CN114578080A - Multi-range sample injection device - Google Patents
Multi-range sample injection device Download PDFInfo
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- CN114578080A CN114578080A CN202210216637.9A CN202210216637A CN114578080A CN 114578080 A CN114578080 A CN 114578080A CN 202210216637 A CN202210216637 A CN 202210216637A CN 114578080 A CN114578080 A CN 114578080A
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- sample
- pipeline
- injection valve
- main channel
- main entrance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a multi-range sample injection device, which comprises an injection valve, a sample injection valve and a sample ring, wherein the injection valve is designed in a double-channel mode, a first main channel and a second main channel are arranged in the center of the injection valve, a plurality of first side channels or second side channels are arranged on the injection valve and correspond to the first main channel or the second main channel, the first side channels are respectively communicated with the first main channel, the second side channels are respectively communicated with the second main channel, the sample rings with different ranges are connected between the first side channels and the second side channels, the first main channel and the second main channel are respectively communicated with the sample injection valve through a first sample injection pipeline and a second sample injection pipeline, and the sample valve is also communicated with the sample pipeline, a reagent pipeline, a reaction pipeline and a waste liquid pipeline. The invention has the characteristics of stable sample introduction, accurate result, obviously accelerated test speed, low cost, simple operation process and the like, and can effectively save the test time.
Description
Technical Field
The invention relates to the technical field of flow analysis instruments, in particular to a multi-range sample injection device.
Background
At present, flow analyzers are generally classified into flow injection analyzers and continuous flow analyzers, and because of easy automation, flow analyzers are more and more accepted by analyzers and become one of the main analyzers in laboratories. Most of flow analysis in the current market adopts a photometric method for detection, the photometric method generally adopts an external standard method, a standard curve needs to be drawn, at the moment, a user needs to prepare a series of standard solutions through gradual dilution to calibrate an instrument, the work of preparing the standard solutions is not difficult, but needs 20-30 minutes to complete, the operation is complex and time-consuming, a plurality of volumetric flasks or pipettes need to be used, and if laboratory vessels are not cleaned completely, pollution is introduced, so that the experiment fails.
The commercial flow analyzer uses a proportional valve to prepare a standard curve online, but the error of dilution is sometimes large due to the response time problem of the proportional valve or the fatigue problem of a pump tube of a peristaltic pump, and the flow analyzer is not suitable for use when the requirement is high. Or for dilution of certain specific compounds, such as anionic surfactants, due to their specific chemical properties, lead to the presence of anionic surfactants adsorbed in the valve body of the proportional valve, resulting in a linear correlation coefficient of the standard curve that does not reach 0.999.
Disclosure of Invention
The invention aims to provide a sample injection device for a flow analyzer, which solves the problems of low manufacturing efficiency and large error in manufacturing a standard curve.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention relates to a multi-range sample injection device, which comprises an injection valve, a sample injection valve and a sample ring, wherein the injection valve is designed in a double-channel mode, a first main channel and a second main channel are arranged in the center of the injection valve, a plurality of first side channels or second side channels corresponding to the first main channel or the second main channel are arranged on the injection valve, the plurality of first side channels are respectively communicated with the first main channel, the plurality of second side channels are respectively communicated with the second main channel, the sample rings with different volumes are connected between the first side channels and the second side channels, the first main channel and the second main channel are respectively communicated with the sample injection valve through a first sample injection pipeline and a second sample injection pipeline, and the sample injection valve can be of an integral structure or a split structure.
Further, the sampling valve is overall structure, one of them opening on the overall structure passes through first kind pipeline with first main entrance, one of them opening on the overall structure passes through second kind pipeline with the opening of second main entrance is linked together, all the other openings on the sampling valve respectively with the sample pipeline the reagent pipeline the reaction line with waste liquid pipeline intercommunication.
Further, the injection valve is the components of a whole that can function independently structure, one of them opening of components of a whole that can function independently structure passes through first kind pipeline with first main entrance, structural wherein another opening of components of a whole that can function independently passes through second kind pipeline with the opening of second main entrance is linked together, all the other openings on the injection valve respectively with the sample pipeline the reagent pipeline the reaction line with waste liquid pipeline intercommunication.
Furthermore, first main entrance, second main entrance set up in the valve body on the circle circumference, and is a plurality of first bypass with the second bypass is circular array and is in first main entrance with the excircle circumference of second main entrance.
Compared with the prior art, the invention has the beneficial technical effects that:
the sample injection valve not only can be used for adjusting the measuring range of the flow injection analyzer, but also can be used for automatically preparing a working curve with a certain measuring range, and has high automation degree.
The invention can realize the full-automatic standard curve making of the sample, does not need to dilute the sample on line, has high automation degree and high working efficiency, and meets the requirement of customers for making the working curve quickly and accurately.
