CN114609404A

CN114609404A - Liquid feeding auxiliary device

Info

Publication number: CN114609404A
Application number: CN202210264453.XA
Authority: CN
Inventors: 王淼
Original assignee: BEIJING INSTITUTE OF HEART LUNG AND BLOOD VESSEL DISEASES; Beijing Anzhen Hospital
Current assignee: BEIJING INSTITUTE OF HEART LUNG AND BLOOD VESSEL DISEASES; Beijing Anzhen Hospital
Priority date: 2022-03-17
Filing date: 2022-03-17
Publication date: 2022-06-10
Anticipated expiration: 2042-03-17
Also published as: CN114609404B

Abstract

The embodiment of the invention discloses a liquid adding auxiliary device, which relates to the technical field of medical examination and inspection instruments and comprises the following components: the body is provided with a plurality of first accommodating grooves and a plurality of second accommodating grooves matched with the first accommodating grooves respectively, the plurality of second accommodating grooves are used for accommodating reaction reagents respectively, and the first accommodating grooves are used for accommodating reaction containers for mixing the reaction reagents and a plurality of samples to be detected; the metering assembly is matched with the first accommodating groove and comprises a fixing part and a balance part which are movably connected, the fixing part is used for being detachably connected with the reaction container, the balance part is used for configuring set weight, and after each reaction reagent in the reaction container and the weight of a plurality of samples to be detected reach the set weight, the reaction container falls into the first accommodating groove. By using the liquid adding auxiliary device provided by the embodiment of the invention, the weight and/or the number of the samples to be detected added into the reaction container can be determined by the time when the reaction container falls into the first accommodating groove, so that the requirement on the memory of an operator is lowered.

Description

Liquid feeding auxiliary device

Technical Field

The invention relates to the technical field of medical examination and inspection instruments, in particular to a liquid adding auxiliary device.

Background

With the development of science and technology, the medical field has made great progress in disease detection and treatment. Under the recent global outbreak of new coronavirus pneumonia, the worldwide biomedical institution is interested in developing detection and treatment methods for the new coronavirus pneumonia. The nucleic acid detection is to collect necessary substances of parts of pharynx, tonsil, faucial arch and the like by a throat swab, or collect secretion in nasal cavity, blood or feces by a nose swab as a sample, and find out whether the nucleic acid of the virus invaded from the outside exists or not, so as to determine whether the detected person is infected by the new coronavirus. In order to improve the detection efficiency, a multi-sample mixed detection (referred to as mixed detection for short) mode is commonly used for people screening. The mode can not only reduce the consumption of detection equipment, but also shorten the detection time, and is a common detection mode when people are screened on a large scale.

In the related art, in the mixed detection process, solutions to be detected of a plurality of persons to be detected (e.g., 5 persons and 10 persons) are sequentially added into a plurality of reaction chambers or a specific chamber in a container (containing groove) in a detection kit, and then reaction reagents are added according to the detection requirements, and operations such as stirring, extraction, standing and the like are performed. The chambers for carrying the liquid to be tested are often arranged in rows and are identical in size and appearance, resulting in being not easily visually distinguishable. In the large-scale sample mixing detection work, when the liquid to be detected of a person to be detected is added, the visual field of an operator needs to be continuously switched among the sampling tube, the pipette tip and the kit to complete the sample adding process, so that the number of the liquid to be detected added into a reaction container of the kit needs to be remembered, and the liquid to be detected needs to be added into which cavity in the next step. Fatigue is easily caused by long-time repeated operation, more energy is possibly needed to memorize the sample adding position, the sample to be detected is also added into the wrong reaction chamber, and the accuracy of the detection result and the timeliness of the detection result report are influenced.

Disclosure of Invention

In view of the above, the present invention is to solve the above problems in the prior art, and to provide a liquid adding auxiliary device, which improves the accuracy of liquid adding.

The liquid adding auxiliary device of the invention comprises: the body is provided with a plurality of first accommodating grooves and a plurality of second accommodating grooves which are respectively matched with the first accommodating grooves, the plurality of second accommodating grooves are respectively used for accommodating reaction reagents and realizing a reaction process, and the first accommodating grooves are used for accommodating reaction containers for mixing the reaction reagents and a plurality of samples to be detected; the metering assembly is matched with the first accommodating groove and comprises a fixing portion and a balancing portion, the fixing portion is movably connected with the balancing portion, the fixing portion is used for being detachably connected with the reaction container, the balancing portion is used for configuring set weight, and after the weight of each reaction reagent in the reaction container and the weight of a plurality of samples to be detected reach the set weight, the reaction container falls into the first accommodating groove.

Preferably, the balancing part includes a first angle limiting part, a supporting frame and a lever, wherein the supporting frame is fixed to the body, the first angle limiting part is fixedly connected to the supporting frame, the lever is rotatably connected to the first angle limiting part, the first angle limiting part is used for limiting an angle range of deflection of the lever, the lever is movably connected to a first counter weight at one side of the first angle limiting part, and the lever is movably connected to the fixing part at the other side of the first angle limiting part.

Preferably in any one of the above schemes, the balance part further comprises a second angle limiting part, the second angle adjusting part is fixedly connected to one end of the lever, one end of the fixing part is rotatably connected with the angle adjusting part, and the other end of the fixing part is detachably connected with the reaction vessel.

Preferably in any one of the above schemes, the second angle limiting member includes a limiting plate, a rotating shaft and a limiting block, wherein the two limiting plates are parallel to each other and are fixedly connected to the lever, the rotating shaft is disposed between the two limiting plates, and the limiting block is fixedly connected to the fixing portion and is rotatably connected to the rotating shaft.

Preferred in any above scheme, balanced portion includes support frame, bearing and annular transmission band, and wherein, the support frame is fixed in the body, and two at least bearings are fixed in the support frame, and two bearings are located to the annular transmission band cover, and connection fixed part and second counter weight can be dismantled to the annular transmission band.

