CN114630889A - 包含细菌内生孢子的颗粒 - Google Patents
包含细菌内生孢子的颗粒 Download PDFInfo
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- CN114630889A CN114630889A CN202080074365.2A CN202080074365A CN114630889A CN 114630889 A CN114630889 A CN 114630889A CN 202080074365 A CN202080074365 A CN 202080074365A CN 114630889 A CN114630889 A CN 114630889A
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- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
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- 150000004823 xylans Chemical class 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/06—Powder; Flakes; Free-flowing mixtures; Sheets
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- C—CHEMISTRY; METALLURGY
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0068—Deodorant compositions
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/381—Microorganisms
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N3/00—Spore forming or isolating processes
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
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Abstract
本发明提供一种包含多个颗粒的组合物,其中所述颗粒包含:按所述颗粒的重量计至少40%的非萌发载体;以及按所述颗粒的重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;并且其中所述颗粒中的每个颗粒具有介于约1mg至约5000mg之间,优选地介于约5mg和约200mg之间的质量。
Description
技术领域
本发明涉及颗粒物衣物洗涤添加剂领域。具体地,本发明涉及包含细菌内生孢子以减少织物恶臭的颗粒。
背景技术
织物上的恶臭甚至在已洗涤之后也似乎是反复出现的问题。
本发明的目的是提供改善织物恶臭的产品。
发明内容
根据本发明的第一方面,提供了一种包含多个颗粒的衣物洗涤添加剂组合物,其中所述颗粒包含:按所述颗粒的重量计至少40%,优选地约45%至约99.999%的非萌发载体;以及按所述颗粒的重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;所述颗粒优选地包含1×102至1×109CFU/g的细菌内生孢子,更优选地1×103至1×106CFU/g的细菌内生孢子。所述颗粒中的每个颗粒具有介于约1mg至约5000mg之间,优选地介于约5mg和约200mg之间的质量。
根据本发明的第二方面,提供了一种产品,所述产品包含含有本发明的组合物的容器。
根据本发明的第三方面,提供了一种用于处理脏污衣物制品的方法,所述方法包括以下步骤:
用洗涤剂组合物处理所述制品;以及
用本发明的组合物处理所述制品。
内生孢子似乎在洗涤期间沉积在衣物制品上,并且在存在热的情况下似乎萌发并减少恶臭。内生孢子似乎在例如汗味物品(其已用本发明的组合物洗涤)的情况下非常有用。内生孢子似乎在存在出汗期间产生的复杂污垢的情况下并且通过所产生的热而萌发,内生孢子减少恶臭。
根据本发明的第四方面,提供了一种用于形成颗粒的方法,所述方法包括以下步骤:
提供前体材料;提供具有多个孔的分配器;使所述前体材料通过所述孔;在所述分配器下方提供移动的传送装置;使所述前体材料沉积到所述移动的传送装置上;以及使所述前体材料冷却以形成多个颗粒;其中所述前体材料优选地包含聚乙二醇,其中所述聚乙二醇具有约2000至约13000的重均分子量;其中所述前体材料包含按所述前体材料的重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;并且其中所述前体材料是在小于约70℃的温度下提供的。已惊讶地发现,内生孢子在经受此方法时未萌发。
最近,提供了本发明的组合物减少来自织物的恶臭的用途。
相对于本发明的第一方面描述的本发明的组合物的元素作必要修改之后适用于本发明的其他方面。
具体实施方式
除非另外指明,本文所用的所有百分比、比率和比例均按组合物的重量百分比计。除非另外明确指出,所有平均值均按组合物的重量计算。除非另外指明,所有比率均计算为重量/重量水平。
除非另外指明,所有的测量均在25℃下进行。
除非另外指明,否则所有组分或组合物水平均是就该组分或组合物的活性部分而言,且不包括可能存在于此类组分或组合物的可商购获得的来源中的杂质,例如残余溶剂或副产物。
细菌内生孢子
一些革兰氏阳性细菌具有两阶段生命周期,其中在某些条件下,诸如响应于营养剥夺而生长细菌可以经历导致孢子或内生孢子形成的复杂发育程序。细菌孢子被由约60种不同蛋白质组成的外壳保护,所述蛋白质组装为具有不透明形态和机械特性的生物化学复杂结构。蛋白质外壳被认为是提供刚性并且主要充当筛以排除外源大毒性分子(诸如裂解酶)的静态结构。孢子在菌种的长期存活中起关键作用,因为它们对极端环境条件具有高度抗性。孢子也能够保持代谢休眠持续数年。用于从营养细胞获得细菌孢子的方法在本领域中是熟知的。在一些实施例中,使营养细菌细胞在液体培养基中生长。从晚期对数生长阶段或早期静止生长阶段开始,细菌可开始孢子化。当细菌已完成孢子化时,可以通过例如使用离心从培养基获得孢子。可使用各种方法来杀死或去除任何剩余的营养细胞。可使用各种方法来从细胞碎片和/或其它材料或物质中纯化孢子。用于产生细菌孢子的一些示例性方法描述于本公开的实施例1中。例如,可使用各种技术,如相差显微镜检查、自动扫描显微镜检查、高分辨率原子力显微镜检查或对热的耐受性,来将细菌孢子与营养细胞区分开。