The invention has the characteristics of stable sample introduction, accurate result, obviously accelerated test speed, low cost, simple operation process and the like, and can effectively save the test time.
Drawings
The invention is further illustrated in the following description with reference to the drawings.
FIG. 1 is a schematic view of a fill valve;
FIG. 2 is a first embodiment of the present invention;
FIG. 3 is a second embodiment of the present invention;
FIG. 4 is a table of the low range measurement data for measuring total phosphorus concentration for different volume sample rings;
FIG. 5 is a graph of total phosphorus low concentration range test work;
FIG. 6 is a table of working data for measuring total phosphorus concentration ranges for different volume sample rings;
FIG. 7 is a graph showing the total phosphorus concentration range;
FIG. 8 is a graph of total phosphorus sample test results;
FIG. 9 is a table of data for the results of testing total phosphorus samples.
Description of the reference numerals: 1. an injection valve; 2. a first main channel; 3. a second main channel; 4. a first bypass; 5. a second bypass channel; 6. a sample loop; 7. a sample injection valve; 8. a first sample introduction pipeline; 9. a second sample introduction pipeline; 10. a reagent line; 11. a sample line; 12. a waste liquid line; 13. a reaction pipeline.
Detailed Description
As shown in fig. 2-3, a multi-range sample injection device comprises an injection valve 1, a sample injection valve 7 and a sample ring 6, wherein the injection valve 1 is designed in a dual-channel manner, a first main channel 2 and a second main channel 3 are arranged at the center of the injection valve 1, a plurality of first bypass channels 4 or second bypass channels 5 are arranged on the injection valve 1 corresponding to the first main channel 2 or the second main channel 3, the first bypass channels 4 are respectively communicated with the first main channel 2, the second bypass channels 5 are respectively communicated with the second main channel 3, the sample ring 6 with different volumes is connected between the first bypass channels 4 and the second bypass channels 5, the first main channel 2 and the second main channel 3 are respectively communicated with the sample injection valve 7 through a first sample injection pipeline 8 and a second sample injection pipeline 9, the sample injection valve 7 is also communicated with a sample pipeline 11, a reagent pipeline 10, a reaction pipeline 13 and a waste liquid pipeline 12.
Specifically, the sample injection valve 7 has two operating states, and is to send the sample into the sample ring 6 in the first operating state, will after the sample ring 6 is full of, unnecessary sample and washing liquid pass through waste liquid pipeline 12 discharges, and the second operating state is that the reagent will the sample in the sample ring 6 pushes in the reaction pipeline 13, passes through unnecessary sample and washing liquid simultaneously waste liquid pipeline 12 discharges.
In this embodiment, the sample injection valve 7 is communicated with the sample pipeline 11 and the first sample injection pipeline 8, a test sample solution enters the first main channel 2 through the first sample injection pipeline 8, the sample ring 6 with a specified volume is filled with the test sample solution through the first main channel 2, sample loading is completed, and redundant samples or cleaning solution is discharged through the second main channel 3 and the second sample injection pipeline 9 through the waste liquid pipeline 12; after the sample loop 6 is filled, switching valve paths, communicating the reagent line 10, the first sample introduction line 8, the sample loop 6, the second sample introduction line 9 and the reaction line 13 through the sample introduction valve 7, allowing a reagent to enter the first main channel 2 through the first sample introduction line 8, conveying the reagent to the sample loop 6 through the first main channel 2, pushing a sample solution in the sample loop 6 to enter the second main channel 3 through the reagent, allowing the sample solution to enter a flow analyzer through the second sample introduction line 9 and the reaction line 13 through the second main channel 3, wherein the sample line 11 of the sample introduction valve 7 is communicated with the waste liquid pipe 12, and directly discharging an excess sample or cleaning liquid through the waste liquid pipe 12; through automatic switch-over difference sample ring 6 can change the volume of advancing, is applicable to the application of different scenes, and need not manual switch-over sample ring 6 not only can be used to the range regulation of flow injection analysis appearance, can also be used to the working curve of configuration certain range.
Specifically, refer to fig. 2, an embodiment of injection valve 7, injection valve 7 is overall structure, the opening on the injection valve 7 communicates with each other for two liang, one of them opening on the overall structure passes through first kind pipeline 8 with first main entrance 2, one of them opening on the overall structure passes through second kind pipeline 9 with the opening of second main entrance 3 is linked together, all the other openings on the injection valve 7 respectively with sample pipeline 11 reagent pipeline 10 reaction pipeline 13 with waste liquid pipeline 12 communicates.
This embodiment simple structure, area is little, is convenient for concentrate and accomodates the pipeline.