Preferably in any one of the above schemes, the liquid adding auxiliary device further comprises a counting assembly, which is matched with the first accommodating groove one by one and connected with the body, and is used for recording the number of the samples to be detected placed in the first accommodating groove.

Above-mentioned scheme is further preferred, the counting assembly includes driving lever and convex counting board, and wherein, the circular arc edge that is close to the counting board is equidistant to be provided with the integer figure in order, and the driving lever is provided with first through-hole, and first through-hole size and integer figure match, and the driving lever removes, and first through-hole frames in order select the integer figure.

In any of the above schemes, preferably, the counting plate is provided with elastic stoppers which are matched with the integer numbers one by one, and the elastic stoppers are used for limiting the shifting rod to move towards the adjacent integer numbers when no external force is applied.

Preferred is in any above-mentioned scheme, and the protrusion counting board is provided with the loose axle, and the driving lever rotates with the counting board and is connected.

Preferably in any one of the above schemes, the counting assembly comprises a hollow tube and a rotating shaft, the rotating shaft is arranged in the hollow tube, wherein a second through hole is arranged on the tube wall penetrating through the hollow tube, integer numbers are sequentially arranged at equal intervals along the circumferential direction of the rotating shaft, the rotating shaft rotates, and the second through hole frames select the integer numbers.

In any of the above schemes, preferably, the hollow tube is fixedly connected with the body, and the rotating shaft is rotatably connected with the body.

In any of the above schemes, preferably, the body is provided with accommodating holes, and the number of the accommodating holes is matched with that of the first accommodating grooves; the counting assembly comprises a counting strip and an elastic piece, wherein gaps are arranged at equal intervals along the length direction of the counting strip, integer numbers are sequentially arranged at equal intervals along the length direction of the counting strip, and the gaps are arranged between two adjacent integer numbers; the elastic piece is movably connected with the body and used for being matched with the notch to limit the movement of the counting strip under the action of no external force.

In any of the above schemes, preferably, the elastic members are arranged in pairs in opposite along the length direction of the containing hole, and gaps matched with the elastic members are arranged on two sides of the counting strip.

Preferably in any one of the above schemes, the counting assembly includes a display screen and a button, and the connecting body is detachable, and the button is electrically connected with the display screen, wherein the display screen is used for displaying integer numbers, and the button is used for controlling the integer numbers displayed on the display screen.

Preferred in any above-mentioned scheme, the button is including increasing progressively button and return button, wherein, increases progressively the button and two liang of a set of first storage tank swing joint bodies of matching of return button, presses to increase progressively the button and is used for controlling the continuous increment of integer digit that the display screen shows, and the return button is used for controlling the display screen to show 0.

Based on the liquid adding auxiliary device provided by the invention, the fixing part is arranged to connect the reaction container and the balance part, and the reaction container and the mixed liquid in the reaction container can automatically fall into the first accommodating groove of the body after reaching the set weight, so that the amount of the sample to be detected added into the reaction container can be effectively recorded, the operation accuracy of an operator is improved, the requirement on the memory of the operator is reduced, and the mixed sample adding process is simple and convenient.

Drawings

The above and other objects, features and advantages of the present invention will become more apparent from the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

FIG. 1 is a schematic structural view of an embodiment of an auxiliary liquid adding device according to the present invention;

FIG. 2 is a schematic side view of another embodiment of the auxiliary liquid adding device of the present invention;

FIG. 3 is a schematic side view of a liquid feeding auxiliary device according to another embodiment of the present invention;

FIG. 4 is a schematic side view of another embodiment of the liquid adding auxiliary device of the present invention;

FIG. 5 is a schematic view of an embodiment of a fixing part and a reaction container;

FIG. 6 is a schematic structural view of an embodiment of a body;

FIG. 7 is a schematic structural diagram of an embodiment of a shift lever;

FIG. 8 is a schematic structural view of another embodiment of the body;

FIG. 9 is a schematic structural view of another embodiment of the body;

FIG. 10 is a partial perspective view of the area A;

fig. 11 is a schematic structural view of a further embodiment of the body.

Reference numerals: 1-body; 11-a first receiving groove; 12-a second accommodating groove; 13-a containment hole; 2-a reaction vessel; 3-a metering assembly; 31-a stationary part; 32-a balance; 321-a first angle limiter; 322-a support frame; 323-lever; 324-a first counterweight; 325-second angle limiting piece; 3251-limiting plate; 3252-a rotating shaft; 3253-a stop block; 326-a bearing; 327-endless conveyor; 328-a second counterweight; 4-a counting assembly; 41-a deflector rod; 411 — first via; 42-counting plate; 421-a movable shaft; 43-a resilient stopper; 44-hollow tube; 441-a second via; 45-a rotating shaft; 46-counting bars; 461-gap; 47-an elastic member; 48-a display screen; 49-a button; 491-increment button; 492-return button.

Detailed Description

The present invention will be described below based on examples, but the present invention is not limited to only these examples. In the following detailed description of the present invention, certain specific details are set forth. It will be apparent to one skilled in the art that the present invention may be practiced without these specific details. Well-known methods, procedures, components and circuits have not been described in detail so as not to obscure the present invention.

Further, those of ordinary skill in the art will appreciate that the drawings provided herein are for illustrative purposes and are not necessarily drawn to scale.

Unless the context clearly requires otherwise, throughout the description, the words "comprise", "comprising", and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is, what is meant is "including, but not limited to".

In the description of the present invention, it is to be understood that the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.

Unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are intended to be inclusive and mean that, for example, they may be fixedly connected or detachably connected or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be interconnected within two elements or in a relationship where two elements interact with each other unless otherwise specifically limited. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In recent years, new coronavirus has spread worldwide, and thus has attracted attention from various countries. The reduction of contact is an effective measure for preventing the infection of the new coronavirus, and people in various countries can quickly screen new coronavirus infectors by positive cooperation and biomedical progress. Nucleic acid detection has become an effective method for identifying individuals infected with a new coronavirus. In practical use, in order to save cost and detection time, nucleic acid detection is usually performed by adopting a mixed sampling (a plurality of collected human samples are placed in 1 sampling tube) and multi-sample mixed detection (a liquid to be detected in a plurality of sampling tubes is filled into 1 specific sample adding cavity in a kit, which is called "mixed detection" for short). When the mixed detection mode is adopted, operators need to process a large amount of liquid to be detected of samples in batches. Aiming at a plurality of reaction containers with the same appearance, operators concentrate for a long time and are easy to fatigue, so that the liquid to be detected of a sample is leaked or mistakenly added into an unspecified reaction container, the corresponding relation between a detection result and a sample adding sequence is wrong, a wrong report result is caused, panic is easy to generate, or abnormal persons cannot be detected timely.

The embodiment of the invention aims to solve the problem that operators in the related art cannot clearly know whether the sample liquid to be tested is added into the reaction container or not and how many samples liquid to be tested are added, and provides the liquid adding auxiliary device. FIG. 1 is a schematic structural view of an embodiment of an auxiliary liquid adding device according to the present invention;

FIG. 2 is a schematic side view of another embodiment of the auxiliary liquid adding device of the present invention; FIG. 3 is a schematic side view of a liquid feeding auxiliary device according to another embodiment of the present invention. As shown in fig. 1 to 3, the liquid adding auxiliary device of the present embodiment may include a body 1 and a metering assembly 3, wherein the body 1 may be provided with a plurality of first receiving grooves 11 and a plurality of second receiving grooves 12 respectively matching the first receiving grooves 11, the plurality of second receiving grooves 12 are respectively used for receiving reaction reagents required in different reaction stages or providing spaces required for completing reactions, and the first receiving grooves 11 are used for receiving the reaction containers 2 for mixing the reaction reagents and a plurality of samples to be detected. The metering assembly 3 can be matched with the first accommodating groove 11 and comprises a fixing portion 31 and a balancing portion 32, the fixing portion 31 is movably connected with the balancing portion 32, the fixing portion 31 is used for detachably connecting the reaction container 2, and the balancing portion 32 is used for configuring the set weight. The reaction reagent and a plurality of sample liquids to be detected (for example, 5 parts of sample liquids to be detected) are sequentially added into the reaction container 2, and when the cumulative weight of the added liquid to be detected reaches a set weight, the reaction container 2 falls into the first accommodating groove 11.

The liquid adding auxiliary device of the embodiment can be used for nucleic acid detection of mixing of a plurality of samples. The first receiving groove 11 may be used as a place for fixing the reaction container 2, and the reaction container 2 is used for accommodating a sample to be detected and mixing and reacting of a reaction reagent. The second container 12 can be used for containing reagents required by different tests. In the nucleic acid detection and other processes, the reaction reagents need to be added in sequence, and the time intervals between the addition of two adjacent reaction reagents are possibly different, so that each first accommodating groove 11 is matched with a plurality of second accommodating grooves 12, so that the whole reaction can be completed at one time, and the required reaction result and extract can be obtained; moreover, the plurality of second accommodating grooves 12 are matched with each first accommodating groove 11, so that the reaction reagents required in the detection process can be arranged in the second accommodating grooves 12 in advance, and the labor intensity of operators is further reduced.

In this embodiment, the reaction container 2 may be directly filled with a reaction reagent and a sample to be detected for performing a detection operation, and the second receiving groove 12 may be directly filled with a reaction reagent to be detected for use after the start of the detection. In addition, the first receiving groove 11 and the second receiving groove 12 of the present embodiment can be respectively placed in a container such as a test tube or a centrifuge tube for receiving a reaction reagent required for detection and a sample to be detected, and the centrifuge tube or the test tube receives the reaction reagent and a mixed solution or a reaction reagent of the sample to be detected. Can conveniently change containers such as the test tube or centrifuging tube of second storage tank 12 and first storage tank 11 after accomplishing the testing process, reduce and detect the cost.

The body 1 of the liquid adding auxiliary device in this embodiment may be as shown in fig. 1, a plurality of first receiving grooves 11 (square) may be sequentially arranged in a row at the edge of the body 1, and second receiving grooves 12 (circular, or other shapes) matching with the first receiving grooves 11 may be sequentially arranged from left to right. The number of the second accommodating grooves 12 arranged on the body 1 can be larger than or equal to the number of the required reaction reagent types, so that the smooth proceeding of the detection process is ensured. Before the liquid adding auxiliary device of the present embodiment is used for detection, the second container 12 or the test tube or centrifuge tube placed in the second container 12 may be respectively placed with the reagent for detection in advance. After the detection is started, the reaction reagent and the liquid sample to be detected are sequentially added into the first accommodating groove 11 according to the adding sequence of the reaction reagent and the sample to be detected.

Referring to fig. 1, in the process of using the liquid adding auxiliary device of this embodiment, the body 1, the reaction container 2 and the metering assembly 3 may be assembled, preferably, after the above structural members are assembled, the opening of the reaction container 2 is vertical upward, so that on one hand, an operator may conveniently drop a reaction reagent and a liquid sample to be detected into the reaction container 2 in a state of the largest opening area; on the other hand, the balance part 32 of the metering assembly 3 can be transmitted to the reaction container 2, so that the phenomenon that the force borne by the reaction container 2 due to the deviation of the orientation of the metering assembly 3 is the component force of the balance part 32 in the vertical direction is avoided, and the measurement results of the reaction container 2, the reaction reagent in the reaction container and the liquid sample to be detected are more accurate.