因为细菌孢子通常是代谢惰性或休眠的环境耐受性结构,所以它们容易被选择用于商业微生物产品中。尽管其坚固性和极端寿命,但是孢子可快速响应于已知为萌发剂的小特异性分子的存在,所述小特异性分子发送通过萌发而解除休眠的有利条件的信号(通过返回到营养细菌而完成生命周期的过程中的初始步骤)。例如,商业微生物产品可被设计成分散到孢子遇到环境中存在的萌发剂的环境中,以萌发成营养细胞并执行预期功能。多种不同的细菌可形成孢子。来自这些组中的任一组的细菌可用于本文所公开的组合物、方法和试剂盒中。例如,以下属的一些细菌可形成内生孢子:醋丝菌(Acetonema)、碱芽孢杆菌(Alkalibacillus)、嗜氨菌(Ammoniphilus)、双芽孢杆菌(Amphibacillus)、厌氧杆菌(Anaerobacter)、Anaerospora、解硫胺素芽孢杆菌(Aneurinibacillus)、无氧芽孢菌(Anoxybacillus)、芽孢杆菌(Bacillus)、短芽孢杆菌(Brevibacillus)、CaldAnaerobacter、喜热菌(Caloramator)、Caminicella、Cerasibacillus、梭菌(Clostridium)、Clostridiisalibacter、科恩氏菌(Cohnella)、树源生孢杆菌(Dendrosporobacter)、脱硫肠状菌(Desulfotomaculum)、脱硫鼠孢菌(Desulfosporomusa)、脱硫芽孢弯曲菌(Desulfosporosinus)、Desulfovirgula、Desulfunispora、脱硫孢菌(Desulfurispora)、产线菌(Filifactor)、线芽孢杆菌(Filobacillus)、Gelria、地芽孢杆菌(Geobacillus)、地生孢杆菌(Geosporobacter)、薄壁芽孢杆菌(Gracilibacillus)、Halonatronum、螺旋杆菌(Heliobacterium)、嗜日菌(Heliophilum)、莱西氏菌(Laceyella)、慢生芽孢杆菌(Lentibacillus)、赖氨酸芽孢杆菌(Lysinibacillus)、麻氏菌(Mahella)、Metabacterium、穆尔氏菌(Moorella)、喜碱菌(Natroniella)、海洋芽孢杆菌(Oceanobacillus)、Orenia、鸟氨酸芽孢杆菌(Ornithinibacillus)、嗜草酸菌(Oxalophagus)、产醋杆菌(Oxobacter)、类芽孢杆菌(Paenibacillus)、海境芽孢杆菌(Paraliobacillus)、暗生孢菌(Pelospora)、消化肠状菌(Pelotomaculum)、鱼芽孢杆菌(Piscibacillus)、扁平丝菌(Planifilum)、海芽孢杆菌(Pontibacillus)、丙酸菌(Propionispora)、盐渍芽孢杆菌(Salinibacillus)、栖盐水芽孢杆菌(Salsuginibacillus)、清野氏菌(Seinonella)、岛津氏菌(Shimazuella)、生孢产醋杆状菌(Sporacetigenium)、SporoAnaerobacter、孢杆菌(Sporobacter)、生孢杆菌(Sporobacterium)、芽孢盐杆菌(Sporohalobacter)、芽孢乳杆菌(Sporolactobacillus)、鼠孢菌(Sporomusa)、芽孢八叠球菌(Sporosarcina)、Sporotalea、芽孢肠状菌(Sporotomaculum)、共养单胞菌(Syntrophomonas)、共养生孢菌(Syntrophospora)、纤细芽孢杆菌(Tenuibacillus)、Tepidibacter、土地芽孢杆菌(Terribacillus)、深海芽孢杆菌(Thalassobacillus)、(Thermoacetogenium)、嗜热放线菌(Thermoactinomyces)、热碱芽孢杆菌(Thermoalkalibacillus)、热厌氧杆菌(ThermoAnaerobacter)、热厌氧单胞菌(Thermoanaeromonas)、热芽孢杆菌(Thermobacillus)、热黄微菌(Thermoflavimicrobium)、Thermovenabulum、肿块芽孢杆菌(Tuberibacillus)、枝芽孢杆菌(Virgibacillus)、和/或Vulcanobacillus。
在一些实施例中,可形成内生孢子的细菌来自芽孢杆菌(Bacillus)属。在各种实施例中,芽孢杆菌(Bacillus)细菌可为以下菌的菌株:嗜碱芽孢杆菌(Bacillusalcalophilus)、蜂房芽孢杆菌(Bacillus alvei)、噬胺芽孢杆菌(Bacillusaminovorans)、解淀粉芽孢杆菌(Bacillus amyloliquefaciens)、Bacillusaneurinolyticus、海水芽孢杆菌(Bacillus aquaemaris)、萎缩芽孢杆菌(Bacillusatrophaeus)、嗜硼芽孢杆菌(Bacillus boroniphilius)、短芽孢杆菌(Bacillus brevis)、热容芽孢杆菌(Bacillus caldolyticus)、中孢芽孢杆菌(Bacillus centrosporus)、蜡样芽孢杆菌(Bacillus cereus)、环状芽孢杆菌(Bacillus circulans)、凝结芽孢杆菌(Bacillus coagulans)、坚强芽孢杆菌(Bacillus firmus)、黄热芽孢杆菌(Bacillusflavothermus)、纺锤芽孢杆菌(Bacillus fusiformis)、球芽孢杆菌(Bacillusglobigii)、Bacillus infernus、幼虫芽孢杆菌(Bacillus larvae)、侧孢芽孢杆菌(Bacillus laterosporus)、迟缓芽孢杆菌(Bacillus lentus)、地衣芽孢杆菌(Bacilluslicheniformis)、巨大芽孢杆菌(Bacillus megaterium)、马铃薯芽孢杆菌(Bacillusmesentericus)、胶冻样芽孢杆菌(Bacillus mucilaginosus)、蕈状芽孢杆菌(Bacillusmycoides)、纳豆芽孢杆菌(Bacillus natto)、泛养芽孢杆菌(Bacillus pantothenticus)、多粘芽孢杆菌(Bacillus polymyxa)、假炭疽芽孢杆菌(Bacillus pseudoanthracis)、短小芽孢杆菌(Bacillus pumilus)、施氏芽孢杆菌(Bacillus schlegelii)、球形芽孢杆菌(Bacillus sphaericus)、耐热芽孢杆菌(Bacillus sporothermodurans)、嗜热脂肪芽孢杆菌(Bacillus stearothermophillus)、枯草芽孢杆菌(Bacillus subtilis)、热葡糖苷酶芽孢杆菌(Bacillus thermoglucosidasius)、苏云金芽孢杆菌(Bacillus thuringiensis)、Bacillus vulgatis、韦氏芽孢杆菌(Bacillus weihenstephanensis)、或者它们的组合。
