CN114555558B - 化合物的盐及其晶型 - Google Patents

化合物的盐及其晶型 Download PDF

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Publication number
CN114555558B
CN114555558B CN202080071856.1A CN202080071856A CN114555558B CN 114555558 B CN114555558 B CN 114555558B CN 202080071856 A CN202080071856 A CN 202080071856A CN 114555558 B CN114555558 B CN 114555558B
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China
Prior art keywords
water
iii
solvent
compound
salt
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CN202080071856.1A
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English (en)
Chinese (zh)
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CN114555558A (zh
Inventor
李文姬
冯玲
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Hutchmed Ltd
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Hutchison Medipharma Ltd
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Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Priority to CN202411778340.7A priority Critical patent/CN119462616A/zh
Priority to CN202411784884.4A priority patent/CN119751422A/zh
Publication of CN114555558A publication Critical patent/CN114555558A/zh
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Publication of CN114555558B publication Critical patent/CN114555558B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/225—Saturated compounds having only one carboxyl group and containing keto groups containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202080071856.1A 2019-10-14 2020-10-13 化合物的盐及其晶型 Active CN114555558B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202411778340.7A CN119462616A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型
CN202411784884.4A CN119751422A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910973785 2019-10-14
CN2019109737853 2019-10-14
PCT/CN2020/120594 WO2021073494A1 (en) 2019-10-14 2020-10-13 The salts of a compound and the crystalline forms thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202411784884.4A Division CN119751422A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型
CN202411778340.7A Division CN119462616A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型

Publications (2)

Publication Number Publication Date
CN114555558A CN114555558A (zh) 2022-05-27
CN114555558B true CN114555558B (zh) 2024-12-17

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CN202080071856.1A Active CN114555558B (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型
CN202411778340.7A Pending CN119462616A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型
CN202411784884.4A Pending CN119751422A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型

Family Applications After (2)

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CN202411778340.7A Pending CN119462616A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型
CN202411784884.4A Pending CN119751422A (zh) 2019-10-14 2020-10-13 化合物的盐及其晶型

Country Status (14)

Country Link
US (1) US12559472B2 (enExample)
EP (1) EP4045484A4 (enExample)
JP (2) JP2022552329A (enExample)
KR (1) KR20220088712A (enExample)
CN (3) CN114555558B (enExample)
AR (1) AR120202A1 (enExample)
AU (1) AU2020367905A1 (enExample)
BR (1) BR112022007035A2 (enExample)
CA (1) CA3154064A1 (enExample)
IL (1) IL292206B2 (enExample)
MX (1) MX2022004274A (enExample)
TW (1) TWI895290B (enExample)
UA (1) UA129777C2 (enExample)
WO (1) WO2021073494A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022411531B2 (en) * 2021-12-13 2025-01-16 Abbisko Therapeutics Co., Ltd. Fgfr4 inhibitor acid salt, preparation method therefor, and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105143185A (zh) * 2013-03-15 2015-12-09 和记黄埔医药（上海）有限公司 新的嘧啶和吡啶化合物以及它们的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR079257A1 (es) * 2009-12-07 2012-01-04 Novartis Ag Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas
CN107660200B (zh) * 2015-04-14 2022-01-11 卫材R&D管理有限公司 结晶fgfr4抑制剂化合物和其用途
TW201833112A (zh) * 2016-12-01 2018-09-16 大陸商和記黃埔醫藥（上海）有限公司 化合物的晶型

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105143185A (zh) * 2013-03-15 2015-12-09 和记黄埔医药（上海）有限公司 新的嘧啶和吡啶化合物以及它们的用途

Also Published As

Publication number Publication date
JP2025143319A (ja) 2025-10-01
CN119462616A (zh) 2025-02-18
IL292206A (en) 2022-06-01
BR112022007035A2 (pt) 2022-06-28
US12559472B2 (en) 2026-02-24
WO2021073494A1 (en) 2021-04-22
IL292206B2 (en) 2026-03-01
EP4045484A4 (en) 2023-09-06
AR120202A1 (es) 2022-02-02
CA3154064A1 (en) 2021-04-22
KR20220088712A (ko) 2022-06-28
TWI895290B (zh) 2025-09-01
AU2020367905A1 (en) 2022-04-21
JP2022552329A (ja) 2022-12-15
CN114555558A (zh) 2022-05-27
US20230121346A1 (en) 2023-04-20
TW202128669A (zh) 2021-08-01
UA129777C2 (uk) 2025-07-30
IL292206B1 (en) 2025-11-01
EP4045484A1 (en) 2022-08-24
CN119751422A (zh) 2025-04-04
MX2022004274A (es) 2022-05-06

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