CN114617778B - Liquid crystal structure composition and preparation method and application thereof - Google Patents
Liquid crystal structure composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN114617778B CN114617778B CN202111104611.7A CN202111104611A CN114617778B CN 114617778 B CN114617778 B CN 114617778B CN 202111104611 A CN202111104611 A CN 202111104611A CN 114617778 B CN114617778 B CN 114617778B
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- China
- Prior art keywords
- phase
- skin care
- liquid crystal
- emulsifier
- crystal structure
- Prior art date
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- 239000004973 liquid crystal related substance Substances 0.000 title claims abstract description 42
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 32
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 239000003906 humectant Substances 0.000 claims abstract description 16
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- -1 pH regulator Substances 0.000 claims abstract description 13
- 230000001804 emulsifying effect Effects 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 7
- 238000007127 saponification reaction Methods 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000022 bacteriostatic agent Substances 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 229960005150 glycerol Drugs 0.000 claims description 4
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims description 4
- 239000006210 lotion Substances 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 4
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 239000011703 D-panthenol Substances 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- 235000004866 D-panthenol Nutrition 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229960003949 dexpanthenol Drugs 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 229940051250 hexylene glycol Drugs 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- LWBVAHQZGAKXPU-BOXHHOBZSA-M sodium;(4s)-4-amino-5-octadecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O LWBVAHQZGAKXPU-BOXHHOBZSA-M 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- 230000037072 sun protection Effects 0.000 claims 2
- 238000013329 compounding Methods 0.000 claims 1
- 239000000686 essence Substances 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 abstract description 11
- 239000007788 liquid Substances 0.000 abstract description 5
- 239000003242 anti bacterial agent Substances 0.000 abstract description 4
- 238000006116 polymerization reaction Methods 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000012071 phase Substances 0.000 description 28
- 230000000052 comparative effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 7
- 239000008269 hand cream Substances 0.000 description 6
- 229940094541 polyglycerin-10 Drugs 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 125000005456 glyceride group Chemical group 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 229940070765 laurate Drugs 0.000 description 2
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 2
- 229960002446 octanoic acid Drugs 0.000 description 2
- 229940049964 oleate Drugs 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229940099549 polyglycerin-3 Drugs 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229940080352 sodium stearoyl lactylate Drugs 0.000 description 2
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 description 2
- MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- PBWGCNFJKNQDGV-UHFFFAOYSA-N 6-phenylimidazo[2,1-b][1,3]thiazol-5-amine Chemical compound N1=C2SC=CN2C(N)=C1C1=CC=CC=C1 PBWGCNFJKNQDGV-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 description 1
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229940090958 behenyl behenate Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229940072106 hydroxystearate Drugs 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- GAQPWOABOQGPKA-UHFFFAOYSA-N octadecyl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCC GAQPWOABOQGPKA-UHFFFAOYSA-N 0.000 description 1
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 1
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of A61K8/9789, in particular to a natural liquid crystal structure composition, a preparation method and application thereof, wherein the preparation raw materials comprise the following components in parts by weight: 5-10 parts of phase A, 8-15 parts of phase B and 70-100 parts of phase C; the preparation raw materials of the phase A at least comprise: a first emulsifier, a skin care agent, and a second emulsifier; the first emulsifier is a polyglycerol derivative, and the average polymerization degree of the polyglycerol derivative is 2-10; the preparation raw materials of the phase B at least comprise: a moisturizing agent; the preparation raw materials of the phase C at least comprise: humectant, antibacterial agent, pH regulator, and water. The composition has a natural liquid crystal structure, is stable in liquid crystal structure, is not interfered by polar or nonpolar surfactants, temperature and liquid level changes, and has good high temperature resistance and low temperature resistance.
Description
Technical Field
The invention relates to the field of A61K8/9789, in particular to a liquid crystal structure composition, a preparation method and application thereof.
Background
The liquid crystal structure has good fluidity and film forming property, is widely used in an emulsifying system of cosmetics, and has various functions of good moisturizing performance, enhancing the permeation of active ingredients, repairing skin barrier layers and the like. However, since the formation of a liquid crystal structure is affected by various factors such as the polarity of an oil phase of an emulsion, high molecular weight polysaccharide of an aqueous phase, polymer, stability at high and low temperatures, etc., it is very difficult to formulate a stable liquid crystal system, and the influence of various factors needs to be considered at the same time.