在一些实施例中,形成孢子的细菌菌株可为芽孢杆菌的菌株,包括:芽孢杆菌(Bacillus)菌种菌株SD-6991;芽孢杆菌(Bacillus)菌种菌株SD-6992;芽孢杆菌(Bacillus)菌种菌株NRRL B-50606;芽孢杆菌(Bacillus)菌种菌株NRRL B-50887;短小芽孢杆菌(Bacillus pumilus)菌株NRRL B-50016;解淀粉芽孢杆菌(Bacillusamyloliquefaciens)菌株NRRL B-50017;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7792(先前被分类为萎缩芽孢杆菌(Bacillus atrophaeus));解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7543(先前被分类为萎缩芽孢杆菌(Bacillusatrophaeus));解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株NRRL B-50018;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7541;解淀粉芽孢杆菌(Bacillusamyloliquefaciens)菌株PTA-7544;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7545;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7546;枯草芽孢杆菌(Bacillus subtilis)菌株PTA-7547;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7549;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7793;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7790;解淀粉芽孢杆菌(Bacillusamyloliquefaciens)菌株PTA-7791;枯草芽孢杆菌(Bacillus subtilis)菌株NRRL B-50136(也称为DA-33R,ATCC保藏号55406);解淀粉芽孢杆菌(Bacillusamyloliquefaciens)菌株NRRL B-50141;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株NRRL B-50399;地衣芽孢杆菌(Bacillus licheniformis)菌株NRRL B-50014;地衣芽孢杆菌(Bacillus licheniformis)菌株NRRL B-50015;解淀粉芽孢杆菌(Bacillusamyloliquefaciens)菌株NRRL B-50607;枯草芽孢杆菌(Bacillus subtilis)菌株NRRL B-50147(也称为300R);解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株NRRL B-50150;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株NRRL B-50154;巨大芽孢杆菌(Bacillus megaterium)PTA-3142;解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株ATCC保藏号55405(也称为300);解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株ATCC保藏号55407(也称为PMX);短小芽孢杆菌(Bacillus pumilus)NRRL B-50398(也称为ATCC700385、PMX-1和NRRL B-50255);蜡样芽孢杆菌(Bacillus cereus)ATCC保藏号700386;苏云金芽孢杆菌(Bacillus thuringiensis)ATCC保藏号700387(上述菌株全部可从Novozymes,Inc.,USA获得);解淀粉芽孢杆菌(Bacillus amyloliquefaciens)FZB24(例如,来自Novozymes的分离物NRRL B-50304和NRRL B-50349)、枯草芽孢杆菌(Bacillus subtilis)(例如,来自Bayer CropScience的MAX和ASO中分离物NRRL B-21661)、短小芽孢杆菌(Bacillus pumilus)(例如,来自Bayer CropScience的分离物NRRL B-50349)、解淀粉芽孢杆菌(Bacillusamyloliquefaciens)TrigoCor(也称为“TrigoCor1448”;例如,来自Cornell University,USA的分离物Embrapa Trigo保藏号144/88.4Lev、Cornell保藏号Pma007BR-97和ATCC保藏号202152)、以及它们的组合。
在一些实施例中,形成孢子的细菌菌株可为解淀粉芽孢杆菌(Bacillusamyloliquefaciens)的菌株。例如,所述菌株可为解淀粉芽孢杆菌(Bacillusamyloliquefaciens)菌株PTA-7543(先前被分类为萎缩芽孢杆菌(Bacillusatrophaeus))、和/或解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株NRRL B-50154、解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株PTA-7543(先前被分类为萎缩芽孢杆菌(Bacillus atrophaeus))、解淀粉芽孢杆菌(Bacillus amyloliquefaciens)菌株NRRLB-50154、或来自其它解淀粉芽孢杆菌(Bacillus amyloliquefaciens)生物体。
在一些实施例中,形成孢子的细菌菌株可为短芽孢杆菌(Brevibacillus)菌种,例如,短短芽孢杆菌(Brevibacillus brevis);美丽短芽孢杆菌(Brevibacillus formosus);侧孢短芽孢杆菌(Brevibacillus laterosporus);或类短短芽孢杆菌(Brevibacillusparabrevis)、或者它们的组合。