In the present embodiment, the metering component 3 may be in the state shown in fig. 3 according to the principle of force balance before the reaction reagent is not added into the reaction container 2 and the liquid sample to be detected is added, wherein one end of the reaction container 2 may be fixed at the position of the first receiving groove 11 far away from the body 1 and aligned with the first receiving groove 11 of the body 1. Then, reaction reagents are added into the reaction container 2 one by one according to a set proportion for subsequent detection of a sample to be detected. In this process, the weight of the reaction vessel 2 and the reaction reagent therein is not enough to reach the set weight, and the position of the reaction vessel 2 is not changed and still above the first receiving groove 11 of the body 1.

After the reaction reagent is dropped into the reaction container 2, the solution of the sample to be detected is dropped into the reaction container 2. Since the filling amount of each liquid to be detected is the same (for example, 200 microliters) during the detection process, when the amount of the liquid to be detected reaches a preset amount (for example, a sample of 5 persons to be detected), the total weight of the reaction container 2 and the reaction reagent therein and the solution of the sample to be detected changes with the balance of the balance part 32, the reaction container 2 instantly falls downward into the first accommodating groove 11 of the body 1, the amount of the solution representing the sample to be detected in the reaction container 2 is the same as the set amount before the operation, and the operation of dropping a specific amount of the sample to be detected in the reaction container 2 is completed.

In the present embodiment, in the case of using the liquid feeding auxiliary device as shown in fig. 1, the reaction vessel 2 is kept away from the main body 1 by the metering assembly 3 until the weight of the reaction vessel 2 and the internal liquid has not reached the set amount before the operation. When the reaction container 2, the reaction reagent in the reaction container and the weight of the sample solution to be detected reach the set amount before operation, the reaction container 2 and the liquid in the reaction container 2 move vertically downwards together due to the momentum of the liquid dropped into the reaction container 2 when the liquid falls into the reaction container 2, and the liquid falls into the first containing groove 11 below. The use of the filling aid of the present embodiment can be used to meter the weight of the sample to be tested that is added to the reaction vessel 2. In one example, assuming that the kind and weight of the reaction reagent required in each reaction container 2 are the same, dropping a certain amount of the solution of the sample to be detected into each reaction container 2 indicates that the sample has been mixed with the reaction reagent.

In the mixed detection process of the reaction vessel 2 for nucleic acid detection, the above-mentioned set amount may be set before the operation according to the number of the mixed detection samples, for example, 10-person mixed detection, 8-person mixed detection, 5-person mixed detection, and the like. Taking 10 persons for mixed detection as an example, the position of the reaction container 2 is not changed in the process of dripping the reaction reagent and 9 parts of sample solution to be detected into the reaction container 2. After the 10 th sample solution to be detected is dripped, the reaction container 2 may instantaneously move downward and fall into the first accommodating groove 11 below, which indicates that the solution of the 10 samples to be detected in the reaction container 2 is completely poured, and the next reaction container 2 may be dripped with the sample solution to be detected.

Through using the liquid feeding auxiliary device of this embodiment, can avoid operating personnel to wait to detect the sample solution in-process because excessive fatigue or operation are skilled enough and cause more or less wrong operation, improve the accuracy of testing result, reduce the probability of repetitive operation in dropwise addition in reaction vessel 2.

Fig. 5 is a schematic structural view of an embodiment in which the fixing part and the reaction vessel are combined, and as shown in fig. 5, in order to ensure that the reaction vessel 2 of the embodiment can smoothly fall into the first receiving container 11 below, the lower part of the reaction vessel 2 may be formed in a truncated cone shape, a truncated pyramid shape, or the like, and a guide surface may be formed below the reaction vessel 2. The height of the reaction vessel 2 may be slightly higher than the depth of the first receiving groove 11, and the fixing portion 31 may be formed in a fork shape and inserted near the opening of the reaction vessel 2. After the reaction container 2 falls into the first containing groove 11, the metering assembly 3 and the reaction container 2 are conveniently separated. After the reaction container 2 falling into the first receiving cavity 11 is separated from the dosing assembly 3, the fixing portion 31 is automatically vertically displaced upward by the balancing portion 32, and is away from the body 1.

With reference to fig. 1 to 3, in some embodiments, the balance portion 32 may include a first angle limiting member 321, a supporting frame 322, and a lever 323, wherein the supporting frame 322 is fixed to the body 1, the first angle limiting member 321 is fixedly connected to the supporting frame 322, the lever 323 is rotatably connected to the first angle limiting member 321, the first angle limiting member 321 is used to limit an angle range of the lever 323, the lever 323 is movably connected to a first counterweight 324 on one side of the first angle limiting member 321, and the lever 323 is movably connected to the fixing portion 31 on the other side of the first angle limiting member 321.

According to the lever principle, the liquid adding auxiliary device of the embodiment is used for prompting an operator that the amount of the sample solution to be detected in the reaction container 2 reaches the set amount before operation by moving one end of the lever 323 fixed with the reaction container 2 downwards and vertically into the first accommodating groove 11 instantly when the weight of the reaction container 2 reaches the set amount before operation. The set amount in this example can be determined by adjusting the position of the first weight 324 on the lever 323, or by replacing a first weight of a different weight. The position of the first counterweight 324 on the lever 323 may be implemented by means of a slot or a thread, and the embodiment is not limited in this respect.

The supporting frame 322 in this embodiment may be higher than the upper surface of the body 1, and the balance assembly 3 and the reaction vessel 2 may be configured to have a space for movement. The first angle limiting member 321 may be disposed at the top end of the supporting frame 322, the lever 323 rotates around the center of the first angle limiting member 321, and the lever 323 is limited by the first angle limiting member 321 to rotate at a maximum angle along the vertical direction. The specific structure of the first angle limiting element 321 is not limited in this embodiment.

In a state where the weight of the reaction container 2 and the liquid in the reaction container 2 does not reach the set amount before the operation, the lever close to the fixing portion 31 abuts on the upper edge of the first angle stopper 321. The lever 323 may be parallel to the plate structures on the upper and lower sides of the first angle limiting member 321 after the reaction vessel 2 and the liquid in the reaction vessel 2 reach the set amount before the operation.

