CN114609404A - Dosing Auxiliary Device - Google Patents

Abstract

The embodiment of the present invention discloses an auxiliary device for adding liquid, which relates to the technical field of medical inspection and testing instruments. The plurality of second accommodating grooves are respectively used for holding reaction reagents, and the first accommodating grooves are used for placing reaction containers for mixing each reaction reagent and a plurality of samples to be detected; the metering component, matched with the first accommodating groove, includes movable The fixed part and the balance part are connected. The fixed part is used to detachably connect the reaction container, and the balance part is used to configure the set weight. After the weight of each reaction reagent and a plurality of samples to be tested in the reaction container reaches the set weight, the reaction container fall into the first accommodating groove. Using the liquid adding auxiliary device of the embodiment of the present invention, the weight and/or quantity of the sample to be tested can be determined by the timing when the reaction container falls into the first accommodating tank, which reduces the requirement on the operator's memory.

Description

Dosing Auxiliary Device

technical field

The invention relates to the technical field of medical inspection and testing instruments, in particular to a liquid addition auxiliary device.

Background technique

With the continuous development of science and technology, the medical field has made great progress in disease detection and treatment. Under the recent global outbreak of the new coronavirus pneumonia, biomedical institutions around the world have devoted themselves to the development of detection and treatment methods for the new coronavirus pneumonia. Nucleic acid testing collects the pharynx, tonsils, palatal arches and other parts through throat swabs, or nasal swabs to collect secretions in the nasal cavity, or blood, or feces as specimens to find out whether there is nucleic acid of foreign invading viruses, to determine whether the tested person is infected with the new coronavirus. Among them, in order to improve the detection efficiency, the method of multi-sample mixed detection (referred to as: mixed detection) is often performed when performing population screening. This method can not only reduce the consumption of testing equipment, but also shorten the testing time. It is a common testing method for large-scale screening of the population.

In the related art, in the mixed detection process, it is necessary to sequentially add the liquid to be tested of a plurality of subjects to be tested (such as: 5 persons, 10 persons) into a plurality of reaction chambers or containers (accommodating tanks) in the detection kit. In a specific chamber, and then add reaction reagents according to the detection requirements and perform operations such as stirring, extraction, and standing. The chambers used to carry the liquid to be tested are often arranged in rows and are identical in size and appearance, making them difficult to distinguish visually. In the large-scale mixed sample detection work, when adding the liquid to be tested, the operator's field of vision needs to be constantly switched between sampling tubes, pipette tips, and kits to complete the sample adding process. Therefore, It is necessary to remember the number of people to be tested in the reaction vessel of the kit and which chamber to be filled with the test solution in the next step. Repeated operations for a long time are prone to fatigue, which may require more energy to memorize the sample injection position, and may also inject the sample to be tested into the wrong reaction chamber, which will affect the accuracy of the test results and detection. Timeliness of results reporting.

SUMMARY OF THE INVENTION

In view of this, the purpose of the present invention is to solve the above-mentioned problems in the prior art, and to provide a liquid addition auxiliary device to improve the accuracy of liquid addition.

The liquid addition auxiliary device of the present invention comprises: a main body, which is provided with a plurality of first accommodating grooves and a plurality of second accommodating grooves respectively matching the first accommodating grooves, and the plurality of second accommodating grooves are respectively used for accommodating the reaction Reagents and the realization of the reaction process, the first accommodating tank is used to place the reaction containers for mixing each reaction reagent and a plurality of samples to be tested; the metering component, matched with the first accommodating tank, includes a fixed part and a balance part, and the fixed part and the balance part The part is movably connected, the fixed part is used to detachably connect the reaction container, and the balance part is used to configure the set weight. After the weight of each reaction reagent and a plurality of samples to be tested in the reaction container reaches the set weight, the reaction container falls into the first place. in the accommodating slot.

Preferably, the balance part includes a first angle limiter, a support frame, and a lever, wherein the support frame is fixed to the body, the first angle limiter is fixedly connected to the support frame, the lever is rotatably connected to the first angle limiter, and the first angle limiter is connected to the first angle limiter. An angle limiter is used to limit the deflection angle range of the lever, the lever is movably connected with the first counterweight on one side of the first angle limiter, and the lever is movably connected to the fixing part on the other side of the first angle limiter.

Preferably in any of the above solutions, the balance part further includes a second angle limiting member, the second angle adjusting member is fixedly connected to one end of the lever, one end of the fixed portion is rotatably connected to the angle adjusting member, and the other end is detachably connected to the reaction vessel.

Preferably in any of the above solutions, the second angle limiter includes a limiter plate, a rotating shaft, and a limiter block, wherein the two limiter plates are parallel to each other and are fixedly connected to the lever, and the rotating shaft is placed between the two limiter plates, The limit block is fixedly connected to the fixed part and rotatably connected to the rotating shaft.

Preferably in any of the above solutions, the balance part includes a support frame, a bearing and an annular transmission belt, wherein the support frame is fixed to the body, at least two bearings are fixed to the support frame, the annular transmission belt is sleeved on the two bearings, and the annular transmission belt can be Disassemble the connecting and fixing part and the second counterweight.

In any of the above solutions, preferably, the liquid adding auxiliary device further includes a counting component, which is matched with the first accommodating groove and connected to the body, and is used to record the number of samples to be detected placed in the first accommodating groove.

It is further preferred in the above scheme that the counting assembly includes a lever and an arc-shaped counting plate, wherein integer numbers are arranged in sequence near the arc edge of the counting plate at equal intervals, the lever is provided with a first through hole, and the first through hole is arranged on the lever. The size of the hole matches the integer number, the lever moves, and the first through hole selects the integer number in sequence.

In any of the above solutions, it is preferable that the counting plate is provided with an elastic stopper, the elastic stopper is matched with the integer numbers one by one, and the elastic stopper is used to restrict the movement of the lever towards the adjacent integer numbers when there is no external force.

