CN114632049B - 一种防脱生发组合物 - Google Patents
一种防脱生发组合物 Download PDFInfo
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- CN114632049B CN114632049B CN202011473313.0A CN202011473313A CN114632049B CN 114632049 B CN114632049 B CN 114632049B CN 202011473313 A CN202011473313 A CN 202011473313A CN 114632049 B CN114632049 B CN 114632049B
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- hair
- extract
- inositol
- hair growth
- growth composition
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Abstract
本发明提供一种防脱生发组合物，其包含(A)桦树汁，和(B)肌醇、大叶藻提取物和酵母发酵物中的一种或多种。
Description
技术领域
本发明涉及一种防脱生发组合物，其包含(A)桦树汁，和(B)肌醇、大叶藻提取物和酵母发酵物中的一种或多种的组合。
背景技术
随着现代社会生活节奏的加快，环境的日益恶化，越来越多的人在高强度的精神压力、加班、熬夜、雾霾等条件下，身体出现不同程度的亚健康问题，其中就包括由此带来的头皮油脂分泌增多、头皮炎症、毛囊萎缩、头发脱落等问题。脱发成为现代人，尤其是年轻人，越来越关注的话题。而现今防脱生发问题的主要解决方法是生发药物和手术。药物治疗主要是非那雄胺和米诺地尔，往往有较严重的副作用，且容易形成药物依赖，一旦停药，脱发更加严重；手术治疗费用较高，有创伤，需要一定的恢复期。因此，开发天然的防脱生发产品，用于解决脱发少发的问题，具有重要的意义。
发明内容
一方面，本发明涉及由(A)桦树汁和(B)肌醇、大叶藻提取物和酵母发酵物中的一种或多种组成的试剂包，和涉及所述试剂包在防脱生发组合物中的用途。
另一方面，本发明涉及由(A)桦树汁，(B)肌醇、大叶藻提取物和酵母发酵物中的一种或多种，何首乌和三肽-1铜组成的试剂包，和涉及所述试剂包在防脱生发组合物中的用途。
再一方面，本发明涉及一种防脱生发组合物，其包含(A)桦树汁，和(B)肌醇、大叶藻提取物和酵母发酵物中的一种或多种。
防脱生发涉及两个非常关键的方面：其一是5α-还原酶的活力，通过抑制5α-还原酶的活力，可以有效减少二氢睾酮的生成，从而避免毛囊萎缩；其二是毛乳头细胞的活力，毛乳头细胞增殖活力强可以影响整个毛囊的状态，使其保持生长期的状态，促进毛发新生，延长毛发生长时间。桦树汁与肌醇、大叶藻提取物和/或酵母发酵物的组合能抑制5α-还原酶的活力，调节毛乳头细胞的增殖与分化，以及防脱生发相关基因的转录和蛋白的表达。
意料不到地，本发明人发现，与单独使用桦树汁、肌醇、大叶藻提取物或酵母发酵物相比，使用桦树汁和肌醇、大叶藻提取物和酵母发酵物中的一种或多种的组合具有显著更好的防脱发功效和生发功效，远高于二者功能叠加效果，表现为更好地抑制5α-还原酶的活力，调节毛乳头与防脱生发相关基因的转录和蛋白的表达，促进毛乳头细胞的增殖与分化，这说明上述物质之间发生了增效作用。