在一些实施例中,形成孢子的细菌菌株可为类芽孢杆菌(Paenibacillus)菌种,例如,蜂房类芽孢杆菌(Paenibacillus alvei);解淀粉类芽孢杆菌(Paenibacillusamylolyticus);固氮类芽孢杆菌(Paenibacillus azotofixans);库氏类芽孢杆菌(Paenibacillus cookii);浸麻类芽孢杆菌(Paenibacillus macerans);多粘类芽孢杆菌(Paenibacillus polymyxa);强壮类芽孢杆菌(Paenibacillus validus)、或者它们的组合。
芽孢杆菌(Bacillus)孢子可具有约2-50微米,适宜地约10-45微米的平均粒径。芽孢杆菌(Bacillus)孢子可在水性载体中的共混物中商购获得,并且不溶于水性载体。其它可商购获得的芽孢杆菌(bacillus)孢子共混物包括但不限于:Freshen FreeTM CAN(10X),其可从Novozymes Biologicals,Inc.获得;Renew Plus(10X),其可从GenesisBiosciences,Inc.获得;和GT(10X、20X和110X),全部可从GenesisBiosciences,Inc.获得。在前述列表中,括号注释(10X、20X和1 1OX)指示芽孢杆菌(Bacillus)孢子的相对浓度。
本文所公开的组合物、方法和产品中使用的细菌孢子可以被或可以不被热活化。在一些实施例中,细菌孢子被热活化。在一些实施例中,细菌孢子未被热灭活。
对于本文所公开的组合物,通常使用细菌孢子群。在一些实施例中,细菌孢子群可包含来自单个细菌菌株的细菌孢子。在一些实施例中,细菌孢子群可包含来自2个、3个、4个、5个或更多个细菌菌株的细菌孢子。通常,细菌孢子群含有大部分孢子和少部分营养细胞。在一些实施例中,细菌孢子群不含有营养细胞。在一些实施例中,细菌孢子群可含有小于约1%、2%、3%、4%、5%、6%、7%、8%、9%、10%、15%、20%、25%、30%、40%或50%的营养细胞,其中细菌孢子的百分比被计算为((营养细胞/(群体中的孢子+群体中的营养细胞))×100)。通常,所公开的组合物中使用的细菌孢子群是稳定的(即未经历萌发),其中群体中的至少一些单独孢子能够萌发。
本公开中使用的细菌孢子群可含有不同浓度的细菌孢子。在各种实施例中,细菌孢子群可含有但不限于至少l×l02、5×l02、l×l03、5×l03、l×l04、5×l04、1×l05、5×l05、l×l06、5×l06、l×l07、5×l07、l×l08、5×l08、l×l09、5×l09、l×l010、5×l010、l×l011、5×l011、l×1012、5×l012、l×l013、5×l013、l×l014、或5×l014个孢子/ml或个孢子/cm3。
所述颗粒可包含按所述颗粒的重量计至少约40%,更优选地至少约50%且小于99.999%的细菌内生孢子。
任选地,对于本文所公开的组合物中的任一种,单独的颗粒可具有约1mg至约5000mg,或者约5mg至约1000mg,或者约5mg至约200mg,或者约10mg至约100mg,或者约20mg至约50mg,或者约35mg至约45mg,或者约38mg,或者它们的组合以及在任何前述范围内的任何mg整数或mg整数范围的质量。具有在前述范围内的质量的颗粒在水中可具有允许颗粒在典型的洗涤循环期间溶解的溶解时间。在多个颗粒中,单独的颗粒可具有选自下列的形状:球形、半球形、压缩的半球形、兵豆形和长方形。
多个颗粒可具有约1mg至约5000mg,或者约5mg至约1000mg,或者约5mg至约200mg,或者约10mg至约100mg,或者约20mg至约50mg,或者约35mg至约45mg,或者约38mg的平均颗粒质量。多个颗粒可具有小于约30mg,或者小于约15mg,或者小于约5mg,或者约3mg的质量标准偏差。在上述范围内的平均颗粒质量可提供允许颗粒在典型的洗涤循环期间溶解的水中溶解时间。不受理论的约束,据信与具有更宽的质量标准偏差的颗粒相比,具有此类质量标准偏差的颗粒可具有更均匀的水中溶解时间。颗粒的质量标准偏差越小,溶解时间越均匀。可设定形成多个颗粒的单独颗粒的质量以提供所期望的溶解时间,该溶解时间可为洗衣机中典型洗涤循环时长的一部分。由重均分子量为约9000的聚乙二醇形成的颗粒可具有约38mg的平均颗粒质量和约3mg的质量标准偏差。
单独的颗粒可具有约0.003cm3至约5cm3的体积。单独的颗粒可具有约0.003cm3至约1cm3的体积。单独的颗粒可具有约0.003cm3至约0.5cm3的体积。单独的颗粒可具有约0.003cm3至约0.2cm3的体积。单独的颗粒可具有约0.003cm3至约0.15cm3的体积。认为较小的颗粒在容器中提供更好的颗粒堆叠以及在洗涤中更快的溶解。
组合物可包含颗粒,该颗粒保留在如ASTM International,ASTM E11-13所指定的10号筛上。组合物可包含颗粒,其中按重量计超过约50%的颗粒保留在如ASTMInternational,ASTM E11–13所指定的10号筛上。组合物可包含颗粒,其中按重量计超过约70%的颗粒保留在如ASTM International,ASTM E11–13所指定的10号筛上。组合物可包含颗粒,其中按重量计超过约90%的颗粒保留在如ASTM International,ASTM E11–13所指定的10号筛上。可期望提供如此类尺寸的颗粒,因为保留在10号筛上的颗粒可比更小的颗粒更易于处理。
组合物可包含颗粒,该颗粒保留在如ASTM International,ASTM E11-13所指定的6号筛上。组合物可包含颗粒,其中按重量计超过约50%的颗粒保留在如ASTMInternational,ASTM E11–13所指定的6号筛上。组合物可包含颗粒,其中按重量计超过约70%的颗粒保留在如ASTM International,ASTM E11–13所指定的6号筛上。组合物可包含颗粒,其中按重量计超过约90%的颗粒保留在如ASTM International,ASTM E11–13所指定的6号筛上。可期望提供如此类尺寸的颗粒,因为保留在6号筛上的颗粒可比更小的颗粒更易于处理。
组合物可包含通过标称筛开口尺寸为22.6mm的筛的颗粒。组合物可包含通过标称筛开口尺寸为22.6mm的筛并且保留在标称筛开口尺寸为0.841mm的筛上的颗粒。颗粒具有的尺寸使得它们保留在标称筛开口尺寸为22.6mm的筛上,对于常见的洗涤循环,它们可趋于具有过长的溶解时间。颗粒具有的尺寸使得它们通过具有0.841mm的标称筛开口尺寸的筛,它们可能太小而无法进行方便的处理。具有在前述范围内的尺寸的颗粒能够提供在溶解时间和颗粒的处理便利性之间的适当平衡。
具有本文所公开的尺寸的颗粒可以足够大,使得当从容器、量杯或其他设备倒入到洗衣盆或洗衣机中时,它们不轻易地在空气中传播。此外,如本文所公开的此类颗粒可容易且准确地从容器倒入量杯中。因此,此类颗粒使得消费者易于控制其递送到洗涤中的孢子的量。