Preferably in any of the above solutions, the protruding counting plate is provided with a movable shaft, and the lever is rotatably connected to the counting plate.

Preferably in any of the above solutions, the counting assembly includes a hollow tube and a rotating shaft, and a part of the rotating shaft is placed in the hollow tube, wherein a second through hole is provided through the wall of the hollow tube, which is arranged in sequence at equal intervals along the circumference of the rotating shaft. There are integer numbers, the shaft rotates, and the second through hole box selects integer numbers.

In any of the above solutions, preferably, the hollow tube is fixedly connected to the body, and the rotating shaft is rotatably connected to the body.

Preferably in any of the above solutions, the body is provided with accommodating holes, and the number of the accommodating holes matches the number of the first accommodating slots; the counting assembly includes a counting bar and an elastic member, wherein gaps are arranged at equal intervals along the length direction of the counting bar, Integer numbers are arranged in sequence along the length direction of the counting bar at equal intervals, and the gap is arranged between two adjacent integer numbers; the elastic piece is movably connected to the body, and is used for cooperating with the gap to restrict the movement of the counting bar without the action of external force.

In any of the above solutions, it is preferable that the elastic pieces are arranged opposite to each other along the length direction of the accommodating hole, and the two sides of the counting bar are provided with notches matching the elastic pieces.

Preferably in any of the above solutions, the counting assembly includes a display screen and a button and is detachably connected to the body, the button is electrically connected to the display screen, wherein the display screen is used to display integer numbers, and the buttons are used to control the integer numbers displayed on the display screen.

Preferably in any of the above solutions, the button includes an increment button and a return button, wherein the increment button and the return button are paired with the first accommodating slot to flexibly connect the body, and pressing the increment button is used to control the display screen displayed. The integer number increases continuously, and the return button is used to control the display to display 0.

Based on the above-mentioned liquid adding auxiliary device provided by the present invention, by setting the fixed part to connect the reaction container and the balance part, the reaction container and the mixed liquid inside can automatically fall into the first accommodating tank of the main body after reaching the set weight, which can effectively record The amount of the sample to be tested added in the reaction vessel improves the operation accuracy of the operator, reduces the requirement on the operator's memory, and makes the mixing and adding process simple.

Description of drawings

The above and other objects, features and advantages of the present invention will become more apparent from the following description of embodiments of the present invention with reference to the accompanying drawings, in which:

Fig. 1 is the structural schematic diagram of an embodiment of the liquid adding auxiliary device of the present invention;

Fig. 2 is the side view structure schematic diagram of another embodiment of the liquid addition auxiliary device of the present invention;

Fig. 3 is the side view structure schematic diagram of still another embodiment of the liquid addition auxiliary device of the present invention;

Fig. 4 is a side view structural schematic diagram of another embodiment of the liquid addition auxiliary device of the present invention;

5 is a schematic structural diagram of an embodiment of a combination of a fixed portion and a reaction vessel;

6 is a schematic structural diagram of an embodiment of a body;

7 is a schematic structural diagram of an embodiment of the lever;

8 is a schematic structural diagram of another embodiment of the body;

9 is a schematic structural diagram of another embodiment of the body;

Fig. 10 is the partial perspective structure schematic diagram of A area;

FIG. 11 is a schematic structural diagram of another embodiment of the body.

Reference numerals: 1-body; 11-first accommodating groove; 12-second accommodating groove; 13-accommodating hole; 2-reaction vessel; 3-metering assembly; 31-fixing part; 32-balance part; 321-first angle limiter; 322-support frame; 323-lever; 324-first counterweight; 325-second angle limiter; 3251-limiting plate; 3252-rotating shaft; 3253-limiting block; 326-bearing; 327-annular conveyor belt; 328-second counterweight; 4-counter assembly; 41-lever; 411-first through hole; 42-counter plate; 421-active shaft; 43-elastic stopper; 44-Hollow tube; 441-Second through hole; 45-Rotating shaft; 46-Counting bar; 461-Notch; 47-Elastic part; 48-Display screen; 49-Button;

Detailed ways

The present invention is described below based on examples, but the present invention is not limited to these examples only. In the following detailed description of the invention, some specific details are described in detail. The present invention can be fully understood by those skilled in the art without the description of these detailed parts. Well-known methods, procedures, procedures, components and circuits have not been described in detail in order to avoid obscuring the essence of the present invention.

Furthermore, those of ordinary skill in the art will appreciate that the drawings provided herein are for illustrative purposes and are not necessarily drawn to scale.

Unless clearly required by the context, words such as "including", "comprising" and the like in the specification should be construed in an inclusive rather than an exclusive or exhaustive sense; that is, in the sense of "including but not limited to".

In the description of the present invention, it should be understood that the terms "first", "second" and the like are used for descriptive purposes only, and should not be construed as indicating or implying relative importance. Also, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

Unless otherwise expressly specified and limited, the terms "installed", "connected", "connected", "fixed" and other terms should be understood in a broad sense, for example, it may be a fixed connection, a detachable connection, or an integral body; It can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal communication between two elements or the interaction relationship between the two elements, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

In recent years, the spread of the new coronavirus around the world has attracted the attention of all countries. Reducing contact is an effective measure to prevent the infection of the new coronavirus. The active cooperation of the people of all countries and the progress of biomedicine can quickly screen out those infected with the new coronavirus. Nucleic acid testing has become an effective method to identify people infected with the new coronavirus. In actual use, in order to save cost and detection time, mixed sampling (putting the collected samples of multiple people into one sampling tube), multi-sample mixed detection (adding the liquid to be detected in multiple sampling tubes into Nucleic acid detection is carried out in a specific sample loading chamber in the kit, referred to as "mixed detection"). When the mixed detection method is adopted, the operator needs to process a large number of samples of the liquid to be tested in batches. For multiple reaction vessels with the same appearance, it is easy for the operator to be fatigued by concentrating for a long time, causing the sample liquid to be tested to be missed or added to the unspecified reaction vessel by mistake, resulting in an error in the corresponding relationship between the test results and the sample addition sequence. It leads to wrong report results, easy to panic, or can not detect abnormal people in time.