本发明中所涉及的桦树汁得自桦木科桦树属，其可来自白桦(Betula alba)、柔毛桦(Betula pubescens)、垂枝桦(Betula pendula)和亚洲白桦(Betula platyphylla)这四个品种。所述桦树汁为在解冻至早春发叶之间，人工在桦树的树干基部钻孔收集而得的无色透明、无沉淀、无杂物，具有桦树清香且营养丰富的汁液。所述桦树汁可商购获得并原样采用，例如可购自大兴安岭超越野生浆果开发有限责任公司。
所述桦树汁的含量为约5-98％重量，优选约10-98％重量，更优选约15-97％重量，基于所述防脱生发组合物的总重量。
所述组分(B)肌醇、大叶藻提取物、酵母发酵物是本领域已知的，它们均可以商购获得，原样用于本发明。所述组分(B)的总含量为约0.001-30％重量，优选约0.01-10％重量，更优选约0.1-5％重量，最优选约0.5-3％重量，基于所述防脱生发组合物的总重量。
在一个实施方案中，本发明的防脱生发组合物同时包含肌醇、大叶藻提取物和酵母发酵物。
在一个实施方案中，本发明的防脱生发组合物还包含何首乌和三肽-1铜，其中何首乌的含量为约0.001-30％，优选0.01-20％，更优选0.01-10％，三肽-1铜的含量为约0.001-10％，优选0.01-10％，更优选0.01-5％,基于所述防脱生发组合物的总重量。
优选地，本发明的防脱生发组合物不包含EDTA盐、多磷酸钠、偏磷酸钠、葡萄糖酸等螯合剂。
除了上述组分(A)和(B)外，所述防脱生发组合物还可任选地包含组分(C)洗发护发组合物中常用的成分。所述组分(C)的实例包括但不限于媒介物、活性成分和辅料等。这些成分都是本领域已知的，本领域技术人员可根据需要选择组分(C)的类型和用量，例如，组分(C)的含量通常为约0-70％重量，基于所述防脱生发组合物的总重量。
所述媒介物是本领域已知的，包括例如稀释剂、分散剂或载体等，其实例包括但不限于乙醇、双丙甘醇、丁二醇等。所述媒介物在所述防脱生发组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.01-20％。
所述活性成分是本领域已知的，包括例如额外的防脱生发剂、保湿剂、发质调理剂等。
所述额外的防脱生发剂的实例包括但不限于独活、当归、白芷、防风、小茴香、蛇床子、白花前胡、羌活、紫苏、黄芩、薄荷、广藿香、荆芥、薰衣草、鼠尾草、石荠、菊花、旋覆花、苍耳子、苍术、白术、雪莲花、土木香、洋甘菊、千里光、高良姜、生姜、莪术、姜黄、郁金、肉豆蔻、白芍、牡丹皮、升麻、秦皮、白鲜皮、陈皮、化橘红、佛手、山楂叶、仙鹤草、细辛、茜草、栀子、甜橙、倒捻子、藜芦、麝香草、茵陈蒿、缬草、夏枯草、马齿苋、泽兰、桑寄生、虎杖、女贞、雪绒花、槐果、葡萄籽、丁香、厚朴、辛夷、八角茴香、肉桂、乌药、荜茇、胡椒、秦艽、龙胆、甘松、没药、乳香、辣椒、射干、徐长卿、芫花、山茱萸、百合、安息香、苏合香、血竭、蔓荆、紫草、芦荟、白屈菜、七叶树、牛蒡子、天胡荽、何首乌、白芥子、半边莲、冰片、威灵仙、穿心莲、大叶紫珠、独一味、红草、两面针、石韦、连翘、藤茶、黄柏、金荞麦、锦鸡儿、知母、荨麻、桃仁、菟丝子、沙棘、人参、日本獐牙菜、三肽-1铜、益母草、茶叶、白桦芽提取物等中的一种或多种。所述防脱生发剂在所述组合物中的含量是本领域已知的，例如其通常占组分(C)总重量的约0.01-50％。
所述保湿剂的实例包括但不限于甘油、双甘油、丁二醇、丙二醇、1,3-丙二醇、双丙甘醇、1,2-戊二醇、聚乙二醇-8、聚乙二醇-32、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、PEG/PPG-17/6共聚物、甘油聚醚-7、甘油聚醚-26、甘油葡糖苷、PPG-10甲基葡糖醚、PPG-20甲基葡糖醚、PEG/PPG/聚丁二醇-8/5/3甘油、蔗糖、海藻糖、鼠李糖、甘露糖、棉子糖、甜菜碱、赤藓醇、木糖醇、尿素、甘油聚醚-5乳酸酯、透明质酸钠、水解透明质酸钠、乙酰化透明质酸钠、聚谷氨酸钠、水解小核菌胶、出芽短梗酶多糖、银耳多糖、酸豆籽多糖等中的一种或多种。所述保湿剂在所述组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.01-30％。