In some embodiments, as shown in fig. 1 to 3, the balancing part 32 may further include a second angle limiting part 325, the second angle adjusting part 325 is fixedly connected to one end of the lever 323, one end of the fixing part 31 is rotatably connected to the angle adjusting part 325, and the other end is detachably connected to the reaction vessel 2. Further, the second angle limiting member 325 may include a limiting plate 3251, a rotating shaft 3252, and a limiting block 3253, wherein the two limiting plates 3251 are parallel to each other and are fixedly connected to the lever 323, the rotating shaft 3252 is disposed between the two limiting plates 3251, and the limiting block 3253 is fixedly connected to the fixing portion 31 and is rotatably connected to the rotating shaft 3252.

The rotating shaft 3252 in this embodiment may be at a middle position of a space surrounded by the fixed limiting plate 3251, and the limiting block 3253 may be rotatably connected to the limiting plate 3251 through the rotating shaft 3252. The upper side of the limiting block 3253 of this embodiment may be an inclined surface, and the lower side may be a combined surface formed by connecting a plane and an arc surface, where the arc surface is to enable the limiting block 3253 to rotate around the rotating shaft 3252, so as to avoid interference from the lower limiting plate 3251. As shown in fig. 3, under the setting quantity state before the sum of the weight of the liquid in the reaction vessel 2 and the weight of the reaction vessel 2 does not reach the operation, one end of the lever 323 connected with the fixing part 31 is tilted upwards to drive the limiting plate 3251 to tilt towards the upper right, and under the state, the upper limiting plate 3251 can be propped against the inclined surface of the upper side of the limiting block 3253 to keep the fixing part 31 horizontal, so that the opening of the reaction vessel 2 is vertically upward, and an operator can conveniently drop the reaction reagent and/or the sample solution to be detected into the reaction vessel 2.

As shown in fig. 2, after the reaction vessel 2 and the liquid therein reach the set amount before operation, the lever 323 is driven to move downwards at one end connected with the fixing portion 31, the limiting block 3253 rotates anticlockwise around the rotating shaft 3252, and in the descending process of the reaction vessel 2, the upper right corner of the inclined plane on the upper side of the limiting block 3253 abuts against the limiting plate 3251 on the upper side, so that the fixing portion 31 is prevented from being transitedly deflected, and the stability of the reaction vessel 2 in the descending process is ensured.

Fig. 4 is a schematic side view of a liquid feeding auxiliary device according to another embodiment of the present invention, as shown in fig. 4, in some embodiments, the balancing portion 32 may include a supporting frame 322, a bearing 326 and an endless belt 327, wherein the supporting frame 322 is fixed to the body 1, at least two bearings 326 are fixed to the supporting frame 322, the endless belt 327 is sleeved on the two bearings 326, and the endless belt 327 detachably connects the fixing portion 31 and the second weight 328. Before a specific operation, the weight of the second weight 328 is set to be the same as the set amount of the solution of the sample to be detected in the reaction container 2 to be added. Until the set amount is reached in the reaction vessel 2, the position of the second weight 328 is not changed. When the weight of the solution of the sample to be detected in the reaction container 2 reaches the set amount, the reaction container 2 moves downward into the second accommodating groove 12, and the second weight 328 moves upward along with the endless conveyor 327. By the change of the position of the second weight 328 and/or the reaction vessel 2, the operator can determine that the weight of the solution of the specimen to be detected in the reaction vessel 2 has reached the above-mentioned set amount.

In addition to the balance portion 32 using the lever principle in the foregoing embodiment, the present embodiment also provides a balance portion 32 that changes the direction of force using a combination of a bearing 326 and an endless belt 327. As shown in fig. 4, two bearings may be disposed on the same side of the upper and lower ends of the supporting frame 322. Since the sum of the weights of the reagent, the sample solution to be detected, and the reaction container 2 is small, the bearing 326 of this embodiment may preferably use a roller bearing or a ball bearing to reduce the influence of the friction between the inner ring and the outer ring of the sliding bearing on the reaction sensitivity. The use of the balancing portion 32 of the present embodiment makes it possible to always keep the opening of the reaction vessel 2 vertically upward with the omission of the second angle adjusting member 325 described above, and occupies a small space.

In order to further accurately record the amount of the sample to be detected, the counting assembly 4 may be disposed on the body 1 for recording the number of drops of the sample solution to be detected, wherein one drop represents a sample solution to be detected for nucleic acid of a person. FIG. 6 is a schematic structural view of an embodiment of a body; FIG. 8 is a schematic structural view of another embodiment of the body; fig. 11 is a schematic structural view of a further embodiment of the body. As shown in fig. 6, 8 and 11, the liquid adding auxiliary device of the present embodiment may further include a counting assembly 4, and the counting assembly 4 may be matched with the first receiving groove 11 one by one and connected to the main body 1. The counting assembly 4 of this embodiment can be used to record the number of samples to be tested placed in the reaction vessel 2. Wherein, every time a sample to be detected is added into the reaction container 2, the counting assembly 4 is used for counting so as to determine the number of the samples to be detected added into the corresponding reaction container 2, thereby avoiding that an operator repeatedly adds the same sample to be detected into the same reaction container 2 due to the mixing, or the sample to be detected is added in an overlooked manner, or the sample to be detected is added in an error manner, and improving the accuracy of the sample addition in the detection process.

Fig. 7 is a schematic structural diagram of an embodiment of the shift lever, and referring to fig. 6 and 7, in some embodiments, the counting assembly 4 may include a shift lever 41 and a circular arc-shaped counting plate 42, wherein the circular arc edge close to the counting plate 42 is provided with integer numbers 10 at equal intervals in sequence, the shift lever 41 is provided with a first through hole 411, the size of the first through hole 411 is matched with the integer number 10, the shift lever 41 moves, and the integer numbers 10 are sequentially selected from the first through hole 411.