多个颗粒可合在一起构成一个剂量以定量投配到洗衣机或洗衣盆中。单剂量的颗粒可包含约1g至约27g的颗粒。单剂量的颗粒可包含约5g至约27g,或者约13g至约27g,或者约14g至约20g,或者约15g至约19g,或者约18g至约19g,或者它们的组合以及在任何前述范围内的任何整数克或整数克范围的质量。形成可构成剂量的多个颗粒的单独的颗粒可具有约1mg至约5000mg,或者约5mg至约1000mg,或者约5mg至约200mg,或者约10mg至约100mg,或者约20mg至约50mg,或者约35mg至约45mg,或者约38mg,或者它们的组合以及在任何前述范围内的任何mg整数或mg整数范围的质量。多个颗粒可由具有不同尺寸、形状和/或质量的颗粒构成。一定剂量的颗粒可各自具有小于约15mm的最大尺寸。一定剂量的每个颗粒可具有小于约1cm的最大尺寸。
本文所公开的颗粒可方便地用于在衣物洗涤过程中处理衣物制品。所述颗粒应与衣物洗涤剂组合使用。所述方法的步骤可以是提供此类包含本文所公开的制剂组分的颗粒。可将一定剂量的颗粒置于量杯中。所述量杯可为包含颗粒的容器的闭合件。量杯可以是可拆卸的和可附接的量杯,其可拆卸且可附接到含有颗粒的容器或此类容器的闭合件。可将量杯中的颗粒剂量分配到洗衣机中。在洗衣机中分配颗粒的步骤可通过以下来进行:将颗粒倒入洗衣机中或将量杯和其中所含颗粒置于洗衣机中,优选地,将颗粒投配到自动洗衣机的滚筒中。
载体
“非萌发”载体在本文中是指不会有助于内生孢子萌发的载体。
载体可为或包含选自以下项的材料:水溶性无机碱金属盐、水溶性碱土金属盐、水溶性有机碱金属盐、水溶性有机碱土金属盐、水溶性碳水化合物、水溶性硅酸盐、水溶性尿素、以及它们的任何组合。碱金属盐可例如选自锂盐、钠盐和钾盐、以及它们的任何组合。可用的碱金属盐可例如选自碱金属氟化物、碱金属氯化物、碱金属溴化物、碱金属碘化物、碱金属硫酸盐、碱金属硫酸氢盐、碱金属磷酸盐、碱金属磷酸一氢盐、碱金属磷酸二氢盐、碱金属碳酸盐、碱金属碳酸一氢盐、碱金属乙酸盐、碱金属柠檬酸盐、碱金属乳酸盐、碱金属丙酮酸盐、碱金属硅酸盐、碱金属抗坏血酸盐、以及它们的组合。
碱金属盐可选自氟化钠、氯化钠、溴化钠、碘化钠、硫酸钠、硫酸氢钠、磷酸钠、磷酸一氢钠、磷酸二氢钠、碳酸钠、碳酸氢钠、乙酸钠、柠檬酸钠、乳酸钠、酒石酸钠、硅酸钠、抗坏血酸钠、氟化钾、氯化钾、溴化钾、碘化钾、硫酸钾、硫酸氢钾、磷酸钾、磷酸一氢钾、磷酸二氢钾、碳酸钾、碳酸一氢钾、乙酸钾、柠檬酸钾、乳酸钾、酒石酸钾、硅酸钾、钾、抗坏血酸、以及它们的组合。碱土金属盐可选自镁盐、钙盐等、以及它们的组合。碱土金属盐可选自碱金属氟化物、碱金属氯化物、碱金属溴化物、碱金属碘化物、碱金属硫酸盐、碱金属硫酸氢盐、碱金属磷酸盐、碱金属磷酸一氢盐、碱金属磷酸二氢盐、碱金属碳酸盐、碱金属碳酸一氢盐、碱金属乙酸盐、碱金属柠檬酸盐、碱金属乳酸盐、碱金属丙酮酸盐、碱金属硅酸盐、碱金属抗坏血酸盐、以及它们的组合。碱土金属盐可选自氟化镁、氯化镁、溴化镁、碘化镁、硫酸镁、磷酸镁、磷酸一氢镁、磷酸二氢镁、碳酸镁、碳酸一氢镁、乙酸镁、柠檬酸镁、乳酸镁、酒石酸镁、硅酸镁、抗坏血酸镁、氟化钙、氯化钙、溴化钙、碘化钙、硫酸钙、磷酸钙、磷酸一氢钙、磷酸二氢钙、碳酸钙、碳酸一氢钙、乙酸钙、柠檬酸钙、乳酸钙、酒石酸钙、硅酸钙、抗坏血酸钙、以及它们的组合。无机盐,诸如无机碱金属盐和无机碱土金属盐,不含碳。有机盐,诸如有机碱金属盐和有机碱土金属盐,含有碳。有机盐可为山梨酸的碱金属盐或碱土金属盐(即,抗坏血酸盐)。山梨酸盐可选自山梨酸钠、山梨酸钾、山梨酸镁、山梨酸钙、以及它们的组合。
载体可为或包含选自以下项的材料:水溶性无机碱金属盐、水溶性有机碱金属盐、水溶性无机碱土金属盐、水溶性有机碱土金属盐、水溶性碳水化合物、水溶性硅酸盐、水溶性尿素、以及它们的组合。载体或水溶性载体可选自氯化钠、氯化钾、氯化钙、氯化镁、硫酸钠、硫酸钾、硫酸镁、碳酸钠、碳酸钾、碳酸氢钠、碳酸氢钾、乙酸钠、乙酸钾、柠檬酸钠、柠檬酸钾、酒石酸钠、酒石酸钾、酒石酸钾钠、乳酸钙、水玻璃、硅酸钠、硅酸钾、右旋糖、果糖、半乳糖、异葡萄糖、葡萄糖、蔗糖、棉子糖、异麦芽酮糖醇、木糖醇、糖果糖、粗砂糖、以及它们的组合。在一个实施方案中,载体或水溶性载体可为氯化钠。在一个实施方案中,载体或水溶性载体可为食盐。
载体可为或包含选自以下项的材料:碳酸氢钠、硫酸钠、碳酸钠、甲酸钠、甲酸钙、氯化钠、蔗糖、麦芽糖糊精、玉米糖浆固体、玉米淀粉、小麦淀粉、大米淀粉、马铃薯淀粉、木薯淀粉、粘土、硅酸盐、柠檬酸羧甲基纤维素、脂肪酸、脂肪醇、氢化牛脂的甘油二酯、甘油、以及它们的组合。
载体可选自水溶性有机碱金属盐、水溶性无机碱土金属盐、水溶性有机碱土金属盐、水溶性碳水化合物、水溶性硅酸盐、水溶性尿素、淀粉、粘土、水不溶性硅酸盐、柠檬酸羧甲基纤维素、脂肪酸、脂肪醇、氢化牛脂的甘油二酯、甘油、聚乙二醇、以及它们的组合。
载体可选自二糖、多糖、硅酸盐、沸石、碳酸盐、硫酸盐、柠檬酸盐、以及它们的组合。
水溶性聚合物的示例包括但不限于聚乙烯醇(PVA)、改性的PVA;聚乙烯基吡咯烷酮;PVA共聚物,诸如PVA/聚乙烯吡咯烷酮和PVA/聚乙烯胺;部分水解的聚醋酸乙烯酯;聚环氧烷,诸如环氧乙烷;聚乙二醇;丙烯酰胺;丙烯酸;纤维素、烷基纤维素,诸如甲基纤维素、乙基纤维素和丙基纤维素;纤维素醚;纤维素酯;纤维素酰胺;聚乙酸乙烯酯;多元羧酸和盐;聚氨基酸或肽;聚酰胺;聚丙烯酰胺;马来酸/丙烯酸的共聚物;多糖,包括淀粉、改性的淀粉;明胶;藻酸盐;葡聚木糖、其它半纤维素多糖,包括木聚糖、葡糖醛酸木聚糖、阿拉伯木聚糖、甘露聚糖、葡甘露聚糖和半乳糖葡甘露聚糖;天然树胶,诸如果胶、黄原胶、角叉菜胶、刺槐豆胶、阿拉伯树胶、黄蓍胶;以及它们的组合。在一个实施方案中,聚合物包含:聚丙烯酸酯,尤其是磺化聚丙烯酸酯和水溶性丙烯酸酯共聚物;以及烷基羟基纤维素,诸如甲基纤维素、羧甲基纤维素钠、改性的羧甲基纤维素、糊精、乙基纤维素、丙基纤维素、羟乙基纤维素、羟丙基甲基纤维素、麦芽糖糊精、聚甲基丙烯酸酯。在又一个实施方案中,聚合物包含:PVA;PVA共聚物;羟丙基甲基纤维素(HPMC);以及它们的混合物。
颗粒可包含按颗粒的重量计至少40%,优选地至少50%且99.999%以下的载体。颗粒可包含按颗粒的重量计约45%至约99.999%的载体。颗粒可包含按颗粒的重量计约45%至约99.99%的载体。
优选地,载体为聚乙二醇(PEG)。PEG可以为用于制备颗粒的便利的材料,因为当颗粒在上述质量范围内时,PEG可具有足够的水溶性以在洗涤循环期间溶解。此外,PEG可容易地以熔体形式加工。PEG的熔融温度可根据PEG的分子量而变化。取决于分子量和/或分子量分布,PEG的熔融温度可足够低,使得当包含PEG和细菌内生孢子的颗粒由包含PEG和内生孢子的熔体形成时,内生孢子的活性保持足够高以能够减少织物的恶臭。