The embodiment of the present invention aims to solve the problem in the above-mentioned related art that the operator cannot remember whether the sample liquid to be tested has been added to the reaction container and how many sample liquids to be tested have been added, and provides a liquid addition auxiliary device. Fig. 1 is the structural schematic diagram of an embodiment of the liquid adding auxiliary device of the present invention;

FIG. 2 is a schematic side view structure diagram of another embodiment of the liquid addition auxiliary device of the present invention; FIG. 3 is a side view structure diagram of another embodiment of the liquid addition auxiliary device of the present invention. As shown in FIGS. 1 to 3 , the liquid adding auxiliary device of this embodiment may include a main body 1 and a metering assembly 3 , wherein the main body 1 may be provided with a plurality of first accommodating grooves 11 and matching the first accommodating grooves 11 respectively. The plurality of second accommodating tanks 12 are respectively used to hold the reaction reagents required for different reaction stages or provide the space required to complete the reaction, and the first accommodating tanks 11 are used to place mixing Reaction containers 2 for each reaction reagent and a plurality of samples to be detected. The metering assembly 3 can be matched with the first accommodating groove 11, and includes a fixed part 31 and a balance part 32, the fixed part 31 and the balance part 32 are movably connected, the fixed part 31 is used for detachably connecting the reaction vessel 2, and the balance part 32 is used for configuration Set weight. Add reaction reagents and a plurality of sample liquids to be tested (for example: 5 parts of sample liquids to be tested) into the reaction container 2 in sequence. When the cumulative weight of the added liquid to be tested reaches the set weight, the reaction container 2 falls into the first container. Put it in the groove 11.

The liquid addition auxiliary device of this embodiment can be used for nucleic acid detection in which multiple samples are mixed. The first accommodating tank 11 may be used as a place for fixing the reaction container 2 , and the reaction container 2 is used for containing the sample to be detected and the mixing and reaction of the reaction reagents. The second accommodating tank 12 can be used to hold reagents required in different experimental procedures required for the reaction. In the process of nucleic acid detection, etc., the reaction reagents need to be added in sequence, and the time interval between the addition of two adjacent reaction reagents may be different. It is possible to complete all the reactions at one time, and obtain the required reaction results and extracts; and for each first containing tank 11 to match a plurality of second containing tanks 12, the second containing tank 12 can be configured in advance in the second containing tank 12 required for the detection process The reaction reagents, thereby reducing the labor intensity of operators.

In this embodiment, the reaction container 2 can be directly injected with the reaction reagent and the sample to be detected for the detection operation, and the second accommodating tank 12 can be directly injected with the reaction reagent to be used after the detection starts. In addition, both the first accommodating tank 11 and the second accommodating tank 12 in this embodiment can be put into containers such as test tubes or centrifuge tubes for containing the reaction reagents required for detection and the samples to be detected. Or the test tube contains the reaction reagent and the mixture or reaction reagent of the sample to be detected. After the detection process is completed, containers such as test tubes or centrifuge tubes in the second accommodating tank 12 and the first accommodating tank 11 can be easily replaced, thereby reducing the detection cost.

In this embodiment, the main body 1 of the liquid adding auxiliary device can be as shown in FIG. 1 , and a plurality of first accommodating grooves 11 (square) can be sequentially arranged on the edge of the main body 1 in a row, and the first accommodating grooves 11 The matching second accommodating grooves 12 (circular, but also other shapes) are arranged in order from left to right. The number of the second accommodating grooves 12 provided in the main body 1 may be greater than or equal to the number of required types of reaction reagents, so as to ensure the smooth progress of the detection process. Before using the liquid addition auxiliary device of this embodiment for detection, the reaction reagent for detection can be placed in the second accommodating tank 12 or in the test tube or centrifuge tube placed in the second accommodating tank 12 in advance. After the detection starts, according to the order of adding the reaction reagent and the sample to be detected, the reaction reagent and the liquid sample to be detected are sequentially added into the first accommodating tank 11 .

Referring to FIG. 1 , in the process of using the liquid adding auxiliary device of the present embodiment, the main body 1, the reaction vessel 2 and the metering assembly 3 can be assembled. Preferably, after the above-mentioned structural components are assembled, the opening of the reaction vessel 2 is vertical On the one hand, it is convenient for the operator to drop the reaction reagent and the liquid sample to be detected into the reaction container 2 under the state of the maximum opening area; 2. It avoids that the force on the reaction container 2 due to the deviation of the orientation of the metering assembly 3 is the component force of the balance part 32 in the vertical direction, so that the measurement results of the reaction container 2 and its internal reaction reagents and the liquid sample to be detected are more accurate. precise.

In this embodiment, the metering component 3 can be in the state shown in FIG. 3 before adding the reaction reagent and the liquid sample to be detected in the reaction container 2 according to the principle of force balance. , wherein one end of the fixed reaction vessel 2 may be located away from the first accommodating groove 11 of the main body 1 and aligned with the first accommodating groove 11 of the main body 1 . Then, the reaction reagents are added one by one in the reaction container 2 according to the set ratio, so as to be used for the subsequent detection of the sample to be detected. During this process, the weight of the reaction container 2 and the reaction reagents in it is insufficient to reach the set weight, and the position of the reaction container 2 remains unchanged and is still above the first accommodating groove 11 of the main body 1 .