所述发质调理剂的实例，包括但不限于脂肪醇、甾醇、脂肪酸、单甘油酯、三甘油脂、羊毛脂、肌氨酸酯、脂肪酸酯、白油、角鲨烷、聚季铵盐-10、聚季铵盐-7、聚季铵盐-39、聚季铵盐-52、聚季铵盐-73、瓜尔胶羟丙基三甲基氯化铵、山嵛基三甲基氯化铵、聚二甲基硅油、PEG-60杏仁油甘油酯、泛醇、聚乙烯吡咯烷酮、明胶、果胶、皂荚提取物、丹参提取物、当归根提取物、丁二醇、何首乌提取物、扁柏叶提取物、姜根提取物、黄芩根提取物、苦参根提取物、胀果甘草根提取物、尿囊素、三七根提取物、木瓜果提取物、燕麦多肽等中的一种或多种。所述发质调理剂在所述组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.01-50％重量。
所述辅料是本领域已知的，包括例如发泡剂、表面活性剂、乳化剂、增稠剂、防腐剂、香料等。
所述发泡剂的实例包括但不限于月桂醇聚醚硫酸酯钠、十三烷醇聚醚硫酸钠、癸基葡糖苷、月桂酰肌氨酸钠、C14-16烯烃磺酸钠、椰子油酸单乙醇酰胺、椰子油酸二乙醇酰胺、椰子油酰基丙基甜菜碱、月桂醇硫酸酯铵、椰油酰两性基乙酸钠等中的一种或多种。所述发泡剂在所述组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.1-50％。
所述表面活性剂的实例包括但不限于椰油酰胺丙基甜菜碱、月桂醇聚醚硫酸酯钠、PEG-150二硬脂酸酯、乙二醇二硬脂酸酯、月桂基聚氧乙烯醚硫酸铵、十二烷基醇醚硫酸钠、棕榈酰胺丙基甜菜碱、椰油酰胺二乙醇胺、十二烷基醚硫酸盐、十二烷基硫酸铵(K12A)、脂肪醇聚乙烯醚硫酸钠(AES)、脂肪醇聚乙烯醚硫酸铵(AESA)、月桂醇醚硫酸铵、月桂醇硫酸铵、月桂醇硫酸钠、十二烷基聚醚硫酸铵、十二烷基醇硫酸铵、椰油基单乙醇酰胺、N-脂肪酰基氨基酸盐、月桂酰胺丙基甜菜碱、椰油酰两性基乙酸钠、月桂酰两性基乙酸钠、月桂醇聚氧乙烯醚硫酸钠、脂肪醇聚氧乙烯醚硫酸钠、十二烷基硫酸钠、烷基糖苷、十二烷基二甲基甜菜碱、咪唑啉两性二醋酸二钠、椰油基两性醋酸钠、聚季銨盐-7、聚季铵盐-10、聚季铵盐-37、羟丙基瓜尔胶羟丙基三甲基氯化銨、羟丙基三甲基氯化铵瓜尔胶、菩提子提取物等中的一种或多种。所述表面活性剂在所述组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.1-50％。
所述乳化剂的实例包括但不限于鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、甲基葡糖倍半硬脂酸酯、PEG-20甲基葡糖倍半硬脂酸酯、PEG-40氢化蓖麻油、PPG-26-丁醇聚醚-26、PEG-4聚甘油-2硬脂酸酯、PEG-60氢化蓖麻油、硬脂醇聚醚-2、硬脂醇聚醚-21、PPG-13-癸基十四醇聚醚-24、鲸蜡硬脂基葡糖苷、PEG-100硬脂酸酯、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、PEG-40硬脂酸酯、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖硬脂酸酯、蔗糖多硬脂酸酯等中的一种或多种。所述乳化剂在所述组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.05-30％。
