CN114641476A - 一类蛋白受体激酶抑制剂的制备和应用 - Google Patents
一类蛋白受体激酶抑制剂的制备和应用 Download PDFInfo
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- CN114641476A CN114641476A CN202080074424.6A CN202080074424A CN114641476A CN 114641476 A CN114641476 A CN 114641476A CN 202080074424 A CN202080074424 A CN 202080074424A CN 114641476 A CN114641476 A CN 114641476A
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Classifications
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Abstract
本发明提供了一种蛋白受体激酶抑制剂的制备方法。具体地，本发明公开了一种式I所示的化合物或其立体异构体或外消旋体或其药学上可接受的盐，其中，各基团的定义如说明书中所述。本发明还公开了上述化合物作为TRK激酶抑制剂的用途。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019111300290 | 2019-11-18 | ||
| CN201911130029.0A CN112812118A (zh) | 2019-11-18 | 2019-11-18 | 一类蛋白受体激酶抑制剂的制备和应用 |
| PCT/CN2020/129913 WO2021098745A1 (zh) | 2019-11-18 | 2020-11-18 | 一类蛋白受体激酶抑制剂的制备和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114641476A true CN114641476A (zh) | 2022-06-17 |
| CN114641476B CN114641476B (zh) | 2023-05-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201911130029.0A Pending CN112812118A (zh) | 2019-11-18 | 2019-11-18 | 一类蛋白受体激酶抑制剂的制备和应用 |
| CN202080074424.6A Active CN114641476B (zh) | 2019-11-18 | 2020-11-18 | 一类蛋白受体激酶抑制剂的制备和应用 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911130029.0A Pending CN112812118A (zh) | 2019-11-18 | 2019-11-18 | 一类蛋白受体激酶抑制剂的制备和应用 |
Country Status (2)
| Country | Link |
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| CN (2) | CN112812118A (zh) |
| WO (1) | WO2021098745A1 (zh) |
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| CN114989176B (zh) * | 2022-07-08 | 2024-08-27 | 深圳市新樾生物科技有限公司 | 咪唑并哒嗪类衍生物及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010033941A1 (en) * | 2008-09-22 | 2010-03-25 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
| WO2010048314A1 (en) * | 2008-10-22 | 2010-04-29 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS |
| WO2012034091A1 (en) * | 2010-09-09 | 2012-03-15 | Irm Llc | Imidazo [1, 2] pyridazin compounds and compositions as trk inhibitors |
-
2019
- 2019-11-18 CN CN201911130029.0A patent/CN112812118A/zh active Pending
-
2020
- 2020-11-18 WO PCT/CN2020/129913 patent/WO2021098745A1/zh active Application Filing
- 2020-11-18 CN CN202080074424.6A patent/CN114641476B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010033941A1 (en) * | 2008-09-22 | 2010-03-25 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
| WO2010048314A1 (en) * | 2008-10-22 | 2010-04-29 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS |
| WO2012034091A1 (en) * | 2010-09-09 | 2012-03-15 | Irm Llc | Imidazo [1, 2] pyridazin compounds and compositions as trk inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114641476B (zh) | 2023-05-02 |
| WO2021098745A1 (zh) | 2021-05-27 |
| CN112812118A (zh) | 2021-05-18 |
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