CN114601632A

CN114601632A - Preparation method of medical cold compress bandage

Info

Publication number: CN114601632A
Application number: CN202210202863.1A
Authority: CN
Inventors: 戚平忠
Original assignee: Shaoxing Meiqi Medical Technology Co ltd
Current assignee: Shaoxing Meiqi Medical Technology Co ltd
Priority date: 2022-03-02
Filing date: 2022-03-02
Publication date: 2022-06-10
Anticipated expiration: 2042-03-02
Also published as: CN114601632B

Abstract

The invention discloses a preparation method of a medical cold compress bandage, which comprises the following steps: (a) preparing an impregnation liquid; according to the mass percentage, the steeping liquid comprises 0.1 to 0.5 percent of menthol, 0.5 to 2 percent of borneol, 20 to 40 percent of alcohol, 5 to 10 percent of propylene glycol, 0.5 to 2 percent of polyethylene glycol, 0.5 to 2 percent of tween, 0.01 to 0.5 percent of sodium carboxymethylcellulose and the balance of water; (b) and (3) sterilizing the packaging bag: sterilizing the packaging bag with the bandage by adopting an electron irradiation sterilization or ozone sterilization method; (c) filling: quantitatively filling the impregnation liquid into a sterilized packaging bag with a bandage by using a filling machine, and then sealing the packaging bag to obtain a finished product. The product of the invention has the functions of cooling, cold compress and inflammation diminishing, can reduce burning pain and is beneficial to promoting the healing of wounds.

Description

Preparation method of medical cold compress bandage

Technical Field

The invention relates to the technical field of medical dressings, in particular to a preparation method of a medical cold compress bandage.

Background

Bandages are widely used as daily care tools due to a variety of types. The effective cold compress can reduce the excitability of nerves and the conduction speed, can reduce the sensitivity of a patient to pain, can change local microcirculation, effectively relieve swelling and pain, can also cause vasoconstriction of the wound part, and inhibit the release of inflammatory transmitters and the permeability of capillaries, thereby controlling the swelling and exudation of local tissues, effectively inhibiting the diffusion of inflammation, improving the treatment effect of a surgical patient, and reducing the occurrence of surgical complications. However, when a cooling device such as a general ice bag is used, a patient needs to hold the ice bag with his/her hands or temporarily remove the ice bag during exercise and turning, which causes great inconvenience in exercise.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a preparation method of a medical cold compress bandage, which has the functions of cooling, cold compress and inflammation diminishing, can reduce burning pain and is beneficial to promoting the healing of wounds.

In order to achieve the purpose, the invention adopts the following technical scheme:

a preparation method of a medical cold compress bandage comprises the following steps:

(a) preparing an impregnation liquid: putting menthol, borneol and alcohol into a mixing device, stirring and dissolving at room temperature, uniformly mixing the obtained first mixed solution with propylene glycol, polyethylene glycol and tween to obtain a second mixed solution, uniformly mixing the second mixed solution with water, then adding sodium carboxymethylcellulose, and continuously and fully mixing to obtain a steeping liquor; in the step (a), the first mixed solution is stirred and mixed for 5-10min, the second mixed solution is stirred and mixed for 5-10min, and the stirring and mixing time after adding water and sodium carboxymethyl cellulose is 25-40 min;

according to the mass percentage, the steeping liquid comprises 0.1 to 0.5 percent of menthol, 0.5 to 2 percent of borneol, 20 to 40 percent of alcohol, 5 to 10 percent of propylene glycol, 0.5 to 2 percent of polyethylene glycol, 0.5 to 2 percent of tween, 0.01 to 0.5 percent of sodium carboxymethylcellulose and the balance of water;

(b) and (3) sterilizing the packaging bag: sterilizing the packaging bag with the bandage by adopting an electron irradiation sterilization or ozone sterilization method for later use;

(c) filling: quantitatively filling the impregnation liquid into a sterilized packaging bag with a bandage by using a filling machine, and then sealing the packaging bag to obtain a finished product.