颗粒可包含按重量计超过约40%的PEG,其具有约2000至约13000的重均分子量。PEG具有较低的成本,可形成为许多不同的形状和尺寸,使未包封香料的扩散最小化,并且很好地溶于水中。PEG具有多种重均分子量。合适的PEG重均分子量范围包括约2,000至约13,000,约4,000至约12,000,或者约5,000至约11,000,或者约6,000至约10,000,或者约7,000至约9,000,或者它们的组合。PEG得自BASF,例如PLURIOL E 8000。
颗粒可包含按颗粒的重量计超过约40%的PEG。颗粒可包含按颗粒的重量计超过约50%的PEG。颗粒可包含按颗粒的重量计超过约60%的PEG。颗粒可包含按组合物的重量计约65%至约99%的PEG。颗粒可包含按组合物的重量计约40%至约99%的PEG。颗粒可包含按组合物的重量计约45%至约99%的PEG。
所述多个颗粒可基本上不含质量小于约10mg的颗粒。这对于限制颗粒在空气中传播的能力是可行的。
取决于应用,颗粒可包含按颗粒的重量计约0.5%至约5%的平衡剂,所述平衡剂选自甘油、聚丙二醇、肉豆蔻酸异丙酯、二丙二醇、1,2-丙二醇、和重均分子量小于2,000的PEG,以及它们的混合物。平衡剂可用于提供具有相同加工特性的颗粒,即使所述颗粒具有不同的配方。例如,产品的两种不同的香味变体可具有不同水平的香料。在使用平衡剂的情况下,PEG在每种香味变体中的水平可相同,并且配方可用平衡剂平衡。这可使得加工更简单,因为香味变体的配方将具有相同水平的PEG并且可具有类似的加工特性。
颗粒可包含抗氧化剂。在生产和使用之间,抗氧化剂可有助于促进颗粒的颜色和/或气味随时间推移的稳定性。颗粒可包含按重量计介于约0.01%至约1%之间的抗氧化剂。颗粒可包含按重量计介于约0.001%至约2%之间的抗氧化剂。颗粒可包含按重量计介于约0.01%至约0.1%之间的抗氧化剂。抗氧化剂可为丁基化羟基甲苯。
染料
颗粒可包含染料。染料可包括通常用于衣物洗涤剂或织物软化剂的那些染料。织物处理组合物可包含按织物处理组合物颗粒的重量计小于约0.1%,或者约0.001%至约0.1%,或者约0.01%至约0.02%,或者它们的组合以及在前述范围的任一者内的任何百分比或百分比范围的染料。合适染料的示例包括但不限于LIQUITINT PINK AM、AQUA AS CYAN15、和VIOLET FL,它们购自Milliken Chemical。采用染料可用于帮助使用者区分具有不同香味的颗粒。
香料
除了载体之外,颗粒还可包含按重量计0.1%至约20%的香料。香料可为未包封的香料、包封的香料、通过香料递送技术提供的香料、或以一些其它方式提供的香料。香料综述于美国专利7,186,680第10栏第56行至第25栏第22行中。颗粒可包含未包封的香料并且基本上不含香料载体,诸如香料微胶囊。颗粒可包含香料载体材料(以及其中所含香料)。香料载体材料的示例描述于美国专利No.7,186,680第25栏第23行至第31栏第7行中。香料载体材料的具体示例可包括环糊精和沸石。
颗粒可包含按颗粒的重量计约0.1%至约20%,或者约1%至约15%,或者2%至约10%,或者它们的组合和在任何前述范围内的任何百分比整数的香料。颗粒可包含按颗粒的重量计约0.1%至约6%的香料。香料可为未包封的香料和/或包封的香料。
颗粒可不含或基本上不含香料载体。颗粒可包含按颗粒的重量计约0.1%至约20%,或者约1%至约15%,或者2%至约10%,或者它们的组合和在任何前述范围内的任何百分比整数的未包封的香料。
颗粒可包含未包封的香料和香料微胶囊。颗粒可包含按颗粒的重量计约0.1%至约20%,或者约1%至约15%,或者约2%至约10%,或者它们的组合和在任何前述范围内的任何百分比整数或百分比整数范围的未包封的香料。此类水平的未包封的香料可适用于本文所公开的具有未包封的香料的任何颗粒。
颗粒可包含未包封的香料和香料微胶囊,但是不含或基本上不含其它香料载体。颗粒可包含未包封的香料和香料微胶囊,并且不含其它香料载体。
颗粒可包含包封的香料。包封的香料可以多个香料微胶囊形式提供。香料微胶囊为包封在外壳内的香料油。外壳可具有小于最大香料芯尺寸的平均外壳厚度。香料微胶囊可为易碎的香料微胶囊。香料微胶囊可为水分活化的香料微胶囊。
香料微胶囊可包括三聚氰胺/甲醛外壳。香料微胶囊可购自Appleton、QuestInternational、或International Flavor&Fragrances或其它合适的来源。香料微胶囊外壳可涂覆有聚合物以增强香料微胶囊附着到织物的能力。如果颗粒设计成织物处理组合物,这可能是期望的。香料微胶囊可为描述于美国专利公布2008/0305982中的那些。
颗粒可包含按颗粒的重量计约0.1%至约20%,或者约0.1%至约10%,或者约1%至约15%,或者2%至约10%,或者它们的组合和在任何前述范围内的任何百分比整数的包封的香料。
颗粒可包含香料微胶囊,但是不含或基本上不含未包封的香料。颗粒可包含按颗粒的重量计约0.1%至约20%,或者约1%至约15%,或者约2%至约10%,或者它们的组合和在任何前述范围内的任何百分比整数的包封的香料。
制备颗粒的方法
本发明的颗粒可使用与WO2017/156095A1,第18页第14行至第21页第3行中所描述方法类似的方法来制备。
实施例/组合
A.一种包含多个颗粒的组合物,其中所述颗粒包含:
按所述颗粒的重量计约40%至约99%的载体;以及
按重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;并且
其中所述颗粒中的每个颗粒具有介于约1mg至约5000mg之间的质量。
B.根据段落A所述的组合物,其中所述颗粒中的每个颗粒具有介于约5mg和约200mg之间的质量。
C.根据段落A或B所述的组合物,其中所述组合物为衣物洗涤添加剂组合物。
D.根据段落A至C所述的组合物,其中所述组合物包含通过标称筛开口尺寸为22.6mm的筛并且保留在标称筛开口尺寸为0.841mm的筛上的颗粒。
E.根据段落A至D中任一段所述的组合物,其中所述载体为水溶性聚合物。
F.根据段落A至E中任一段所述的组合物,其中所述颗粒包含按所述颗粒的重量计超过45%至约99%的所述载体。
G.根据段落A至F中任一段所述的组合物,其中所述载体和所述细菌内生孢子彼此基本上均匀地混合。
H.根据段落A至G中任一段所述的组合物,其中所述内生孢子处于颗粒物形式中。
I.根据段落A至H中任一段所述的组合物,其中所述颗粒包含按所述颗粒的重量计约0.5%至小于3%的所述细菌内生孢子。
J.根据段落A至I中任一段所述的组合物,其中所述颗粒包含按重量计约0.1%至约20%的香料。
K.根据段落A至J中任一段所述的组合物,其中所述载体为聚乙二醇,其中所述聚乙二醇具有约2000至约13000的重均分子量。
L.根据段落A至K中任一段所述的组合物,其中所述颗粒包含按重量计约0.1%至约10%的包封的香料。
M.根据段落A至L中任一段所述的组合物,其中所述细菌内生孢子至少包含来自芽孢杆菌(Bacillus)属的细菌。