所述增稠剂的实例包括但不限于卡波姆类、丙烯酸(酯)类及其衍生物、黄原胶、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素等高分子聚合物中的一种或多种。所述增稠剂在所述组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.1-30％。
所述防腐剂的实例包括但不限于羟苯甲酯、羟苯乙酯、羟苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、双(羟甲基)咪唑烷基脲、山梨酸钾、苯甲酸钠、氯苯甘醚、脱氢乙酸钠等中的一种或多种。所述防腐剂在所述防脱生发组合物中的含量是本领域已知的，例如，其通常占组分(C)总重量的约0.01-30％。
本发明的防脱生发组合物可以通过本领域已知的任何合适的方法制备。例如，使用本领域中常用的溶解槽、乳化锅、分散器、输送泵等设备制备。制备时先将水溶性物质投入水相溶解釜，油溶性物质投入油相溶解釜，将两个釜的温度加热至约80℃，其中对于易结块的原料，可先用分散器将其预分散。待溶解完成后将油相和水相输送至乳化锅中，均质乳化约5-15分钟。乳化完成后将料体温度降至常温，加入任选的香精、防腐剂等，并视需要调节产物的pH。相关检测指标都合格后方可灌装出货。以上制备方法可根据剂型要求进行删减或调整。
本发明的防脱生发组合物可以是洗去型的洗发香波形式，也可以是留存型的生发液形式，且其可根据需要制备成各种剂型，例如膏、霜、乳液、液体等。
实施例
以下结合实施例，对本发明进行进一步详细说明。但是，应当理解为，这些实施例、对比例仅仅是用于更详细地说明本发明，而不应理解为用于以任何形式限制本发明所附权利要求书的范围。
实施例1：5α-还原酶活力的抑制
在本实施例中，考察和对比了桦树汁、肌醇、大叶藻提取物、酵母发酵物以及它们的组合物对5α-还原酶活性的影响。
1.测试方法
实验仪器：天平、破壁机、恒温振荡器、高速冷冻离心机、酶标仪。
实验试剂与耗材：
非那雄胺：上海现代制药股份有限公司(片剂5mg/片)；
还原型辅酶Ⅱ(NADPH)：美国Roche公司(粉剂10mg)；
睾酮Elisa试剂盒：武汉优尔生公司(货号：CEA458Ge)；
5α-还原酶粗酶：自备；
PBS：武汉博士德公司；
苯甲基磺酰氟(PMSF)：美国Sigma公司；
二硫苏糖醇(DTT)：美国Sigma公司；
1M Tris-HCl：武汉博士德公司。
样品加样信息：
单一原料上样量为一整份原料；复配原料中各原料的加入量为：整份原料/复配原料数目。
体外5α-还原酶活性影响分析步骤如下：
(1)粗酶制备：取正常健康小鼠5只，颈部脱臼致死，打开腹腔，取其睾丸，分为数份，置于2mL EP管中，按1:4比例加入适量粗酶提取液，于4℃下破壁机破碎制成匀浆液，4℃高速冷冻离心(10000rpm/分钟，10分钟)，取其上清液4℃保存。BCA法测定蛋白浓度，1mg/mL以上即可进行后续实验；
(2)空白对照的测定:分别取2组200μL EP管(每组4个)，均加入5α-还原酶粗酶、PBS溶液(pH＝7.4)、还原型辅酶Ⅱ，一组混合后立即放入沸水中煮沸5分钟，离心后吸取50μL液体进行后续Elisa检测，为空白对照组起始睾酮含量；另一组混合后放置恒温摇床中混匀60分钟，放入沸水中煮沸5分钟，离心后吸取50μL液体进行后续Elisa检测，其与起始含量的差值为空白对照组转化后睾酮含量；
(3)样品组的测定:分别取2组200μL EP管(每组4个)，均加入5α-还原酶粗酶、PBS溶液(pH＝7.4)、还原型辅酶Ⅱ和测试原料，一组混合后立即放入沸水中煮沸5分钟，离心后吸取50μL液体进行后续Elisa检测，为抑制剂组起始睾酮含量；另一组混合后放置恒温摇床中混匀60分钟，放入沸水中煮沸5分钟，离心后吸取50μL液体进行后续Elisa检测，其与起始含量的差值为抑制剂组转化后睾酮含量。实验每次4个平行样。