CN110974742a discloses a liquid crystal structure moisturizing and repairing hand cream and a preparation method thereof, which have moisturizing and repairing effects, but have poor skin permeability and are easy to be absorbed by surface rubbing mud.
CN111297699a discloses a moisturizing body lotion with a good liquid crystal structure and a preparation method thereof, wherein polymers such as polyglycerol ether are adopted to endow the composition with moisturizing property and stability, however, the introduction of the polymers brings instability of the liquid crystal structure.
Aiming at the problems in the prior art, the composition can form a stable liquid crystal structure under the conditions of different types of grease, polymers, polysaccharide and even high electrolyte content, and greatly simplifies the development difficulty of a liquid crystal emulsification system.
Disclosure of Invention
The first aspect of the invention provides a liquid crystal structure composition, which comprises the following raw materials in parts by weight: 5-10 parts of phase A, 8-15 parts of phase B and 70-100 parts of phase C;
the preparation raw materials of the phase A at least comprise: a first emulsifier, a skin care agent, and a second emulsifier; the first emulsifier is a polyglycerol derivative, and the average polymerization degree of the polyglycerol derivative is 2-10;
the preparation raw materials of the phase B at least comprise: a moisturizing agent;
the preparation raw materials of the phase C at least comprise: humectant, antibacterial agent, pH regulator, and water.
As a preferred embodiment, the weight ratio of the first emulsifier, the skin care agent, and the second emulsifier is (1-2): (2-6): (1.8-3).
As a preferred embodiment, the saponification value of the polyglycerol derivative is from 100 to 170mgKOH/g.
Saponification value refers to milligrams of potassium hydroxide consumed by alkali hydrolysis of 1g of oil, indirectly indicating the relative molecular mass of the polyglycerol derivative. The applicant found that when the saponification value of the polyglycerol derivative is 100-170mgKOH/g, the prepared composition has good refreshing and moisturizing effects, is not greasy, has a stable liquid crystal structure, and is presumably because the proper relative molecular mass can achieve the effects of partially infiltrating the skin and partially retaining the film on the skin surface.
Preferably, the polyglycerol derivative comprises at least one of a polyglycerol-2 derivative, a polyglycerol-3 derivative, a polyglycerol-6 derivative and a polyglycerol-10 derivative.
Preferably, the polyglycerin derivative includes at least one of polyglycerin-2 diisostearate, polyglycerin-2 triisostearate, polyglycerin-2 oleate, polyglycerin-2 dimerized hydroxystearate, polyglycerin-3 diisostearate, polyglycerin-3 methylglucdistearate, polyglycerin-6 dicaprate, polyglycerin-6 caprylate, polyglycerin-6 laurate, polyglycerin-6 octastearate, polyglycerin-10 pentastearate, polyglycerin-10 myristyl stearate, polyglycerin-10 oleate, polyglycerin-10 laurate.
In order to achieve better water-oil balance effect, it is further preferable that the polyglycerol derivative is polyglycerol-10 pentastearate, the saponification value is 140-170mgKOH/g, the HLB value is 6-8, and the polyglycerol derivative is purchased from Wohan XinxinJiali biotechnology Co.
As a preferred embodiment, the skin care agent has a carbon number of 14-22.
Preferably, the skin care agent comprises at least one of hydrogenated rapeseed oil alcohol, hydrogenated castor oil, stearyl stearate, stearyl behenate, behenyl behenate.
Further preferably, the skin care agent is hydrogenated rapeseed oil alcohol.
The applicant found that the liquid crystal structure stability of the composition is greatly improved when hydrogenated rapeseed oil alcohol is added, and the original liquid crystal structure can be stably maintained when the emulsifiers with different polarities and non-polarities are faced. Hydrogenated rapeseed oil alcohol is a source of fatty alcohol, the number of carbon atoms is between 14 and 22, and the applicant speculates that the combination of carbon chains with different lengths and the winding of the carbon chains in a three-dimensional space greatly enhance the three-dimensional stability of a liquid crystal structure, and also can show a certain degree of shrinkage and expansion stress when facing different polar grease, so as to strengthen the stability of the structure.
