation chamber 81 is achieved.
In another embodiment, the air outlet of the air supply duct 1 is located in the installation chamber 81, the air inlet of the air return duct 3 is located in the installation chamber 81, and the air outlet of the air return duct 3 extends to the air inlet of the air heater 2.
In another embodiment, a temperature sensor is arranged in the grease conveying pipeline 8, so that the temperature sensor can detect the temperature in the grease conveying pipeline 8 conveniently, the temperature is controlled within a preset temperature range all the time, and the influence of too low temperature on the mobility of phospholipid molecules is avoided.
The specific working principle is as follows:
the preparation of liposomes is exemplified. In winter or use in the north, when starting liposome extruder, start air heater 2 in advance, air heater 2 works and will hot-blast drum into installation cavity 81 and air supply pipe 1 in, preheat grease pipeline 8, preheat in the back grease gets into grease pipeline 8, because grease pipeline 8 has certain heat, reduce the condition that the caking appears in the grease in transportation process, if there is the grease of caking to be cut by the branch cutting net 4 that sets up in grease pipeline 8 in transportation process, then melt fast through the heated air circulation heat transfer again, avoid blocking grease to adhere to on the inside wall of grease pipeline 8. Because the slitting net 4 is woven by metal wires drawn from pure gold, the slitting net has extremely high corrosion resistance and good heat conduction performance, and can conveniently and quickly slit blocky grease.
For convenience, massive grease is cut by cutting net 4 fast, and the size of cutting net 4 that is located grease conveying pipeline 8 increases progressively in proper order from the feed liquor end one end of grease conveying pipeline 8 towards the play liquid end, and the grease that conveniently has just agglomerated is cut by cutting net 4, and the mesh that is located play liquid end is greater than the mesh of feed liquor end and is for convenience in the grease gets into subsequent treatment facility fast.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described above, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (6)

1. A heat exchange mechanism for use in the preparation of lipid based drugs, the heat exchange mechanism being mounted within a lipid delivery conduit, the heat exchange mechanism comprising:
the air supply pipeline is arranged in the grease conveying pipeline, and an air inlet of the air supply pipeline is positioned at one end of a liquid outlet of the grease conveying pipeline;
the air outlet of the hot air blower is connected with the air inlet of the air supply pipeline;
the air inlet of the air return pipeline is connected with the air outlet of the air supply pipeline, and the air outlet of the air return pipeline is arranged at the air inlet of the air heater;
the cutting nets are sequentially arranged along the conveying direction of the grease conveying pipeline, the cutting nets and the grease conveying pipeline are coaxially arranged, one end of each cutting net is obliquely arranged along the conveying direction of oil, the sizes of meshes of the cutting nets are sequentially increased along the liquid inlet end of the grease conveying pipeline towards the liquid outlet end, cutting edges are arranged at one ends of the cutting nets towards the liquid inlet, and the oblique directions of two adjacent cutting nets are opposite or have a certain angle difference;
one end of the auxiliary air supply pipeline is communicated with an air inlet of the air heater, and the other end of the auxiliary air supply pipeline is connected into the installation cavity;
one end of the auxiliary air return pipeline is communicated with the mounting cavity at the other end of the grease conveying pipeline, and the other end of the auxiliary air return pipeline extends to an air inlet of the air heater;
the oil conveying pipeline comprises an air supply pipeline, an air return pipeline and an air supply pipeline, wherein an installation cavity is arranged inside the pipe wall of the oil conveying pipeline, the air return pipeline is arranged in the installation cavity, a plurality of through holes communicated with the installation cavity are formed in the inner side wall of the oil conveying pipeline along the axis direction of the oil conveying pipeline, two groups of through holes are formed in one group, two adjacent groups of through holes are formed in the opposite side walls of the oil conveying pipeline, one end of the air supply pipeline extends into the installation cavity, and then the air supply pipeline sequentially penetrates through the through holes along the axis direction of the oil conveying pipeline; the slitting net is a filter screen structure formed by a plurality of metal wires, and the slitting net is in contact with the air supply pipeline.
2. The heat exchange mechanism for the preparation of lipid drugs according to claim 1, further comprising:
and the heat insulation felt is wrapped on the outer side of the grease conveying pipeline.
3. The heat exchange mechanism for the preparation of lipid drugs as claimed in claim 1, wherein the air supply duct is connected with the inner wall of the lipid delivery duct in smooth transition.
4. The heat exchange mechanism for the preparation of lipid drugs according to claim 1, wherein the lipid delivery duct, the air supply duct and the air return duct are of an integrally molded structure.
5. The heat exchange mechanism for the preparation of lipid drugs as claimed in claim 1, wherein the heat blower is an electromagnetic type heat blower.
6. The heat exchange mechanism for the preparation of lipid drugs according to claim 1, wherein the metal wire is drawn from pure gold.
CN202210566266.7A 2022-05-24 2022-05-24 Heat exchange mechanism for preparing lipid drugs Active CN114645988B (en)

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EP1091623A2 (en) * 1999-10-09 2001-04-11 EADS Airbus GmbH Heating conductor with raccording element and/or closing element and its manufacturing process
CN214789807U (en) * 2021-04-23 2021-11-19 成都理工大学 Natural gas line heat preservation device
CN114469734A (en) * 2021-10-13 2022-05-13 成都科建生物医药有限公司 Preparation device and preparation method of anthracycline liposome

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