5α-还原酶抑制率按如下公式计算：
I％＝(△A0-△An)/△A0*100％
其中：
△A0----对照组睾酮减少量；
△An----抑制剂组睾酮减少量。
2.测试结果
如下表所示
| 样品 | 酶活抑制率 |
| 桦树汁 | 20％±2％ |
| 肌醇 | 17％±3％ |
| 大叶藻提取物 | 9％±2％ |
| 酵母发酵物 | 13％±3％ |
| 桦树汁+肌醇 | 47％±3％ |
| 桦树汁+大叶藻提取物 | 36％±2％ |
| 桦树汁+酵母发酵物 | 54％±3％ |
| 桦树汁+肌醇+大叶藻提取物+酵母发酵物 | 87％±5％ |
以上结果表明，在抑制5α-还原酶方面，与单独使用桦树汁及肌醇、大叶藻提取物、酵母发酵物中任意一种相比，桦树汁与肌醇、大叶藻提取物和/或酵母发酵物的组合使用效果更为显著，尤其是桦树汁与肌醇、大叶藻提取物和酵母发酵物共同使用时，效果远远优于四种物质功效的叠加，表面它们之间显著的增效作用。
实施例2：对防脱生发相关基因和蛋白表达的影响
在本实施例中，考察和对比了桦树汁、肌醇、大叶藻提取物、酵母发酵物以及它们的组合物对防脱生发相关基因和蛋白表达的影响。
1.测试方法
本实验所用毛乳头细胞由广东博溪生物科技有限公司生产。
实验仪器：CO2培养箱(Thermo)、超净工作台(苏净安泰)、倒置显微镜(Olympus)、微量振荡器(其林贝尔)、酶标仪(BioTek)、恒温箱(泰斯特)、荧光定量PCR仪(BioRad)、普通PCR仪(博日)。
实验试剂：Mesenchymal Stem Cell Medium(ScienCell)、PBS(博士德)、DHT(Sigma)、VEGF ELISA试剂盒(Abcam)、RNAiso Plus(Takara)、反转录试剂盒(Takara)、荧光染料(Takara)。
单一原料上样量为一整份原料；复配原料中各原料的加入量为：整份原料/复配原料数目。
基于毛乳头细胞的基因和蛋白表达分析步骤如下：
(1)接种：以适宜的毛乳头细胞接种量接种至6孔板中，37℃，5％CO2培养箱孵育过夜；
(2)配液：按照如下实验设计表配置受试物工作液。
实验设计如下表：
(3)给药：根据上表实验具体设计，待6孔板中细胞铺板率达到40-50％时，进行分组给药，每孔给药量为2mL，每组设3个复孔。37℃，5％CO2培养箱继续培养24小时。
(4)分别收集细胞上清液和细胞：
a.收集细胞上清：培养24小时后，收集细胞培养上清液于EP管中，收集完后将用于VEGF含量检测的样品置于-80℃冰箱冷冻保存；
b.收集细胞：培养24小时后，收集细胞上清后，1mL/孔PBS清洗两次，每孔加入1mLRNAiso Plus，吹打裂解细胞后，收样。
(5)VEGF含量的检测：根据VEGF ELISA试剂盒的操作说明书进行检测分析。
(6)AR基因表达检测：提取RNA，反转录至cDNA后，进行荧光定量PCR检测，采用2-△△CT方法进行结果计算。
2.结果统计分析
应用GraphPad Prism Program软件作图，各组间采用T-test统计分析。
测试结果如下表所示。
| 样品 | VEGF蛋白(pg/mL) | AR基因(相对转录量) |
| 阴性对照 | 706±6 | 1.00±0.05 |
| 桦树汁 | 814±6 | 0.82±0.03 |
| 肌醇 | 781±21 | 0.89±0.05 |
| 大叶藻提取物 | 766±17 | 0.90±0.07 |
| 酵母发酵物 | 792±23 | 0.84±0.05 |
