CN114558241B - 一种基于聚合物可溶性微针的给药式内窥镜装置 - Google Patents
一种基于聚合物可溶性微针的给药式内窥镜装置 Download PDFInfo
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Abstract
本发明公开了一种基于聚合物可溶性微针的给药式内窥镜装置,包括:可溶性微针贴片、内窥镜、PDMS基体,此PDMS基体一表面与内窥镜导管前端支撑基板相连,另一表面与微针贴片相连。该微针给药装置使用可溶性微针,不仅可以用于小分子药物递送,还可用于疫苗、胰岛素和蛋白多肽等生物大分子药物的递送。在使用此给药装置时,通过在内窥镜操作端施加压力,使内窥镜内部支撑基板伸出,将微针贴片脱离于PDMS基体后贴敷于患处,从而实现内窥镜检查的同时进行精准给药。
Description
技术领域
本发明涉及生物医疗技术领域,更具体地,涉及一种聚合物可溶性微针的给药式内窥镜装置。
背景技术
药物进入人体的主要输送方式包括注射和口服。近年来,微针给药方式越来越吸引人们的关注。微针一种类似注射针头的微米级空心或实心针,用单晶硅材料、金属或高分子聚合物制作而成,直径在30-80微米,长度100-1000微米。它可以恰好穿过角质层而不触及痛觉神经,在起到促渗作用的同时又不引起痛感和皮肤损伤。
近年来随着高分子聚合物材料的发展,可溶性微针的发展十分的迅速。可溶性微针的结构类似于固体微针,但其往往是由各种可以在皮肤内溶解的聚合物或多糖等生物相容性材料组成的。可溶性微针在刺穿角质层后,针体在皮肤内溶解并释放药物。
相较固体微针,可溶性微针可以在皮肤内溶解,即使在皮肤内断裂也不会对人体产生较为严重的损伤,且残留少,生物污染风险更低。可溶性微针在使用后往往不产生残留,这是其最大的优点,但正因其针体完全溶解在皮肤中,用来制作可溶性微针的材料需严格考察生物毒性,以避免对人体产生预期外的毒副作用。
内窥镜技术由于其诊疗的高准确性,创伤小,不易感染,手术后恢复快,几乎没有疤痕等优点而受到了医学界的广泛关注,成为了全球医疗器械行业增长最快的产品之一,但内窥镜在检查患处时,不能够实现立即给药。
因此,本发明利用内窥镜和可溶性微针相结合,设计出了一款可以在内窥镜检查患处的同时实现精准给药,能够极大提高工作效率,并且使药物吸收效果更好。
发明内容
有鉴于此,本发明提供一种可以定量控制、高效、准确和可重复利用的一种可溶性微针的给药式内窥镜装置。
为实现上述目的,本发明采用的技术方案为一种基于聚合物可溶性微针的给药式内窥镜装置,包括:可溶性微针贴片,可溶性微针贴片与PDMS基体贴附连接;所述PDMS基体结构的一面设有凹槽,用于连接内窥镜导管并锁紧,PDMS基体结构的另一面平滑,用于连接可溶性微针贴片;还包括内窥镜,内窥镜的导管头部设有凸起,用于与PDMS基体的凹槽相配合,起到锁紧结构作用。
进一步地,上述的可溶性微针贴片为聚合物可溶性微针,材料为PVP(聚乙烯吡咯烷酮)、HA(透明质酸)、PVA(聚乙烯醇)等可溶性基材及其复合材料。
进一步地,可溶性微针贴片的微针高度200-2000微米,底部直径100-500微米,尖端逐渐变细,尖端宽度为10-50微米。
进一步地,为满足内窥镜工作,在PDMS基体中央开直径与内窥镜镜头直径大小相同的通孔。
进一步地,内窥镜头部设有突起与PDMS基体上的凹槽相配合,利用弹性和尺寸差锁紧结构,突起的直径略大于凹槽直径,高度与PDMS基体凹槽一致。
进一步地,微针贴片与PDMS基体机械连接(粘接连接、卡扣式连接、螺纹连接等)。为满足内窥镜工作,在微针贴片上开直径与内窥镜镜头直径大小相同通孔。
进一步地,微针贴片为替换结构,当可溶性微针贴片使用过后,可用新微针贴片替换,实现反复利用,以达到成本降低。
可溶性微针材料为PVP(聚乙烯吡咯烷酮)、HA(透明质酸)、PVA(聚乙烯醇)等可溶性基材及其复合材料。PVA有较高强度,生物可溶性高,HA含水效果好,将这两种材料的优点结合起来,从而达到较好的效果。采用分别干燥,再黏合的制备方法,不仅减少了制备周期,还提高了微针成型效果。利用HA/PVA片的粘合性好特点,在微针阵列上均匀涂抹PVA粘合剂,将基底和针体直接黏合,最后真空干燥箱中进行干燥,即可得到可溶性微针阵列。
通过PDMS基体使可溶性微针贴片和内窥镜导管连接起来,并起到与内窥镜导管锁紧的作用。
为满足内窥镜工作,在PDMS基体中间开直径为内窥镜镜头直径的通孔。在PDMS基体开三个小通孔,用于内窥镜发光部和机械手通过。
