CN114636531B - 基于真空度衰减的硬质包装容器密封性的测试装置及方法 - Google Patents
基于真空度衰减的硬质包装容器密封性的测试装置及方法 Download PDFInfo
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- CN114636531B CN114636531B CN202210241687.2A CN202210241687A CN114636531B CN 114636531 B CN114636531 B CN 114636531B CN 202210241687 A CN202210241687 A CN 202210241687A CN 114636531 B CN114636531 B CN 114636531B
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- 238000004806 packaging method and process Methods 0.000 title claims abstract description 106
- 238000012360 testing method Methods 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 36
- 238000007789 sealing Methods 0.000 claims abstract description 29
- 238000012795 verification Methods 0.000 claims abstract description 29
- 238000010998 test method Methods 0.000 claims abstract description 12
- 230000035945 sensitivity Effects 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims description 79
- 239000000523 sample Substances 0.000 claims description 55
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- 238000013178 mathematical model Methods 0.000 abstract description 9
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- 239000007924 injection Substances 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 238000004364 calculation method Methods 0.000 description 6
- 239000000565 sealant Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
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- 238000003860 storage Methods 0.000 description 5
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- 229960004099 azithromycin Drugs 0.000 description 4
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- 230000007774 longterm Effects 0.000 description 3
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- 239000011148 porous material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
- G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
- G01M3/32—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
- G01M3/3236—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators by monitoring the interior space of the containers
- G01M3/3263—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators by monitoring the interior space of the containers using a differential pressure detector
Abstract
Description
时间(min) | 压力(pa) |
0 | -85839.7 |
5 | -77910.8 |
15 | -62742.3 |
20 | -55502.8 |
25 | -48263.3 |
35 | -34473.8 |
40 | -28613.2 |
45 | -23097.4 |
时间(min) | 压力(pa) |
0 | -85150.2 |
50 | -74118.6 |
98 | -63087.0 |
230 | -37921.2 |
263 | -32405.4 |
323 | -24476.4 |
375 | -19650.1 |
时间(min) | 真空度(pa) |
0 | -84808.5 |
62 | -80326.8 |
351 | -63434.0 |
1480 | -14479.5 |
Claims (6)
Priority Applications (1)
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CN202210241687.2A CN114636531B (zh) | 2022-03-11 | 2022-03-11 | 基于真空度衰减的硬质包装容器密封性的测试装置及方法 |
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CN202210241687.2A CN114636531B (zh) | 2022-03-11 | 2022-03-11 | 基于真空度衰减的硬质包装容器密封性的测试装置及方法 |
Publications (2)
Publication Number | Publication Date |
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CN114636531A CN114636531A (zh) | 2022-06-17 |
CN114636531B true CN114636531B (zh) | 2024-02-27 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN117165649A (zh) * | 2023-08-30 | 2023-12-05 | 中国食品药品检定研究院 | 一种基于容器密封完整性检测物理与微生物法关联性分析方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1519550A (zh) * | 1997-05-26 | 2004-08-11 | 泄漏测试的方法与装置 | |
CN206074200U (zh) * | 2016-09-30 | 2017-04-05 | 江西科伦药业有限公司 | 一种输液袋注药点密封性检测装置 |
CN111665184A (zh) * | 2020-07-01 | 2020-09-15 | 中国航空工业集团公司北京长城计量测试技术研究所 | 一种药品包装阳性样品微孔测量装置 |
CN211927209U (zh) * | 2020-05-18 | 2020-11-13 | 重庆市食品药品检验检测研究院 | 一种真空衰减法测试药品包装容器完整性的测试装置 |
CN112051009A (zh) * | 2020-09-24 | 2020-12-08 | 北京卫星环境工程研究所 | 卫星单点漏率测试用正压标准漏孔标定装置及方法 |
CN112857709A (zh) * | 2021-01-14 | 2021-05-28 | 北京赛而生物药业有限公司 | 一种检测药品包装密封性的方法和装置 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9857264B2 (en) * | 2013-10-15 | 2018-01-02 | Fukuda Co., Ltd. | Leak testing apparatus and method |
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2022
- 2022-03-11 CN CN202210241687.2A patent/CN114636531B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1519550A (zh) * | 1997-05-26 | 2004-08-11 | 泄漏测试的方法与装置 | |
CN206074200U (zh) * | 2016-09-30 | 2017-04-05 | 江西科伦药业有限公司 | 一种输液袋注药点密封性检测装置 |
CN211927209U (zh) * | 2020-05-18 | 2020-11-13 | 重庆市食品药品检验检测研究院 | 一种真空衰减法测试药品包装容器完整性的测试装置 |
CN111665184A (zh) * | 2020-07-01 | 2020-09-15 | 中国航空工业集团公司北京长城计量测试技术研究所 | 一种药品包装阳性样品微孔测量装置 |
CN112051009A (zh) * | 2020-09-24 | 2020-12-08 | 北京卫星环境工程研究所 | 卫星单点漏率测试用正压标准漏孔标定装置及方法 |
CN112857709A (zh) * | 2021-01-14 | 2021-05-28 | 北京赛而生物药业有限公司 | 一种检测药品包装密封性的方法和装置 |
Non-Patent Citations (1)
Title |
---|
"注射剂包装密封完整性检测技术研究进展";陈江等;《中国药业》;20210120;第30卷(第2期);第5-11页 * |
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Inventor after: Zhao Daiguo Inventor after: Lan Wanling Inventor after: Jiang Yan Inventor after: Fan Nengquan Inventor after: Guo Yanyan Inventor after: Zhang Xiaochun Inventor after: Yang Jian Inventor before: Zhao Daiguo Inventor before: Lan Wanling Inventor before: Jiang Yan Inventor before: Guo Yanyan Inventor before: Zhang Xiaochun Inventor before: Yang Jian |
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Effective date of registration: 20231011 Address after: No.8, Xinwen Road, hi tech West District, Chengdu, Sichuan 610000 Applicant after: Sichuan Institute of drug inspection (Sichuan Medical Device Testing Center) Applicant after: CHONGQING INSTITUTE FOR FOOD AND DRUG CONTROL Address before: No.8, Xinwen Road, hi tech West District, Chengdu, Sichuan 610000 Applicant before: Sichuan Institute of drug inspection (Sichuan Medical Device Testing Center) |
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