| 桦树汁+肌醇 | 1220±28 | 0.48±0.04 |
| 桦树汁+大叶藻提取物 | 1298±25 | 0.47±0.03 |
| 桦树汁+酵母发酵物 | 1305±28 | 0.51±0.05 |
| 桦树汁+肌醇+大叶藻提取物+酵母发酵物 | 1527±33 | 0.29±0.04 |
以上结果表明，与单独使用桦树汁、肌醇、大叶藻提取物或酵母发酵物相比，桦树汁与肌醇、大叶藻提取物或酵母发酵物的组合物明显提高了毛乳头周围血管微循环相关的VEGF蛋白(血管内皮生长因子)的表达量，有效抑制了与雄激素信号传递相关的AR(雄性激素受体)基因的转录，尤其地，桦树汁与肌醇、大叶藻提取物和酵母发酵物的组合物显示了更加显著的效果。
实施例3：对毛乳头细胞增殖能力的影响
在本实施例中，考察和对比了桦树汁、肌醇、大叶藻提取物、酵母发酵物以及它们的组合物对毛乳头细胞增殖能力的影响。
1.测试方法
本实验所用毛乳头细胞由广东博溪生物科技有限公司生产。
实验仪器：CO2培养箱(Thermo)、超净工作台(苏净安泰)、倒置显微镜(Olympus)、微量振荡器(其林贝尔)、酶标仪(BioTek)、恒温箱(泰斯特)。
实验试剂及耗材：Mesenchymal Stem Cell Medium(ScienCell)、PBS(博士德)、MTT(Sigma)、DMSO(Sigma)。
单一原料上样量为一整份原料；复配原料中各原料的加入量为：整份原料/复配原料数目。
操作方法：
(1)制备细胞悬液：取对数生长期细胞消化后接种至96孔板中，37℃，5％CO2培养箱孵育过夜；
(2)给药：待96孔板中细胞铺板率达到20-30％时，将预先配制好的加有待测样品的培养液进行分组给药，每孔给药量为200μL，每组设3个复孔。同时对0小时分组的细胞进行MTT检测，其他时间点的细胞于37℃，5％CO2培养箱继续培养；
(3)检测：细胞分别孵育培养48小时，弃掉上清，加入MTT工作液，37℃避光孵育。4小时后弃掉上清，每孔加150μL DMSO，酶标仪490nm读取OD值；
(4)计算公式：
2.测试结果,如下表所示:
| 样品 | 促进毛乳头细胞增殖率 |
| 桦树汁 | 18％±2％ |
| 肌醇 | 8％±1％ |
| 大叶藻提取物 | 9％±2％ |
| 酵母发酵物 | 12％±3％ |
| 桦树汁+肌醇 | 27％±3％ |
| 桦树汁+大叶藻提取物 | 30％±4％ |
| 桦树汁+酵母发酵物 | 25％±3％ |
| 桦树汁+肌醇+大叶藻提取物+酵母发酵物 | 72％±5％ |
MTT值测试结果表明，与单独使用桦树汁、肌醇、大叶藻提取物、酵母发酵物相比，桦树汁与肌醇、大叶藻提取物或酵母发酵物的组合物促进毛乳头细胞增殖的能力有较大幅度的提高，尤其地，桦树汁与肌醇、大叶藻提取物和酵母发酵物的组合物显示了更加显著的促进效果，远远高于四种物质单独功效的叠加。
实施例4：防脱生发液
所述防脱生发液配方如下表所示(重量％)：
上述防脱生发液制备方法如下：
1.首先将A相各组分按照质量配比加入主锅，并加热至80℃，混合；
2.将B相各组分按照质量配比加入边锅，加热融化并搅拌均匀，并将其投入到A相中，与A相搅拌混合均匀；
3.将C相中的精氨酸、葡萄糖酸锌、PCA锌、大叶藻提取物、肌醇依次加入主锅中，并搅拌均匀；
4.将D相中的二氨基嘧啶氧化物和丙二醇依次加入主锅中，并搅拌均匀；
5.将主锅降温至50℃，依次加入E相的乙醇和戊二醇，并搅拌均匀；
6.再次将主锅降温至45℃，加入F相的酵母发酵物，并搅拌均匀；
7.将G相中的吐温-20和香精混合后预溶，并搅拌至透明后加入到主锅中，再次搅拌均匀；
8.最后向主锅中加入H相，搅拌均匀后，冷却至室温，检测合格后出料得到防脱发生发液。