为满足内窥镜工作,在微针贴片上开直径为内窥镜镜头直径的通孔。在微针贴片上开一个小通孔用于内窥镜发光部通过。
连接基体的材料为PDMS。
内窥镜导管前端设有发光部和机械手。
与现有技术相比较,该微针给药装置使用可溶性微针,不仅可以用于小分子药物递送,还可用于疫苗、胰岛素和蛋白多肽等生物大分子药物的递送。在使用此给药装置时,通过在内窥镜操作端施加压力,使内窥镜内部支撑基板伸出,将微针贴片脱离于PDMS基体后贴敷于患处,从而实现内窥镜检查的同时进行精准给药。
附图说明
图1为微针贴片立体图。
图2为PDMS基体立体图(正面)。
图3为PDMS基体立体图(反面)。
图4为内窥镜剖视图。
图5为整体组合图。
图6为整体组合图。
图中:1、可溶性微针贴片,2、PDMS基体,3、内窥镜。
具体实施方式
参考如下面参考附图详细描述的实施方式,本公开的其他优点和特征以及实现其他优点和特征的方法将变得显而易见。然而,本公开不限于下面公开的实施方式,而是可以以许多不同的形式实施。那些实施方式仅允许完成本公开。这些实施方式允许本领域技术人员完全理解本公开。本公开的范围不由实施方式限定,而是由所附权利要求限定。
为了使公众对本发明有彻底的了解,在以下本发明优选实施例中详细说明了具体的细节,而对本领域技术人员来说没有这些细节的描述也可以完全理解本发明。
以下结合附图进一步说明,图1为可溶性微针贴片立体图,中央有直径为内窥镜镜头直径的通孔方便内窥镜通过。微针阵列为垂直于基体并均匀排布形成的微针阵列;所述的微针包括载药针体和不载药基座;所述的载药针体为圆锥体,其载药针体底部最大边长为500μm,针体高度最大为2000μm。
用于连接微针贴片和内窥镜导管的PDMS基体,PDMS基体一面设有凹槽,另一面平整。
内窥镜导管前端有与PDMS基体相配合的突起。
PDMS基体的存在,使微针贴片和内窥镜导管连接起来,并起到与内窥镜导管锁紧的作用。
为满足内窥镜工作,在PDMS基体中间开直径为内窥镜镜头直径的通孔。在PDMS基体上需开三个小通孔用于内窥镜发光部和机械手通过。
为满足内窥镜工作,在微针贴片上开直径为内窥镜镜头直径的通孔。在微针贴片上需开一个小通孔用于内窥镜发光部通过。
连接基体的材料为PDMS。
内窥镜导管前端设有发光部和机械手。
图2为PDMS基体立体图,中央有直径为内窥镜镜头直径的通孔方便内窥镜通过。另外设有一个内窥镜发光部通过孔,和两个操作机械手通过孔。
图3为PDMS基体另一方向的立体图。
根据图5所示,使用时将微针贴片连接在PDMS基体的一端上,PDMS基体的另一端与内窥镜前端利用凹槽与突起相连接,并起到锁紧的作用。
当内窥镜伸入体内发现患处时,例如胃镜手术,目前采用电烧电凝或者套扎等方式,在手术后会留下一定的创面,利用此装置可以实现在手术过后用压力或用机械手将微针贴片作用于患处,实现对伤口的立即给药并促进伤口的快速愈合。
当一次给药结束后,可以再次将新的微针贴片连接到PDMS基体上,实现多次利用,以降低成本。
Claims (2)
1.一种基于聚合物可溶性微针的给药式内窥镜装置,其特征在于:包括:可溶性微针贴片,可溶性微针贴片与PDMS基体贴附连接;所述PDMS基体结构的一面设有凹槽,用于连接内窥镜导管并锁紧,PDMS基体结构的另一面平滑,用于连接可溶性微针贴片;还包括内窥镜,内窥镜的导管头部设有凸起,用于与PDMS基体的凹槽相配合,起到锁紧结构作用;
上述的可溶性微针贴片为聚合物可溶性微针,材料为PVP聚乙烯吡咯烷酮、HA透明质酸、PVA聚乙烯醇等可溶性基材及其复合材料;
可溶性微针贴片的微针高度200-2000微米,底部直径100-500微米,尖端逐渐变细,尖端宽度为10-50微米;
为满足内窥镜工作,在PDMS基体中央开直径与内窥镜镜头直径大小相同的通孔;
内窥镜头部设有突起与PDMS基体上的凹槽相配合,利用弹性和尺寸差锁紧结构,突起的直径大于凹槽直径,高度与PDMS基体凹槽一致;
微针贴片与PDMS基体机械连接,机械连接包括粘接连接、卡扣式连接、螺纹连接;
微针贴片为替换结构,当可溶性微针贴片使用过后,用新可溶性微针贴片替换,实现反复利用;
在PDMS基体中间开直径为内窥镜镜头直径的通孔;在PDMS基体开三个小通孔,用于内窥镜发光部和机械手通过;在微针贴片上开直径为内窥镜镜头直径的通孔;在微针贴片上开一个小通孔用于内窥镜发光部通过。
2.根据权利要求1所述的一种基于聚合物可溶性微针的给药式内窥镜装置,其特征在于:内窥镜导管前端设有发光部和机械手。
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