The weight ratio of the impregnation liquid to the bandage in the finished product is 2: 1.

The impregnation liquid comprises 0.2-0.3% of menthol, 0.7-1.8% of borneol, 32-40% of alcohol, 8-9.6% of propylene glycol, 0.5-1% of polyethylene glycol, 1-2% of tween, 0.2-0.4% of sodium carboxymethylcellulose and the balance of water.

The tween is one of tween 20, tween 60 or tween 80.

Mixing arrangement includes frame, stirring rake, adorns cyclic annular support piece in the frame admittedly, sets up the upper tank body and the lower tank body in the frame from top to bottom, support piece includes runner and the annular feed liquor chamber of upper and lower intercommunication, down the jar body transverse rotation pass support piece and down jar internal chamber and feed liquor chamber be linked together, the horizontal slip inlays in the support piece and is equipped with the sealing member, the sealing member is used for communicateing or cutting off runner middle part, the upper tank body includes the liquid outlet, the upper tank body is in support piece top and the liquid outlet stretches into runner upper port, stirring rake longitudinal rotation passes the upper tank body, support piece upper portion and stretches into down the jar body behind the feed liquor chamber.

The sunken feed liquor chamber that forms of support piece annular inner wall, the jar body is including the relative A jar portion and the B jar portion that set up down, A jar portion and B jar portion rotate with support piece respectively and are connected, leave the clearance between shown A jar portion and B jar portion and form the annular of intercommunication with the feed liquor chamber and connect the chamber.

The flow channel comprises a transverse second channel formed by sinking one side wall at the upper part of the supporting piece, a first channel formed by sinking the upper surface of the supporting piece and communicated with the second channel up and down, and a third channel formed by sinking the inner wall at the upper part of the liquid inlet cavity, wherein the inner side of the second channel is communicated with the third channel.

The sealing element is embedded in the second channel through a sealing ring in a sealing mode, and the sealing element is driven to move through the air cylinder.

The upper part of the support piece is provided with a feed pipe which is communicated with the third channel, the lower part of the support piece is provided with a discharge pipe which is communicated with the liquid inlet cavity.

In the step (a), the first mixed solution and the second mixed solution are mixed in the upper tank body, and the second mixed solution, water and sodium carboxymethyl cellulose are mixed in the lower tank body.

The invention has the beneficial effects that: through reasonable preparation of the raw materials of the impregnation liquid and by utilizing the synergistic effect of the menthol and the borneol, the bandage has the effects of cooling, cold compress and inflammation diminishing, reduces burning pain and is beneficial to promoting the healing of wounds; meanwhile, through the improved design of the mixing device, the mixing and homogenizing effects are improved

Drawings

FIG. 1 is a block diagram of a mixing device according to the present invention;

FIG. 2 is a schematic view of the mixing device of the present invention with the flow channels fully connected;

fig. 3 is a schematic structural diagram of the product of the invention.

In the figure: the device comprises a frame 1, an upper tank body 2, a liquid outlet 21, a lower tank body 3, a tank part A31, a tank part B32, a connecting cavity 33, a second motor 34, a stirring paddle 4, a first motor 41, a support piece 5, a flow passage 51, a first passage 511, a second passage 512, a third passage 513, a liquid inlet cavity 52, a feed pipe 53, a discharge pipe 54, a sealing piece 6, a cylinder 61, a bandage body 7, steeping liquor 8 and a packaging bag 9.