After the reaction reagent is dropped into the reaction container 2 , the solution of the sample to be detected is dropped into the reaction container 2 . Since the filling volume of each liquid to be tested is the same during the detection process (for example: 200 microliters), when the amount of liquid to be tested reaches the preset amount (for example: the sample of 5 people to be tested), The total weight of the reaction container 2, the reaction reagents inside it and the solution of the sample to be detected and the balance of the balance part 32 change, and the reaction container 2 falls down instantly and falls into the first accommodating tank 11 of the main body 1, indicating the reaction The addition amount of the solution of the sample to be detected in the container 2 is the same as the set amount before the operation, and the dripping operation of the specific amount of the sample to be detected that should be added in the reaction container 2 is completed.

It should be noted that, in the process of using the liquid addition auxiliary device shown in FIG. 1 in this embodiment, before the weight of the reaction container 2 and the internal liquid does not reach the set amount before operation, the function of the reaction container 2 in the metering component 3 The bottom has been in a state away from the main body 1. When the weight of the reaction container 2 and the reaction reagent and the sample solution to be detected in the reaction container 2 reaches the set amount before the operation, due to the momentum of the liquid dropped into the reaction container 2 when it falls into the reaction container 2, the reaction container 2 and its interior The liquid moves vertically downward together and falls into the first accommodating groove 11 below. Using the liquid addition auxiliary device of this embodiment can be used to measure the weight of the sample to be tested added into the reaction container 2 . In one example, assuming that the type and weight of the required reaction reagents in each reaction container 2 are the same, each sample to be tested is dropped into the reaction container 2 through a specific amount of the solution of the sample to be tested to indicate that it has been mixed with the reaction reagent.

When the reaction container 2 is used in the mixed detection process of nucleic acid detection, the aforementioned set amount can be set before the operation according to the number of mixed samples, for example, 10 people, 8 people, 5 people, etc. Taking the mixed test of 10 people as an example, during the process of dropping the reaction reagent and 9 sample solutions to be tested in the reaction container 2, the position of the reaction container 2 remains unchanged. After dropping the 10th sample solution to be detected, the reaction vessel 2 can be displaced downwards instantly and falls into the first accommodating tank 11 below, indicating that the solution of the 10 samples to be detected in the reaction vessel 2 has been filled After completion, the operation of dripping the sample solution to be detected can be performed on the next reaction container 2 .

By using the liquid adding auxiliary device of this embodiment, the operator can avoid the wrong operation of adding more or less due to excessive fatigue or unskilled operation during the dropwise addition of the sample solution to be tested in the reaction container 2, thereby improving the accuracy of the test results. , reducing the probability of repeated operations.

In addition, FIG. 5 is a schematic structural diagram of an embodiment of the combination of the fixing part and the reaction vessel. As shown in FIG. 5 , in order to ensure that the reaction vessel 2 of this embodiment can smoothly fall into the first accommodating groove 11 below, the reaction vessel 2 can be The lower part of the container 2 is formed into a circular truncated shape, a pyramid shape, etc., and a guide surface is formed below the reaction container 2 . The height of the reaction container 2 may be slightly higher than the depth of the first accommodating groove 11 , and the fixing portion 31 may be set in two fork shapes and inserted near the opening of the reaction container 2 . After the reaction container 2 falls into the first accommodating tank 11 , it is convenient to separate the metering assembly 3 and the reaction container 2 . After the reaction container 2 falling into the first accommodating groove 11 is separated from the dose assembly 3 , the fixing portion 31 automatically moves vertically upward under the action of the balancing portion 32 , away from the main body 1 .

1-3, in some embodiments, the balance portion 32 may include a first angle limiter 321, a support frame 322, and a lever 323, wherein the support frame 322 is fixed to the body 1, and the first angle limiter 321 It is fixedly connected with the support frame 322 , the lever 323 is rotatably connected to the first angle limiter 321 , the first angle limiter 321 is used to limit the angular range of the deflection of the lever 323 , and the lever 323 moves on one side of the first angle limiter 321 A first counterweight 324 is connected, and the lever 323 is movably connected to the fixed portion 31 on the other side of the first angle limiting member 321 .

The liquid adding auxiliary device of this embodiment is based on the lever principle. When the liquid added in the reaction container 2 and the weight of the reaction container 2 reach the set amount before the operation, one end of the lever 323 to which the reaction container 2 is fixed is instantly vertical. It moves downward and falls into the first accommodating tank 11 to remind the operator that the amount of the sample solution to be detected in the reaction container 2 has reached the set amount before the operation. In this example, the set amount can be determined by adjusting the position of the first counterweight 324 on the lever 323, or by replacing the first counterweight with different weights. Wherein, the position of the first counterweight 324 on the lever 323 may be realized by means such as a slot or a thread, which is not specifically limited in this embodiment.

In this embodiment, the support frame 322 may be higher than the upper surface of the body 1 , and other structures of the balance assembly 3 and the reaction vessel 2 leave room for movement. The first angle limiter 321 can be disposed on the top of the support frame 322, the lever 323 rotates around the center of the first angle limiter 321, and the first angle limiter 321 limits the lever 323 from rotating in the vertical direction. For the maximum angle, the first angle limiting member 321 in this embodiment may be composed of two plate-like structures parallel to each other in the vertical direction, or may be a rectangular parallelepiped structure with openings at both ends in the horizontal direction. This embodiment does not limit the specific structure of the first angle limiting member 321 .

When the weight of the reaction container 2 and the liquid in the reaction container 2 does not reach the set amount before the operation, the lever close to the fixing part 31 pushes against the upper edge of the first angle limiter 321 . After the weight of the reaction vessel 2 and the liquid in the reaction vessel 2 reaches the set amount before the operation, the lever 323 can be parallel to the plate structures on the upper and lower sides of the first angle limiting member 321 .