As a preferred embodiment, the second emulsifier has a relative molecular mass of 300-900.
Preferably, the second emulsifier comprises a glyceride derivative.
Preferably, the glyceride derivative comprises at least one of glycerol monooleate, glycerol monostearate, glycerol trioleate and glycerol tristearate.
In order to enhance the stability of the liquid crystal structure at different liquid levels, it is further preferred that the glyceride derivative is glycerol monooleate.
As a preferred embodiment, the second emulsifier further comprises sodium stearoyl glutamate and/or sodium stearoyl lactylate.
The liquid crystal structure is extremely easy to be influenced by different temperature changes and liquid level changes to cause the problem of unstable structure, and the applicant discovers that when the anionic emulsifiers with different gradients and relative molecular masses are selected to be matched with each other, the stability of the liquid crystal structure at different interfaces and the hydrophilic-lipophilic balance at different temperatures can be obviously improved, so that the application range of the composition is greatly expanded.
The present invention is not particularly limited to the moisturizing agent, and the moisturizing agent may be at least one selected from, but not limited to, polydimethylsiloxane, caprylic capric triglyceride, and isohexadecane.
As a preferred embodiment, the humectant comprises at least one of glycerin, propylene glycol, sodium hyaluronate, xanthan gum, carbomer, trehalose, D-panthenol, squalane.
As a preferred embodiment, the bacteriostatic agent comprises at least one of magnesium sulfate, phenoxyethanol, ethylhexyl glycerol, octyl glycol, hexylene glycol, nipagin ester and sorbic acid.
The present invention is not particularly limited to the pH adjustor, and the pH adjustor may be at least one selected from, but not limited to, disodium EDTA, tetrasodium EDTA, citric acid, and sodium citrate.
As a preferred embodiment, the weight ratio of the humectant, the bacteriostat, the pH regulator and the water is (7-9): (0.8-1.3): (0.05-0.2): (70-90).
The second aspect of the present invention provides a method for preparing a liquid crystal structure composition, comprising the steps of:
(1) Adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to prepare a premix; (2) Adding water into an emulsifying pot, adding a pre-mixed humectant into the emulsifying pot, heating, adding premix, starting to homogenize, cooling, adding a bacteriostat and a pH regulator, uniformly stirring, and discharging.
The third aspect of the invention provides an application of a liquid crystal structure composition in skin care emulsion, skin care essence, skin care water, skin care mask liquid, skin care face cream, skin care eye cream, hand cream, skin care body lotion, skin care spray, sun cream, sun spray and skin care sleeping mask.
Compared with the prior art, the invention has the following beneficial effects:
1. the composition has a liquid crystal structure, is stable in structure, is not interfered by polar or nonpolar surfactants, temperature and liquid level changes, and has good high temperature resistance and low temperature resistance.
2. The composition has good moisturizing effect, high moisturizing rate and better long-acting moisturizing effect through human body test, and fresh and non-greasy use feeling.
3. The composition of the invention has wide application area and can be widely added into various skin care products.
Detailed Description
Example 1
The first aspect of the present embodiment provides a liquid crystal structure composition, which is prepared from the following raw materials in parts by weight: 7.7 parts of phase A, 10 parts of phase B and 82.3 parts of phase C;
the preparation raw materials of the phase A comprise: a first emulsifier, a skin care agent, and a second emulsifier;
the preparation raw materials of the phase B comprise: a moisturizing agent;
the preparation raw materials of the phase C comprise: humectant, antibacterial agent, pH regulator, and water.
The first emulsifier is polyglycerol-10 pentastearate, has a saponification value of 140-170mgKOH/g and an HLB value of 6-8, and is purchased from Wohenchen Jiali biotechnology Co., ltd.
The skin care agent is hydrogenated rapeseed oil alcohol, purchased from Beijing Lingbao technology Co.