In this embodiment, the body 1 may be provided with a step near the first receiving groove 11 for fixing the counting plate 42 and the shift lever 41. In this embodiment, the shift lever 41 may be rotatably connected to the counting plate 42, a plurality of integer numbers 10 arranged in sequence may be disposed on the counting plate 42 at equal angular intervals near the arc edge, wherein the number of the integer numbers 10 may be set according to the number of the samples to be detected added into the reaction container 2, may be the same as the number of the samples to be detected added into the reaction container 2, or may be greater than the number of the samples to be detected added into the reaction container 2, and this embodiment is not specifically limited herein. Specifically, in the process of using the liquid adding auxiliary device of the embodiment, the shifting lever 41 is shifted once according to the predetermined sequence every time a sample to be detected is added into the reaction container 2, so that the adjacent numbers of the first through holes 411 arranged on the shifting lever 41 are exposed, and the above operations are repeated until a set number of samples to be detected are added into the reaction container 2.

In this embodiment, the arrangement order of the numbers arranged on the counting plate 42 may be gradually increased clockwise, for example, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or gradually decreased clockwise, for example, 9, 8, 7, 6, 5, 4, 3, 2, 1, 0, etc. It may also be A, B, C, D, E, F, G, H, or I, II, III, IV, V, VI, VII, VIII, IX, etc. The position where the integer number 10 is 0 may be an initial position to indicate that the reaction container 2 corresponding to the counting plate 42 has not been loaded with the sample to be detected. In another example, the position of 9 in the previous example can be used as the starting position, the number of samples to be detected added to the reaction container 2 is increased, and the number of the counting plate 42 exposed through the first through hole 411 is gradually decreased. The order in which the integer numbers 10 are arranged is not particularly limited in this embodiment. In other embodiments, a plurality of point clusters may be provided on the counting plate 42 to characterize the numbers. Or different colored circles may be provided to represent different numbers, but the operator is required to remember the correspondence between the colors and the numbers.

In some embodiments, the counting plate 42 is provided with elastic blocking members 43, the elastic blocking members 43 match the integer numbers 10 one by one, and the elastic blocking members 43 are used for limiting the movement of the shift lever 41 towards the adjacent integer numbers 10 when no external force is applied. The protruding counting plate 42 is provided with a movable shaft 421, and the shift lever 41 is rotatably connected with the counting plate 42. In the present embodiment, the movable shaft 421 can limit the axial movement of the shift lever 41 along the movable shaft 421, but does not limit the circumferential rotation of the shift lever 41 along the movable shaft 421. An elastic stop member 43 is protruded beside each integer number 10 on the counting plate 42, and the elastic stop member 43 can be an elastic stop rod arranged in parallel with the movable shaft 421. The elastic stopper 43 can stop the rotation of the shift lever 41 along the circumferential direction of the movable shaft 421 when the shift lever 41 is not under the action of external force; when the operator applies force to the shift lever 41, the shift lever 41 pushes the elastic stopper 43 to deform the elastic stopper 43, and the shift lever 41 is shifted to the position of the adjacent number, which indicates that the adding operation of the number of samples to be detected corresponding to the next integer number is completed.

In this embodiment, the movable shaft 421 and the elastic stopper 43 are matched to make the shift lever 41 stay at a position corresponding to a certain integer 10, so as to avoid the sample to be detected from being disturbed in number due to the shift to the positions of other integer 10 by its own weight. In addition, the cooperation of the movable shaft 421 and the elastic stopper 43 enables the operator to take his or her hands out for a period of time to deal with other matters, thereby avoiding the operation of the operator that always holds the shift lever 41 to count, and providing convenience for the operator to count.

In some embodiments, referring to fig. 8, the counting assembly 4 may include a hollow tube 44 and a rotating shaft 45, and a portion of the rotating shaft 45 is disposed in the hollow tube 44, wherein a second through hole 441 is disposed through a wall of the hollow tube 44, the integer number 10 is sequentially disposed at equal intervals along a circumferential direction of the rotating shaft 45, the rotating shaft 45 rotates, and the second through hole 441 frames the integer number 10. The operator can determine the number of the samples to be detected added through the framed integer number 10, or the next sample to be detected is added for the next time.

Further, in some embodiments, the hollow tube 44 is fixedly connected to the body 1, and the rotating shaft 45 is rotatably connected to the body 1. In the embodiment, the hollow tube 44 is used for shielding the part of the rotating shaft 45 connected with the body 1 and other numbers except the integer number 10 exposing the second through hole 441 except the area of the second through hole 441 penetrating through the hollow tube. In one example, the hollow tube 44 and the rotating shaft 45 are perpendicular to the side of the body 1, so that the operator can determine the number of samples to be detected by observing the number 10 of the second through hole 441 exposed from the upper side or the oblique upper side, thereby providing convenience for the operator.

In some embodiments, fig. 9 is a schematic structural view of yet another embodiment of the body; fig. 10 is a partial perspective structural diagram of the region a. As shown in fig. 9 and 10, the body 1 of the present embodiment may be provided with accommodating holes 13, and the number of the accommodating holes 13 matches with the number of the first accommodating grooves 11; the counting assembly 4 may include a counting bar 46 and an elastic member 47, wherein notches 461 are disposed at equal intervals along the length direction of the counting bar 46, integer numbers 10 are sequentially disposed at equal intervals along the length direction of the counting bar 46, and the notches 461 are disposed between two adjacent integer numbers 10; the elastic element 47 is movably connected to the body 1, and is used for cooperating with the notch 461 to limit the movement of the counting bar 46 when the counting bar 46 has no external force.