In some embodiments, as shown in FIGS. 1-3 , the balance portion 32 may further include a second angle limiting member 325 , the second angle adjusting member 325 is fixedly connected to one end of the lever 323 , and one end of the fixed portion 31 is rotated to connect the angle The other end of the adjusting member 325 is detachably connected to the reaction vessel 2 . Further, the second angle limiting member 325 may include a limiting plate 3251, a rotating shaft 3252, and a limiting block 3253, wherein the two limiting plates 3251 are parallel to each other and are fixedly connected to the lever 323, and the rotating shaft 3252 is placed on the two limiting plates 3251 In between, the limiting block 3253 is fixedly connected to the fixing portion 31 and rotatably connected to the rotating shaft 3252 .

The rotating shaft 3252 in this embodiment may be at the middle position of the space enclosed by the fixed limiting plate 3251 , and the limiting block 3253 may be connected to the limiting plate 3251 through the rotating shaft 3252 . The upper side of the limiting block 3253 in this embodiment can be an inclined surface, and the lower side can be a combined surface formed by connecting a plane and a circular arc surface. It is interfered by the lower limit plate 3251. As shown in FIG. 3 , when the weight of the liquid in the reaction container 2 and the sum of the weight of the reaction container 2 do not reach the set amount before the operation, one end of the lever 323 connected to the fixed portion 31 is lifted upwards, driving the limit plate 3251 is inclined to the upper right, in this state, the upper limit plate 3251 can be held against the upper limit plate 3251 by the upper slope of the limit block 3253, so that the fixing part 31 can be kept horizontal, and then the opening of the reaction vessel 2 is vertically upward, which is convenient for The operator drops the reaction reagent and/or the sample solution to be detected into the reaction container 2 .

As shown in FIG. 2 , after the reaction vessel 2 and the liquid in it reach the set amount before operation, the end of the lever 323 connected to the fixed part 31 is driven to move downward, the limit block 3253 rotates counterclockwise around the rotating shaft 3252, and the reaction vessel 2. During the descending process, the upper right corner of the upper slope of the limiting block 3253 bears against the limiting plate 3251 on the upper side, so that the fixed part 31 avoids transitional deflection and ensures the stability of the reaction vessel 2 during the descending process.

FIG. 4 is a schematic side view of the structure of another embodiment of the liquid adding auxiliary device of the present invention. As shown in FIG. 4 , in some embodiments, the balance part 32 may include a support frame 322, a bearing 326 and an annular transmission belt 327, wherein, The support frame 322 is fixed to the main body 1 , at least two bearings 326 are fixed to the support frame 322 , an annular transmission belt 327 is sleeved on the two bearings 326 , and the annular transmission belt 327 is detachably connected to the fixed portion 31 and the second counterweight 328 . Before the specific operation, the weight of the second counterweight 328 is configured to be the same as the set amount of the solution of the sample to be detected in the reaction vessel 2 that needs to be added. The position of the second counterweight 328 remains unchanged until the set amount is reached in the reaction vessel 2 . When the weight of the solution of the sample to be detected in the reaction container 2 reaches the set amount, the reaction container 2 moves downward into the second accommodating tank 12 , and the second counterweight 328 moves upward with the endless conveyor belt 327 . By changing the position of the second weight 328 and/or the reaction container 2, the operator can determine that the weight of the solution of the sample to be detected in the reaction container 2 has reached the above-mentioned set amount.

In addition to the balance portion 32 using the lever principle in the foregoing embodiment, the present embodiment also provides a balance portion 32 , which uses a combination of a bearing 326 and an endless transmission belt 327 to change the direction of force. As shown in FIG. 4 , two bearings may be provided on the same side of the upper and lower ends of the support frame 322 . Since the total weight of the reaction reagent, the sample solution to be detected and the reaction container 2 is relatively small, the bearing 326 of this embodiment can preferably use a roller bearing or a ball bearing to reduce the reaction sensitivity of the friction force between the inner ring and the outer ring in the sliding bearing. Impact. By using the balance part 32 of this embodiment, the opening of the reaction vessel 2 can be kept vertically upward all the time, and the space occupied is small when the above-mentioned second angle adjusting member 325 is omitted.

In order to further accurately record the quantity of the sample to be detected, a counting component 4 can be provided in the main body 1 to record the number of drops of the sample solution to be detected, wherein one drop represents a human nucleic acid sample solution to be detected. FIG. 6 is a schematic structural diagram of an embodiment of a body; FIG. 8 is a schematic structural diagram of another embodiment of a body; and FIG. 11 is a schematic structural diagram of another embodiment of the body. As shown in FIG. 6 , FIG. 8 and FIG. 11 , the liquid adding auxiliary device of this embodiment may further include a counting assembly 4 , and the counting assembly 4 can be matched with the first accommodating grooves 11 one by one and connected to the body 1 . The counting component 4 of this embodiment can be used to record the number of samples to be tested placed in the reaction container 2 . Wherein, each time a sample to be detected is added into the reaction container 2, the counting component 4 is used for counting to determine the quantity of the sample to be detected that has been added into the corresponding reaction container 2, so as to avoid the operator from mixing up the same reaction container 2. The same sample to be tested is added repeatedly, or the sample to be tested is omitted, or the sample to be tested is added by mistake, which improves the accuracy of sample addition during the detection process.

FIG. 7 is a schematic structural diagram of an embodiment of the lever. With reference to FIGS. 6 and 7 , in some embodiments, the counting assembly 4 may include a lever 41 and an arc-shaped counting plate 42 , wherein a circle close to the counting plate 42 The arc edge is sequentially provided with integer numbers 10 at equal intervals, the lever 41 is provided with a first through hole 411, the size of the first through hole 411 matches the integer number 10, the lever 41 moves, and the first through hole 411 selects an integer in sequence Number 10.