N.根据段落A至M中任一段所述的组合物,其中所述多个颗粒基本上不含质量小于约10mg的颗粒。
O.根据段落A至N中任一段所述的组合物,其中所述载体选自蔗糖、蔗糖膨润土、水溶性有机碱金属盐、水溶性无机碱土金属盐、水溶性有机碱土金属盐、水溶性碳水化合物、水溶性硅酸盐、水溶性尿素、淀粉、粘土、水不溶性硅酸盐、柠檬酸、羧甲基纤维素、脂肪酸、脂肪醇、氢化牛脂的甘油二酯、甘油、聚乙二醇、以及它们的组合。
P.一种用于处理衣物制品的方法,所述方法包括以下步骤:
提供颗粒,所述颗粒包含:
按所述颗粒的重量计约40%至约99%的载体;以及
按重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;
将一定剂量的所述颗粒置于量杯中;以及
将所述剂量的所述颗粒分配到洗衣机中;
其中所述颗粒中的每个颗粒具有介于约1mg至约5000mg之间的质量。
Q.根据段落P所述的方法,其中所述载体为聚乙二醇,其中所述聚乙二醇具有约2000至约13000的重均分子量。
R.一种用于形成颗粒的方法,所述方法包括以下步骤:
提供前体材料;
提供具有多个孔的分配器;
使所述前体材料通过所述孔;
在所述分配器下方提供移动的传送装置;
使所述前体材料沉积到所述移动的传送装置上;以及
使所述前体材料冷却以形成多个颗粒;
其中所述前体材料包含聚乙二醇,其中所述聚乙二醇具有约2000至约13000的重均分子量;
其中所述前体材料包含按所述前体材料的重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;并且
其中所述前体材料是在小于约70℃的温度下提供的。
实施例1:孢子的制备
使将用于制备孢子的细菌在液体培养物中对数生长。当对数培养物中的碳、氮和/或磷变为极限(例如,对数生长晚期)时,营养细胞开始孢子化。继续温育培养物,直到估计在培养物中没有另外的孢子形成。在一些情况下,从生产运行的培养物获得孢子。然后将培养物离心以沉淀孢子以及剩余的细胞和碎片。当将这些孢子沉淀悬浮于水中时,洗涤,再次悬浮于水中,并且使孢子悬浮液沉降在管中,通常形成三个可见层。使用样品的显微镜检查来确认存在处于期望纯度下的相亮孢子(>99%相亮孢子)。如果没有实现纯度,则重复水洗涤直到达到所需纯度。
实施例2:具有芽孢杆菌(Bacillus)菌种内生孢子的PEG
8000颗粒的制备
为了制备小批量的含有芽孢杆菌(Bacillus)孢子粉末的PEG 8000颗粒,遵循以下程序。将约100g的PEG(Pluriol E 8000)称重并在烘箱中在80℃下熔融。向熔体添加预称重0.01克的芽孢杆菌(Bacillus)孢子粉末(针对组合物1,组合物2无孢子)以递送1.0×108个菌落形成单位(CFU)的芽孢杆菌(Bacillus)孢子并且使用Flacktek高速混合器以3500rpm混合30秒。在无菌条件下并且在生物安全柜中,使用无菌刮刀将热PEG熔体孢子混合物转移到颗粒模板中并在模板上均匀地铺展。使组合物混合物冷却至室温保持大约5分钟以形成固体颗粒。将凝固的颗粒从模板上刮下并转移到无菌容器中以用于储存直到需要。
实施例3:具有芽孢杆菌(Bacillus)菌种内生孢子的PEG 8000颗粒的活力
使用热休克方法和孢子计数程序来评估孢子在热PEG8000熔体中制备过程期间、在机械高速混合和珠粒模板上制粒期间的活力和存活能力。
孢子悬浮液样品:由具有芽孢杆菌(Bacillus)孢子的PEG 8000颗粒构成的组合物1和仅由PEG 8000颗粒构成的组合物2各自被无菌地抽取并单独地测量为1克颗粒组合物,并且各自被转移到含有9mL无菌盐水(0.85%NaCl)的管中。将管涡旋大约30秒以分散孢子并重构成均匀溶液。
热休克和孢子计数。将孢子悬浮液样品置于80℃的水浴中持续15分钟以刺激孢子萌发并杀死存在的任何营养细胞。热处理后,使悬浮液在碎冰水浴中冷却,并立即置于-20℃冷冻机中持续15分钟。然后在使用前使样品达到室温。然后无菌地测量热休克样品,并且通过将1mL等分试样转移到9mL无菌盐水中来连续稀释以制成10-1-10-7)。将10-1、10-3、10-5和10-7稀释度的一毫升等分试样(1ml)经由无菌接种环倾注到单独的固体营养生长培养基平板(胰酶大豆琼脂-TSA)上。将TSA生长平板在37℃的温度下温育24-48小时并手动计数芽孢杆菌(Bacillus)菌落。仅计数具有25–250个菌落的平板以进行统计表示。从颗粒回收的芽孢杆菌(Bacillus)菌落与供应商所列相当(在±10%内)。热休克过程后粉末中芽孢杆菌(Bacillus)孢子的活力和水平与供应商标签上所列相当,并且等于添加到热PEG熔体中的调整量。配制具有芽孢杆菌(Bacillus)孢子的珠粒的过程对孢子的完整性没有负面影响,并且与孢子粉末混合物中的实际孢子计数相比,在4个月内珠粒中孢子的稳定性在8.04-8.48Log之间(其中SD低于±0.5Log),如表2中所示。
恶臭测试
将孢子粉末直接施加在磷酸盐缓冲液中
下表中示出了直接施加在不同物品上的孢子粉末的恶臭去除。
孢子粉末是在磷酸盐缓冲盐水(PBS pH 7.4)溶液中制备的,并且被直接施加到具有非常强烈恶臭的涤棉T恤和浴巾的预选样本(5×5英寸)上。对照测试溶液由仅施加PBS(无孢子)构成。将织物在37℃下温育,并且在每个处理时间点之后,将织物在Tide Free(无香料)洗涤剂中洗涤,然后干燥并重新放大以评估恶臭。与对照相比,使用孢子的直接施加测试在所有时间点显示出明显的恶臭减少,其中在96小时处具有高度明显的恶臭减少。
通过洗涤(TTW)施加本发明的颗粒
在下表中示出了在衣物洗涤过程在浴巾上使用的本发明的颗粒的恶臭去除。
将孢子粉末制成PEG 8000颗粒。孢子颗粒成品(FP)含有0.01%孢子粉末,相当于100ppm的对应于1.0×108总CFU芽孢杆菌(Bacillus)孢子。将具有强烈恶臭的浴毛巾切成样本,并且用Tide free洗涤剂和处于剂量下的孢子珠粒在快速洗涤中洗涤,以通过洗涤递送通过0.055ppm的相当于5.5×106CFU孢子的洗涤浓度,而对照测试仅用Tide Free洗涤剂来洗涤。将浴巾样本在37℃下温育,并且在每个时间点之后,由熟悉浴巾恶臭的志愿者将样本的嗅觉评估重新放大。要求判断者选择具有强烈恶臭的浴巾。
实施例4:通过洗涤(TTW)施加本发明的颗粒
以与实施例2的PEG 8000颗粒类似的方式来制备Pyrex晶体颗粒、非离子表面活性剂颗粒和乙酸钠颗粒。在下表中示出了在衣物洗涤过程在浴巾上使用的颗粒的恶臭去除。
本文所公开的量纲和值不应理解为严格限于所引用的精确数值。相反,除非另外指明,否则每个此类量纲旨在表示所述值以及围绕该值功能上等同的范围。例如,公开为“40mm”的量纲旨在表示“约40mm”。