Specifically, refer to fig. 3, an implementation of injection valve 7, injection valve 7 is the components of a whole that can function independently structure, one of them opening of components of a whole that can function independently structure passes through first introduction pipeline 8 with first main entrance 2, one of them opening of components of a whole that can function independently structure passes through second introduction pipeline 9 with the opening of second main entrance 3 is linked together, all the other openings on injection valve 7 respectively with sample pipeline 11 reagent pipeline 10 reaction pipeline 13 with waste liquid pipeline 12 communicates.
The fault tolerance of the using process is high, and irrecoverable results such as sample pollution and even damage to a detection instrument caused by misoperation are avoided.
Specifically, the first main channel 2 and the second main channel 3 are arranged on the circumference of the inner circle of the valve body, and the first bypass channel 4 and the second bypass channel 5 are arranged in a circular array on the circumference of the outer circle of the first main channel 2 and the second main channel 3.
The using process of the invention is as follows:
referring to fig. 1, the first main channel 2(m) communicates with one of the first bypass channels 4(f, g, h, i, j), the second main channel 3(n) communicates with a corresponding one of the second bypass channels 5(k, a, b, c, d, e), and sample rings 6 of different volumes are connected between the first bypass channel 4 and the second bypass channel 5.
Referring to fig. 2 or fig. 3, the injection valve 1, the injection valve 7 and the flow analyzer are installed as described above, so that the flow analyzer is provided with sample rings 6 with different volumes to realize the test of samples with different measuring ranges; it utilizes the mobile injection analysis appearance to cooperate the device to realize the full-automatic injection of different volume standard samples, and the test of standard curve is accomplished to cooperation instrument, need not to dilute the sample, through the different sample ring 6 of automatic switch-over, can change the sample volume, is applicable to the application of different scenes, and need not the manual sample ring 6 of switching-over.
The first embodiment of the invention, referring to fig. 4-9, in combination with a flow analyzer, tests total phosphorus in water are taken as an example, the volume of the sample ring 6 connected to the injection valve 1 is shown in fig. 4, the common working curve of low concentration range and the working curve of high concentration range are respectively tested by using 125ppb standard solution and 1000ppb standard solution, the linear correlation coefficient R of the working curve reaches 0.9998, and the relative error does not exceed 2%.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the scope of the present invention is defined by the claims.
Claims (4)
1. A multi-range sample injection device, characterized by: including injection valve (1), injection valve (7) and sample ring (6), injection valve (1) is the design of binary channels, the center of injection valve (1) is equipped with first main entrance (2) and second main entrance (3), be equipped with on injection valve (1) a plurality of with first main entrance (2) or corresponding first by-pass (4) or second by-pass (5) of second main entrance (3), a plurality of first by-pass (4) respectively with first main entrance (2) intercommunication, a plurality of second by-pass (5) respectively with second main entrance (3) intercommunication, be connected with different volumes between first by-pass (4), the second by-pass (5) sample ring (6), the first main entrance (2), the second main entrance (3) respectively through first sample pipeline (8), second sample ring (9) with injection valve (7) intercommunication, the sample injection valve (7) can be of an integral structure or a split structure.
2. The multirange sample injection device of claim 1, wherein: sampling valve (7) is overall structure, one of them opening on the overall structure passes through first kind pipeline (8) with first main entrance (2), one of them opening on the overall structure passes through second kind pipeline (9) with the opening of second main entrance (3) is linked together, all the other openings on sampling valve (7) respectively with sample pipeline (11) reagent pipeline (10) reaction pipeline (13) with waste liquid pipeline (12) intercommunication.
3. The multi-range sample injection device of claim 1, wherein: injection valve (7) are for dividing the body structure, divide structural one of them opening of body to pass through first kind pipeline (8) with first main entrance (2), divide structural wherein another opening of body to pass through second kind pipeline (9) with the opening of second main entrance (3) is linked together, all the other openings on injection valve (7) respectively with sample pipeline (11) reagent pipeline (10) reaction pipeline (13) with waste liquid pipeline (12) intercommunication.
4. The multi-range sample injection device of claim 1, wherein: the first main channel (2) and the second main channel (3) are arranged on the circumference of the inner circle of the valve body, and the first side channel (4) and the second side channel (5) are arranged on the circumference of the outer circle of the first main channel (2) and the second main channel (3) in a circular array.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210216637.9A CN114578080A (en) | 2022-03-07 | 2022-03-07 | Multi-range sample injection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210216637.9A CN114578080A (en) | 2022-03-07 | 2022-03-07 | Multi-range sample injection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114578080A true CN114578080A (en) | 2022-06-03 |
Family
ID=81772802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210216637.9A Withdrawn CN114578080A (en) | 2022-03-07 | 2022-03-07 | Multi-range sample injection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114578080A (en) |
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2022
- 2022-03-07 CN CN202210216637.9A patent/CN114578080A/en not_active Withdrawn
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Application publication date: 20220603 |