In this embodiment, the body 1 may be provided with a step near the first accommodating groove 11 for fixing the counter board 42 and the lever 41 . In this embodiment, the lever 41 can be rotatably connected to the counting plate 42, and a plurality of integer numbers 10 arranged in sequence can be arranged at equal angular intervals on the counting plate 42 near the arc edge, wherein the number of integer numbers 10 It can be set according to the number of samples to be detected added to the reaction vessel 2, which can be the same as the number of samples to be detected added to the reaction vessel 2, or it can be greater than the number of samples to be detected added to the reaction vessel 2. The embodiments are not specifically limited herein. In the process of using the liquid adding auxiliary device of the present embodiment, each time a sample to be detected is added into the reaction vessel 2, the lever 41 is toggled once in a predetermined order, so that the first through holes 411 provided on the lever 41 are exposed adjacent to each other. , repeat the above operation until the set number of samples to be detected are added into the reaction vessel 2 and stop.

In this embodiment, the order of the numbers arranged on the counting board 42 may be gradually increased in a clockwise direction, for example, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or Gradually decrease in a clockwise direction, such as 9, 8, 7, 6, 5, 4, 3, 2, 1, 0, etc. It can also be A, B, C, D, E, F, G, H, or I, II, III, IV, V, VI, VII, VIII, IX, etc. Wherein, the position where the integer number 10 is 0 may be the initial position, which is used to indicate that the reaction container 2 corresponding to the counter plate 42 has not yet added the sample to be detected. In another example, the position 9 in the previous example can be used as the starting position, the number of samples to be tested added in the reaction vessel 2 increases, and the number exposed through the first through hole 411 on the counting plate 42 gradually decreases. The order in which the integer number 10 is arranged is not specifically limited in this embodiment. In other embodiments, a plurality of dot clusters may be provided on the counter plate 42 to represent numbers. Or set circles with different colors to represent different numbers, but the operator needs to memorize the corresponding relationship between colors and numbers.

In some embodiments, the counting plate 42 is provided with an elastic blocking member 43, the elastic blocking member 43 is matched with the integer number 10 one by one, and the elastic blocking member 43 is used to limit the movement of the lever 41 toward the adjacent integer number 10 when no external force acts . The protruding counting plate 42 is provided with a movable shaft 421 , and the lever 41 is rotatably connected with the counting plate 42 . In this embodiment, the movable shaft 421 can limit the axial movement of the shift rod 41 along the movable shaft 421 , but does not limit the rotation of the shift rod 41 along the circumferential direction of the movable shaft 421 . An elastic blocking member 43 is protruded next to each integer number 10 on the counting plate 42 . When the lever 41 is not under the action of external force, the elastic blocking member 43 can stop the rotation of the lever 41 along the circumferential direction of the movable shaft 421; when the operator exerts force on the lever 41, the lever 41 pushes the elastic blocking member 43 to make the elastic blocking member 43 elastic. The stopper 43 is deformed, and the lever 41 is moved to the position of the adjacent number, indicating that the addition operation of the number of samples to be detected corresponding to the next integer number is completed.

In this embodiment, through the cooperation of the movable shaft 421 and the elastic stopper 43, the lever 41 can stay at the position corresponding to a certain integer number 10, so as to avoid being transferred to the position of other integer numbers 10 by its own gravity, resulting in confusion in the number of samples to be tested. . In addition, through the cooperation of the movable shaft 421 and the elastic block 43, the operator can be free to deal with other matters for a period of time, which avoids the operator's operation of counting by holding the lever 41 all the time, and provides convenience for the operator to count.

In some embodiments, referring to FIG. 8 , the counting assembly 4 may include a hollow tube 44 and a rotating shaft 45 , and a part of the rotating shaft 45 is placed in the hollow tube 44 , wherein a second through hole 441 is provided through the wall of the hollow tube 44 , The integer number 10 is arranged in sequence along the circumferential direction of the rotating shaft 45 at equal intervals, the rotating shaft 45 rotates, and the second through hole 441 selects the integer number 10 in a frame. The operator can determine the number of samples to be tested that have been added by the integer number 10 selected by the box, or the next sample to be added to be tested is the number of times to add samples to be tested.

Further, in some embodiments, the hollow tube 44 is fixedly connected to the body 1 , and the rotating shaft 45 is rotatably connected to the body 1 . In this embodiment, except for the second through hole 441 , the hollow tube 44 is used to shield the part of the rotating shaft 45 connected to the main body 1 and other numbers except the integer number 10 that exposes the second through hole 441 . In one example, the hollow tube 44 and the rotating shaft 45 are both perpendicular to the side surface of the main body 1, so that the operator can observe the integer number 10 exposed by the second through hole 441 from above or obliquely above it to determine the number of samples to be added to be tested. Provides convenience to operators.

In some embodiments, FIG. 9 is a schematic structural diagram of another embodiment of the body; FIG. 10 is a partial perspective structural schematic diagram of the A region. As shown in FIG. 9 and FIG. 10 , the main body 1 of this embodiment may be provided with accommodating holes 13, and the number of the accommodating holes 13 and the first accommodating slots 11 match; the counting assembly 4 may include a counting bar 46 and an elastic member 47, Among them, gaps 461 are arranged at equal intervals along the length direction of the counting bar 46, and integer numbers 10 are arranged at equal intervals along the length direction of the counting bar 46, and the gaps 461 are arranged between two adjacent integer numbers 10; the elastic member 47 is movably connected The main body 1 is used for cooperating with the notch 461 to restrict the movement of the counting bar 46 when the counting bar 46 has no external force.

In this embodiment, the accommodating holes 13 are matched with the first accommodating grooves 11 one by one, and the length direction of the accommodating holes 13 may be the direction of the first accommodating groove 11 toward the matching second accommodating groove 12 . The counting bar 46 can extend into the accommodating hole 13 , and leave a part at the opening of the accommodating hole 13 , and this part is used for the operator to manually pull the counting bar 46 out of the accommodating hole 13 one by one. When the counting bar 46 is gradually pulled out of the accommodating hole 13 , the nearest number that is exposed from the accommodating hole 13 and is close to the main body 1 can be identified as the number of samples to be detected.