The second emulsifier glyceryl monooleate and sodium stearyl glutamate are compounded according to the weight ratio of 1:0.1.
The weight ratio of the first emulsifier to the skin care agent to the second emulsifier is 1.5:4:2.2
The moistening agent is polydimethylsiloxane, caprylic acid and capric acid triglyceride and is compounded according to the weight ratio of 1:4.
The humectant is composed of xanthan gum, glycerin and sodium hyaluronate in a weight ratio of 0.5:8:0.1.
The bacteriostat is compounded by magnesium sulfate, phenoxyethanol and ethylhexyl glycerol according to the weight ratio of 3:8:1.
The pH regulator is EDTA disodium.
The weight ratio of the humectant to the bacteriostatic agent to the pH regulator to the water is 8.6:1.2:0.1:72.4.
the second aspect of the present embodiment provides a method for preparing a liquid crystal structure composition, including the following steps:
(1) Adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to 75 ℃ to prepare premix; (2) Adding water into an emulsifying pot, adding a pre-mixed humectant into the emulsifying pot, heating to 75 ℃, adding premix, starting homogenizing at 3000rpm for 10 minutes, cooling to 40 ℃, adding a bacteriostatic agent and a pH regulator, uniformly stirring, and discharging.
In a third aspect, the present embodiment provides an application of a liquid crystal structure composition in a hand cream.
Example 2
The first aspect of the present embodiment provides a liquid crystal structure composition, which is prepared from the following raw materials in parts by weight: 7.5 parts of phase A, 10 parts of phase B and 82.5 parts of phase C;
the preparation raw materials of the phase A comprise: a first emulsifier, a skin care agent, and a second emulsifier;
the preparation raw materials of the phase B comprise: a moisturizing agent;
the preparation raw materials of the phase C comprise: humectant, antibacterial agent, pH regulator, and water.
The first emulsifier is polyglycerol-10 pentastearate, has a saponification value of 140-170mgKOH/g and an HLB value of 6-8, and is purchased from Wohenchen Jiali biotechnology Co., ltd.
The skin care agent is hydrogenated rapeseed oil alcohol.
The second emulsifier glyceryl monooleate and sodium stearoyl lactylate are compounded according to the weight ratio of 4:1.
The weight ratio of the first emulsifier to the skin care agent to the second emulsifier is 1:4:2.5.
the moistening agent is polydimethylsiloxane, caprylic acid and capric acid triglyceride and is compounded according to the weight ratio of 1:4.
The polydimethylsiloxane is purchased from the dow chemistry.
The humectant is composed of xanthan gum, glycerin and sodium hyaluronate in a weight ratio of 0.5:8:0.1.
The bacteriostat is compounded by magnesium sulfate, phenoxyethanol and ethylhexyl glycerol according to the weight ratio of 3:8:1.
The pH regulator is EDTA disodium.
The weight ratio of the humectant to the bacteriostatic agent to the pH regulator to the water is 8.6:1.2:0.1:72.4.
the second aspect of the present embodiment provides a method for preparing a liquid crystal structure composition, including the following steps:
(1) Adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to 75 ℃ to prepare premix; (2) Adding water into an emulsifying pot, adding a pre-mixed humectant into the emulsifying pot, heating to 75 ℃, adding premix, starting homogenizing at 3000rpm for 10 minutes, cooling to 40 ℃, adding a bacteriostatic agent and a pH regulator, uniformly stirring, and discharging.
In a third aspect, the present embodiment provides an application of a liquid crystal structure composition in a hand cream.
Comparative example 1
In a first aspect, this comparative example provides a liquid crystal structured composition, the specific embodiment being the same as example 1, except that the skin care agent is cetostearyl alcohol.
A second aspect of this comparative example provides a method for preparing a liquid crystal structure composition, the embodiment being the same as example 1.
In a third aspect, the present comparative example provides the use of a liquid crystal structured composition in a hand cream.
Comparative example 2
In a first aspect, the present comparative example provides a liquid crystal structure composition, the specific embodiment is the same as example 1, except that the second emulsifier is glycerol monooleate.
A second aspect of this comparative example provides a method for preparing a liquid crystal structure composition, the embodiment being the same as example 1.