In this embodiment, the accommodating holes 13 are arranged in a one-to-one matching manner with the first accommodating grooves 11, and the length direction of the accommodating holes 13 may be the direction of the first accommodating grooves 11 facing the second accommodating grooves 12 matching with the first accommodating grooves. The counting bar 46 can be inserted into the housing hole 13, and a portion for the operator to pull the counting bar 46 out of the housing hole 13 by hand is left at the opening of the housing hole 13. The counting bar 46 is gradually pulled out of the containing hole 13, and the number which is exposed out of the containing hole 13 and is closest to the body 1 can be regarded as the number of the added samples to be detected.

Before specific use, the counting bar 46 can be inserted into the accommodating hole 13 in its entirety, leaving only a portion for the operator to hold. After the sample to be detected is added to the reaction container 2 once, the operator may pull the counting bar 46 to expose a portion of the counting bar 46 where the integer number 10 is 1, which indicates that the sample to be detected has been added to the reaction container 2, and so on until a predetermined number of samples to be detected are added to the reaction container 2.

The elastic element 47 is disposed on the body 1 and disposed at equal intervals along the length direction of the accommodating hole 13, and one side of the counting bar 46 is provided with a gap 461 matched with the elastic element 47. The elastic element 47 and the gap 461 cooperate to keep the counting bar 46 and the body 1 in a relatively static state to some extent in this embodiment. When the operator pulls the counter bar 46, the elastic member 47 can be retracted, so that the counter bar 46 can be pulled by the operator. When the operator reaches the next gap 461, the elastic element 47 extends in a larger space to generate a collision sound, the operator stops pulling the counting bar 46, and the elastic element 47 is matched with the gap 461 to keep the part of the counting bar 46 pulled out of the accommodating hole 13 unchanged when no external force is applied by the operator, so that the accurate integer number 10 is provided for the operator.

In one example, the elastic element 47 may be a component formed by connecting a triangular hard plate and a spring as shown in fig. 10, or may be a combination of a triangular hard plate and an elastic rubber strip, and the embodiment is not limited in detail herein. The notches 461 in the counting bar 46, which match the triangular rigid plates of the elastic members 47, may also be triangular. The bevel edge of the counting bar 46 at the notch 461 is matched with the bevel edge of the triangular hard plate of the elastic element 47, so that a certain blocking effect is achieved, and the force required by an operator for pulling the counting bar 46 can be reduced.

In some embodiments, the count bar 46 may be a disposable consumable, with the thickness of the count bar 46 at the gap 461 being less than the thickness of the other portions. The operator can easily break off the part of the integer 10 corresponding to the number of samples to be detected, so that the interference of the used integer 10 on the counting bar 46 to the currently used integer 10 can be further avoided.

In some embodiments, the elastic elements 47 may be disposed in various manners, the elastic elements 47 may be disposed opposite to each other in pairs along the length direction of the accommodating hole 13, and notches 461 matching with the elastic elements 47 are disposed on two sides of the counting bar 46. In other embodiments, as shown in FIG. 10, the elastic member 47 may be disposed at one side of the counting bar 46. In one example, the width of the end of the counting bar 46 extending into the accommodating hole 13 can be gradually reduced to a predetermined value. It is convenient for the operator to insert the counting bar 46 into the housing hole 13 during the preparation process.

Fig. 11 is a schematic structural view of a further embodiment of the body, as shown in fig. 11, in some embodiments, the counting assembly 4 may include a display screen 48 and a button 49, the display screen 48 and the button 49 are detachably connected to the body 1, the button 49 is electrically connected to the display screen 48, wherein the display screen 48 is used for displaying the integer number 10, and the button 49 is used for controlling the integer number 10 displayed on the display screen 48. In this embodiment, the display screen 48 and the button 49 may be disposed on the body 1 near the first receiving groove 11, wherein the position of the display screen 48 between the button 49 and the first receiving groove 11 is convenient for an operator to observe the integer number 10 on the display screen quickly.

The button 49 may include an increment button 491 and a return button 492, wherein the increment button 491 and the return button 492 may be set two by two to match with the first receiving cavity 11 to movably connect the body 1, the increment button 491 is pressed to control the integer number 10 displayed on the display screen 48 to continuously increment, and the return button 492 is used to control the display screen 48 to display 0. Pressing the increment button 491 can sequentially increment the integer number 10 displayed on the display screen 48 until the return button 492 is pressed after the sample to be tested added into the reaction vessel 2 is increased to a preset number.

Because the number of the samples to be detected added into the reaction container 2 is large, the use frequency of the incremental button 491 is higher than that of the return button 492, so that the return button 492 can be arranged at the position between the incremental button 491 and the first accommodating groove 11, and the incremental button 491 is close to the edge position of the body 1, so that the incremental button 491 can be effectively prevented from being arranged at the position between the return button 492 and the first accommodating groove 11, and the wrong pressing caused by small operation space can be effectively avoided. The reset button 492 is disposed between the increment button 491 and the first receiving groove 11, so that a larger operation space can be reserved for the increment button 491 pressed for multiple times, and the probability of pressing the wrong button by an operator is reduced.

In the above embodiments, the body 1 shown in fig. 6, 8 and 11 can be respectively matched with the metering assembly 3 shown in fig. 1 to 4, wherein the metering assembly 3 can be used for metering the weight of the reaction container 2 and the liquid therein. The counting assembly 4 can count the reaction reagents and the sample solution to be detected added into the reaction container 4, and can be applied to the adding process of the mixed reaction solution, for example, two drops of the reaction reagents a and five drops of the reaction reagents b are added into the reaction container 2, or ten drops of the sample solution to be detected of different sampling personnel are added into the reaction container 2. The metering component 3 is matched with the counting component 4, so that the total weight of the reaction container 2 and the internal liquid can be determined through the preset amount, the dropping number of the solution added into the reaction container 2 can also be determined, and the accuracy of the adding amount of the sample to be detected and the accuracy of the adding amount of the reaction reagent for detecting nucleic acid are further enhanced.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A liquid feeding auxiliary device, characterized by comprising:

the sample detection device comprises a body (1) and a detection device, wherein the body (1) is provided with a plurality of first accommodating grooves (11) and a plurality of second accommodating grooves (12) which are respectively matched with the first accommodating grooves (11), the second accommodating grooves (12) are respectively used for accommodating reaction reagents, and the first accommodating grooves (11) are used for accommodating reaction containers (2) for mixing the reaction reagents and a plurality of samples to be detected;

metering component (3), with first storage tank (11) match, including fixed part (31) and balancing part (32), fixed part (31) with balancing part (32) swing joint, fixed part (31) are used for dismantling the connection reaction vessel (2), balancing part (32) are used for the configuration to set for the weight, each reactant in reaction vessel (2) reaches with a plurality of weight of waiting to detect the sample set for after the weight, reaction vessel (2) fall into in first storage tank (11).