Before specific use, the entire counting bar 46 can be inserted into the accommodating hole 13, and only the part for the operator to hold is left. After adding the sample to be detected once in the reaction vessel 2, the operator can pull the counting bar 46 to expose the part of the counting bar 46 where the integer number 10 is 1, indicating that a sample to be detected has been added to the reaction vessel 2, so as to By analogy, until a predetermined number of samples to be detected are added into the reaction vessel 2 .

The elastic members 47 are arranged on the main body 1 and are arranged at equal intervals along the length direction of the accommodating hole 13 , and a notch 461 matching the elastic member 47 is provided on one side of the counting bar 46 . In this embodiment, the cooperation between the elastic member 47 and the notch 461 can keep the counting bar 46 and the main body 1 in a relatively static state to a certain extent. When the operator pulls the counting bar 46, the elastic member 47 can retract, so that the counting bar 46 can be pulled by the operator. When the next notch 461 is reached, the elastic member 47 stretches when it encounters a large space, making a collision sound, and the operator stops pulling the counting bar 46. The elastic member 47 cooperates with the notch 461 to keep the counting bar 46 when there is no external force applied by the operator. The portion that is pulled out of the receiving hole 13 remains unchanged, providing the operator with the exact integer number 10.

In one example, the elastic member 47 may be an assembly of a triangular rigid plate and a spring as shown in FIG. 10 , or a combination of a triangular rigid plate and an elastic rubber strip, which is not specifically limited in this embodiment. Matching with the triangular hard plate of the elastic member 47 , the notch 461 on the counting bar 46 can also be triangular. The hypotenuse of the counting bar 46 at the notch 461 cooperates with the hypotenuse of the triangular hard plate of the elastic member 47 , which not only plays a certain blocking role, but also reduces the force required by the operator to pull the counting bar 46 .

In some embodiments, the counting bar 46 may be a disposable consumable, and the thickness of the counting bar 46 at the notch 461 is smaller than that of other parts. It is convenient for the operator to break off the part of the integer number 10 corresponding to the number of samples to be detected, which can further avoid the interference of the used integer number 10 on the counting bar 46 with the currently used integer number 10 .

In some embodiments, the elastic members 47 can be arranged in various manners. The elastic members 47 can be arranged opposite to each other along the length direction of the accommodating hole 13 . In other embodiments, as shown in FIG. 10 , the elastic member 47 may be disposed on one side of the counting bar 46 . In one example, the width of one end of the counting bar 46 extending into the accommodating hole 13 can be gradually reduced to a predetermined value. It is convenient for the operator to insert the counting bar 46 into the accommodating hole 13 during the preparation process.

FIG. 11 is a schematic structural diagram of another embodiment of the body. As shown in FIG. 11 , in some embodiments, the counting assembly 4 may include a display screen 48 and a button 49 . The display screen 48 and the button 49 are detachably connected to the body 1 , and the button 49 It is electrically connected to the display screen 48 , wherein the display screen 48 is used to display the integer number 10 , and the button 49 is used to control the display screen 48 to display the integer number 10 . In this embodiment, the display screen 48 and the button 49 can be arranged on the main body 1 close to the first accommodating slot 11 , wherein the display screen 48 is located between the button 49 and the first accommodating slot 11 , which is convenient for the operator to quickly observe to the integer number 10 on the display.

The button 49 may include an increment button 491 and a return button 492, wherein the increment button 491 and the return button 492 can be matched with the first accommodating slot 11 to be flexibly connected to the body 1 in pairs, and the increment button 491 is used to control the display screen 48 by pressing the increment button 491. The displayed integer number 10 is incremented continuously, and the reset button 492 is used to control the display screen 48 to display 0. Press the increment button 491 to sequentially increment the integer number 10 displayed on the display screen 48 until the sample to be tested added in the reaction vessel 2 increases to the preset number, and then press the return button 492 .

Due to the large number of samples to be tested added into the reaction vessel 2, the frequency of use of the increment button 491 is higher than that of the return button 492. Therefore, the return button 492 can be set between the increment button 491 and the first accommodating slot 11. The increment button 491 is close to the edge position of the main body 1, so that the increment button 491 can be effectively avoided to be set between the return button 492 and the first accommodating slot 11, and the wrong pressing caused by the small operation space can be avoided. . Setting the return button 492 between the increment button 491 and the first accommodating slot 11 can leave a larger operating space for the increment button 491 that is pressed multiple times, and reduce the probability of the operator pressing the wrong button.

In the above embodiment, the body 1 shown in FIG. 6 , FIG. 8 and FIG. 11 can respectively match the metering assembly 3 shown in FIGS. The weight of the liquid achieves metering. The counting component 4 can count the reaction reagents added to the reaction container 4 and the sample solution to be detected, and can be applied to the addition process of the mixed reaction solution. For example, two drops of the reaction reagent a and five drops of the reaction reagent b are added to the reaction container 2. , or add ten drops of solutions of samples to be detected by different sampling personnel into the reaction container 2 . The metering component 3 cooperates with the counting component 4 to determine not only the total weight of the reaction vessel 2 and the internal liquid by the preset amount, but also the number of drops of the solution added to the reaction vessel 2, which further enhances the accuracy of the addition amount of the sample to be detected. properties and the accuracy of the amount of reagents added for nucleic acid detection.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims (15)

1. A liquid feeding auxiliary device, characterized by comprising:

the sample detection device comprises a body (1) and a detection device, wherein the body (1) is provided with a plurality of first accommodating grooves (11) and a plurality of second accommodating grooves (12) which are respectively matched with the first accommodating grooves (11), the second accommodating grooves (12) are respectively used for accommodating reaction reagents, and the first accommodating grooves (11) are used for accommodating reaction containers (2) for mixing the reaction reagents and a plurality of samples to be detected;

metering component (3), with first storage tank (11) match, including fixed part (31) and balancing part (32), fixed part (31) with balancing part (32) swing joint, fixed part (31) are used for dismantling the connection reaction vessel (2), balancing part (32) are used for the configuration to set for the weight, each reactant in reaction vessel (2) reaches with a plurality of weight of waiting to detect the sample set for after the weight, reaction vessel (2) fall into in first storage tank (11).