Detailed Description

The invention is further described with reference to the accompanying drawings and the detailed description below:

example 1

(a) preparing an impregnation liquid: putting Mentholum, Borneolum Syntheticum, and ethanol into mixing device, stirring at room temperature for dissolving, and stirring for 5 min; uniformly mixing the obtained first mixed solution with propylene glycol, polyethylene glycol and tween to obtain a second mixed solution, and stirring and mixing for 5 min; uniformly mixing the second mixed solution with water, adding sodium carboxymethylcellulose, and continuously and fully mixing to obtain an impregnation solution, wherein the mixing time is 30min to obtain the impregnation solution; according to the mass percentage, the steeping liquor comprises 0.3 percent of menthol, 0.5 percent of borneol, 35.8 percent of alcohol, 7.5 percent of propylene glycol, 1 percent of polyethylene glycol, 1 percent of tween, 0.2 percent of sodium carboxymethylcellulose and the balance of water; the tween is one of tween 20, tween 60 or tween 80.

(b) And (3) sterilizing the packaging bag: sterilizing the packaging bag with the bandage by adopting an electron irradiation sterilization or ozone sterilization method for later use.

(c) Filling: quantitatively filling the impregnation liquid into a sterilized packaging bag with a bandage by using a filling machine, and then sealing the packaging bag to obtain a finished product. The structure of the obtained medical cold compress bandage product is shown in figure 3.

Examples 2 to 10

The medical cold compress bandage is produced according to the method of example 1 and the proportion and preparation conditions shown in table 1. The Tween used in the embodiments 2-10 is one of Tween 80, Tween 60, Tween 20 and Tween 60 in sequence

TABLE 1

Comparative example 1

The medical cold compress bandage is produced according to the method, the proportion and the process conditions of the example 5, and the difference is that the menthol is not added.

Comparative example 2

The medical cold compress bandage is produced according to the method, the proportion and the process conditions of the embodiment 5, and the difference is that borneol is not added.

Antibacterial property and clinical efficacy tests were performed on the medical cold compress bandages prepared in examples 1-10 and comparative examples 1-2 (360 patients of the same type were randomly selected and divided into 12 groups of 30 patients each using the bandage prepared in the same example or comparative example to test efficacy), and the results are shown in table 2, which indicates that the compound of menthol and borneol of the impregnation liquid of the present invention has synergistic antibacterial and healing efficacy enhancing effects.

TABLE 2

The impregnation liquid is prepared from multi-component raw materials, the stirring mode of a mixing device used in the processing and production process of the impregnation liquid is single at present, the problem of uneven mixing of the impregnation liquid exists, the uniform mixing can be completed only by long-time stirring, the production efficiency is reduced, and the effect of the bandage after impregnation liquid is soaked is also influenced.

As shown in fig. 1-2, the mixing device used in the production of the medical cold compress bandage according to the embodiment of the present invention includes a frame 1, a stirring paddle 4, an annular support member 5 fixedly installed in the frame 1, and an upper tank 2 and a lower tank 3 vertically installed on the frame 1, wherein the support member 5 includes a flow passage 51 and an annular liquid inlet cavity 52 which are vertically communicated, the lower tank 3 transversely rotates to pass through the support member 5, an inner cavity of the lower tank 3 is communicated with the liquid inlet cavity 52, a sealing member 6 is transversely slidably embedded in the support member 5, the sealing member 6 is used for communicating or blocking the middle of the flow passage 51, the upper tank 2 includes a liquid outlet 21, the upper tank 2 is located above the support member 5, the liquid outlet 21 extends into an upper port of the flow passage 52, and the stirring paddle 4 longitudinally rotates to pass through the upper portions of the upper tank 2 and the support member 5 and extends into the lower tank 3 after passing through the liquid inlet cavity 52. The paddle 4 is driven to rotate by a first motor 41.

Support piece 5 annular inner wall is sunken to form feed liquor chamber 52, jar body 3 is including the relative A jar portion 31 and the B jar portion 32 that set up down, A jar portion 31 and B jar portion 32 rotate with support piece 5 respectively and are connected, leave the clearance and form the annular of feed liquor chamber 52 intercommunication and connect the chamber 33 between shown A jar portion 31 and B jar portion 32. The a tank portion 31 and the B tank portion 32 are also sealed with the support 5 by a gasket. The a tank part 31 and the B tank part 32 are each driven to rotate in the same direction by a second motor 34. When the A tank part 31 and the B tank part 32 are led to rotate, the liquid inlet cavity 52 is always communicated with the inner cavity of the lower tank body 3.