除非明确排除或以其它方式限制,本文中引用的每一篇文献,包括任何交叉引用或相关专利或专利申请以及本申请对其要求优先权或其有益效果的任何专利申请或专利,均据此全文以引用方式并入本文。对任何文献的引用不是对其作为与本发明的任何所公开或本文受权利要求书保护的现有技术的认可,或不是对其自身或与任何一个或多个参考文献的组合提出、建议或公开任何此类发明的认可。此外,当本发明中术语的任何含义或定义与以引用方式并入的文献中相同术语的任何含义或定义矛盾时,应当服从在本发明中赋予该术语的含义或定义。
虽然已举例说明和描述了本发明的具体实施方案,但是对于本领域技术人员来说显而易见的是,在不脱离本发明的实质和范围的情况下可作出各种其他变化和修改。因此,本文旨在于所附权利要求中涵盖属于本发明范围内的所有此类变化和修改。
Claims (14)
1.一种包含多个颗粒的组合物,其中所述颗粒包含:
按所述颗粒的重量计至少40%的非萌发载体;以及
按所述颗粒的重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;并且
其中所述颗粒中的每个颗粒具有介于约1mg至约5000mg之间,优选地介于约5mg和约200mg之间的质量。
2.根据权利要求1所述的组合物,其中所述细菌组合物包含处于以下水平的细菌内生孢子:约1×102至约1×109CFU/g颗粒,优选地约1×103至约1×106CFU/g颗粒。
3.根据权利要求1或2中任一项所述的组合物,其中所述内生孢子包含来自芽孢杆菌(Bacillus)属的细菌。
4.根据权利要求1或2中任一项所述的组合物,其中所述内生孢子包含选自以下项的细菌:枯草芽孢杆菌(Bacillus subtilis)、解淀粉芽孢杆菌(Bacillusamyloliquefaciens)、地衣芽孢杆菌(Bacillus licheniformis)、巨大芽孢杆菌(Bacillusmegaterium)、短小芽孢杆菌(Bacillus pumilus)、以及它们的混合物。
5.根据前述权利要求中任一项所述的组合物,其中所述载体选自蔗糖、膨润土、水溶性有机碱金属盐、水溶性无机碱土金属盐、水溶性有机碱土金属盐、水溶性碳水化合物、水溶性硅酸盐、水溶性尿素、淀粉、粘土、水不溶性硅酸盐、柠檬酸、乙醇酸、羧甲基纤维素、脂肪酸、脂肪醇、氢化牛脂的甘油二酯、甘油、聚乙二醇、聚乙烯醇、以及它们的组合。
6.根据前述权利要求中任一项所述的组合物,其中所述载体包括水溶性聚合物。
7.根据前述权利要求中任一项所述的组合物,其中所述颗粒包含按重量计约0.1%至约20%的香料。
8.根据前述权利要求中任一项所述的组合物,其中所述多个颗粒基本上不含质量小于约10mg的颗粒。
9.根据前述权利要求中任一项所述的组合物,其中所述载体包括聚乙二醇,其中所述聚乙二醇具有约2000至约13000的重均分子量。
10.一种产品,所述产品包含容器以及根据前述权利要求中任一项所述的组合物。
11.一种用于处理脏污衣物制品的方法,所述方法包括以下步骤:
用洗涤剂组合物处理所述制品;以及
用根据前述权利要求中任一项所述的组合物处理所述制品。
12.根据前述权利要求所述的方法,所述方法包括以下步骤:
将根据权利要求1至10中任一项所述的组合物置于量杯中;以及
将此剂量的所述组合物分配到洗衣机中。
13.一种用于形成颗粒的方法,所述方法包括以下步骤:
提供前体材料;
提供具有多个孔的分配器;
使所述前体材料通过所述孔;
在所述分配器下方提供移动的传送装置;
使所述前体材料沉积到所述移动的传送装置上;以及
使所述前体材料冷却以形成多个颗粒;
其中所述前体材料包含聚乙二醇,其中所述聚乙二醇具有约2000至约13000的重均分子量;
其中所述前体材料包含按所述前体材料的重量计约0.0001%至约5%的细菌组合物,所述细菌组合物包含细菌内生孢子;并且
其中所述前体材料是在低于约70℃的温度下提供的。
14.根据权利要求1至10中任一项所述的组合物用于减少来自织物的恶臭的用途。
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- 2020-11-02 CA CA3154364A patent/CA3154364A1/en active Pending
- 2020-11-02 EP EP20205117.3A patent/EP3819361A1/en active Pending
- 2020-11-02 MX MX2022004171A patent/MX2022004171A/es unknown
- 2020-11-02 US US17/086,631 patent/US11959048B2/en active Active
- 2020-11-02 WO PCT/US2020/070732 patent/WO2021092615A1/en active Application Filing
- 2020-11-02 CN CN202080074365.2A patent/CN114630889A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US20160121286A1 (en) * | 2014-11-04 | 2016-05-05 | The Procter & Gamble Company | Apparatus and process for forming particles |
US20190002819A1 (en) * | 2015-12-28 | 2019-01-03 | Novozymes Bioag A/S | Heat priming of bacterial spores |
US20170260481A1 (en) * | 2016-03-08 | 2017-09-14 | The Procter & Gamble Company | Particles including enzyme |
US20190284647A1 (en) * | 2016-09-29 | 2019-09-19 | Novozymes A/S | Spore Containing Granule |
US20190264141A1 (en) * | 2016-11-01 | 2019-08-29 | Novozymes A/S | Multi-Core Granules |
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JP2023501292A (ja) | 2023-01-18 |
WO2021092615A1 (en) | 2021-05-14 |
US11959048B2 (en) | 2024-04-16 |
US20210130737A1 (en) | 2021-05-06 |
MX2022004171A (es) | 2022-05-02 |
EP3819361A1 (en) | 2021-05-12 |
CA3154364A1 (en) | 2021-05-14 |
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