2. The auxiliary device according to claim 1, wherein the balancing unit (32) comprises a first angle limiting unit (321), a supporting frame (322), and a lever (323), wherein the supporting frame (322) is fixed to the body (1), the first angle limiting unit (321) is fixedly connected to the supporting frame (322), the lever (323) is rotatably connected to the first angle limiting unit (321), the first angle limiting unit (321) is used to limit the angle range of the lever (323) to deflect, a first counterweight (324) is movably connected to one side of the first angle limiting unit (321) of the lever (323), and the lever (323) is movably connected to the fixing unit (31) at the other side of the first angle limiting unit (321).

3. A liquid feeding aid according to claim 2, characterized in that said balancing member (32) further comprises a second angle limiting member (325), said second angle adjusting member (325) is fixedly connected to one end of said lever (323), said fixing member (31) is rotatably connected to said angle adjusting member (325) at one end and detachably connected to said reaction vessel (2) at the other end.

4. The auxiliary device according to claim 3, wherein the second angle limiting member (325) comprises a limiting plate (3251), a rotating shaft (3252) and a limiting plate (3253), wherein the two limiting plates (3251) are parallel to each other and are fixedly connected to the lever (323), the rotating shaft (3252) is disposed between the two limiting plates (3251), and the limiting plate (3253) is fixedly connected to the fixing portion (31) and is rotatably connected to the rotating shaft (3252).

5. The auxiliary device as claimed in claim 1, wherein the balancing unit (32) comprises a supporting frame (322), bearings (326) and a belt (327), wherein the supporting frame (322) is fixed to the body (1), at least two of the bearings (326) are fixed to the supporting frame (322), the belt (327) is sleeved on the two bearings (326), and the belt (327) is detachably connected to the fixing unit (31) and the second weight (328).

6. A filling aid according to any one of claims 1 to 5, characterized in that it further comprises a counting assembly (4) fitted one-to-one with said first receiving groove (11) and connected to said body (1) for recording the number of samples to be tested inserted in said first receiving groove (11).

7. The liquid adding auxiliary device according to claim 6, characterized in that the counting assembly (4) comprises a shifting lever (41) and a circular arc-shaped counting plate (42), wherein integer numbers (10) are sequentially arranged at equal intervals near the circular arc edge of the counting plate (42), the shifting lever (41) is provided with a first through hole (411), the size of the first through hole (411) is matched with the integer numbers (10), the shifting lever (41) moves, and the first through hole (411) sequentially frames the integer numbers (10).

8. Liquid filling aid according to claim 7, characterized in that said counting plate (42) is provided with elastic stops (43), said elastic stops (43) matching said integer numbers (10) one to one, said elastic stops (43) being adapted to limit the movement of said deflector rod (41) towards the adjacent integer numbers (10) when no external force is applied.

9. The auxiliary device for filling liquid according to claim 8, wherein a movable shaft (421) is provided to protrude from said counting plate (42), and said deflector rod (41) is rotatably connected to said counting plate (42).

10. The liquid adding auxiliary device according to claim 6, characterized in that the counting assembly (4) comprises a hollow tube (44) and a rotating shaft (45), part of the rotating shaft (45) is arranged in the hollow tube (44), wherein a second through hole (441) is arranged through the wall of the hollow tube (44), integer numbers (10) are sequentially arranged at equal intervals along the circumference of the rotating shaft (45), the rotating shaft (45) rotates, and the integer numbers (10) are framed by the second through hole (441).

11. A filling aid according to claim 10, characterized in that said hollow tube (44) is fixedly connected to said body (1) and said shaft (45) is rotatably connected to said body (1).

12. The filling aid according to claim 6, characterized in that said body (1) is provided with containing holes (13), said containing holes (13) matching in number said first containing grooves (11); the counting assembly (4) comprises a counting strip (46) and an elastic piece (47), wherein gaps (461) are arranged at equal intervals along the length direction of the counting strip (46), integer numbers (10) are sequentially arranged at equal intervals along the length direction of the counting strip (46), and the gaps (461) are arranged between two adjacent integer numbers (10); elastic component (47) swing joint body (1) is used for under counting strip (46) do not have the exogenic action cooperation breach (461) restriction the motion of counting strip (46).

13. The auxiliary device as claimed in claim 12, wherein the elastic members (47) are disposed opposite to each other in pairs along the length direction of the receiving groove (13), and the notches (461) matching with the elastic members (47) are disposed on both sides of the counting bar (46).

14. Liquid filling aid according to claim 6, characterized in that the counting assembly (4) comprises a display screen (48) and a button (49) and is removably connected to the body (1), the button (49) being electrically connected to the display screen (48), wherein the display screen (48) is adapted to display an integer number (10) and the button (49) is adapted to control the display of the integer number (10) of the display screen (48).

15. The liquid adding auxiliary device according to claim 14, wherein said button (49) comprises an increment button (491) and a return button (492), wherein said increment button (491) and said return button (492) are matched with said first receiving groove (11) in a pairwise manner to movably connect said body (1), pressing said increment button (491) is used for controlling said integer number (10) displayed by said display screen (48) to continuously increment, and said return button (492) is used for controlling said display screen (48) to display 0.

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