The flow passage 51 comprises a transverse second passage 512 formed by recessing one side wall of the upper part of the support 5, a first passage 511 formed by recessing the upper surface of the support 5 and communicated with the second passage 512 up and down, and a third passage 513 formed by recessing the inner wall of the upper part of the liquid inlet cavity 52, wherein the inner side of the second passage 512 is communicated with the third passage 513. The first passage 511, the second passage 512, and the third passage 513 constitute a transverse Z-shaped flow passage 51. In practice, the support member 5 comprises an annular main body portion and an abutting portion formed by an upper surface projection of the main body portion, the upper tank 2 is crimped on the abutting portion, and the liquid outlet 21 extends into the first passage 511. The sealing element 6 is embedded in the second channel 512 through two sealing rings, and the sealing element 6 is driven to move by the air cylinder 61. Two sealing rings are embedded on the sealing element 6, when the sealing element 6 cuts off the flow passage 51, the two sealing rings are respectively positioned at two sides of the lower end of the first passage 511 to realize sealing, and when the sealing element 6 moves outwards, one sealing ring positioned at the inner side is sealed with the outer side of the second passage 512.

The upper portion of the support piece 5 is provided with a feeding pipe 53, the feeding pipe 53 is communicated with the third channel 513, the lower portion of the support piece 5 is provided with a discharging pipe 54, the discharging pipe 54 is communicated with the liquid inlet cavity 52, and by means of the structural design, circumferential rotation of the lower tank body 3 can be guaranteed without influencing feeding and discharging.

In the step a, the first mixed solution and the second mixed solution are mixed in the upper tank body 2, and the second mixed solution, water and sodium carboxymethyl cellulose are mixed in the lower tank body 3.

The specific process for preparing the impregnation liquid by adopting the mixing device is as follows: at the beginning, the sealing element 6 cuts off the flow passage 51, and the menthol, the borneol and the alcohol are put into the upper tank body 2 and stirred and dissolved at room temperature; adding propylene glycol, polyethylene glycol and tween, and uniformly mixing the obtained first mixed solution with the propylene glycol, the polyethylene glycol and the tween to obtain a second mixed solution; the first motor 41 drives the sealing element 6 to move outwards to enable the flow channel 51 to be completely communicated, a second mixed liquid is discharged and enters the inner cavities of the tank part A31 and the tank part B32 through the liquid outlet 21, the flow channel 51 and the liquid inlet cavity 52, and the flow channel 51 is blocked by the sealing element 6 after the second mixed liquid is discharged; adding water into the lower tank 3 through the feed pipe 53 for mixing, and adding sodium carboxymethyl cellulose into the lower tank 3 through the feed pipe 53 for mixing; when the mixing is carried out in the lower tank body 3, the mixing of menthol, borneol, alcohol, propylene glycol, polyethylene glycol and tween can be carried out in the upper tank body 2, thus saving the production time.

According to the mixing device, the stirring paddle 4 capable of rotating horizontally and the lower tank body 3 capable of rotating vertically and circumferentially are arranged, so that materials in the lower tank body 3 can be stirred horizontally and circumferentially and vertically and circumferentially at the same time, and the mixing and homogenizing effects are effectively improved; and through the cooperation design of the upper tank body 2, the lower tank body 3, the supporting piece 5 and the stirring paddle 4, the separation and synchronous stirring of the premix and the final mixed liquid are realized, and the production time is favorably shortened. A traditional mixing and stirring device is adopted to prepare impregnation liquid, the bandage is prepared according to the method in the embodiment 1, and performance tests are carried out, compared with the embodiment 1, the antibacterial rate of escherichia coli is reduced by 3.2%, the antibacterial rate of candida albicans is reduced by 1.7%, the antibacterial rate of staphylococcus aureus is reduced by 2.4%, and the number of people with the wound basically healed is reduced by 5 in the same time.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A preparation method of a medical cold compress bandage is characterized by comprising the following steps:

(a) preparing an impregnation liquid: putting menthol, borneol and alcohol into a mixing device, stirring and dissolving at room temperature, uniformly mixing the obtained first mixed solution with propylene glycol, polyethylene glycol and tween to obtain a second mixed solution, uniformly mixing the second mixed solution with water, then adding sodium carboxymethylcellulose, and continuously and fully mixing to obtain a steeping liquor;

2. A method of preparing a medical cold compress bandage according to claim 1, in which the weight ratio of impregnating solution to bandage in the finished product is 2: 1.

3. The method of claim 1, wherein the soaking solution comprises menthol 0.2-0.3%, borneol 0.7-1.8%, alcohol 32-40%, propylene glycol 8-9.6%, polyethylene glycol 0.5-1%, tween 1-2%, sodium carboxymethylcellulose 0.2-0.4%, and water in balance.

4. The method of claim 1, wherein tween is tween 20, tween 60 or tween 80.

5. The preparation method of a medical cold compress bandage as claimed in claim 1, wherein the mixing device comprises a frame (1), a stirring paddle (4), an annular support member (5) fixedly mounted in the frame (1), an upper tank body (2) and a lower tank body (3) arranged on the frame (1) up and down, the support member (5) comprises a flow channel (51) and an annular liquid inlet cavity (52) which are communicated up and down, the lower tank body (3) transversely rotates to pass through the support member (5) and the inner cavity of the lower tank body (3) is communicated with the liquid inlet cavity (52), a sealing member (6) is transversely slidably embedded in the support member (5), the sealing member (6) is used for communicating or separating the middle part of the flow channel (51), the upper tank body (2) comprises a liquid outlet (21), the upper tank body (2) is positioned above the support member (5) and the liquid outlet (21) extends into the upper port of the flow channel (52), the stirring paddle (4) longitudinally rotates to penetrate through the upper tank body (2) and the upper part of the supporting piece (5) and extends into the lower tank body (3) after passing through the liquid inlet cavity (52).

6. A method for preparing a medical cold compress bandage according to claim 5, characterized in that the annular inner wall of the support member (5) is recessed to form a liquid inlet chamber (52), the lower cup (3) comprises an A cup part (31) and a B cup part (32) which are oppositely arranged, the A cup part (31) and the B cup part (32) are respectively and rotatably connected with the support member (5), and a gap is left between the A cup part (31) and the B cup part (32) to form an annular connecting chamber (33) which is communicated with the liquid inlet chamber (52).

7. A method for preparing a medical cold compress bandage, as claimed in claim 5, characterized in that the flow channel (51) comprises a transverse second channel (512) formed by a recess in the upper side wall of the support (5), a first channel (511) formed by a recess in the upper surface of the support (5) and communicating with the second channel (512) up and down, and a third channel (513) formed by a recess in the upper side wall of the liquid inlet chamber (52), the inner side of the second channel (512) communicating with the third channel (513).

8. A method for preparing a medical cold compress bandage according to claim 7, characterized in that the sealing element (6) is sealingly embedded in the second channel (512) by means of a sealing ring (61), and the sealing element (6) is driven in motion by means of a cylinder (62).

9. A method for preparing a medical cold compress bandage according to claim 7, characterized in that the support (5) is provided with a feed pipe (53) at the upper part, the feed pipe (53) is connected to the third channel (513), the support (5) is provided with a discharge pipe (54) at the lower part, and the discharge pipe (54) is connected to the inlet chamber (52).

10. The method for preparing a medical cold compress bandage according to claim 5, wherein in step (a), the first mixture and the second mixture are mixed in the upper pot (2), and the second mixture is mixed with water and sodium carboxymethyl cellulose in the lower pot (3).