临床人体试验:选取150名脱发患者，随机分成五组，分别使用上述五种防脱生发液，每组男女各半。受试者每天涂于头皮部，并按摩吸收，3个月后测量志愿者单位面积头发密度、平均头发直径和头发生长速度。得到如下结果：
以上结果表明，与包含单独的桦树汁、肌醇的防脱生发液相比，包含桦树汁和肌醇的组合的防脱生发液具有显著改善的生发功效，包括单位面积的头发密度更高，平均头发直径更粗，头发的生长速度也明显加快。尤其地，包含桦树汁与肌醇、大叶藻提取物和酵母发酵物的组合的防脱生发液显示了更加显著的生发功效。
实施例6：防脱洗发水
所述防脱洗发水的配方如下表所示(重量％)：
上述防脱洗发水制备方法如下：
按照上述表中的比例加入去离子水或桦树汁，将其加热到80℃，并持续半小时。将十二烷基醇醚硫酸钠、椰油酰谷氨酸钠、瓜尔胶、肌醇、酵母发酵物按照顺序依次加入水中，持续搅拌，保持10分钟。对上述混合物进行均质20-30分钟；预先将1,2-戊二醇、1,3-CG、D-泛醇、薄荷醇、桉树叶油、大叶藻提取物、何首乌混合好，待上述均质混合物温度降到室温时，加入体系中,搅拌10分钟。加入柠檬酸和氯化钠。调节pH为5-7，最后加入余量的去离子水至100％重量。经1200目过滤后，灌装，得到防脱洗发水。
临床人体试验：选取140名脱发患者(脱发数大于100根/天)，随机分成七组，分别使用上述七种防脱洗发水。受试者每隔一天洗一次头，早晚2次梳理头发，收集脱落头发并计数。每个月记录一次，持续使用和记录3个月，得到如下结果：
以上结果表明，与包含桦树汁、肌醇、大叶藻提取物和/或酵母发酵物的防脱洗发水相比，包含桦树汁、肌醇、大叶藻提取物和酵母发酵物的防脱洗发水具有更显著的防脱发功效，而且，进一步包含何首乌和三肽-1铜的防脱洗发水显示了更加好的防脱发功效。
以上所述实施例的技术方案是本发明优选实施方式，在不脱离本发明原理的前提下还可以进行若干改进和变换，这些改进和变化也应视为在本发明的保护范围内。
Claims (14)
1.一种防脱生发组合物，其包含(A)桦树汁，和(B)肌醇、大叶藻提取物和酵母发酵物的混合物。
2.权利要求1所述的防脱生发组合物，其中所述(A)桦树汁的含量为5-98％重量，基于所述防脱生发组合物的总重量。
3.权利要求2所述的防脱生发组合物，其中所述(A)桦树汁的含量为10-98％重量。
4.权利要求3所述的防脱生发组合物，其中所述(A)桦树汁的含量为15-97％重量。
5.权利要求1-4中任一项所述的防脱生发组合物，其中所述(B)肌醇、大叶藻提取物和酵母发酵物的混合物的含量为0.001-30％重量，基于所述防脱生发组合物的总重量。
6.权利要求5所述的防脱生发组合物，其中所述(B)肌醇、大叶藻提取物和酵母发酵物的混合物的含量为0.01-10％重量。
7.权利要求6所述的防脱生发组合物，其中所述(B)肌醇、大叶藻提取物和酵母发酵物的混合物的含量为0.1-5％重量。
8.权利要求7所述的防脱生发组合物，其中所述(B)肌醇、大叶藻提取物和酵母发酵物的混合物的含量为0.5-3％重量。
9.权利要求1-4任一项所述的防脱生发组合物，其进一步包含何首乌和三肽-1铜。
10.权利要求9所述的防脱生发组合物，其中何首乌的含量为0.001-30％，基于所述防脱生发组合物的总重量。
11.由(A)桦树汁和(B)肌醇、大叶藻提取物和酵母发酵物的混合物组成的试剂包。
12.权利要求11所述的试剂包在制备防脱生发组合物中的用途。
13.由(A)桦树汁，(B)肌醇、大叶藻提取物和酵母发酵物的混合物，何首乌和三肽-1铜组成的试剂包。
14.权利要求13所述的试剂包在制备防脱生发组合物中的用途。
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