2. The auxiliary device according to claim 1, wherein the balancing unit (32) comprises a first angle limiting unit (321), a supporting frame (322), and a lever (323), wherein the supporting frame (322) is fixed to the body (1), the first angle limiting unit (321) is fixedly connected to the supporting frame (322), the lever (323) is rotatably connected to the first angle limiting unit (321), the first angle limiting unit (321) is used to limit the angle range of the lever (323) to deflect, a first counterweight (324) is movably connected to one side of the first angle limiting unit (321) of the lever (323), and the lever (323) is movably connected to the fixing unit (31) at the other side of the first angle limiting unit (321).

3. A liquid feeding aid according to claim 2, characterized in that said balancing member (32) further comprises a second angle limiting member (325), said second angle adjusting member (325) is fixedly connected to one end of said lever (323), said fixing member (31) is rotatably connected to said angle adjusting member (325) at one end and detachably connected to said reaction vessel (2) at the other end.

4. The auxiliary device according to claim 3, wherein the second angle limiting member (325) comprises a limiting plate (3251), a rotating shaft (3252) and a limiting plate (3253), wherein the two limiting plates (3251) are parallel to each other and are fixedly connected to the lever (323), the rotating shaft (3252) is disposed between the two limiting plates (3251), and the limiting plate (3253) is fixedly connected to the fixing portion (31) and is rotatably connected to the rotating shaft (3252).

5. The auxiliary device as claimed in claim 1, wherein the balancing unit (32) comprises a supporting frame (322), bearings (326) and a belt (327), wherein the supporting frame (322) is fixed to the body (1), at least two of the bearings (326) are fixed to the supporting frame (322), the belt (327) is sleeved on the two bearings (326), and the belt (327) is detachably connected to the fixing unit (31) and the second weight (328).

6. A filling aid according to any one of claims 1 to 5, characterized in that it further comprises a counting assembly (4) fitted one-to-one with said first receiving groove (11) and connected to said body (1) for recording the number of samples to be tested inserted in said first receiving groove (11).

7. The liquid adding auxiliary device according to claim 6, characterized in that the counting assembly (4) comprises a shifting lever (41) and a circular arc-shaped counting plate (42), wherein integer numbers (10) are sequentially arranged at equal intervals near the circular arc edge of the counting plate (42), the shifting lever (41) is provided with a first through hole (411), the size of the first through hole (411) is matched with the integer numbers (10), the shifting lever (41) moves, and the first through hole (411) sequentially frames the integer numbers (10).

8. Liquid filling aid according to claim 7, characterized in that said counting plate (42) is provided with elastic stops (43), said elastic stops (43) matching said integer numbers (10) one to one, said elastic stops (43) being adapted to limit the movement of said deflector rod (41) towards the adjacent integer numbers (10) when no external force is applied.

9. The auxiliary device for filling liquid according to claim 8, wherein a movable shaft (421) is provided to protrude from said counting plate (42), and said deflector rod (41) is rotatably connected to said counting plate (42).

10. The liquid adding auxiliary device according to claim 6, characterized in that the counting assembly (4) comprises a hollow tube (44) and a rotating shaft (45), part of the rotating shaft (45) is arranged in the hollow tube (44), wherein a second through hole (441) is arranged through the wall of the hollow tube (44), integer numbers (10) are sequentially arranged at equal intervals along the circumference of the rotating shaft (45), the rotating shaft (45) rotates, and the integer numbers (10) are framed by the second through hole (441).

11. A filling aid according to claim 10, characterized in that said hollow tube (44) is fixedly connected to said body (1) and said shaft (45) is rotatably connected to said body (1).

12. The filling aid according to claim 6, characterized in that said body (1) is provided with containing holes (13), said containing holes (13) matching in number said first containing grooves (11); the counting assembly (4) comprises a counting strip (46) and an elastic piece (47), wherein gaps (461) are arranged at equal intervals along the length direction of the counting strip (46), integer numbers (10) are sequentially arranged at equal intervals along the length direction of the counting strip (46), and the gaps (461) are arranged between two adjacent integer numbers (10); elastic component (47) swing joint body (1) is used for under counting strip (46) do not have the exogenic action cooperation breach (461) restriction the motion of counting strip (46).

13. The auxiliary device as claimed in claim 12, wherein the elastic members (47) are disposed opposite to each other in pairs along the length direction of the receiving groove (13), and the notches (461) matching with the elastic members (47) are disposed on both sides of the counting bar (46).

14. Liquid filling aid according to claim 6, characterized in that the counting assembly (4) comprises a display screen (48) and a button (49) and is removably connected to the body (1), the button (49) being electrically connected to the display screen (48), wherein the display screen (48) is adapted to display an integer number (10) and the button (49) is adapted to control the display of the integer number (10) of the display screen (48).

15. The liquid adding auxiliary device according to claim 14, wherein said button (49) comprises an increment button (491) and a return button (492), wherein said increment button (491) and said return button (492) are matched with said first receiving groove (11) in a pairwise manner to movably connect said body (1), pressing said increment button (491) is used for controlling said integer number (10) displayed by said display screen (48) to continuously increment, and said return button (492) is used for controlling said display screen (48) to display 0.