In a third aspect, the present comparative example provides the use of a liquid crystal structured composition in a hand cream.
Performance testing
The stability test method comprises the following steps: the compositions of examples and comparative examples of the same quality were placed in an environment of-18℃at 5℃for 30 days and an environment of 8 cycles, respectively, in which 1 cycle was placed in an environment of-8℃and-40℃for 24 hours, respectively, to observe the appearance of the compositions.
The moisture retention test method comprises the following steps:
1. 30 subjects were selected and randomized into two groups, one group of 15 tested the example 1 formulation and one group of 15 tested the comparative example 1 formulation.
2. Before the test, the subject needs to clean the inner side of the forearm with water, wipe it clean with dry facial tissues, sit still for 30min in a room with a relative humidity of 50% at 25 ℃ and not drink water, and keep relaxed.
3. After the skin is clean and dry, the inner side of the front arm is divided into 3 test areas on average, and the skin moisture basic values W1 of the skin of the three test areas are recorded by a skin tester respectively. The skin tester was purchased from Beijing Jin Hongfan commercial, inc., derma-Expert MC760.
4. The soybean sizes of the compositions in examples and comparative examples were taken and uniformly and clockwise circled and applied to three test areas, and the moisture values W2 of the skin of the three test areas were recorded for 2 hours and 4 hours after application, respectively, with a moisture rate of = (W2-W1)/W1 of 100%.
Claims (5)
1. The liquid crystal structure composition is characterized by comprising the following preparation raw materials in parts by weight: 5-10 parts of phase A, 8-15 parts of phase B and 70-100 parts of phase C;
the preparation raw materials of the phase A at least comprise: a first emulsifier, a skin care agent, a second emulsifier;
the preparation raw materials of the phase B at least comprise: a moisturizing agent;
the preparation raw materials of the phase C at least comprise: humectant, bacteriostat, pH regulator, water;
the first emulsifier is polyglycerol-10 pentastearate, the saponification value is 140-170mgKOH/g, and the HLB value is 6-8;
the skin care agent is hydrogenated rapeseed oil alcohol;
the second emulsifier is compounded by glycerol monooleate and sodium stearyl glutamate in a weight ratio of 1:0.1 or in a weight ratio of 4:1;
the moistening agent is formed by compounding polydimethylsiloxane and caprylic/capric triglyceride in a weight ratio of 1:4;
the weight ratio of the first emulsifier to the skin care agent to the second emulsifier is 1.5:4:2.2 or 1:4:2.5.
2. the liquid crystal structure composition of claim 1, wherein the humectant comprises at least one of glycerin, propylene glycol, sodium hyaluronate, xanthan gum, carbomer, trehalose, D-panthenol, squalane.
3. A liquid crystal structure composition according to claim 1, wherein the bacteriostat comprises at least one of magnesium sulfate, phenoxyethanol, ethylhexyl glycerol, octyl glycol, hexylene glycol, nipagin ester, sorbic acid.
4. A method for preparing a liquid crystal structure composition according to any one of claims 1 to 3, comprising the steps of: (1) Adding the preparation raw materials of the phase A and the phase B into an oil phase pot, stirring and heating to prepare a premix; (2) Adding water into an emulsifying pot, adding a pre-mixed humectant into the emulsifying pot, heating, adding premix, starting to homogenize, cooling, adding a bacteriostatic agent and a pH regulator, uniformly stirring, and discharging.
5. Use of a liquid crystal structured composition according to any one of claims 1 to 3 in skin care lotions, skin care essences, lotions, skin care masks, skin care creams, skin care eye creams, hand creams, skin care sprays, sun protection creams, sun protection sprays, skin care sleeping masks.
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| CN115887304B (en) * | 2022-12-20 | 2023-10-03 | 科乐美(广州)生物科技有限公司 | Emulsifier composition, skin care cream containing same and preparation method of skin care cream |
| CN117257660A (en) * | 2023-09-12 | 2023-12-22 | 广州海龟爸爸生物科技有限公司 | Powder slurry capable of enhancing sun-proof performance and improving makeup-holding effect, and preparation method and application thereof |
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